{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:33:34Z","timestamp":1792683214674,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8049","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2025,2,6]]},"DOI":"10.1038\/s41586-024-08335-7","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T11:02:04Z","timestamp":1735729324000},"page":"244-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Aspartate signalling drives lung metastasis via alternative translation"],"prefix":"10.1038","volume":"638","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-4476","authenticated-orcid":false,"given":"Ginevra","family":"Doglioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3422-3627","authenticated-orcid":false,"given":"Juan","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4184","authenticated-orcid":false,"given":"Sebastian","family":"Igelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-2051","authenticated-orcid":false,"given":"Patricia","family":"Altea-Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-8726","authenticated-orcid":false,"given":"Arnaud","family":"Blomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"La Rovere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-6848","authenticated-orcid":false,"given":"Xiao-Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-4838","authenticated-orcid":false,"given":"Tine","family":"Tricot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-1390","authenticated-orcid":false,"given":"Max","family":"Nobis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-6869","authenticated-orcid":false,"given":"Ning","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-0060","authenticated-orcid":false,"given":"Marine","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"El Kharraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7642-0875","authenticated-orcid":false,"given":"Panagiotis","family":"Karras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Heng","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella A.","family":"Solari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-5220","authenticated-orcid":false,"given":"Luiza","family":"Martins Nascentes Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Allies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Scopelliti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-1244","authenticated-orcid":false,"given":"Matteo","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-7410","authenticated-orcid":false,"given":"Ines","family":"Vermeire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9777-1607","authenticated-orcid":false,"given":"Dorien","family":"Broekaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-7686","authenticated-orcid":false,"given":"Ana Margarida","family":"Ferreira Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Neven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Maetens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Van Baelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0078-248X","authenticated-orcid":false,"given":"H. Furkan","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Planque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Floris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Sickmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-852X","authenticated-orcid":false,"given":"Alpaslan","family":"Tasdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-9837","authenticated-orcid":false,"given":"Jean-Christophe","family":"Marine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-5451","authenticated-orcid":false,"given":"Colinda L. G. J.","family":"Scheele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-5579","authenticated-orcid":false,"given":"Christine","family":"Desmedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-4828","authenticated-orcid":false,"given":"Geert","family":"Bultynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Close","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-9296","authenticated-orcid":false,"given":"Sarah-Maria","family":"Fendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"8335_CR1","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.21037\/jtd.2020.04.28","volume":"13","author":"WD Gerull","year":"2021","unstructured":"Gerull, W. D., Puri, V. & Kozower, B. D. The epidemiology and biology of pulmonary metastases. J. Thorac. Dis. 13, 2585\u20132589 (2021).","journal-title":"J. Thorac. Dis."},{"key":"8335_CR2","doi-asserted-by":"publisher","first-page":"W1","DOI":"10.1097\/RTI.0b013e3182010bf9","volume":"26","author":"T-LH Mohammed","year":"2011","unstructured":"Mohammed, T.-L. H. et al. ACR appropriateness criteria screening for pulmonary metastases. J. Thorac. Imag. 26, W1\u2013W3 (2011).","journal-title":"J. Thorac. Imag."},{"key":"8335_CR3","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41556-022-00881-4","volume":"24","author":"SB Crist","year":"2022","unstructured":"Crist, S. B. et al. Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells. Nat. Cell Biol. 24, 538\u2013553 (2022).","journal-title":"Nat. Cell Biol."},{"key":"8335_CR4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrc.2017.6","volume":"17","author":"H Peinado","year":"2017","unstructured":"Peinado, H. et al. Pre-metastatic niches: organ-specific homes for metastases. Nat. Rev. Cancer 17, 302\u2013317 (2017).","journal-title":"Nat. Rev. Cancer"},{"key":"8335_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fonc.2019.00219","volume":"9","author":"G Doglioni","year":"2019","unstructured":"Doglioni, G., Parik, S. & Fendt, S. M. Interactions in the (pre)metastatic niche support metastasis formation. Front. Oncol. 9, 219 (2019).","journal-title":"Front. Oncol."},{"key":"8335_CR6","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s43018-023-00513-2","volume":"4","author":"P Altea-Manzano","year":"2023","unstructured":"Altea-Manzano, P. et al. A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-\u03baB signaling. Nat. Cancer 4, 344\u2013364 (2023).","journal-title":"Nat. Cancer"},{"key":"8335_CR7","doi-asserted-by":"publisher","first-page":"7326","DOI":"10.1093\/nar\/gkx479","volume":"45","author":"V Pelechano","year":"2017","unstructured":"Pelechano, V. & Alepuz, P. eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences. Nucleic Acids Res. 45, 7326\u20137338 (2017).","journal-title":"Nucleic Acids Res."},{"key":"8335_CR8","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00726-009-0408-7","volume":"38","author":"MH Park","year":"2010","unstructured":"Park, M. H., Nishimura, K., Zanelli, C. F. & Valentini, S. R. Functional significance of eIF5A and its hypusine modification in eukaryotes. Amino Acids 38, 491\u2013500 (2010).","journal-title":"Amino Acids"},{"key":"8335_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15267","volume":"8","author":"I Elia","year":"2017","unstructured":"Elia, I. et al. Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. Nat. Commun. 8, 15267 (2017).","journal-title":"Nat. Commun."},{"key":"8335_CR10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41586-019-0977-x","volume":"568","author":"I Elia","year":"2019","unstructured":"Elia, I. et al. Breast cancer cells rely on environmental pyruvate to shape the metastatic niche. Nature 568, 117\u2013121 (2019).","journal-title":"Nature"},{"key":"8335_CR11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.copbio.2015.02.003","volume":"34","author":"JM Buescher","year":"2015","unstructured":"Buescher, J. M. et al. A roadmap for interpreting 13C metabolite labeling patterns from cells. Curr. Opin. Biotechnol. 34, 189\u2013201 (2015).","journal-title":"Curr. Opin. Biotechnol."},{"key":"8335_CR12","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1124\/mol.107.037333","volume":"72","author":"K Erreger","year":"2007","unstructured":"Erreger, K. et al. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol. Pharmacol. 72, 907 (2007).","journal-title":"Mol. Pharmacol."},{"key":"8335_CR13","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41586-018-0039-9","volume":"556","author":"X Song","year":"2018","unstructured":"Song, X. et al. Mechanism of NMDA receptor channel block by MK-801 and memantine. Nature 556, 515\u2013519 (2018).","journal-title":"Nature"},{"key":"8335_CR14","doi-asserted-by":"publisher","first-page":"baw100","DOI":"10.1093\/database\/baw100","volume":"2016","author":"AD Rouillard","year":"2016","unstructured":"Rouillard, A. D. et al. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database 2016, baw100 (2016).","journal-title":"Database"},{"key":"8335_CR15","doi-asserted-by":"publisher","first-page":"11024","DOI":"10.1073\/pnas.191352298","volume":"98","author":"AE West","year":"2001","unstructured":"West, A. E. et al. Calcium regulation of neuronal gene expression. Proc. Natl Acad. Sci. USA 98, 11024\u201311031 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"8335_CR16","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1021\/acs.jmedchem.5b00468","volume":"58","author":"F Xie","year":"2015","unstructured":"Xie, F. et al. Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity. J. Med. Chem. 58, 5075\u20135087 (2015).","journal-title":"J. Med. Chem."},{"key":"8335_CR17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1046\/j.1523-1747.2002.01641.x","volume":"118","author":"F Verrecchia","year":"2002","unstructured":"Verrecchia, F. & Mauviel, A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J. Invest. Dermatol. 118, 211\u2013215 (2002).","journal-title":"J. Invest. Dermatol."},{"key":"8335_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-024-00637-3","volume":"10","author":"T Geukens","year":"2024","unstructured":"Geukens, T. et al. Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program. NPJ Breast Cancer 10, 31 (2024).","journal-title":"NPJ Breast Cancer"},{"key":"8335_CR19","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41416-019-0620-5","volume":"122","author":"L Vettore","year":"2020","unstructured":"Vettore, L., Westbrook, R. L. & Tennant, D. A. New aspects of amino acid metabolism in cancer. Br. J. Cancer 122, 150\u2013156 (2020).","journal-title":"Br. J. Cancer"},{"key":"8335_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10549-009-0556-1","volume":"122","author":"WG North","year":"2010","unstructured":"North, W. G., Gao, G., Memoli, V. A., Pang, R. H. & Lynch, L. Breast cancer expresses functional NMDA receptors. Breast Cancer Res. Treat. 122, 307\u2013314 (2010).","journal-title":"Breast Cancer Res. Treat."},{"key":"8335_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cell.2013.02.051","volume":"153","author":"L Li","year":"2013","unstructured":"Li, L. & Hanahan, D. Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion. Cell 153, 86\u2013100 (2013).","journal-title":"Cell"},{"key":"8335_CR22","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","volume":"573","author":"Q Zeng","year":"2019","unstructured":"Zeng, Q. et al. Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature 573, 526\u2013531 (2019).","journal-title":"Nature"},{"key":"8335_CR23","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1158\/2159-8290.CD-24-0174","volume":"14","author":"S Krieg","year":"2024","unstructured":"Krieg, S., Fernandes, S. I., Kolliopoulos, C., Liu, M. & Fendt, S.-M. Metabolic signaling in cancer metastasis. Cancer Discov. 14, 934\u2013952 (2024).","journal-title":"Cancer Discov."},{"key":"8335_CR24","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.bbrc.2019.09.075","volume":"519","author":"R G\u00fcth","year":"2019","unstructured":"G\u00fcth, R. et al. DHPS-dependent hypusination of eIF5A1\/2 is necessary for TGF\u03b2\/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53. Biochem. Biophys. Res. Commun. 519, 838\u2013845 (2019).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"8335_CR25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41586-024-07302-6","volume":"629","author":"P Karras","year":"2024","unstructured":"Karras, P., Black, J. R. M., McGranahan, N. & Marine, J. C. Decoding the interplay between genetic and non-genetic drivers of metastasis. Nature 629, 543\u2013554 (2024).","journal-title":"Nature"},{"key":"8335_CR26","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1158\/2159-8290.CD-20-0844","volume":"10","author":"S-M Fendt","year":"2020","unstructured":"Fendt, S.-M., Frezza, C. & Erez, A. Targeting metabolic plasticity and flexibility dynamics for cancer therapy. Cancer Discov. 10, 1797\u20131807 (2020).","journal-title":"Cancer Discov."},{"key":"8335_CR27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.trecan.2020.09.005","volume":"7","author":"LJ Lee","year":"2021","unstructured":"Lee, L. J. et al. Cancer plasticity: the role of mRNA translation. Trends Cancer 7, 134\u2013145 (2021).","journal-title":"Trends Cancer"},{"key":"8335_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-1-4939-8769-6_4","volume":"1862","author":"M van Gorsel","year":"2019","unstructured":"van Gorsel, M., Elia, I. & Fendt, S. M. 13C tracer analysis and metabolomics in 3D cultured cancer cells. Methods Mol. Biol. 1862, 53\u201366 (2019).","journal-title":"Methods Mol. Biol."},{"key":"8335_CR29","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nmeth.1314","volume":"6","author":"EK Schmidt","year":"2009","unstructured":"Schmidt, E. K., Clavarino, G., Ceppi, M. & Pierre, P. SUnSET, a nonradioactive method to monitor protein synthesis. Nat. Methods 6, 275\u2013277 (2009).","journal-title":"Nat. Methods"},{"key":"8335_CR30","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1084\/jem.20160397","volume":"213","author":"S Delaunay","year":"2016","unstructured":"Delaunay, S. et al. Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. J. Exp. Med. 213, 2503\u20132523 (2016).","journal-title":"J. Exp. Med."},{"key":"8335_CR31","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1093\/nar\/gkx940","volume":"46","author":"S Liang","year":"2018","unstructured":"Liang, S. et al. Polysome-profiling in small tissue samples. Nucleic Acids Res. 46, e3 (2018).","journal-title":"Nucleic Acids Res."},{"key":"8335_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"8335_CR33","first-page":"275","volume":"18","author":"M Stephens","year":"2017","unstructured":"Stephens, M. False discovery rates: a new deal. Biostatistics 18, 275\u2013294 (2017).","journal-title":"Biostatistics"},{"key":"8335_CR34","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"8335_CR35","doi-asserted-by":"publisher","unstructured":"Korotkevich, G. et al. Fast gene set enrichment analysis. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/060012 (2021).","DOI":"10.1101\/060012"},{"key":"8335_CR36","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739\u20131740 (2011).","journal-title":"Bioinformatics"},{"key":"8335_CR37","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon, A. et al. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 1, 417\u2013425 (2015).","journal-title":"Cell Syst."},{"key":"8335_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"8335_CR39","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.celrep.2016.09.042","volume":"17","author":"S Christen","year":"2016","unstructured":"Christen, S. et al. Breast cancer-derived lung metastases show increased pyruvate carboxylase-dependent anaplerosis. Cell Rep. 17, 837\u2013848 (2016).","journal-title":"Cell Rep."},{"key":"8335_CR40","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.molcel.2020.11.027","volume":"81","author":"G Rinaldi","year":"2021","unstructured":"Rinaldi, G. et al. In vivo evidence for serine biosynthesis-defined sensitivity of lung metastasis, but not of primary breast tumors, to mTORC1 inhibition. Mol. Cell 81, 386\u2013397 e387 (2021).","journal-title":"Mol. Cell"},{"key":"8335_CR41","doi-asserted-by":"publisher","first-page":"988872","DOI":"10.3389\/fonc.2022.988872","volume":"12","author":"S Parik","year":"2022","unstructured":"Parik, S. et al. GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide. Front. Oncol. 12, 988872 (2022).","journal-title":"Front. Oncol."},{"key":"8335_CR42","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587 e3529 (2021).","journal-title":"Cell"},{"key":"8335_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa151","volume":"9","author":"MD Young","year":"2020","unstructured":"Young, M. D. & Behjati, S. SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data. Gigascience 9, giaa151 (2020).","journal-title":"Gigascience"},{"key":"8335_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-023-02978-x","volume":"24","author":"P Janssen","year":"2023","unstructured":"Janssen, P. et al. The effect of background noise and its removal on the analysis of single-cell expression data. Genome Biol. 24, 140 (2023).","journal-title":"Genome Biol."},{"key":"8335_CR45","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","volume":"566","author":"J Cao","year":"2019","unstructured":"Cao, J. et al. The single-cell transcriptional landscape of mammalian organogenesis. Nature 566, 496\u2013502 (2019).","journal-title":"Nature"},{"key":"8335_CR46","doi-asserted-by":"publisher","unstructured":"McInnes, M., Healy, J. & Melville, J. UMAP: uniform manifold approximation and projection for dimension reduction. Preprint at arXiv https:\/\/doi.org\/10.48550\/arXiv.1802.03426 (2018).","DOI":"10.48550\/arXiv.1802.03426"},{"key":"8335_CR47","doi-asserted-by":"publisher","unstructured":"Blondel V. D., Guillaume J.-L., Lambiotte R. & Lefebvre E. Fast unfolding of communities in large networks. J. Stat. Mech. https:\/\/doi.org\/10.1088\/1742-5468\/2008\/10\/P10008 (2008).","DOI":"10.1088\/1742-5468\/2008\/10\/P10008"},{"key":"8335_CR48","doi-asserted-by":"publisher","first-page":"979","DOI":"10.12688\/f1000research.73600.2","volume":"10","author":"P-L Germain","year":"2022","unstructured":"Germain, P.-L., Lun, A., Garcia Meixide, C., Macnair, W. & Robinson, M. D. Doublet identification in single-cell sequencing data using scDblFinder. F1000Research 10, 979 (2022).","journal-title":"F1000Research"},{"key":"8335_CR49","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1242\/dev.131466","volume":"143","author":"JF Denis","year":"2016","unstructured":"Denis, J. F. et al. Activation of Smad2 but not Smad3 is required to mediate TGF-\u03b2 signaling during axolotl limb regeneration. Development 143, 3481\u20133490 (2016).","journal-title":"Development"},{"key":"8335_CR50","doi-asserted-by":"publisher","first-page":"eaai8504","DOI":"10.1126\/scitranslmed.aai8504","volume":"9","author":"C Vennin","year":"2017","unstructured":"Vennin, C. et al. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Sci. Transl. Med. 9, eaai8504 (2017).","journal-title":"Sci. Transl. Med."},{"key":"8335_CR51","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","volume":"16","author":"ZG Fridlender","year":"2009","unstructured":"Fridlender, Z. G. et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN. Cancer Cell 16, 183\u2013194 (2009).","journal-title":"Cancer Cell"},{"key":"8335_CR52","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08335-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08335-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08335-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:03:02Z","timestamp":1780480982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08335-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":52,"journal-issue":{"issue":"8049","published-print":{"date-parts":[[2025,2,6]]}},"alternative-id":["8335"],"URL":"https:\/\/doi.org\/10.1038\/s41586-024-08335-7","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"30 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"S.-M.F. has received funding from BlackBelt Therapeutics, Auron Therapeutics, Gilead and Alesta Therapeutics, is on the advisory board of Alesta Therapeutics and has consulted for Fund+ and Droia Ventures. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}