{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:28:32Z","timestamp":1792826912475,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"8044","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2025,1,2]]},"DOI":"10.1038\/s41586-024-08331-x","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T16:02:24Z","timestamp":1735747344000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Upconverting microgauges reveal intraluminal force dynamics in vivo"],"prefix":"10.1038","volume":"637","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-4791","authenticated-orcid":false,"given":"Jason R.","family":"Casar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire A.","family":"McLellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-1930","authenticated-orcid":false,"given":"Ariel","family":"Stiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Siefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Parakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malaya","family":"Gaerlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-7040","authenticated-orcid":false,"given":"X. Wendy","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-1272","authenticated-orcid":false,"given":"Miriam B.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-4357","authenticated-orcid":false,"given":"Jennifer A.","family":"Dionne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"8331_CR1","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1039\/c2lc00001f","volume":"12","author":"SR Lockery","year":"2012","unstructured":"Lockery, S. R. et al. A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. Lab Chip 12, 2211\u20132220 (2012).","journal-title":"Lab Chip"},{"key":"8331_CR2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41589-019-0256-z","volume":"15","author":"Y Oh","year":"2019","unstructured":"Oh, Y. et al. An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging. Nat. Chem. Biol. 15, 433\u2013436 (2019).","journal-title":"Nat. Chem. Biol."},{"key":"8331_CR3","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1113\/jphysiol.2010.189126","volume":"588","author":"H Tsutsui","year":"2010","unstructured":"Tsutsui, H., Higashijima, S.-I., Miyawaki, A. & Okamura, Y. Visualizing voltage dynamics in zebrafish heart. J. Physiol. 588, 2017\u20132021 (2010).","journal-title":"J. Physiol."},{"key":"8331_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.devcel.2011.06.015","volume":"21","author":"J Eyckmans","year":"2011","unstructured":"Eyckmans, J., Boudou, T., Yu, X. & Chen, C. S. A hitchhiker\u2019s guide to mechanobiology. Dev. Cell 21, 35\u201347 (2011).","journal-title":"Dev. Cell"},{"key":"8331_CR5","doi-asserted-by":"publisher","first-page":"17080","DOI":"10.1038\/natrevmats.2017.80","volume":"3","author":"RD Mehlenbacher","year":"2017","unstructured":"Mehlenbacher, R. D., Kolbl, R., Lay, A. & Dionne, J. A. Nanomaterials for in vivo imaging of mechanical forces and electrical fields. Nat. Rev. Mater. 3, 17080 (2017).","journal-title":"Nat. Rev. Mater."},{"key":"8331_CR6","doi-asserted-by":"publisher","first-page":"20620","DOI":"10.3390\/s141120620","volume":"14","author":"L Yu","year":"2014","unstructured":"Yu, L., Kim, B. J. & Meng, E. Chronically implanted pressure sensors: challenges and state of the field. Sensors 14, 20620\u201320644 (2014).","journal-title":"Sensors"},{"key":"8331_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0168-1605(02)00054-5","volume":"77","author":"EY Wuytack","year":"2002","unstructured":"Wuytack, E. Y., Diels, A. M. J. & Michiels, C. W. Bacterial inactivation by high-pressure homogenisation and high hydrostatic pressure. Int. J. Food Microbiol. 77, 205\u2013212 (2002).","journal-title":"Int. J. Food Microbiol."},{"key":"8331_CR8","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.ces.2008.10.002","volume":"64","author":"F Dons\u00ec","year":"2009","unstructured":"Dons\u00ec, F., Ferrari, G., Lenza, E. & Maresca, P. Main factors regulating microbial inactivation by high-pressure homogenization: operating parameters and scale of operation. Chem. Eng. Sci. 64, 520\u2013532 (2009).","journal-title":"Chem. Eng. Sci."},{"key":"8331_CR9","first-page":"140","volume":"4","author":"B Chumpitazi","year":"2008","unstructured":"Chumpitazi, B. & Nurko, S. Pediatric gastrointestinal motility disorders: challenges and a clinical update. Gastroenterol. Hepatol. 4, 140\u2013148 (2008).","journal-title":"Gastroenterol. Hepatol."},{"key":"8331_CR10","doi-asserted-by":"publisher","unstructured":"Dorsher, P. T. & McIntosh, P. M. Neurogenic bladder. Adv. Urol. https:\/\/doi.org\/10.1155\/2012\/816274 (2012).","DOI":"10.1155\/2012\/816274"},{"key":"8331_CR11","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1161\/CIRCULATIONAHA.104.494476","volume":"112","author":"M Shah","year":"2005","unstructured":"Shah, M., Akar, F. G. & Tomaselli, G. F. Molecular basis of arrhythmias. Circulation 112, 2517\u20132529 (2005).","journal-title":"Circulation"},{"key":"8331_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s42254-018-0001-7","volume":"1","author":"M Krieg","year":"2018","unstructured":"Krieg, M. et al. Atomic force microscopy-based mechanobiology. Nat. Rev. Phys. 1, 41\u201357 (2018).","journal-title":"Nat. Rev. Phys."},{"key":"8331_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/gut.2007.127993","volume":"57","author":"MR Fox","year":"2008","unstructured":"Fox, M. R. & Bredenoord, A. J. Oesophageal high-resolution manometry: moving from research into clinical practice. Gut 57, 405\u2013423 (2008).","journal-title":"Gut"},{"key":"8331_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/srep41436","volume":"7","author":"J-H Chen","year":"2017","unstructured":"Chen, J.-H. et al. Intraluminal pressure patterns in the human colon assessed by high-resolution manometry. Sci. Rep. 7, 41436 (2017).","journal-title":"Sci. Rep."},{"key":"8331_CR15","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1111\/j.1742-4658.2008.06461.x","volume":"275","author":"F Meng","year":"2008","unstructured":"Meng, F., Suchyna, T. M. & Sachs, F. A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J. 275, 3072\u20133087 (2008).","journal-title":"FEBS J."},{"key":"8331_CR16","doi-asserted-by":"publisher","first-page":"12568","DOI":"10.1073\/pnas.1204390109","volume":"109","author":"N Borghi","year":"2012","unstructured":"Borghi, N. et al. E-cadherin is under constitutive actomyosin-generated tension that is increased at cell\u2013cell contacts upon externally applied stretch. Proc. Natl Acad. Sci. USA 109, 12568\u201312573 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"8331_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nature09198","volume":"466","author":"C Grashoff","year":"2010","unstructured":"Grashoff, C. et al. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature 466, 263\u2013266 (2010).","journal-title":"Nature"},{"key":"8331_CR18","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ncb2915","volume":"16","author":"M Krieg","year":"2014","unstructured":"Krieg, M., Dunn, A. R. & Goodman, M. B. Mechanical control of the sense of touch by \u03b2-spectrin. Nat. Cell Biol. 16, 224\u2013233 (2014).","journal-title":"Nat. Cell Biol."},{"key":"8331_CR19","doi-asserted-by":"publisher","first-page":"7078","DOI":"10.1016\/j.biomaterials.2010.05.065","volume":"31","author":"L Xiong","year":"2010","unstructured":"Xiong, L., Yang, T., Yang, Y., Xu, C. & Li, F. Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors. Biomaterials 31, 7078\u20137085 (2010).","journal-title":"Biomaterials"},{"key":"8331_CR20","doi-asserted-by":"publisher","first-page":"9059","DOI":"10.1016\/j.biomaterials.2011.08.038","volume":"32","author":"J-C Zhou","year":"2011","unstructured":"Zhou, J.-C. et al. Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals. Biomaterials 32, 9059\u20139067 (2011).","journal-title":"Biomaterials"},{"key":"8331_CR21","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1021\/acscentsci.9b00300","volume":"5","author":"A Lay","year":"2019","unstructured":"Lay, A. et al. Optically robust and biocompatible mechanosensitive upconverting nanoparticles. ACS Cent. Sci. 5, 1211\u20131222 (2019).","journal-title":"ACS Cent. Sci."},{"key":"8331_CR22","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1126\/science.aaq1144","volume":"359","author":"S Chen","year":"2018","unstructured":"Chen, S. et al. Near-infrared deep brain stimulation via upconversion nanoparticle\u2013mediated optogenetics. Science 359, 679\u2013684 (2018).","journal-title":"Science"},{"key":"8331_CR23","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1021\/acsnano.7b00944","volume":"11","author":"J Xu","year":"2017","unstructured":"Xu, J. et al. Highly emissive dye-sensitized upconversion nanostructure for dual-photosensitizer photodynamic therapy and bioimaging. ACS Nano 11, 4133\u20134144 (2017).","journal-title":"ACS Nano"},{"key":"8331_CR24","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.biomaterials.2007.10.051","volume":"29","author":"DK Chatterjee","year":"2008","unstructured":"Chatterjee, D. K., Rufaihah, A. J. & Zhang, Y. Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. Biomaterials 29, 937\u2013943 (2008).","journal-title":"Biomaterials"},{"key":"8331_CR25","doi-asserted-by":"publisher","first-page":"5808","DOI":"10.1002\/anie.201005159","volume":"50","author":"M Haase","year":"2011","unstructured":"Haase, M. & Sch\u00e4fer, H. Upconverting nanoparticles. Angew. Chem. Int. Ed. 50, 5808\u20135829 (2011).","journal-title":"Angew. Chem. Int. Ed."},{"key":"8331_CR26","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.1021\/acs.nanolett.7b00963","volume":"17","author":"A Lay","year":"2017","unstructured":"Lay, A. et al. Upconverting nanoparticles as optical sensors of nano- to micro-newton forces. Nano Lett. 17, 4172\u20134177 (2017).","journal-title":"Nano Lett."},{"key":"8331_CR27","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1021\/acs.jpclett.1c03841","volume":"13","author":"CA McLellan","year":"2022","unstructured":"McLellan, C. A. et al. Engineering bright and mechanosensitive alkaline-earth rare-earth upconverting nanoparticles. J. Phys. Chem. Lett. 13, 1547\u20131553 (2022).","journal-title":"J. Phys. Chem. Lett."},{"key":"8331_CR28","doi-asserted-by":"publisher","first-page":"4454","DOI":"10.1021\/acs.nanolett.8b01535","volume":"18","author":"A Lay","year":"2018","unstructured":"Lay, A. et al. Bright, mechanosensitive upconversion with cubic-phase heteroepitaxial core\u2013shell nanoparticles. Nano Lett. 18, 4454\u20134459 (2018).","journal-title":"Nano Lett."},{"key":"8331_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature04657","volume":"441","author":"TCY Kwok","year":"2006","unstructured":"Kwok, T. C. Y. et al. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441, 91\u201395 (2006).","journal-title":"Nature"},{"key":"8331_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/srep14427","volume":"5","author":"C Sch\u00fcler","year":"2015","unstructured":"Sch\u00fcler, C., Fischer, E., Shaltiel, L., Steuer Costa, W. & Gottschalk, A. Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans. Sci. Rep. 5, 14427 (2015).","journal-title":"Sci. Rep."},{"key":"8331_CR31","doi-asserted-by":"publisher","first-page":"6066","DOI":"10.1093\/emboj\/16.20.6066","volume":"16","author":"RYN Lee","year":"1997","unstructured":"Lee, R. Y. N., Lobel, L., Hengartner, M., Horvitz, H. R. & Avery, L. Mutations in the \u03b11 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. EMBO J. 16, 6066\u20136076 (1997).","journal-title":"EMBO J."},{"key":"8331_CR32","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1534\/genetics.115.176099","volume":"200","author":"AK Corsi","year":"2015","unstructured":"Corsi, A. K., Wightman, B. & Chalfie, M. A transparent window into biology: a primer on Caenorhabditis elegans. Genetics 200, 387\u2013407 (2015).","journal-title":"Genetics"},{"key":"8331_CR33","doi-asserted-by":"publisher","first-page":"7241","DOI":"10.1021\/acs.nanolett.6b03683","volume":"16","author":"S Fischer","year":"2016","unstructured":"Fischer, S., Bronstein, N. D., Swabeck, J. K., Chan, E. M. & Alivisatos, A. P. Precise tuning of surface quenching for luminescence enhancement in core\u2013shell lanthanide-doped nanocrystals. Nano Lett. 16, 7241\u20137247 (2016).","journal-title":"Nano Lett."},{"key":"8331_CR34","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1021\/acs.jpcc.6b09301","volume":"121","author":"S Lahtinen","year":"2017","unstructured":"Lahtinen, S. et al. Disintegration of hexagonal NaYF4:Yb3+,Er3+ upconverting nanoparticles in aqueous media: the role of fluoride in solubility equilibrium. J. Phys. Chem. C 121, 656\u2013665 (2017).","journal-title":"J. Phys. Chem. C"},{"key":"8331_CR35","doi-asserted-by":"publisher","first-page":"6360","DOI":"10.1007\/s12274-018-2159-9","volume":"11","author":"M Kraft","year":"2018","unstructured":"Kraft, M., W\u00fcrth, C., Muhr, V., Hirsch, T. & Resch-Genger, U. Particle-size-dependent upconversion luminescence of NaYF4: Yb, Er nanoparticles in organic solvents and water at different excitation power densities. Nano Res. 11, 6360\u20136374 (2018).","journal-title":"Nano Res."},{"key":"8331_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/acsphotonics.0c00894","volume":"8","author":"JR Casar","year":"2021","unstructured":"Casar, J. R., McLellan, C. A., Siefe, C. & Dionne, J. A. Lanthanide-based nanosensors: refining nanoparticle responsiveness for single particle imaging of stimuli. ACS Photonics 8, 3\u201317 (2021).","journal-title":"ACS Photonics"},{"key":"8331_CR37","doi-asserted-by":"publisher","first-page":"255601","DOI":"10.1088\/0957-4484\/19\/25\/255601","volume":"19","author":"H Qian","year":"2008","unstructured":"Qian, H., Li, Z. & Zhang, Y. Multicolor polystyrene nanospheres tagged with up-conversion fluorescent nanocrystals. Nanotechnology 19, 255601 (2008).","journal-title":"Nanotechnology"},{"key":"8331_CR38","doi-asserted-by":"publisher","first-page":"20093","DOI":"10.1073\/pnas.0904036106","volume":"106","author":"C Fang-Yen","year":"2009","unstructured":"Fang-Yen, C., Avery, L. & Samuel, A. D. T. Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 106, 20093\u201320096 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"8331_CR39","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1152\/jn.00444.2021","volume":"128","author":"IR Brenner","year":"2022","unstructured":"Brenner, I. R., Raizen, D. M. & Fang-Yen, C. Pharyngeal timing and particle transport defects in Caenorhabditis elegans feeding mutants. J. Neurophysiol. 128, 302\u2013309 (2022).","journal-title":"J. Neurophysiol."},{"key":"8331_CR40","doi-asserted-by":"publisher","first-page":"e0233059","DOI":"10.1371\/journal.pone.0233059","volume":"15","author":"AP Sparacio","year":"2020","unstructured":"Sparacio, A. P., Trojanowski, N. F., Snetselaar, K., Nelson, M. D. & Raizen, D. M. Teething during sleep: ultrastructural analysis of pharyngeal muscle and cuticular grinder during the molt in Caenorhabditis elegans. PLoS ONE 15, e0233059 (2020).","journal-title":"PLoS ONE"},{"key":"8331_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1098\/rspb.1991.0119","volume":"246","author":"J Hodgkin","year":"1991","unstructured":"Hodgkin, J. & Barnes, T. M. More is not better: brood size and population growth in a self-fertilizing nematode. Proc. R. Soc. Lond. B 246, 19\u201324 (1991).","journal-title":"Proc. R. Soc. Lond. B"},{"key":"8331_CR42","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/0896-6273(94)90207-0","volume":"12","author":"DM Raizen","year":"1994","unstructured":"Raizen, D. M. & Avery, L. Electrical activity and behavior in the pharynx of Caenorhabditis elegans. Neuron 12, 483\u2013495 (1994).","journal-title":"Neuron"},{"key":"8331_CR43","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/genetics\/133.4.897","volume":"133","author":"L Avery","year":"1993","unstructured":"Avery, L. The genetics of feeding in Caenorhabditis elegans. Genetics 133, 897\u2013917 (1993).","journal-title":"Genetics"},{"key":"8331_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1471-2180-12-49","volume":"12","author":"C Portal-Celhay","year":"2012","unstructured":"Portal-Celhay, C., Bradley, E. R. & Blaser, M. J. Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans. BMC Microbiol. 12, 49 (2012).","journal-title":"BMC Microbiol."},{"key":"8331_CR45","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.devcel.2019.03.010","volume":"49","author":"S Kumar","year":"2019","unstructured":"Kumar, S. et al. Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response. Dev. Cell 49, 100\u2013117 (2019).","journal-title":"Dev. Cell"},{"key":"8331_CR46","doi-asserted-by":"publisher","first-page":"e2000633","DOI":"10.1371\/journal.pbio.2000633","volume":"15","author":"NM Vega","year":"2017","unstructured":"Vega, N. M. & Gore, J. Stochastic assembly produces heterogeneous communities in the Caenorhabditis elegans intestine. PLoS Biol. 15, e2000633 (2017).","journal-title":"PLoS Biol."},{"key":"8331_CR47","unstructured":"Johnson, K. L. Contact Mechanics (Cambridge Univ. Press, 1987)."},{"key":"8331_CR48","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1021\/acs.biochem.7b00346","volume":"56","author":"GK Auer","year":"2017","unstructured":"Auer, G. K. & Weibel, D. B. Bacterial cell mechanics. Biochemistry 56, 3710\u20133724 (2017).","journal-title":"Biochemistry"},{"key":"8331_CR49","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1098\/rspa.1971.0141","volume":"324","author":"KL Johnson","year":"1971","unstructured":"Johnson, K. L., Kendall, K. & Roberts, A. D. Surface energy and the contact of elastic solids. Proc. R. Soc. Lond. A 324, 301\u2013313 (1971).","journal-title":"Proc. R. Soc. Lond. A"},{"key":"8331_CR50","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.polymer.2016.06.010","volume":"98","author":"TS Guruprasad","year":"2016","unstructured":"Guruprasad, T. S., Bhattacharya, S. & Basu, S. Size effect in microcompression of polystyrene micropillars. Polymer 98, 118\u2013128 (2016).","journal-title":"Polymer"},{"key":"8331_CR51","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/nature01135","volume":"419","author":"LA Herndon","year":"2002","unstructured":"Herndon, L. A. et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808\u2013814 (2002).","journal-title":"Nature"},{"key":"8331_CR52","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/gerona\/glr072","volume":"67","author":"L Kashyap","year":"2012","unstructured":"Kashyap, L., Perera, S. & Fisher, A. L. Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans. J. Gerontol. A 67, 56\u201365 (2012).","journal-title":"J. Gerontol. A"},{"key":"8331_CR53","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1021\/la204020m","volume":"28","author":"G Jiang","year":"2012","unstructured":"Jiang, G., Pichaandi, J., Johnson, N. J. J., Burke, R. D. & van Veggel, F. C. J. M. An effective polymer cross-linking strategy to obtain stable dispersions of upconverting NaYF4 nanoparticles in buffers and biological growth media for biolabeling applications. Langmuir 28, 3239\u20133247 (2012).","journal-title":"Langmuir"},{"key":"8331_CR54","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676\u2013682 (2012).","journal-title":"Nat. Methods"},{"key":"8331_CR55","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1021\/nl903046r","volume":"10","author":"S Schietinger","year":"2010","unstructured":"Schietinger, S., Aichele, T., Wang, H.-Q., Nann, T. & Benson, O. Plasmon-enhanced upconversion in single NaYF4:Yb3+\/Er3+ codoped nanocrystals. Nano Lett. 10, 134\u2013138 (2010).","journal-title":"Nano Lett."},{"key":"8331_CR56","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1063\/1.325277","volume":"49","author":"HK Mao","year":"1978","unstructured":"Mao, H. K., Bell, P. M., Shaner, J. W. & Steinberg, D. J. Specific volume measurements of Cu, Mo, Pd, and Ag and calibration of the ruby R1 fluorescence pressure gauge from 0.06 to 1 Mbar. J. Appl. Phys. 49, 3276\u20133283 (1978).","journal-title":"J. Appl. Phys."},{"key":"8331_CR57","doi-asserted-by":"publisher","first-page":"075413","DOI":"10.1088\/0022-3727\/42\/7\/075413","volume":"42","author":"S Klotz","year":"2009","unstructured":"Klotz, S., Chervin, J.-C., Munsch, P. & Le Marchand, G. Hydrostatic limits of 11 pressure transmitting media. J. Phys. D 42, 075413 (2009).","journal-title":"J. Phys. D"},{"key":"8331_CR58","doi-asserted-by":"publisher","first-page":"e3002672","DOI":"10.1371\/journal.pbio.3002672","volume":"22","author":"E Fryer","year":"2024","unstructured":"Fryer, E. et al. A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans. PLoS Biol. 22, e3002672 (2024).","journal-title":"PLoS Biol."},{"key":"8331_CR59","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1126\/science.6805073","volume":"216","author":"HR Horvitz","year":"1982","unstructured":"Horvitz, H. R., Chalfie, M., Trent, C., Sulston, J. E. & Evans, P. D. Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216, 1012\u20131014 (1982).","journal-title":"Science"},{"key":"8331_CR60","doi-asserted-by":"crossref","unstructured":"Carnall, W. T., Crosswhite, H. & Crosswhite, H. M. Energy Level Structure and Transition Probabilities in the Spectra of the Trivalent Lanthanides in LaF3 (US Department of Energy, Office of Scientific and Technical Information, 1978).","DOI":"10.2172\/6417825"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08331-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08331-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08331-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T17:03:05Z","timestamp":1735750985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08331-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":60,"journal-issue":{"issue":"8044","published-print":{"date-parts":[[2025,1,2]]}},"alternative-id":["8331"],"URL":"https:\/\/doi.org\/10.1038\/s41586-024-08331-x","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"24 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}