{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:15:26Z","timestamp":1794003326811,"version":"4.8.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7993","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2024,1,4]]},"DOI":"10.1038\/s41586-023-06830-x","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T12:02:28Z","timestamp":1702468948000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Control of lipolysis by a population of oxytocinergic sympathetic neurons"],"prefix":"10.1038","volume":"625","author":[{"given":"Erwei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-2443","authenticated-orcid":false,"given":"Zeran","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon I.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-1156","authenticated-orcid":false,"given":"Samuel","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-8585","authenticated-orcid":false,"given":"Paul","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-708X","authenticated-orcid":false,"given":"Evan D.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"6830_CR1","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nrendo.2017.115","volume":"13","author":"EA Lawson","year":"2017","unstructured":"Lawson, E. A. The effects of oxytocin on eating behaviour and metabolism in humans. Nat. Rev. Endocrinol. 13, 700\u2013709 (2017).","journal-title":"Nat. Rev. Endocrinol."},{"key":"6830_CR2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fnins.2015.00497","volume":"9","author":"A Romano","year":"2016","unstructured":"Romano, A., Tempesta, B., Micioni Di Bonaventura, M. V. & Gaetani, S. From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders. Front. Neurosci. 9, 497 (2016).","journal-title":"Front. Neurosci."},{"key":"6830_CR3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1210\/endrev\/bnz012","volume":"41","author":"SE McCormack","year":"2020","unstructured":"McCormack, S. E., Blevins, J. E. & Lawson, E. A. Metabolic effects of oxytocin. Endocr. Rev. 41, 121\u2013145 (2020).","journal-title":"Endocr. Rev."},{"key":"6830_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/obr.12757","volume":"20","author":"C Ding","year":"2019","unstructured":"Ding, C., Leow, M. S. & Magkos, F. Oxytocin in metabolic homeostasis: implications for obesity and diabetes management. Obes. Rev. 20, 22\u201340 (2019).","journal-title":"Obes. Rev."},{"key":"6830_CR5","doi-asserted-by":"publisher","first-page":"R431","DOI":"10.1152\/ajpregu.00441.2014","volume":"308","author":"JE Blevins","year":"2015","unstructured":"Blevins, J. E. et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 308, R431\u2013R438 (2015).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"6830_CR6","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.physbeh.2015.05.023","volume":"152","author":"JE Blevins","year":"2015","unstructured":"Blevins, J. E. & Baskin, D. G. Translational and therapeutic potential of oxytocin as an anti-obesity strategy: insights from rodents, nonhuman primates and humans. Physiol. Behav. 152, 438\u2013449 (2015).","journal-title":"Physiol. Behav."},{"key":"6830_CR7","doi-asserted-by":"publisher","first-page":"e25565","DOI":"10.1371\/journal.pone.0025565","volume":"6","author":"N Deblon","year":"2011","unstructured":"Deblon, N. et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS ONE 6, e25565 (2011).","journal-title":"PLoS ONE"},{"key":"6830_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/198293a0","volume":"198","author":"RL Burt","year":"1963","unstructured":"Burt, R. L., Leake, N. H. & Dannenburg, W. N. Metabolic activity of oxytocin in the puerperium. Nature 198, 293 (1963).","journal-title":"Nature"},{"key":"6830_CR9","doi-asserted-by":"publisher","first-page":"26808","DOI":"10.1073\/pnas.1913611116","volume":"116","author":"L Sun","year":"2019","unstructured":"Sun, L. et al. Oxytocin regulates body composition. Proc. Natl Acad. Sci. USA 116, 26808\u201326815 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"6830_CR10","doi-asserted-by":"publisher","first-page":"110903","DOI":"10.1016\/j.mce.2020.110903","volume":"514","author":"J Yuan","year":"2020","unstructured":"Yuan, J., Zhang, R., Wu, R., Gu, Y. & Lu, Y. The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis. Mol. Cell. Endocrinol. 514, 110903 (2020).","journal-title":"Mol. Cell. Endocrinol."},{"key":"6830_CR11","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","volume":"3","author":"GF Grabner","year":"2021","unstructured":"Grabner, G. F., Xie, H., Schweiger, M. & Zechner, R. Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nat. Metab. 3, 1445\u20131465 (2021).","journal-title":"Nat. Metab."},{"key":"6830_CR12","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1096\/fasebj.14.10.1345","volume":"14","author":"C Sengen\u00e8s","year":"2000","unstructured":"Sengen\u00e8s, C., Berlan, M., de Glisezinski, I., Lafontan, M. & Galitzky, J. Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J. 14, 1345\u20131351 (2000).","journal-title":"FASEB J."},{"key":"6830_CR13","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","volume":"98","author":"B Jurek","year":"2018","unstructured":"Jurek, B. & Neumann, I. D. The oxytocin receptor: from intracellular signaling to behavior. Physiol. Rev. 98, 1805\u20131908 (2018).","journal-title":"Physiol. Rev."},{"key":"6830_CR14","first-page":"91","volume":"21","author":"M Iovino","year":"2021","unstructured":"Iovino, M. et al. Oxytocin signaling pathway: from cell biology to clinical implications. Endocr. Metab. Immune Disord. Drug Targets 21, 91\u2013110 (2021).","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"6830_CR15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1101\/gad.333617.119","volume":"34","author":"R El-Merahbi","year":"2020","unstructured":"El-Merahbi, R. et al. The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. Genes Dev. 34, 495\u2013510 (2020).","journal-title":"Genes Dev."},{"key":"6830_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ygcen.2019.05.011","volume":"281","author":"J Zong","year":"2019","unstructured":"Zong, J. et al. Bromodomain-containing protein 2 promotes lipolysis via ERK\/HSL signalling pathway in white adipose tissue of mice. Gen. Comp. Endocrinol. 281, 105\u2013116 (2019).","journal-title":"Gen. Comp. Endocrinol."},{"key":"6830_CR17","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1210\/en.2007-1710","volume":"149","author":"H-J Lee","year":"2008","unstructured":"Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G. & Young, W. S. 3rd A conditional knockout mouse line of the oxytocin receptor. Endocrinology 149, 3256\u20133263 (2008).","journal-title":"Endocrinology"},{"key":"6830_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.cmet.2011.02.005","volume":"13","author":"J Eguchi","year":"2011","unstructured":"Eguchi, J. et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 13, 249\u2013259 (2011).","journal-title":"Cell Metab."},{"key":"6830_CR19","doi-asserted-by":"publisher","first-page":"45456","DOI":"10.1074\/jbc.M104436200","volume":"276","author":"AS Greenberg","year":"2001","unstructured":"Greenberg, A. S. et al. Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J. Biol. Chem. 276, 45456\u201345461 (2001).","journal-title":"J. Biol. Chem."},{"key":"6830_CR20","doi-asserted-by":"publisher","first-page":"43615","DOI":"10.1074\/jbc.M301809200","volume":"278","author":"C-L Su","year":"2003","unstructured":"Su, C.-L. et al. Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes. J. Biol. Chem. 278, 43615\u201343619 (2003).","journal-title":"J. Biol. Chem."},{"key":"6830_CR21","doi-asserted-by":"publisher","first-page":"11341","DOI":"10.1016\/S0021-9258(18)99168-4","volume":"266","author":"AS Greenberg","year":"1991","unstructured":"Greenberg, A. S. et al. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266, 11341\u201311346 (1991).","journal-title":"J. Biol. Chem."},{"key":"6830_CR22","doi-asserted-by":"publisher","first-page":"15837","DOI":"10.1074\/jbc.M601097200","volume":"281","author":"H Miyoshi","year":"2006","unstructured":"Miyoshi, H. et al. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and-independent mechanisms. J. Biol. Chem. 281, 15837\u201315844 (2006).","journal-title":"J. Biol. Chem."},{"key":"6830_CR23","doi-asserted-by":"publisher","first-page":"6494","DOI":"10.1073\/pnas.101042998","volume":"98","author":"J Tansey","year":"2001","unstructured":"Tansey, J. et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl Acad. Sci. USA 98, 6494\u20136499 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"6830_CR24","doi-asserted-by":"crossref","unstructured":"Emont, M. P. et al. A single-cell atlas of human and mouse white adipose tissue. Nature 603, 926\u2013933 (2022).","DOI":"10.1038\/s41586-022-04518-2"},{"key":"6830_CR25","doi-asserted-by":"publisher","first-page":"R1445","DOI":"10.1152\/ajpregu.00068.2008","volume":"294","author":"NA Brito","year":"2008","unstructured":"Brito, N. A., Brito, M. N. & Bartness, T. J. Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation. Am. J. Physiol. Reg. Integr. Comp. Physiol. 294, R1445\u2013R1452 (2008).","journal-title":"Am. J. Physiol. Reg. Integr. Comp. Physiol."},{"key":"6830_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.regpep.2006.03.008","volume":"135","author":"B Ohlsson","year":"2006","unstructured":"Ohlsson, B., Truedsson, M., Djerf, P. & Sundler, F. Oxytocin is expressed throughout the human gastrointestinal tract. Regul. Pept. 135, 7\u201311 (2006).","journal-title":"Regul. Pept."},{"key":"6830_CR27","doi-asserted-by":"publisher","first-page":"13084","DOI":"10.1038\/s41598-018-31361-1","volume":"8","author":"G Dayanithi","year":"2018","unstructured":"Dayanithi, G. et al. Vasopressin and oxytocin in sensory neurones: expression, exocytotic release and regulation by lactation. Sci. Rep. 8, 13084 (2018).","journal-title":"Sci. Rep."},{"key":"6830_CR28","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.celrep.2016.12.087","volume":"18","author":"HC Roh","year":"2017","unstructured":"Roh, H. C. et al. Simultaneous transcriptional and epigenomic profiling from specific cell types within heterogeneous tissues in vivo. Cell Rep. 18, 1048\u20131061 (2017).","journal-title":"Cell Rep."},{"key":"6830_CR29","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.cmet.2017.12.011","volume":"27","author":"J Chi","year":"2018","unstructured":"Chi, J. et al. Three-dimensional adipose tissue imaging reveals regional variation in beige fat biogenesis and PRDM16-dependent sympathetic neurite density. Cell Metab. 27, 226\u2013236.e3 (2018).","journal-title":"Cell Metab."},{"key":"6830_CR30","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1002\/cne.25031","volume":"529","author":"C Huesing","year":"2021","unstructured":"Huesing, C. et al. Sympathetic innervation of inguinal white adipose tissue in the mouse. J. Comp. Neurol. 529, 1465\u20131485 (2021).","journal-title":"J. Comp. Neurol."},{"key":"6830_CR31","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41586-021-03830-7","volume":"597","author":"F Cardoso","year":"2021","unstructured":"Cardoso, F. et al. Neuro-mesenchymal units control ILC2 and obesity via a brain\u2013adipose circuit. Nature 597, 410\u2013414 (2021).","journal-title":"Nature"},{"key":"6830_CR32","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1016\/j.celrep.2016.05.034","volume":"15","author":"NR Sciolino","year":"2016","unstructured":"Sciolino, N. R. et al. Recombinase-dependent mouse lines for chemogenetic activation of genetically defined cell types. Cell Rep. 15, 2563\u20132573 (2016).","journal-title":"Cell Rep."},{"key":"6830_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.physbeh.2017.08.024","volume":"190","author":"M Fran\u00e7ois","year":"2018","unstructured":"Fran\u00e7ois, M., Qualls-Creekmore, E., Berthoud, H.-R., M\u00fcnzberg, H. & Yu, S. Genetics-based manipulation of adipose tissue sympathetic innervation. Physiol. Behav. 190, 21\u201327 (2018).","journal-title":"Physiol. Behav."},{"key":"6830_CR34","doi-asserted-by":"publisher","first-page":"E801","DOI":"10.1152\/ajpendo.1993.265.5.E801","volume":"265","author":"S Klein","year":"1993","unstructured":"Klein, S., Sakurai, Y., Romijn, J. A. & Carroll, R. M. Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men. Am. J. Physiol. Endocrinol. Metab. 265, E801\u2013E806 (1993).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"6830_CR35","doi-asserted-by":"publisher","first-page":"558S","DOI":"10.1093\/ajcn\/72.2.558S","volume":"72","author":"JF Horowitz","year":"2000","unstructured":"Horowitz, J. F. & Klein, S. Lipid metabolism during endurance exercise. Am. J. Clin. Nutr. 72, 558S\u2013563S (2000).","journal-title":"Am. J. Clin. Nutr."},{"key":"6830_CR36","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/nrendo.2017.80","volume":"13","author":"MC Petersen","year":"2017","unstructured":"Petersen, M. C., Vatner, D. F. & Shulman, G. I. Regulation of hepatic glucose metabolism in health and disease. Nat. Rev. Endocrinol. 13, 572\u2013587 (2017).","journal-title":"Nat. Rev. Endocrinol."},{"key":"6830_CR37","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1126\/science.1123965","volume":"312","author":"G Haemmerle","year":"2006","unstructured":"Haemmerle, G. et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312, 734\u2013737 (2006).","journal-title":"Science"},{"key":"6830_CR38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2337\/db15-0941","volume":"65","author":"S Wueest","year":"2016","unstructured":"Wueest, S. et al. Mesenteric fat lipolysis mediates obesity-associated hepatic steatosis and insulin resistance. Diabetes 65, 140\u2013148 (2016).","journal-title":"Diabetes"},{"key":"6830_CR39","doi-asserted-by":"crossref","unstructured":"Niu, J., Tong, J. & Blevins, J. E. Oxytocin as an anti-obesity treatment. Front. Neurosci. 15, 743546 (2021).","DOI":"10.3389\/fnins.2021.743546"},{"key":"6830_CR40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41586-019-1156-9","volume":"569","author":"X Zeng","year":"2019","unstructured":"Zeng, X. et al. Innervation of thermogenic adipose tissue via a calsyntenin 3\u03b2\u2013S100b axis. Nature 569, 229\u2013235 (2019).","journal-title":"Nature"},{"key":"6830_CR41","unstructured":"US National Library of Medicine. ClinicalTrials.gov www.clinicaltrials.gov\/study\/NCT03091725?term=NCT03091725&rank=1 (2023)."},{"key":"6830_CR42","doi-asserted-by":"crossref","unstructured":"Chi, J., Crane, A., Wu, Z. & Cohen, P. Adipo-Clear: a tissue clearing method for three-dimensional imaging of adipose tissue. J. Vis. Exp. 137, e58271 (2018).","DOI":"10.3791\/58271-v"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06830-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06830-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06830-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T09:14:43Z","timestamp":1704446083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-023-06830-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":42,"journal-issue":{"issue":"7993","published-print":{"date-parts":[[2024,1,4]]}},"alternative-id":["6830"],"URL":"https:\/\/doi.org\/10.1038\/s41586-023-06830-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.27.509745","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"29 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"E.D.R. receives consulting fees from Novartis. All other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}