{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:18:45Z","timestamp":1792412325741,"version":"4.4.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"7992","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2023,12,21]]},"DOI":"10.1038\/s41586-023-06775-1","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T17:02:05Z","timestamp":1699376525000},"page":"663-671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Recognition of methamphetamine and other amines by trace amine receptor TAAR1"],"prefix":"10.1038","volume":"624","author":[{"given":"Heng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-2922","authenticated-orcid":false,"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-5480","authenticated-orcid":false,"given":"Xinheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingning","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-369X","authenticated-orcid":false,"given":"Wenbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4176-8844","authenticated-orcid":false,"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-8144","authenticated-orcid":false,"given":"H. Eric","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-3901","authenticated-orcid":false,"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"6775_CR1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1124\/pr.117.015305","volume":"70","author":"RR Gainetdinov","year":"2018","unstructured":"Gainetdinov, R. R., Hoener, M. C. & Berry, M. D. Trace amines and their receptors. Pharmacol. Rev. 70, 549\u2013620 (2018).","journal-title":"Pharmacol. Rev."},{"key":"6775_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10571-020-00792-8","volume":"40","author":"J Liu","year":"2020","unstructured":"Liu, J., Wu, R. & Li, J.-X. TAAR1 and psychostimulant addiction. Cell. Mol. Neurobiol. 40, 229\u2013238 (2020).","journal-title":"Cell. Mol. Neurobiol."},{"key":"6775_CR3","unstructured":"Most overdose deaths involve illicitly manufactured fentanyls. CDC www.cdc.gov\/drugoverdose\/featured-topics\/overdose-deaths-data.html (2020)."},{"key":"6775_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.pharmthera.2017.07.002","volume":"180","author":"MD Berry","year":"2017","unstructured":"Berry, M. D., Gainetdinov, R. R., Hoener, M. C. & Shahid, M. Pharmacology of human trace amine-associated receptors: therapeutic opportunities and challenges. Pharmacol. Ther. 180, 161\u2013180 (2017).","journal-title":"Pharmacol. Ther."},{"key":"6775_CR5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.neubiorev.2020.09.028","volume":"120","author":"S Dodd","year":"2021","unstructured":"Dodd, S. et al. Trace amine-associated receptor 1 (TAAR1): a new drug target for psychiatry? Neurosci. Biobehavi. Rev. 120, 537\u2013541 (2021).","journal-title":"Neurosci. Biobehavi. Rev."},{"key":"6775_CR6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1021\/acsmedchemlett.1c00527","volume":"13","author":"MLR Heffernan","year":"2022","unstructured":"Heffernan, M. L. R. et al. Ulotaront: A TAAR1 agonist for the treatment of schizophrenia. ACS Med. Chem. Lett. 13, 92\u201398 (2022).","journal-title":"ACS Med. Chem. Lett."},{"key":"6775_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41380-021-01250-7","volume":"27","author":"PC Nair","year":"2022","unstructured":"Nair, P. C. et al. Binding of SEP-363856 within TAAR1 and the 5HT1A receptor: implications for the design of novel antipsychotic drugs. Mol. Psychiatry 27, 88\u201394 (2022).","journal-title":"Mol. Psychiatry"},{"key":"6775_CR8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3109\/15563650.2010.516752","volume":"48","author":"LJ Schep","year":"2010","unstructured":"Schep, L. J., Slaughter, R. J. & Beasley, D. M. The clinical toxicology of metamfetamine. Clin. Toxicol. 48, 675\u2013694 (2010).","journal-title":"Clin. Toxicol."},{"key":"6775_CR9","doi-asserted-by":"publisher","first-page":"113795","DOI":"10.1016\/j.expneurol.2021.113795","volume":"344","author":"S Jayanthi","year":"2021","unstructured":"Jayanthi, S., Daiwile, A. P. & Cadet, J. L. Neurotoxicity of methamphetamine: main effects and mechanisms. Exp. Neurol. 344, 113795 (2021).","journal-title":"Exp. Neurol."},{"key":"6775_CR10","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1111\/add.14755","volume":"114","author":"B Chan","year":"2019","unstructured":"Chan, B. et al. Pharmacotherapy for methamphetamine\/amphetamine use disorder\u2014a systematic review and meta-analysis. Addiction 114, 2122\u20132136 (2019).","journal-title":"Addiction"},{"key":"6775_CR11","doi-asserted-by":"crossref","unstructured":"Bisagno, V. & Cadet, J. L. in Handbook of Neurotoxicity (ed. Kostrzewa, R.M.) 563\u2013585 (Springer, 2022).","DOI":"10.1007\/978-3-031-15080-7_80"},{"key":"6775_CR12","doi-asserted-by":"crossref","unstructured":"Grandy, D. K. in Neuropathology of Drug Addictions and Substance Misuse (ed. Preedy, V. R.) 108\u2013116 (Academic Press, 2016).","DOI":"10.1016\/B978-0-12-800212-4.00010-8"},{"key":"6775_CR13","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1471-4159.2010.07109.x","volume":"116","author":"GM Miller","year":"2011","unstructured":"Miller, G. M. The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J. Neurochem. 116, 164\u2013176 (2011).","journal-title":"J. Neurochem."},{"key":"6775_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1471-4159.2004.02501.x","volume":"90","author":"MD Berry","year":"2004","unstructured":"Berry, M. D. Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J. Neurochem. 90, 257\u2013271 (2004).","journal-title":"J. Neurochem."},{"key":"6775_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/13543776.2020.1708900","volume":"30","author":"M Tonelli","year":"2020","unstructured":"Tonelli, M. & Cichero, E. Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010\u2013present). Expert Opin.Ther. Pat. 30, 137\u2013145 (2020).","journal-title":"Expert Opin.Ther. Pat."},{"key":"6775_CR16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10571-019-00774-5","volume":"40","author":"Z Xu","year":"2020","unstructured":"Xu, Z. & Li, Q. TAAR agonists. Cell. Mol. Neurobiol. 40, 257\u2013272 (2020).","journal-title":"Cell. Mol. Neurobiol."},{"key":"6775_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.pbb.2011.10.025","volume":"101","author":"C Achat-Mendes","year":"2012","unstructured":"Achat-Mendes, C., Lynch, L. J., Sullivan, K. A., Vallender, E. J. & Miller, G. M. Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol. Biochem. Behav. 101, 201\u2013207 (2012).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"6775_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fnins.2015.00039","volume":"9","author":"R Cotter","year":"2015","unstructured":"Cotter, R. et al. The trace amine-associated receptor 1 modulates methamphetamine\u2019s neurochemical and behavioral effects. Front. Neurosci. 9, 39 (2015).","journal-title":"Front. Neurosci."},{"key":"6775_CR19","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41380-019-0469-2","volume":"26","author":"SM Underhill","year":"2021","unstructured":"Underhill, S. M. et al. Amphetamines signal through intracellular TAAR1 receptors coupled to G\u03b113 and G\u03b1S in discrete subcellular domains. Mol. Psychiatry 26, 1208\u20131223 (2021).","journal-title":"Mol. Psychiatry"},{"key":"6775_CR20","doi-asserted-by":"publisher","first-page":"e0151023","DOI":"10.1371\/journal.pone.0151023","volume":"11","author":"S-i Eyun","year":"2016","unstructured":"Eyun, S.-i, Moriyama, H., Hoffmann, F. G. & Moriyama, E. N. Molecular evolution and functional divergence of trace amine\u2013associated receptors. PLoS ONE 11, e0151023 (2016).","journal-title":"PLoS ONE"},{"key":"6775_CR21","doi-asserted-by":"crossref","unstructured":"Accorroni, A. & Zucchi, R. in Trace Amines and Neurological Disorders (eds Farooqui, T. & Farooqui, A. A.) 151\u2013164 (Academic Press, 2016).","DOI":"10.1016\/B978-0-12-803603-7.00011-2"},{"key":"6775_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.conb.2015.01.001","volume":"34","author":"SD Liberles","year":"2015","unstructured":"Liberles, S. D. Trace amine-associated receptors: ligands, neural circuits, and behaviors. Curr. Opin. Neurobiol. 34, 1\u20137 (2015).","journal-title":"Curr. Opin. Neurobiol."},{"key":"6775_CR23","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.neubiorev.2021.09.020","volume":"131","author":"Y Alnefeesi","year":"2021","unstructured":"Alnefeesi, Y. et al. Trace amine-associated receptor 1 (TAAR1): potential application in mood disorders: a systematic review. Neurosci. Biobehav. Rev. 131, 192\u2013210 (2021).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"6775_CR24","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1124\/jpet.107.132647","volume":"324","author":"L Lothar","year":"2008","unstructured":"Lothar, L. et al. Trace amine-associated receptor 1 modulates dopaminergic activity. J. Pharmacol. Exp. Ther. 324, 948 (2008).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"6775_CR25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/mp.2012.57","volume":"18","author":"FG Revel","year":"2013","unstructured":"Revel, F. G. et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol. Psychiatry 18, 543\u2013556 (2013).","journal-title":"Mol. Psychiatry"},{"key":"6775_CR26","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1007\/s40263-021-00871-4","volume":"35","author":"R Wu","year":"2021","unstructured":"Wu, R. & Li, J.-X. Potential of ligands for trace amine-associated receptor 1 (TAAR1) in the management of substance use disorders. CNS Drugs 35, 1239\u20131248 (2021).","journal-title":"CNS Drugs"},{"key":"6775_CR27","doi-asserted-by":"publisher","first-page":"5244","DOI":"10.1016\/j.bmcl.2012.06.060","volume":"22","author":"G Galley","year":"2012","unstructured":"Galley, G., Stalder, H., Goergler, A., Hoener, M. C. & Norcross, R. D. Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg. Med. Chem. Lett. 22, 5244\u20135248 (2012).","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"6775_CR28","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1021\/acsmedchemlett.5b00449","volume":"7","author":"G Galley","year":"2016","unstructured":"Galley, G. et al. Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists. ACS Med. Chem. Lett. 7, 192\u2013197 (2016).","journal-title":"ACS Med. Chem. Lett."},{"key":"6775_CR29","doi-asserted-by":"publisher","first-page":"110555","DOI":"10.1016\/j.pnpbp.2022.110555","volume":"117","author":"\u00cd Raony","year":"2022","unstructured":"Raony, \u00cd., Domith, I., Lourenco, M. V., Paes-de-Carvalho, R. & Pandolfo, P. Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD. Prog. Neuropsychopharmacol. Biol. Psychiatry 117, 110555 (2022).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"6775_CR30","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1038\/npp.2014.88","volume":"39","author":"Y Pei","year":"2014","unstructured":"Pei, Y. et al. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology 39, 2299\u20132308 (2014).","journal-title":"Neuropsychopharmacology"},{"key":"6775_CR31","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1124\/mol.108.048884","volume":"74","author":"LS Barak","year":"2008","unstructured":"Barak, L. S. et al. Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Mol. Pharmacol. 74, 585\u2013594 (2008).","journal-title":"Mol. Pharmacol."},{"key":"6775_CR32","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1038\/s41386-022-01421-2","volume":"47","author":"M Saarinen","year":"2022","unstructured":"Saarinen, M. et al. TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1\/5-HT(1A) receptor agonist SEP-383856. Neuropsychopharmacology 47, 2319\u20132329 (2022).","journal-title":"Neuropsychopharmacology"},{"key":"6775_CR33","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41586-021-03376-8","volume":"592","author":"P Xu","year":"2021","unstructured":"Xu, P. et al. Structural insights into the lipid and ligand regulation of serotonin receptors. Nature 592, 469\u2013473 (2021).","journal-title":"Nature"},{"key":"6775_CR34","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1124\/jpet.106.115402","volume":"321","author":"EA Reese","year":"2007","unstructured":"Reese, E. A., Bunzow, J. R., Arttamangkul, S., Sonders, M. S. & Grandy, D. K. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J. Pharmacol. Exp. Ther. 321, 178\u2013186 (2007).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"6775_CR35","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.str.2012.04.010","volume":"20","author":"E Chun","year":"2012","unstructured":"Chun, E. et al. Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure 20, 967\u2013976 (2012).","journal-title":"Structure"},{"key":"6775_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17933-8","volume":"11","author":"J Duan","year":"2020","unstructured":"Duan, J. et al. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat. Commun. 11, 4121 (2020).","journal-title":"Nat. Commun."},{"key":"6775_CR37","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1038\/aps.2016.69","volume":"37","author":"P Liu","year":"2016","unstructured":"Liu, P. et al. The structural basis of the dominant negative phenotype of the G\u03b1i1\u03b21\u03b32 G203A\/A326S heterotrimer. Acta Pharmacol. Sin. 37, 1259\u20131272 (2016).","journal-title":"Acta Pharmacol. Sin."},{"key":"6775_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06002-w","volume":"9","author":"S Maeda","year":"2018","unstructured":"Maeda, S. et al. Development of an antibody fragment that stabilizes GPCR\/G-protein complexes. Nat. Commun. 9, 3712 (2018).","journal-title":"Nat. Commun."},{"key":"6775_CR39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.tips.2014.11.001","volume":"36","author":"V Isberg","year":"2015","unstructured":"Isberg, V. et al. Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends Pharmacol. Sci. 36, 22\u201331 (2015).","journal-title":"Trends Pharmacol. Sci."},{"key":"6775_CR40","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.cell.2021.01.027","volume":"184","author":"Y Zhuang","year":"2021","unstructured":"Zhuang, Y. et al. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell 184, 931\u2013942.e918 (2021).","journal-title":"Cell"},{"key":"6775_CR41","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1021\/cb800304d","volume":"4","author":"ES Tan","year":"2009","unstructured":"Tan, E. S. et al. The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). ACS Chem. Biol. 4, 209\u2013220 (2009).","journal-title":"ACS Chem. Biol."},{"key":"6775_CR42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/cbdd.12018","volume":"81","author":"E Cichero","year":"2013","unstructured":"Cichero, E., Espinoza, S., Gainetdinov, R. R., Brasili, L. & Fossa, P. Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modelling and docking studies. Chem. Biol. Drug Des. 81, 509\u2013516 (2013).","journal-title":"Chem. Biol. Drug Des."},{"key":"6775_CR43","doi-asserted-by":"publisher","first-page":"120553","DOI":"10.1016\/j.lfs.2022.120553","volume":"300","author":"S Liao","year":"2022","unstructured":"Liao, S., Pino, M. J. Jr., Deleon, C., Lindner-Jackson, M. & Wu, C. Interaction analyses of hTAAR1 and mTAAR1 with antagonist EPPTB. Life Sci. 300, 120553 (2022).","journal-title":"Life Sci."},{"key":"6775_CR44","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1021\/jm401316v","volume":"57","author":"EA Reese","year":"2014","unstructured":"Reese, E. A. et al. Exploring the determinants of trace amine-associated receptor 1\u2019s functional selectivity for the stereoisomers of amphetamine and methamphetamine. J. Med. Chem. 57, 378\u2013390 (2014).","journal-title":"J. Med. Chem."},{"key":"6775_CR45","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1016\/j.molcel.2022.05.031","volume":"82","author":"S Huang","year":"2022","unstructured":"Huang, S. et al. GPCRs steer G(i) and G(s) selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol. Cell 82, 2681\u20132695.e2686 (2022).","journal-title":"Mol. Cell"},{"key":"6775_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31823-1","volume":"13","author":"M Su","year":"2022","unstructured":"Su, M. et al. Structures of \u03b21-adrenergic receptor in complex with Gs and ligands of different efficacies. Nat. Commun. 13, 4095 (2022).","journal-title":"Nat. Commun."},{"key":"6775_CR47","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/s41586-022-05258-z","volume":"610","author":"AL Kaplan","year":"2022","unstructured":"Kaplan, A. L. et al. Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity. Nature 610, 582\u2013591 (2022).","journal-title":"Nature"},{"key":"6775_CR48","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41421-022-00412-3","volume":"8","author":"Y Tan","year":"2022","unstructured":"Tan, Y. et al. Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A. Cell Discov. 8, 50 (2022).","journal-title":"Cell Discov."},{"key":"6775_CR49","doi-asserted-by":"publisher","first-page":"8966","DOI":"10.1073\/pnas.151105198","volume":"98","author":"B Borowsky","year":"2001","unstructured":"Borowsky, B. et al. Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proc. Natl Acad. Sci. USA 98, 8966\u20138971 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"6775_CR50","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41421-020-0176-9","volume":"6","author":"Y Zhang","year":"2020","unstructured":"Zhang, Y. et al. Single-particle cryo-EM structural studies of the \u03b22AR\u2013Gs complex bound with a full agonist formoterol. Cell Discov. 6, 45 (2020).","journal-title":"Cell Discov."},{"key":"6775_CR51","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41589-019-0457-5","volume":"16","author":"S Imai","year":"2020","unstructured":"Imai, S. et al. Structural equilibrium underlying ligand-dependent activation of \u03b22-adrenoreceptor. Nat. Chem. Biol. 16, 430\u2013439 (2020).","journal-title":"Nat. Chem. Biol."},{"key":"6775_CR52","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nature18636","volume":"535","author":"DP Staus","year":"2016","unstructured":"Staus, D. P. et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature 535, 448\u2013452 (2016).","journal-title":"Nature"},{"key":"6775_CR53","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3389\/fphar.2018.00953","volume":"9","author":"VM Lam","year":"2018","unstructured":"Lam, V. M. et al. Behavioral effects of a potential novel TAAR1 antagonist. Front. Pharmacol. 9, 953 (2018).","journal-title":"Front. Pharmacol."},{"key":"6775_CR54","doi-asserted-by":"publisher","first-page":"20081","DOI":"10.1073\/pnas.0906522106","volume":"106","author":"A Bradaia","year":"2009","unstructured":"Bradaia, A. et al. The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc. Natl Acad. Sci. USA 106, 20081\u201320086 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"6775_CR55","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41586-023-06106-4","volume":"618","author":"L Guo","year":"2023","unstructured":"Guo, L. et al. Structural basis of amine odorant perception by a mammal olfactory receptor. Nature 618, 193\u2013200 (2023).","journal-title":"Nature"},{"key":"6775_CR56","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature18966","volume":"536","author":"B Carpenter","year":"2016","unstructured":"Carpenter, B., Nehm\u00e9, R., Warne, T., Leslie, A. G. & Tate, C. G. Structure of the adenosine A(2A) receptor bound to an engineered G protein. Nature 536, 104\u2013107 (2016).","journal-title":"Nature"},{"key":"6775_CR57","doi-asserted-by":"publisher","first-page":"e35946","DOI":"10.7554\/eLife.35946","volume":"7","author":"J Garc\u00eda-Nafr\u00eda","year":"2018","unstructured":"Garc\u00eda-Nafr\u00eda, J., Lee, Y., Bai, X., Carpenter, B. & Tate, C. G. Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein. eLife 7, e35946 (2018).","journal-title":"eLife"},{"key":"6775_CR58","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jsb.2005.07.007","volume":"152","author":"DN Mastronarde","year":"2005","unstructured":"Mastronarde, D. N. Automated electron microscope tomography using robust prediction of specimen movements. J. Struct. Biol. 152, 36\u201351 (2005).","journal-title":"J. Struct. Biol."},{"key":"6775_CR59","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nmeth.4193","volume":"14","author":"SQ Zheng","year":"2017","unstructured":"Zheng, S. Q. et al. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Nat. Methods 14, 331\u2013332 (2017).","journal-title":"Nat. Methods"},{"key":"6775_CR60","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nmeth.4169","volume":"14","author":"A Punjani","year":"2017","unstructured":"Punjani, A., Rubinstein, J. L., Fleet, D. J. & Brubaker, M. A. cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Nat. Methods 14, 290\u2013296 (2017).","journal-title":"Nat. Methods"},{"key":"6775_CR61","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583\u2013589 (2021).","journal-title":"Nature"},{"key":"6775_CR62","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen, E. F. et al. UCSF Chimera\u2013a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605\u20131612 (2004).","journal-title":"J. Comput. Chem."},{"key":"6775_CR63","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D\u00a060, 2126\u20132132 (2004).","journal-title":"Acta Crystallogr. D"},{"key":"6775_CR64","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1107\/S2059798318002425","volume":"74","author":"TI Croll","year":"2018","unstructured":"Croll, T. I. ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Acta Crystallogr. D\u00a074, 519\u2013530 (2018).","journal-title":"Acta Crystallogr. D"},{"key":"6775_CR65","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1107\/S0909049503024130","volume":"11","author":"PD Adams","year":"2004","unstructured":"Adams, P. D. et al. Recent developments in the PHENIX software for automated crystallographic structure determination. J. Synchrotron Radiat. 11, 53\u201355 (2004).","journal-title":"J. Synchrotron Radiat."},{"key":"6775_CR66","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","volume":"30","author":"EF Pettersen","year":"2021","unstructured":"Pettersen, E. F. et al. UCSF ChimeraX: structure visualization for researchers, educators, and developers. Protein Sci. 30, 70\u201382 (2021).","journal-title":"Protein Sci."},{"key":"6775_CR67","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ymeth.2021.10.009","volume":"203","author":"FI Wang","year":"2022","unstructured":"Wang, F. I., Ding, G., Ng, G. S., Dixon, S. J. & Chidiac, P. Luciferase-based GloSensor\u2122 cAMP assay: temperature optimization and application to cell-based kinetic studies. Methods 203, 249\u2013258 (2022).","journal-title":"Methods"},{"key":"6775_CR68","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1038\/npp.2012.109","volume":"37","author":"FG Revel","year":"2012","unstructured":"Revel, F. G. et al. Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine. Neuropsychopharmacology 37, 2580\u20132592 (2012).","journal-title":"Neuropsychopharmacology"},{"key":"6775_CR69","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/s41589-020-0535-8","volume":"16","author":"RHJ Olsen","year":"2020","unstructured":"Olsen, R. H. J. et al. TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. Nat. Chem. Biol. 16, 841\u2013849 (2020).","journal-title":"Nat. Chem. Biol."},{"key":"6775_CR70","doi-asserted-by":"publisher","first-page":"5.6.1","DOI":"10.1002\/cpbi.3","volume":"54","author":"B Webb","year":"2016","unstructured":"Webb, B. & Sali, A. Comparative Protein Structure Modeling Using MODELLER. Curr. Protoc. Bioinformatics 54, 5.6.1\u20135.6.37 (2016).","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"6775_CR71","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1002\/prot.26382","volume":"90","author":"L Heo","year":"2022","unstructured":"Heo, L. & Feig, M. Multi-state modeling of G-protein coupled receptors at experimental accuracy. Proteins 90, 1873\u20131885 (2022).","journal-title":"Proteins"},{"key":"6775_CR72","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1021\/ct100578z","volume":"7","author":"MH Olsson","year":"2011","unstructured":"Olsson, M. H., S\u00f8ndergaard, C. R., Rostkowski, M. & Jensen, J. H. PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions. J. Chem. Theory Comput. 7, 525\u2013537 (2011).","journal-title":"J. Chem. Theory Comput."},{"key":"6775_CR73","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/jcc.21367","volume":"31","author":"K Vanommeslaeghe","year":"2010","unstructured":"Vanommeslaeghe, K. et al. CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J. Comput. Chem. 31, 671\u2013690 (2010).","journal-title":"J. Comput. Chem."},{"key":"6775_CR74","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1002\/jcc.23702","volume":"35","author":"EL Wu","year":"2014","unstructured":"Wu, E. L. et al. CHARMM-GUI Membrane Builder toward realistic biological membrane simulations. J. Comput. Chem. 35, 1997\u20132004 (2014).","journal-title":"J. Comput. Chem."},{"key":"6775_CR75","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nmeth.4067","volume":"14","author":"J Huang","year":"2017","unstructured":"Huang, J. et al. CHARMM36m: an improved force field for folded and intrinsically disordered proteins. Nat. Methods 14, 71\u201373 (2017).","journal-title":"Nat. Methods"},{"key":"6775_CR76","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1021\/ct400314y","volume":"9","author":"R Salomon-Ferrer","year":"2013","unstructured":"Salomon-Ferrer, R., G\u00f6tz, A. W., Poole, D., Le Grand, S. & Walker, R. C. Routine microsecond molecular dynamics simulations with AMBER on GPUs. 2. Explicit solvent particle mesh Ewald. J. Chem. Theory Comput. 9, 3878\u20133888 (2013).","journal-title":"J. Chem. Theory Comput."},{"key":"6775_CR77","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1021\/ct300418h","volume":"8","author":"BR Miller 3rd","year":"2012","unstructured":"Miller, B. R. 3rd et al. MMPBSA.py: an efficient program for end-state free energy calculations. J. Chem. Theory Comput. 8, 3314\u20133321 (2012).","journal-title":"J. Chem. Theory Comput."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06775-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06775-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06775-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T08:03:20Z","timestamp":1703145800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06775-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":77,"journal-issue":{"issue":"7992","published-print":{"date-parts":[[2023,12,21]]}},"alternative-id":["6775"],"URL":"https:\/\/doi.org\/10.1038\/s41586-023-06775-1","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"5 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}