{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:48:42Z","timestamp":1792705722804,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8049","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2025,2,6]]},"DOI":"10.1038\/s41586-024-08352-6","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T11:02:41Z","timestamp":1735729361000},"page":"206-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance"],"prefix":"10.1038","volume":"638","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-688X","authenticated-orcid":false,"given":"Kazuhiro","family":"Furuhashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-6771","authenticated-orcid":false,"given":"Miwako","family":"Kakiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-1529","authenticated-orcid":false,"given":"Hiroko","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ummarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Ebralidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-2968","authenticated-orcid":false,"given":"Mahmoud A.","family":"Bassal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuyuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-3354","authenticated-orcid":false,"given":"Min-guk","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-632X","authenticated-orcid":false,"given":"Shoichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-4590","authenticated-orcid":false,"given":"Hiroaki","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1140-7853","authenticated-orcid":false,"given":"Boris","family":"Reizis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Frangos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-4370","authenticated-orcid":false,"given":"David M.","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Tenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionita C.","family":"Ghiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-0194","authenticated-orcid":false,"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-9488","authenticated-orcid":false,"given":"Joji","family":"Fujisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"8352_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrm2319","volume":"9","author":"DL Jones","year":"2008","unstructured":"Jones, D. L. & Wagers, A. J. No place like home: anatomy and function of the stem cell niche. Nat. Rev. Mol. Cell Biol. 9, 11\u201321 (2008).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"8352_CR2","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.devcel.2021.05.018","volume":"56","author":"S Comazzetto","year":"2021","unstructured":"Comazzetto, S., Shen, B. & Morrison, S. J. Niches that regulate stem cells and hematopoiesis in adult bone marrow. Dev. Cell 56, 1848\u20131860 (2021).","journal-title":"Dev. Cell"},{"key":"8352_CR3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nature12984","volume":"505","author":"SJ Morrison","year":"2014","unstructured":"Morrison, S. J. & Scadden, D. T. The bone marrow niche for haematopoietic stem cells. Nature 505, 327\u2013334 (2014).","journal-title":"Nature"},{"key":"8352_CR4","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","volume":"121","author":"MJ Kiel","year":"2005","unstructured":"Kiel, M. J. et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109\u20131121 (2005).","journal-title":"Cell"},{"key":"8352_CR5","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature10783","volume":"481","author":"L Ding","year":"2012","unstructured":"Ding, L., Saunders, T. L., Enikolopov, G. & Morrison, S. J. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481, 457\u2013462 (2012).","journal-title":"Nature"},{"key":"8352_CR6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11885","volume":"495","author":"L Ding","year":"2013","unstructured":"Ding, L. & Morrison, S. J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495, 231\u2013235 (2013).","journal-title":"Nature"},{"key":"8352_CR7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nature15250","volume":"526","author":"M Acar","year":"2015","unstructured":"Acar, M. et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature 526, 126\u2013130 (2015).","journal-title":"Nature"},{"key":"8352_CR8","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/s41586-021-03298-5","volume":"591","author":"B Shen","year":"2021","unstructured":"Shen, B. et al. A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. Nature 591, 438\u2013444 (2021).","journal-title":"Nature"},{"key":"8352_CR9","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature17638","volume":"532","author":"AP Kusumbe","year":"2016","unstructured":"Kusumbe, A. P. et al. Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature 532, 380\u2013384 (2016).","journal-title":"Nature"},{"key":"8352_CR10","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature13145","volume":"507","author":"AP Kusumbe","year":"2014","unstructured":"Kusumbe, A. P., Ramasamy, S. K. & Adams, R. H. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507, 323\u2013328 (2014).","journal-title":"Nature"},{"key":"8352_CR11","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/nature02040","volume":"425","author":"LM Calvi","year":"2003","unstructured":"Calvi, L. M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841\u2013846 (2003).","journal-title":"Nature"},{"key":"8352_CR12","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nature02041","volume":"425","author":"J Zhang","year":"2003","unstructured":"Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836\u2013841 (2003).","journal-title":"Nature"},{"key":"8352_CR13","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nature12612","volume":"502","author":"Y Kunisaki","year":"2013","unstructured":"Kunisaki, Y. et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 502, 637\u2013643 (2013).","journal-title":"Nature"},{"key":"8352_CR14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/ncb3475","volume":"19","author":"N Asada","year":"2017","unstructured":"Asada, N. et al. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat. Cell Biol. 19, 214\u2013223 (2017).","journal-title":"Nat. Cell Biol."},{"key":"8352_CR15","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.devcel.2018.01.016","volume":"44","author":"S Pinho","year":"2018","unstructured":"Pinho, S. et al. Lineage-biased hematopoietic stem cells are regulated by distinct niches. Dev. Cell 44, 634\u2013641 (2018).","journal-title":"Dev. Cell"},{"key":"8352_CR16","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ni1328","volume":"7","author":"JY Niederkorn","year":"2006","unstructured":"Niederkorn, J. Y. See no evil, hear no evil, do no evil: the lessons of immune privilege. Nat. Immunol. 7, 354\u2013359 (2006).","journal-title":"Nat. Immunol."},{"key":"8352_CR17","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10160","volume":"474","author":"J Fujisaki","year":"2011","unstructured":"Fujisaki, J. et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 474, 216\u2013219 (2011).","journal-title":"Nature"},{"key":"8352_CR18","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.stem.2018.01.017","volume":"22","author":"Y Hirata","year":"2018","unstructured":"Hirata, Y. et al. CD150high bone marrow Tregs maintain hematopoietic stem cell quiescence and immune privilege via adenosine. Cell Stem Cell 22, 445\u2013453 (2018).","journal-title":"Cell Stem Cell"},{"key":"8352_CR19","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.3324\/haematol.2018.198283","volume":"104","author":"Y Hirata","year":"2019","unstructured":"Hirata, Y., Kakiuchi, M., Robson, S. C. & Fujisaki, J. CD150high CD4 T cells and CD150high regulatory T cells regulate hematopoietic stem cell quiescence via CD73. Haematologica 104, 1136\u20131142 (2019).","journal-title":"Haematologica"},{"key":"8352_CR20","doi-asserted-by":"publisher","first-page":"e0141785","DOI":"10.1371\/journal.pone.0141785","volume":"10","author":"Y Hirata","year":"2015","unstructured":"Hirata, Y. et al. MHC class I expression by donor hematopoietic stem cells is required to prevent NK cell attack in allogeneic, but not syngeneic recipient mice. PLoS ONE 10, e0141785 (2015).","journal-title":"PLoS ONE"},{"key":"8352_CR21","doi-asserted-by":"publisher","first-page":"92.e1","DOI":"10.1016\/j.bbmt.2020.09.017","volume":"27","author":"M Kakiuchi","year":"2021","unstructured":"Kakiuchi, M., Hirata, Y., Robson, S. C. & Fujisaki, J. Paradoxical regulation of allogeneic bone marrow engraftment and immune privilege by mesenchymal cells and adenosine. Transplant. Cell. Ther. 27, 92.e1\u201392 (2021).","journal-title":"Transplant. Cell. Ther."},{"key":"8352_CR22","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3324\/haematol.2019.221820","volume":"106","author":"M Kakiuchi","year":"2021","unstructured":"Kakiuchi, M., Hirata, Y., Robson, S. C. & Fujisaki, J. Transfer of stem cell niche-residential regulatory T cells prevents post-irradiation bone marrow injury. Haematologica 106, 891\u2013893 (2021).","journal-title":"Haematologica"},{"key":"8352_CR23","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1098\/rsif.2011.0177","volume":"8","author":"D Lu","year":"2011","unstructured":"Lu, D. & Kassab, G. S. Role of shear stress and stretch in vascular mechanobiology. J. R. Soc. Interface 8, 1379\u20131385 (2011).","journal-title":"J. R. Soc. Interface"},{"key":"8352_CR24","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1002\/stem.1773","volume":"32","author":"A Nogueira-Pedro","year":"2014","unstructured":"Nogueira-Pedro, A. et al. Nitric oxide-induced murine hematopoietic stem cell fate involves multiple signaling proteins, gene expression, and redox modulation. Stem Cells 32, 2949\u20132960 (2014).","journal-title":"Stem Cells"},{"key":"8352_CR25","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1016\/j.bbagen.2012.10.019","volume":"1830","author":"R Tiribuzi","year":"2013","unstructured":"Tiribuzi, R. et al. Nitric oxide depletion alters hematopoietic stem cell commitment toward immunogenic dendritic cells. Biochim. Biophys. Acta 1830, 2830\u20132838 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"8352_CR26","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/nm.3960","volume":"21","author":"S Gur-Cohen","year":"2015","unstructured":"Gur-Cohen, S. et al. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat. Med. 21, 1307\u20131317 (2015).","journal-title":"Nat. Med."},{"key":"8352_CR27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/978-1-61779-170-3_18","volume":"758","author":"RB Tjalkens","year":"2011","unstructured":"Tjalkens, R. B., Carbone, D. L. & Wu, G. Detection of nitric oxide formation in primary neural cells and tissues. Methods Mol. Biol. 758, 267\u2013277 (2011).","journal-title":"Methods Mol. Biol."},{"key":"8352_CR28","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.freeradbiomed.2007.05.025","volume":"43","author":"S Lepiller","year":"2007","unstructured":"Lepiller, S. et al. Imaging of nitric oxide in a living vertebrate using a diamino-fluorescein probe. Free Radic. Biol. Med. 43, 619\u2013627 (2007).","journal-title":"Free Radic. Biol. Med."},{"key":"8352_CR29","first-page":"297","volume":"11","author":"C Ngwa","year":"2019","unstructured":"Ngwa, C. & Liu, F. CD200\u2013CD200R signaling and diseases: a potential therapeutic target? Int. J. Physiol. Pathophysiol. Pharmacol. 11, 297\u2013309 (2019).","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"8352_CR30","doi-asserted-by":"publisher","first-page":"640774","DOI":"10.3389\/fphys.2021.640774","volume":"12","author":"ZM Wang","year":"2021","unstructured":"Wang, Z. M., Gao, X. F., Zhang, J. J. & Chen, S. L. Primary cilia and atherosclerosis. Front. Physiol. 12, 640774 (2021).","journal-title":"Front. Physiol."},{"key":"8352_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/ncb3091","volume":"17","author":"FK Bangs","year":"2015","unstructured":"Bangs, F. K., Schrode, N., Hadjantonakis, A. K. & Anderson, K. V. Lineage specificity of primary cilia in the mouse embryo. Nat. Cell Biol. 17, 113\u2013122 (2015).","journal-title":"Nat. Cell Biol."},{"key":"8352_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41569-022-00770-1","volume":"20","author":"E Trimm","year":"2023","unstructured":"Trimm, E. & Red-Horse, K. Vascular endothelial cell development and diversity. Nat. Rev. Cardiol. 20, 197\u2013210 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"8352_CR33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.stem.2009.01.006","volume":"4","author":"AT Hooper","year":"2009","unstructured":"Hooper, A. T. et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 4, 263\u2013274 (2009).","journal-title":"Cell Stem Cell"},{"key":"8352_CR34","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature17040","volume":"529","author":"S Rafii","year":"2016","unstructured":"Rafii, S., Butler, J. M. & Ding, B. S. Angiocrine functions of organ-specific endothelial cells. Nature 529, 316\u2013325 (2016).","journal-title":"Nature"},{"key":"8352_CR35","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/ncb2108","volume":"12","author":"H Kobayashi","year":"2010","unstructured":"Kobayashi, H. et al. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat. Cell Biol. 12, 1046\u20131056 (2010).","journal-title":"Nat. Cell Biol."},{"key":"8352_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04726-3","volume":"9","author":"C Xu","year":"2018","unstructured":"Xu, C. et al. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nat. Commun. 9, 2449 (2018).","journal-title":"Nat. Commun."},{"key":"8352_CR37","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.immuni.2016.08.007","volume":"45","author":"CM Sawai","year":"2016","unstructured":"Sawai, C. M. et al. Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals. Immunity 45, 597\u2013609 (2016).","journal-title":"Immunity"},{"key":"8352_CR38","doi-asserted-by":"publisher","first-page":"672625","DOI":"10.3389\/fcell.2021.672625","volume":"9","author":"D Paulson","year":"2021","unstructured":"Paulson, D. et al. Loss of primary cilia protein IFT20 dysregulates lymphatic vessel patterning in development and inflammation. Front. Cell Dev. Biol. 9, 672625 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"8352_CR39","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1681\/ASN.2012020154","volume":"24","author":"N Sharma","year":"2013","unstructured":"Sharma, N. et al. Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption. J. Am. Soc. Nephrol. 24, 456\u2013464 (2013).","journal-title":"J. Am. Soc. Nephrol."},{"key":"8352_CR40","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41586-020-03129-z","volume":"591","author":"S Dong","year":"2021","unstructured":"Dong, S. et al. Chaperone-mediated autophagy sustains haematopoietic stem-cell function. Nature 591, 117\u2013123 (2021).","journal-title":"Nature"},{"key":"8352_CR41","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/fncel.2018.00339","volume":"12","author":"L Casares-Crespo","year":"2018","unstructured":"Casares-Crespo, L., Calatayud-Baselga, I., Garcia-Corzo, L. & Mira, H. On the role of basal autophagy in adult neural stem cells and neurogenesis. Front. Cell. Neurosci. 12, 339 (2018).","journal-title":"Front. Cell. Neurosci."},{"key":"8352_CR42","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.stem.2023.02.010","volume":"30","author":"BA Chua","year":"2023","unstructured":"Chua, B. A. et al. Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis. Cell Stem Cell 30, 460\u2013472.e6 (2023).","journal-title":"Cell Stem Cell"},{"key":"8352_CR43","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/152308601300185179","volume":"3","author":"DA Wink","year":"2001","unstructured":"Wink, D. A. et al. Mechanisms of the antioxidant effects of nitric oxide. Antioxid. Redox Signal. 3, 203\u2013213 (2001).","journal-title":"Antioxid. Redox Signal."},{"key":"8352_CR44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/hon.2206","volume":"35","author":"S Aref","year":"2017","unstructured":"Aref, S., Azmy, E. & El-Gilany, A. H. Upregulation of CD200 is associated with regulatory T cell expansion and disease progression in multiple myeloma. Hematol. Oncol. 35, 51\u201357 (2017).","journal-title":"Hematol. Oncol."},{"key":"8352_CR45","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.stem.2018.03.013","volume":"22","author":"R Yamamoto","year":"2018","unstructured":"Yamamoto, R. et al. Large-scale clonal analysis resolves aging of the mouse hematopoietic stem cell compartment. Cell Stem Cell 22, 600\u2013607 (2018).","journal-title":"Cell Stem Cell"},{"key":"8352_CR46","doi-asserted-by":"publisher","first-page":"5021","DOI":"10.1158\/0008-5472.CAN-20-3251","volume":"81","author":"IZ Khan","year":"2021","unstructured":"Khan, I. Z. et al. The CD200\u2013CD200R axis promotes squamous cell carcinoma metastasis via regulation of cathepsin K. Cancer Res. 81, 5021\u20135032 (2021).","journal-title":"Cancer Res."},{"key":"8352_CR47","doi-asserted-by":"publisher","first-page":"ra48","DOI":"10.1126\/scisignal.2004911","volume":"7","author":"H Kalyanaraman","year":"2014","unstructured":"Kalyanaraman, H. et al. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci. Signal. 7, ra48 (2014).","journal-title":"Sci. Signal."},{"key":"8352_CR48","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1083\/jcb.200412022","volume":"169","author":"M Komatsu","year":"2005","unstructured":"Komatsu, M. et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169, 425\u2013434 (2005).","journal-title":"J. Cell Biol."},{"key":"8352_CR49","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1242\/dev.093351","volume":"140","author":"M Ehling","year":"2013","unstructured":"Ehling, M., Adams, S., Benedito, R. & Adams, R. H. Notch controls retinal blood vessel maturation and quiescence. Development 140, 3051\u20133061 (2013).","journal-title":"Development"},{"key":"8352_CR50","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.4049\/jimmunol.166.5.2970","volume":"166","author":"H Ito","year":"2001","unstructured":"Ito, H., Kurtz, J., Shaffer, J. & Sykes, M. CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40\u2013CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J. Immunol. 166, 2970\u20132981 (2001).","journal-title":"J. Immunol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08352-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08352-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08352-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T22:59:29Z","timestamp":1738796369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08352-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":50,"journal-issue":{"issue":"8049","published-print":{"date-parts":[[2025,2,6]]}},"alternative-id":["8352"],"URL":"https:\/\/doi.org\/10.1038\/s41586-024-08352-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2469338\/v1","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"11 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"S.C.R. is a scientific founder of Purinomia Biotech and consults for eGenesis; his interests are reviewed and managed by HMFP at the Beth Israel Deaconess Medical Center following their conflict-of-interest policies. All other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}