{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:57:18Z","timestamp":1793764638342,"version":"4.6.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"8025","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2024,8,15]]},"DOI":"10.1038\/s41586-024-07685-6","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T12:01:55Z","timestamp":1720612915000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":181,"title":["Dissociable hindbrain GLP1R circuits for satiety and aversion"],"prefix":"10.1038","volume":"632","author":[{"given":"Kuei-Pin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha A.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misgana Y.","family":"Ghidewon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"McKnight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-0035","authenticated-orcid":false,"given":"Milena S.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel T.","family":"Nyema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.","family":"Hanchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9964-2826","authenticated-orcid":false,"given":"Nisha","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenoukoume S. K.","family":"Gbenou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice E.","family":"Adriaenssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Bolding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber L.","family":"Alhadeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"7685_CR1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1001\/jama.2021.1831","volume":"325","author":"TA Wadden","year":"2021","unstructured":"Wadden, T. A. et al. Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: The STEP 3 Randomized Clinical Trial. JAMA 325, 1403\u20131413 (2021).","journal-title":"JAMA"},{"key":"7685_CR2","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1056\/NEJMoa2032183","volume":"384","author":"JPH Wilding","year":"2021","unstructured":"Wilding, J. P. H. et al. Once-weekly semaglutide in adults with overweight or obesity. N. Engl. J. Med. 384, 989\u20131002 (2021).","journal-title":"N. Engl. J. Med."},{"key":"7685_CR3","unstructured":"World Obesity Federation. World Obesity Atlas 2023 (World Obesity Federation, 2023)."},{"key":"7685_CR4","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1056\/NEJMoa2301972","volume":"389","author":"AM Jastreboff","year":"2023","unstructured":"Jastreboff, A. M. et al. Triple-hormone-receptor agonist retatrutide for obesity \u2014 a phase 2 trial. N. Engl. J. Med. 389, 514\u2013526 (2023).","journal-title":"N. Engl. J. Med."},{"key":"7685_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1056\/NEJMoa2206038","volume":"387","author":"AM Jastreboff","year":"2022","unstructured":"Jastreboff, A. M. et al. Tirzepatide once Wweekly for the treatment of obesity. N. Engl. J. Med. 387, 205\u2013216 (2022).","journal-title":"N. Engl. J. Med."},{"key":"7685_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","volume":"30","author":"TD Muller","year":"2019","unstructured":"Muller, T. D. et al. Glucagon-like peptide 1 (GLP-1). Mol. Metab. 30, 72\u2013130 (2019).","journal-title":"Mol. Metab."},{"key":"7685_CR7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.physbeh.2010.02.029","volume":"100","author":"MR Hayes","year":"2010","unstructured":"Hayes, M. R., De Jonghe, B. C. & Kanoski, S. E. Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiol. Behav. 100, 503\u2013510 (2010).","journal-title":"Physiol. Behav."},{"key":"7685_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.2337\/db15-0973","volume":"65","author":"J-P Krieger","year":"2016","unstructured":"Krieger, J.-P. et al. Knockdown of GLP-1 receptors in vagal afferents affects normal food iIntake and glycemia. Diabetes 65, 34\u201343 (2016).","journal-title":"Diabetes"},{"key":"7685_CR9","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1210\/en.2011-0174","volume":"152","author":"SE Kanoski","year":"2011","unstructured":"Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J. & Hayes, M. R. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 152, 3103\u20133112 (2011).","journal-title":"Endocrinology"},{"key":"7685_CR10","doi-asserted-by":"publisher","unstructured":"Gabery, S. et al. Semaglutide lowers body weight in rodents via distributed neural pathways. JCI Insight 5, https:\/\/doi.org\/10.1172\/jci.insight.133429 (2020).","DOI":"10.1172\/jci.insight.133429"},{"key":"7685_CR11","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1210\/en.2017-00812","volume":"159","author":"CB Jensen","year":"2018","unstructured":"Jensen, C. B. et al. Characterization of the glucagonlike peptide-1 receptor in male mouse brain using a novel antibody and in situ hybridization. Endocrinology 159, 665\u2013675 (2018).","journal-title":"Endocrinology"},{"key":"7685_CR12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5","volume":"403","author":"I Merchenthaler","year":"1999","unstructured":"Merchenthaler, I., Lane, M. & Shughrue, P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261\u2013280 (1999).","journal-title":"J. Comp. Neurol."},{"key":"7685_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.neuron.2020.11.010","volume":"109","author":"C Zhang","year":"2021","unstructured":"Zhang, C. et al. Area postrema cell types that mediate nausea-associated behaviors. Neuron 109, 461\u2013472 (2021).","journal-title":"Neuron"},{"key":"7685_CR14","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1016\/j.cell.2022.10.001","volume":"185","author":"Z Xie","year":"2022","unstructured":"Xie, Z. et al. The gut-to-brain axis for toxin-induced defensive responses. Cell 185, 4298\u20134316 (2022).","journal-title":"Cell"},{"key":"7685_CR15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cmet.2012.06.015","volume":"16","author":"HJ Grill","year":"2012","unstructured":"Grill, H. J. & Hayes, M. R. Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metab. 16, 296\u2013309 (2012).","journal-title":"Cell Metab."},{"key":"7685_CR16","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s42255-021-00363-1","volume":"3","author":"MQ Ludwig","year":"2021","unstructured":"Ludwig, M. Q. et al. A genetic map of the mouse dorsal vagal complex and its role in obesity. Nat. Metab. 3, 530\u2013545 (2021).","journal-title":"Nat. Metab."},{"key":"7685_CR17","doi-asserted-by":"publisher","unstructured":"Adriaenssens, A. et al. Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding. 8, https:\/\/doi.org\/10.1172\/jci.insight.164921 (2023).","DOI":"10.1172\/jci.insight.164921"},{"key":"7685_CR18","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1681\/ASN.2004060512","volume":"16","author":"JS Lindberg","year":"2005","unstructured":"Lindberg, J. S. et al. Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study. J. Am. Soc. Nephrol. 16, 800\u2013807 (2005).","journal-title":"J. Am. Soc. Nephrol."},{"key":"7685_CR19","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.2174\/092986707782794096","volume":"14","author":"PE Harrington","year":"2007","unstructured":"Harrington, P. E. & Fotsch, C. Calcium sensing receptor activators: calcimimetics. Curr. Med. Chem. 14, 3027\u20133034 (2007).","journal-title":"Curr. Med. Chem."},{"key":"7685_CR20","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1016\/j.neuropharm.2011.12.022","volume":"62","author":"SE Kanoski","year":"2012","unstructured":"Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C. & Hayes, M. R. The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology 62, 1916\u20131927 (2012).","journal-title":"Neuropharmacology"},{"key":"7685_CR21","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1037\/0735-7036.97.2.140","volume":"97","author":"ML Pelchat","year":"1983","unstructured":"Pelchat, M. L., Grill, H. J., Rozin, P. & Jacobs, J. Quality of acquired responses to tastes by Rattus norvegicus depends on type of associated discomfort. J. Comp. Psychol. 97, 140\u2013153 (1983).","journal-title":"J. Comp. Psychol."},{"key":"7685_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0006-8993(78)90568-1","volume":"143","author":"HJ Grill","year":"1978","unstructured":"Grill, H. J. & Norgren, R. The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res. 143, 263\u2013279 (1978).","journal-title":"Brain Res."},{"key":"7685_CR23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neures.2014.09.002","volume":"93","author":"A Watakabe","year":"2015","unstructured":"Watakabe, A. et al. Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex. Neurosci. Res. 93, 144\u2013157 (2015).","journal-title":"Neurosci. Res."},{"key":"7685_CR24","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.2337\/db12-1498","volume":"62","author":"HE Wilson-P\u00e9rez","year":"2013","unstructured":"Wilson-P\u00e9rez, H. E. et al. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes 62, 2380\u20132385 (2013).","journal-title":"Diabetes"},{"key":"7685_CR25","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41386-022-01448-5","volume":"48","author":"S Murphy","year":"2023","unstructured":"Murphy, S. et al. Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus. Neuropsychopharmacology 48, 351\u2013361 (2023).","journal-title":"Neuropsychopharmacology"},{"key":"7685_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainres.2010.03.059","volume":"1350","author":"L Rinaman","year":"2010","unstructured":"Rinaman, L. Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure. Brain Res. 1350, 18\u201334 (2010).","journal-title":"Brain Res."},{"key":"7685_CR27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fnana.2015.00040","volume":"9","author":"D Wang","year":"2015","unstructured":"Wang, D. et al. Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Front. Neuroanat. 9, 40 (2015).","journal-title":"Front. Neuroanat."},{"key":"7685_CR28","doi-asserted-by":"publisher","first-page":"4582","DOI":"10.1523\/JNEUROSCI.3729-14.2015","volume":"35","author":"ME Carter","year":"2015","unstructured":"Carter, M. E., Han, S. & Palmiter, R. D. Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion. J. Neurosci. 35, 4582\u20134586 (2015).","journal-title":"J. Neurosci."},{"key":"7685_CR29","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cmet.2016.04.006","volume":"23","author":"CA Campos","year":"2016","unstructured":"Campos, C. A., Bowen, A. J., Schwartz, M. W. & Palmiter, R. D. Parabrachial CGRP neurons control meal termination. Cell Metab 23, 811\u2013820 (2016).","journal-title":"Cell Metab"},{"key":"7685_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature12596","volume":"503","author":"ME Carter","year":"2013","unstructured":"Carter, M. E., Soden, M. E., Zweifel, L. S. & Palmiter, R. D. Genetic identification of a neural circuit that suppresses appetite. Nature 503, 111\u2013114 (2013).","journal-title":"Nature"},{"key":"7685_CR31","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.neuron.2019.02.028","volume":"102","author":"MM Li","year":"2019","unstructured":"Li, M. M. et al. The paraventricular hypothalamus regulates satiety and prevents obesity via two genetically distinct circuits. Neuron 102, 653\u2013667 (2019).","journal-title":"Neuron"},{"key":"7685_CR32","doi-asserted-by":"publisher","unstructured":"Zhang, S. X. et al. Competition between stochastic neuropeptide signals calibrates the rate of satiation. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2023.07.11.548551 (2023).","DOI":"10.1101\/2023.07.11.548551"},{"key":"7685_CR33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nn.4442","volume":"20","author":"H Fenselau","year":"2017","unstructured":"Fenselau, H. et al. A rapidly acting glutamatergic ARC\u2192PVH satiety circuit postsynaptically regulated by \u03b1-MSH. Nat. Neurosci. 20, 42\u201351 (2017).","journal-title":"Nat. Neurosci."},{"key":"7685_CR34","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1037\/0735-7044.102.6.942","volume":"102","author":"AC Spector","year":"1988","unstructured":"Spector, A. C., Breslin, P. & Grill, H. J. Taste reactivity as a dependent measure of the rapid formation of conditioned taste aversion: a tool for the neural analysis of taste-visceral associations. Behav. Neurosci. 102, 942\u2013952 (1988).","journal-title":"Behav. Neurosci."},{"key":"7685_CR35","doi-asserted-by":"publisher","first-page":"101240","DOI":"10.1016\/j.molmet.2021.101240","volume":"53","author":"GKC Dowsett","year":"2021","unstructured":"Dowsett, G. K. C. et al. A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing. Mol Metab 53, 101240 (2021).","journal-title":"Mol Metab"},{"key":"7685_CR36","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","volume":"4","author":"SC Cork","year":"2015","unstructured":"Cork, S. C. et al. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Mol. Metab. 4, 718\u2013731 (2015).","journal-title":"Mol. Metab."},{"key":"7685_CR37","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1111\/j.1460-9568.1995.tb00650.x","volume":"7","author":"R G\u00f6ke","year":"1995","unstructured":"G\u00f6ke, R., Larsen, P. J., Mikkelsen, J. D. & Sheikh, S. P. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur. J. Neurosci. 7, 2294\u20132300 (1995).","journal-title":"Eur. J. Neurosci."},{"key":"7685_CR38","doi-asserted-by":"publisher","first-page":"R465","DOI":"10.1152\/ajpregu.00179.2014","volume":"307","author":"AL Alhadeff","year":"2014","unstructured":"Alhadeff, A. L. & Grill, H. J. Hindbrain nucleus tractus solitarius glucagon-like peptide-1 receptor signaling reduces appetitive and motivational aspects of feeding. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R465\u2013R470 (2014).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"7685_CR39","doi-asserted-by":"publisher","first-page":"eaay8071","DOI":"10.1126\/scitranslmed.aay8071","volume":"12","author":"SM Fortin","year":"2020","unstructured":"Fortin, S. M. GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats., Sci. Transl. Med. 12, eaay8071 (2020).","journal-title":"Sci. Transl. Med."},{"key":"7685_CR40","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.cmet.2011.02.001","volume":"13","author":"MR Hayes","year":"2011","unstructured":"Hayes, M. R. et al. Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metab. 13, 320\u2013330 (2011).","journal-title":"Cell Metab."},{"key":"7685_CR41","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1038\/npp.2016.246","volume":"42","author":"AL Alhadeff","year":"2017","unstructured":"Alhadeff, A. L. et al. Endogenous glucagon-like peptide-1 receptor signaling in the nucleus tractus solitarius is required for food intake control. Neuropsychopharmacology 42, 1471\u20131479 (2017).","journal-title":"Neuropsychopharmacology"},{"key":"7685_CR42","doi-asserted-by":"publisher","first-page":"101407","DOI":"10.1016\/j.molmet.2021.101407","volume":"55","author":"A Costa","year":"2022","unstructured":"Costa, A. et al. Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation. Mol. Metab. 55, 101407 (2022).","journal-title":"Mol. Metab."},{"key":"7685_CR43","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41586-022-05161-7","volume":"609","author":"A Ilanges","year":"2022","unstructured":"Ilanges, A. et al. Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour. Nature 609, 761\u2013771 (2022).","journal-title":"Nature"},{"key":"7685_CR44","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1172\/JCI75276","volume":"124","author":"A Secher","year":"2014","unstructured":"Secher, A. et al. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J. Clin. Invest. 124, 4473\u20134488 (2014).","journal-title":"J. Clin. Invest."},{"key":"7685_CR45","doi-asserted-by":"publisher","first-page":"372","DOI":"10.2337\/db16-1102","volume":"66","author":"MA Burmeister","year":"2017","unstructured":"Burmeister, M. A. et al. The hypothalamic glucagon-like peptide 1 receptor Is sufficient but not necessary for the regulation of energy balance and glucose homeostasis in mice. Diabetes 66, 372\u2013384 (2017).","journal-title":"Diabetes"},{"key":"7685_CR46","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1210\/en.2007-1743","volume":"149","author":"MR Hayes","year":"2008","unstructured":"Hayes, M. R., Skibicka, K. P. & Grill, H. J. Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology 149, 4059\u20134068 (2008).","journal-title":"Endocrinology"},{"key":"7685_CR47","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.cmet.2018.07.017","volume":"28","author":"G D\u2019Agostino","year":"2018","unstructured":"D\u2019Agostino, G. et al. Nucleus of the solitary tract serotonin 5-HT2C receptors modulate food intake. Cell Metab. 28, 619\u2013630 (2018).","journal-title":"Cell Metab."},{"key":"7685_CR48","doi-asserted-by":"publisher","unstructured":"Webster, A. N. et al. Molecular connectomics reveals a glucagon-like peptide 1 sensitive neural circuit for satiety. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2023.10.31.564990 (2023).","DOI":"10.1101\/2023.10.31.564990"},{"key":"7685_CR49","doi-asserted-by":"publisher","first-page":"e12225","DOI":"10.7554\/eLife.12225","volume":"5","author":"G D'Agostino","year":"2016","unstructured":"D\u2019Agostino, G. et al. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit., eLife 5, e12225 (2016).","journal-title":"eLife"},{"key":"7685_CR50","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.neuroscience.2017.06.049","volume":"358","author":"CW Roman","year":"2017","unstructured":"Roman, C. W., Sloat, S. R. & Palmiter, R. D. A tale of two circuits: CCKNTS neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions. Neuroscience 358, 316\u2013324 (2017).","journal-title":"Neuroscience"},{"key":"7685_CR51","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.cmet.2019.12.012","volume":"31","author":"W Cheng","year":"2020","unstructured":"Cheng, W. et al. Calcitonin receptor neurons in the mouse nucleus tractus solitarius control energy balance via the non-aversive suppression of feeding. Cell Metab. 31, 301\u2013312 (2020).","journal-title":"Cell Metab."},{"key":"7685_CR52","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/s41586-022-05139-5","volume":"609","author":"C Ran","year":"2022","unstructured":"Ran, C., Boettcher, J. C., Kaye, J. A., Gallori, C. E. & Liberles, S. D. A brainstem map for visceral sensations. Nature 609, 320\u2013326 (2022).","journal-title":"Nature"},{"key":"7685_CR53","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41586-023-06758-2","volume":"624","author":"T Ly","year":"2023","unstructured":"Ly, T. et al. Sequential appetite suppression by oral and visceral feedback to the brainstem. Nature 624, 130\u2013137 (2023).","journal-title":"Nature"},{"key":"7685_CR54","doi-asserted-by":"publisher","first-page":"996179","DOI":"10.3389\/fpubh.2022.996179","volume":"10","author":"Y Shu","year":"2022","unstructured":"Shu, Y. et al. Gastrointestinal adverse events associated with semaglutide: a pharmacovigilance study based on FDA adverse event reporting system. Front. Public Health 10, 996179 (2022).","journal-title":"Front. Public Health"},{"key":"7685_CR55","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nature11270","volume":"488","author":"D Atasoy","year":"2012","unstructured":"Atasoy, D., Betley, J. N., Su, H. H. & Sternson, S. M. Deconstruction of a neural circuit for hunger. Nature 488, 172\u2013177 (2012).","journal-title":"Nature"},{"key":"7685_CR56","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.cell.2009.04.022","volume":"137","author":"Q Wu","year":"2009","unstructured":"Wu, Q., Boyle, M. P. & Palmiter, R. D. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137, 1225\u20131234 (2009).","journal-title":"Cell"},{"key":"7685_CR57","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.psyneuen.2012.11.009","volume":"38","author":"E Egecioglu","year":"2013","unstructured":"Egecioglu, E. et al. The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents. Psychoneuroendocrinology 38, 1259\u20131270 (2013).","journal-title":"Psychoneuroendocrinology"},{"key":"7685_CR58","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nn.4540","volume":"20","author":"LM Tuesta","year":"2017","unstructured":"Tuesta, L. M. et al. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat. Neurosci. 20, 708\u2013716 (2017).","journal-title":"Nat. Neurosci."},{"key":"7685_CR59","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1038\/npp.2015.362","volume":"41","author":"HD Schmidt","year":"2016","unstructured":"Schmidt, H. D. et al. Glucagon-like peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine. Neuropsychopharmacology 41, 1917\u20131928 (2016).","journal-title":"Neuropsychopharmacology"},{"key":"7685_CR60","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-0871-6","volume":"22","author":"RJ Wickham","year":"2020","unstructured":"Wickham, R. J. Nausea and vomiting: a palliative care imperative. Curr. Oncol. Rep. 22, 1 (2020).","journal-title":"Curr. Oncol. Rep."},{"key":"7685_CR61","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","volume":"166","author":"EK Williams","year":"2016","unstructured":"Williams, E. K. et al. Sensory neurons that detect stretch and nutrients in the digestive system. Cell 166, 209\u2013221 (2016).","journal-title":"Cell"},{"key":"7685_CR62","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nn.3078","volume":"15","author":"L Madisen","year":"2012","unstructured":"Madisen, L. et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat. Neurosci. 15, 793\u2013802 (2012).","journal-title":"Nat. Neurosci."},{"key":"7685_CR63","doi-asserted-by":"publisher","first-page":"112894","DOI":"10.1016\/j.physbeh.2020.112894","volume":"221","author":"K-P Huang","year":"2020","unstructured":"Huang, K.-P. et al. Sex differences in response to short-term high fat diet in mice. Physiol. Behav. 221, 112894 (2020).","journal-title":"Physiol. Behav."},{"key":"7685_CR64","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.cell.2018.02.057","volume":"173","author":"AL Alhadeff","year":"2018","unstructured":"Alhadeff, A. L. et al. A neural circuit for the suppression of pain by a competing need state. Cell 173, 140\u2013152 (2018).","journal-title":"Cell"},{"key":"7685_CR65","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.cmet.2020.12.018","volume":"33","author":"N Goldstein","year":"2021","unstructured":"Goldstein, N. et al. Hypothalamic detection of macronutrients via multiple gut-brain pathways. Cell Metab. 33, 676\u2013687 (2021).","journal-title":"Cell Metab."},{"key":"7685_CR66","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1016\/j.celrep.2019.10.040","volume":"29","author":"S Min","year":"2019","unstructured":"Min, S. et al. Arterial baroreceptors sense blood pressure through decorated aortic claws. Cell Rep. 29, 2192\u20132201 (2019).","journal-title":"Cell Rep"},{"key":"7685_CR67","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1111\/dom.14663","volume":"24","author":"M Ghidewon","year":"2022","unstructured":"Ghidewon, M. et al. Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms. Diabetes Obes. Metab. 24, 1010\u20131020 (2022).","journal-title":"Diabetes Obes. Metab."},{"key":"7685_CR68","doi-asserted-by":"publisher","first-page":"8122","DOI":"10.1523\/JNEUROSCI.20-21-08122.2000","volume":"20","author":"CL Wyvell","year":"2000","unstructured":"Wyvell, C. L. & Berridge, K. C. Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward \u201cwanting\u201d without enhanced \u201cliking\u201d or response reinforcement. J. Neurosci. 20, 8122\u20138130 (2000).","journal-title":"J. Neurosci."},{"key":"7685_CR69","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0149-7634(94)00026-W","volume":"19","author":"KC Berridge","year":"1995","unstructured":"Berridge, K. C. & Peci\u00f1a, S. Benzodiazepines, appetite, and taste palatability. Neurosci. Biobehav. Rev. 19, 121\u2013131 (1995).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"7685_CR70","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1126\/science.1065635","volume":"294","author":"D Ren","year":"2001","unstructured":"Ren, D. et al. A prokaryotic voltage-gated sodium channel. Science 294, 2372\u20132375 (2001).","journal-title":"Science"},{"key":"7685_CR71","doi-asserted-by":"publisher","first-page":"e38173","DOI":"10.7554\/eLife.38173","volume":"8","author":"A Giovannucci","year":"2019","unstructured":"Giovannucci, A. et al. CaImAn an open source tool for scalable calcium imaging data analysis., eLife 8, e38173 (2019).","journal-title":"eLife"},{"key":"7685_CR72","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jneumeth.2017.07.031","volume":"291","author":"EA Pnevmatikakis","year":"2017","unstructured":"Pnevmatikakis, E. A. & Giovannucci, A. NoRMCorre: an online algorithm for piecewise rigid motion correction of calcium imaging data. J. Neurosci. Methods 291, 83\u201394 (2017).","journal-title":"J. Neurosci. Methods"},{"key":"7685_CR73","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","volume":"18","author":"C Stringer","year":"2021","unstructured":"Stringer, C., Wang, T., Michaelos, M. & Pachitariu, M. Cellpose: a generalist algorithm for cellular segmentation. Nat. Methods 18, 100\u2013106 (2021).","journal-title":"Nat. Methods"},{"key":"7685_CR74","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuron.2015.11.037","volume":"89","author":"EA Pnevmatikakis","year":"2016","unstructured":"Pnevmatikakis, E. A. et al. Simultaneous denoising, deconvolution, and demixing of calcium imaging data. Neuron 89, 285\u2013299 (2016).","journal-title":"Neuron"},{"key":"7685_CR75","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41586-020-2199-7","volume":"580","author":"H-E Tan","year":"2020","unstructured":"Tan, H.-E. et al. The gut\u2013brain axis mediates sugar preference. Nature 580, 511\u2013516 (2020).","journal-title":"Nature"},{"key":"7685_CR76","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"7685_CR77","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587 (2021).","journal-title":"Cell"},{"key":"7685_CR78","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.2337\/dbi21-0003","volume":"70","author":"MQ Ludwig","year":"2021","unstructured":"Ludwig, M. Q., Todorov, P. V., Egerod, K. L., Olson, D. P. & Pers, T. H. Single-cell mapping of GLP-1 and GIP receptor expression in the dorsal vagal complex. Diabetes 70, 1945\u20131955 (2021).","journal-title":"Diabetes"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07685-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07685-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07685-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T08:11:01Z","timestamp":1723623061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07685-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":78,"journal-issue":{"issue":"8025","published-print":{"date-parts":[[2024,8,15]]}},"alternative-id":["7685"],"URL":"https:\/\/doi.org\/10.1038\/s41586-024-07685-6","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]},"assertion":[{"value":"18 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the Monell Chemical Senses Center has filed a patent application related to potential therapeutic compounds.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}