{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:54:46Z","timestamp":1790434486605,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8030","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2024,9,19]]},"DOI":"10.1038\/s41586-024-07783-5","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T16:02:22Z","timestamp":1725465742000},"page":"704-709","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The hepatitis C virus envelope protein complex is a dimer of heterodimers"],"prefix":"10.1038","volume":"633","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0917-3971","authenticated-orcid":false,"given":"Elias Honer\u00f8d","family":"Augestad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-1597","authenticated-orcid":false,"given":"Christina","family":"Holmboe Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gr\u00f8nberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-9568","authenticated-orcid":false,"given":"Andreas","family":"Soerensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Vel\u00e1zquez-Moctezuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Fanalista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-4806","authenticated-orcid":false,"given":"Jens","family":"Bukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-7109","authenticated-orcid":false,"given":"Kaituo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8631-3539","authenticated-orcid":false,"given":"Pontus","family":"Gourdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-9478","authenticated-orcid":false,"given":"Jannick","family":"Prentoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"7783_CR1","unstructured":"Hepatitis C Fact sheet. World Health Organization http:\/\/www.who.int\/mediacentre\/factsheets\/fs164\/en\/ (2024)."},{"key":"7783_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1126\/science.abn9884","volume":"378","author":"A Torrents de la Pena","year":"2022","unstructured":"Torrents de la Pena, A. et al. Structure of the hepatitis C virus E1E2 glycoprotein complex. Science 378, 263\u2013269 (2022).","journal-title":"Science"},{"key":"7783_CR3","doi-asserted-by":"publisher","first-page":"e59776","DOI":"10.1371\/journal.pone.0059776","volume":"8","author":"JL Law","year":"2013","unstructured":"Law, J. L. et al. A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1\/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans. PLoS ONE 8, e59776 (2013).","journal-title":"PLoS ONE"},{"key":"7783_CR4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/vaccines8010090","volume":"8","author":"JD Duncan","year":"2020","unstructured":"Duncan, J. D., Urbanowicz, R. A., Tarr, A. W. & Ball, J. K. Hepatitis C virus vaccine: challenges and prospects. Vaccines 8, 90 (2020).","journal-title":"Vaccines"},{"key":"7783_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39690-0","volume":"14","author":"J Capella-Pujol","year":"2023","unstructured":"Capella-Pujol, J. et al. Signatures of VH1\u201369-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins. Nat. Commun. 14, 4036 (2023).","journal-title":"Nat. Commun."},{"key":"7783_CR6","doi-asserted-by":"publisher","first-page":"e02309","DOI":"10.1128\/JVI.02309-16","volume":"91","author":"H Freedman","year":"2017","unstructured":"Freedman, H. et al. Computational prediction of the heterodimeric and higher-order structure of gpE1\/gpE2 envelope glycoproteins encoded by hepatitis C virus. J. Virol. 91, e02309\u2013e02316 (2017).","journal-title":"J. Virol."},{"key":"7783_CR7","doi-asserted-by":"publisher","first-page":"10333","DOI":"10.1128\/JVI.00991-15","volume":"89","author":"P Falson","year":"2015","unstructured":"Falson, P. et al. Hepatitis C virus envelope glycoprotein E1 forms trimers at the surface of the virion. J. Virol. 89, 10333\u201310346 (2015).","journal-title":"J. Virol."},{"key":"7783_CR8","doi-asserted-by":"publisher","first-page":"a036830","DOI":"10.1101\/cshperspect.a036830","volume":"10","author":"G Gerold","year":"2020","unstructured":"Gerold, G., Moeller, R. & Pietschmann, T. Hepatitis C virus entry: protein interactions and fusion determinants governing productive hepatocyte invasion. Cold Spring Harb. Perspect. Med. 10, a036830 (2020).","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"7783_CR9","doi-asserted-by":"publisher","first-page":"eabb5938","DOI":"10.1126\/sciadv.abb5938","volume":"6","author":"EH Augestad","year":"2020","unstructured":"Augestad, E. H. et al. Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity. Sci. Adv. 6, eabb5938 (2020).","journal-title":"Sci. Adv."},{"key":"7783_CR10","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1002\/hep.28705","volume":"64","author":"J Prentoe","year":"2016","unstructured":"Prentoe, J., Vel\u00e1zquez-Moctezuma, R., Foung, S. K., Law, M. & Bukh, J. Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity. Hepatology 64, 1881\u20131892 (2016).","journal-title":"Hepatology"},{"key":"7783_CR11","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.3389\/fimmu.2018.01411","volume":"9","author":"Y Tong","year":"2018","unstructured":"Tong, Y., Lavillette, D., Li, Q. & Zhong, J. Role of hepatitis C virus envelope glycoprotein E1 in virus entry and assembly. Front. Immunol. 9, 1411 (2018).","journal-title":"Front. Immunol."},{"key":"7783_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nm1698","volume":"14","author":"M Law","year":"2008","unstructured":"Law, M. et al. Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat. Med. 14, 25\u201327 (2008).","journal-title":"Nat. Med."},{"key":"7783_CR13","doi-asserted-by":"publisher","first-page":"6205","DOI":"10.1073\/pnas.1114927109","volume":"109","author":"E Giang","year":"2012","unstructured":"Giang, E. et al. Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc. Natl Acad. Sci. USA 109, 6205\u20136210 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7783_CR14","doi-asserted-by":"publisher","first-page":"8738","DOI":"10.1073\/pnas.94.16.8738","volume":"94","author":"M Yanagi","year":"1997","unstructured":"Yanagi, M., Purcell, R. H., Emerson, S. U. & Bukh, J. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc. Natl Acad. Sci. USA 94, 8738\u20138743 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7783_CR15","doi-asserted-by":"publisher","first-page":"4560","DOI":"10.1073\/pnas.0501275102","volume":"102","author":"JC Meunier","year":"2005","unstructured":"Meunier, J. C. et al. Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1. Proc. Natl Acad. Sci. USA 102, 4560\u20134565 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7783_CR16","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nature13117","volume":"509","author":"AG Khan","year":"2014","unstructured":"Khan, A. G. et al. Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2. Nature 509, 381\u2013384 (2014).","journal-title":"Nature"},{"key":"7783_CR17","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.chom.2018.10.009","volume":"24","author":"AI Flyak","year":"2018","unstructured":"Flyak, A. I. et al. HCV broadly neutralizing antibodies use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design. Cell Host Microbe 24, 703\u2013716.e703 (2018).","journal-title":"Cell Host Microbe"},{"key":"7783_CR18","doi-asserted-by":"publisher","first-page":"eabb5642","DOI":"10.1126\/sciadv.abb5642","volume":"6","author":"N Tzarum","year":"2020","unstructured":"Tzarum, N. et al. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target. Sci. Adv. 6, eabb5642 (2020).","journal-title":"Sci. Adv."},{"key":"7783_CR19","doi-asserted-by":"publisher","first-page":"eaav1882","DOI":"10.1126\/sciadv.aav1882","volume":"5","author":"N Tzarum","year":"2019","unstructured":"Tzarum, N. et al. Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies. Sci. Adv. 5, eaav1882 (2019).","journal-title":"Sci. Adv."},{"key":"7783_CR20","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/s41586-021-03913-5","volume":"598","author":"A Kumar","year":"2021","unstructured":"Kumar, A. et al. Structural insights into hepatitis C virus receptor binding and entry. Nature 598, 521\u2013525 (2021).","journal-title":"Nature"},{"key":"7783_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36183-y","volume":"14","author":"A Kumar","year":"2023","unstructured":"Kumar, A. et al. Regions of hepatitis C virus E2 required for membrane association. Nat. Commun. 14, 433 (2023).","journal-title":"Nat. Commun."},{"key":"7783_CR22","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1126\/science.1243876","volume":"342","author":"L Kong","year":"2013","unstructured":"Kong, L. et al. Hepatitis C virus E2 envelope glycoprotein core structure. Science 342, 1090\u20131094 (2013).","journal-title":"Science"},{"key":"7783_CR23","doi-asserted-by":"publisher","first-page":"110859","DOI":"10.1016\/j.celrep.2022.110859","volume":"39","author":"JM Pfaff-Kilgore","year":"2022","unstructured":"Pfaff-Kilgore, J. M. et al. Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening. Cell Rep. 39, 110859 (2022).","journal-title":"Cell Rep."},{"key":"7783_CR24","doi-asserted-by":"publisher","first-page":"e1009720","DOI":"10.1371\/journal.ppat.1009720","volume":"17","author":"CH Olesen","year":"2021","unstructured":"Olesen, C. H., Augestad, E. H., Troise, F., Bukh, J. & Prentoe, J. In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus. PLoS Pathog. 17, e1009720 (2021).","journal-title":"PLoS Pathog."},{"key":"7783_CR25","doi-asserted-by":"publisher","first-page":"13085","DOI":"10.1128\/JVI.01939-12","volume":"86","author":"L Kong","year":"2012","unstructured":"Kong, L. et al. Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33. J. Virol. 86, 13085\u201313088 (2012).","journal-title":"J. Virol."},{"key":"7783_CR26","doi-asserted-by":"publisher","first-page":"9499","DOI":"10.1073\/pnas.1202924109","volume":"109","author":"L Kong","year":"2012","unstructured":"Kong, L. et al. Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1. Proc. Natl Acad. Sci. USA 109, 9499\u20139504 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7783_CR27","doi-asserted-by":"publisher","first-page":"12768","DOI":"10.1073\/pnas.1609780113","volume":"113","author":"L Kong","year":"2016","unstructured":"Kong, L. et al. Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen. Proc. Natl. Acad Sci. USA 113, 12768\u201312773 (2016).","journal-title":"Proc. Natl. Acad Sci. USA"},{"key":"7783_CR28","doi-asserted-by":"publisher","first-page":"e3002174","DOI":"10.1371\/journal.pbio.3002174","volume":"21","author":"MR Oliver","year":"2023","unstructured":"Oliver, M. R. et al. Structures of the Hepaci-, Pegi-, and Pestiviruses envelope proteins suggest a novel membrane fusion mechanism. PLoS Biol. 21, e3002174 (2023).","journal-title":"PLoS Biol."},{"key":"7783_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/hep.28111","volume":"63","author":"PM Perin","year":"2016","unstructured":"Perin, P. M. et al. Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology 63, 49\u201362 (2016).","journal-title":"Hepatology"},{"key":"7783_CR30","doi-asserted-by":"publisher","first-page":"8752","DOI":"10.1128\/JVI.02642-06","volume":"81","author":"D Lavillette","year":"2007","unstructured":"Lavillette, D. et al. Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus. J. Virol. 81, 8752\u20138765 (2007).","journal-title":"J. Virol."},{"key":"7783_CR31","doi-asserted-by":"publisher","first-page":"9505","DOI":"10.1073\/pnas.1307527110","volume":"110","author":"MT Catanese","year":"2013","unstructured":"Catanese, M. T. et al. Ultrastructural analysis of hepatitis C virus particles. Proc. Natl Acad. Sci. USA 110, 9505\u20139510 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7783_CR32","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/j.cell.2018.02.054","volume":"172","author":"FA Rey","year":"2018","unstructured":"Rey, F. A. & Lok, S. M. Common features of enveloped viruses and implications for immunogen design for next-generation vaccines. Cell 172, 1319\u20131334 (2018).","journal-title":"Cell"},{"key":"7783_CR33","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.coviro.2021.07.006","volume":"50","author":"EH Augestad","year":"2021","unstructured":"Augestad, E. H., Bukh, J. & Prentoe, J. Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1. Curr. Opin. Virol. 50, 69\u201375 (2021).","journal-title":"Curr. Opin. Virol."},{"key":"7783_CR34","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1006\/viro.1994.1629","volume":"205","author":"Y Matsuura","year":"1994","unstructured":"Matsuura, Y. et al. Processing of E1 and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells. Virology 205, 141\u2013150 (1994).","journal-title":"Virology"},{"key":"7783_CR35","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12985-021-01611-2","volume":"18","author":"T Hu","year":"2021","unstructured":"Hu, T., Wu, Z., Wu, S., Chen, S. & Cheng, A. The key amino acids of E protein involved in early flavivirus infection: viral entry. Virol. J. 18, 136 (2021).","journal-title":"Virol. J."},{"key":"7783_CR36","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1128\/JVI.00684-12","volume":"87","author":"TH Carlsen","year":"2013","unstructured":"Carlsen, T. H., Scheel, T. K., Ramirez, S., Foung, S. K. & Bukh, J. Characterization of hepatitis C virus recombinants with chimeric E1\/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry. J. Virol. 87, 1385\u20131399 (2013).","journal-title":"J. Virol."},{"key":"7783_CR37","doi-asserted-by":"publisher","first-page":"12776","DOI":"10.1128\/JVI.00901-13","volume":"87","author":"SB Serre","year":"2013","unstructured":"Serre, S. B., Krarup, H. B., Bukh, J. & Gottwein, J. M. Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance. J .Virol. 87, 12776\u201312793 (2013).","journal-title":"J .Virol."},{"key":"7783_CR38","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1128\/JVI.02017-13","volume":"88","author":"J Prentoe","year":"2014","unstructured":"Prentoe, J. et al. Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus. J. Virol. 88, 1725\u20131739 (2014).","journal-title":"J. Virol."},{"key":"7783_CR39","doi-asserted-by":"publisher","first-page":"5885","DOI":"10.1038\/srep05885","volume":"4","author":"TS Dodev","year":"2014","unstructured":"Dodev, T. S. et al. A tool kit for rapid cloning and expression of recombinant antibodies. Sci. Rep. 4, 5885 (2014).","journal-title":"Sci. Rep."},{"key":"7783_CR40","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583\u2013589 (2021).","journal-title":"Nature"},{"key":"7783_CR41","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"P Emsley","year":"2010","unstructured":"Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr. D 66, 486\u2013501 (2010).","journal-title":"Acta Crystallogr. D"},{"key":"7783_CR42","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1107\/S2059798318006551","volume":"74","author":"PV Afonine","year":"2018","unstructured":"Afonine, P. V. et al. Real-space refinement in PHENIX for cryo-EM and crystallography. Acta Crystallogr. D 74, 531\u2013544 (2018).","journal-title":"Acta Crystallogr. D"},{"key":"7783_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39031-1","volume":"14","author":"J He","year":"2023","unstructured":"He, J., Li, T. & Huang, S.-Y. Improvement of cryo-EM maps by simultaneous local and non-local deep learning. Nat. Commun. 14, 3217 (2023).","journal-title":"Nat. Commun."},{"key":"7783_CR44","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/pro.3330","volume":"27","author":"CJ Williams","year":"2018","unstructured":"Williams, C. J. et al. MolProbity: more and better reference data for improved all\u2010atom structure validation. Protein Sci. 27, 293\u2013315 (2018).","journal-title":"Protein Sci."},{"key":"7783_CR45","first-page":"82","volume":"40","author":"WL DeLano","year":"2002","unstructured":"DeLano, W. L. Pymol: an open-source molecular graphics tool. CCP4 Newsl. Protein Crystallogr. 40, 82\u201392 (2002).","journal-title":"CCP4 Newsl. Protein Crystallogr."},{"key":"7783_CR46","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen, E. F. et al. UCSF Chimera\u2014a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605\u20131612 (2004).","journal-title":"J. Comput. Chem."},{"key":"7783_CR47","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","volume":"30","author":"EF Pettersen","year":"2021","unstructured":"Pettersen, E. F. et al. UCSF ChimeraX: Structure visualization for researchers, educators, and developers. Protein Sci. 30, 70\u201382 (2021).","journal-title":"Protein Sci."},{"key":"7783_CR48","doi-asserted-by":"publisher","first-page":"e4582","DOI":"10.1002\/pro.4582","volume":"32","author":"B Yariv","year":"2023","unstructured":"Yariv, B. et al. Using evolutionary data to make sense of macromolecules with a \u201cface-lifted\u201d ConSurf. Protein Sci. 32, e4582 (2023).","journal-title":"Protein Sci."},{"key":"7783_CR49","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1743-422X-5-46","volume":"5","author":"KB Rothwangl","year":"2008","unstructured":"Rothwangl, K. B., Manicassamy, B., Uprichard, S. L. & Rong, L. Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: putative CD81 binding region 1 is not involved in CD81 binding. Virol. J. 5, 46 (2008).","journal-title":"Virol. J."},{"key":"7783_CR50","doi-asserted-by":"publisher","first-page":"8695","DOI":"10.1128\/JVI.00271-06","volume":"80","author":"AM Owsianka","year":"2006","unstructured":"Owsianka, A. M. et al. Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding. J. Virol. 80, 8695\u20138704 (2006).","journal-title":"J. Virol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07783-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07783-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07783-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T22:08:59Z","timestamp":1726783739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-07783-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":50,"journal-issue":{"issue":"8030","published-print":{"date-parts":[[2024,9,19]]}},"alternative-id":["7783"],"URL":"https:\/\/doi.org\/10.1038\/s41586-024-07783-5","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"8 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}