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One mosquito species,\n                    <jats:italic>Aedes<\/jats:italic>\n                    <jats:italic>aegypti<\/jats:italic>\n                    , is a primary vector of viruses that cause dengue, yellow fever and Zika. The attraction of\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    female mosquitos to humans requires integrating multiple cues, including CO\n                    <jats:sub>2<\/jats:sub>\n                    from breath, organic odours from skin and visual cues, all sensed at mid and long ranges, and other cues sensed at very close range\n                    <jats:sup>3\u20136<\/jats:sup>\n                    . Here we identify a cue that\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    use as part of their sensory arsenal to find humans. We demonstrate that\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    sense the infrared (IR) radiation emanating from their targets and use this information in combination with other cues for highly effective mid-range navigation. Detection of thermal IR requires the heat-activated channel TRPA1, which is expressed in neurons at the tip of the antenna. Two opsins are co-expressed with TRPA1 in these neurons and promote the detection of lower IR intensities. We propose that radiant energy causes local heating at the end of the antenna, thereby activating temperature-sensitive receptors in thermosensory neurons. The realization that thermal IR radiation is an outstanding mid-range directional cue expands our understanding as to how mosquitoes are exquisitely effective in locating hosts.\n                  <\/jats:p>","DOI":"10.1038\/s41586-024-07848-5","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T03:59:21Z","timestamp":1724385561000},"page":"615-623","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Thermal infrared directs host-seeking behaviour in Aedes aegypti mosquitoes"],"prefix":"10.1038","volume":"633","author":[{"given":"Avinash","family":"Chandel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas A.","family":"DeBeaubien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-0806","authenticated-orcid":false,"given":"Anindya","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff T.","family":"Meyerhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas A.","family":"Krumholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangqu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-3932","authenticated-orcid":false,"given":"Vincent L.","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-1482","authenticated-orcid":false,"given":"Craig","family":"Montell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"7848_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41564-018-0214-7","volume":"4","author":"WR Shaw","year":"2019","unstructured":"Shaw, W. 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