{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:56:35Z","timestamp":1790290595220,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"8051","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2025,2,20]]},"DOI":"10.1038\/s41586-024-08440-7","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:05:40Z","timestamp":1737543940000},"page":"760-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["RELM\u03b2 sets the threshold for microbiome-dependent oral tolerance"],"prefix":"10.1038","volume":"638","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-7017","authenticated-orcid":false,"given":"Emmanuel","family":"Stephen-Victor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2338-0176","authenticated-orcid":false,"given":"Gavin A.","family":"Kuziel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Martinez-Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bat-Erdene","family":"Jugder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1532-8642","authenticated-orcid":false,"given":"Mehdi","family":"Benamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel L.","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Abdel-Gadir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-6110","authenticated-orcid":false,"given":"Jason","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Saint-Denis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-2955","authenticated-orcid":false,"given":"Kari C.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Phipatanakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida Abi","family":"Farraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faye","family":"Holder-Niles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-4857","authenticated-orcid":false,"given":"David T.","family":"Breault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schmitz-Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Rachid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-0431","authenticated-orcid":false,"given":"Elena","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-0675","authenticated-orcid":false,"given":"Seth","family":"Rakoff-Nahoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-2762","authenticated-orcid":false,"given":"Talal A.","family":"Chatila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"8440_CR1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.immuni.2020.07.025","volume":"53","author":"E Stephen-Victor","year":"2020","unstructured":"Stephen-Victor, E., Crestani, E. & Chatila, T. A. Dietary and microbial determinants in food allergy. Immunity 53, 277\u2013289 (2020).","journal-title":"Immunity"},{"key":"8440_CR2","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.cell.2020.12.007","volume":"184","author":"EB Florsheim","year":"2021","unstructured":"Florsheim, E. B., Sullivan, Z. A., Khoury-Hanold, W. & Medzhitov, R. Food allergy as a biological food quality control system. Cell 184, 1440\u20131454 (2021).","journal-title":"Cell"},{"key":"8440_CR3","doi-asserted-by":"crossref","first-page":"13596","DOI":"10.1073\/pnas.0404034101","volume":"101","author":"D Artis","year":"2004","unstructured":"Artis, D. et al. RELM\u03b2\/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc. Natl Acad. Sci. USA 101, 13596\u201313600 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"8440_CR4","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1084\/jem.20091268","volume":"206","author":"DR Herbert","year":"2009","unstructured":"Herbert, D. R. et al. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J. Exp. Med. 206, 2947\u20132957 (2009).","journal-title":"J. Exp. Med."},{"key":"8440_CR5","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41591-019-0461-z","volume":"25","author":"A Abdel-Gadir","year":"2019","unstructured":"Abdel-Gadir, A. et al. Microbiota therapy acts via a regulatory T cell MyD88\/RORgammat pathway to suppress food allergy. Nat. Med. 25, 1164\u20131174 (2019).","journal-title":"Nat. Med."},{"key":"8440_CR6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nature11047","volume":"484","author":"NW Palm","year":"2012","unstructured":"Palm, N. W., Rosenstein, R. K. & Medzhitov, R. Allergic host defences. Nature 484, 465\u2013472 (2012).","journal-title":"Nature"},{"key":"8440_CR7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3476","volume":"13","author":"WC Gause","year":"2013","unstructured":"Gause, W. C., Wynn, T. A. & Allen, J. E. Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. Nat. Rev. Immunol. 13, 607\u2013614 (2013).","journal-title":"Nat. Rev. Immunol."},{"key":"8440_CR8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2017.07.004","volume":"47","author":"L Tordesillas","year":"2017","unstructured":"Tordesillas, L., Berin, M. C. & Sampson, H. A. Immunology of food allergy. Immunity 47, 32\u201350 (2017).","journal-title":"Immunity"},{"key":"8440_CR9","doi-asserted-by":"crossref","first-page":"a016352","DOI":"10.1101\/cshperspect.a016352","volume":"7","author":"LE Cheng","year":"2014","unstructured":"Cheng, L. E. & Locksley, R. M. Allergic inflammation\u2013innately homeostatic. Cold Spring Harb. Perspect. Biol. 7, a016352 (2014).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"8440_CR10","doi-asserted-by":"crossref","first-page":"11027","DOI":"10.1073\/pnas.1711395114","volume":"114","author":"DC Propheter","year":"2017","unstructured":"Propheter, D. C., Chara, A. L., Harris, T. A., Ruhn, K. A. & Hooper, L. V. Resistin-like molecule \u03b2 is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc. Natl Acad. Sci. USA 114, 11027\u201311033 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"8440_CR11","doi-asserted-by":"crossref","first-page":"eabe6723","DOI":"10.1126\/science.abe6723","volume":"374","author":"Z Hu","year":"2021","unstructured":"Hu, Z. et al. Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Science 374, eabe6723 (2021).","journal-title":"Science"},{"key":"8440_CR12","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jaci.2010.11.009","volume":"127","author":"CB Mathias","year":"2011","unstructured":"Mathias, C. B. et al. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J. Allergy Clin. Immunol. 127, 795\u2013805 (2011).","journal-title":"J. Allergy Clin. Immunol."},{"key":"8440_CR13","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.immuni.2015.02.004","volume":"42","author":"M Noval Rivas","year":"2015","unstructured":"Noval Rivas, M. et al. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity 42, 512\u2013523 (2015).","journal-title":"Immunity"},{"key":"8440_CR14","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4049\/jimmunol.0803130","volume":"182","author":"A Munitz","year":"2009","unstructured":"Munitz, A. et al. Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation. J. Immunol. 182, 2357\u20132363 (2009).","journal-title":"J. Immunol."},{"key":"8440_CR15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature16161","volume":"529","author":"J von Moltke","year":"2016","unstructured":"von Moltke, J., Ji, M., Liang, H. E. & Locksley, R. M. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529, 221\u2013225 (2016).","journal-title":"Nature"},{"key":"8440_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2018.05.014","volume":"174","author":"C Schneider","year":"2018","unstructured":"Schneider, C. et al. A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling. Cell 174, 271\u2013284 (2018).","journal-title":"Cell"},{"key":"8440_CR17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature16527","volume":"529","author":"F Gerbe","year":"2016","unstructured":"Gerbe, F. et al. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529, 226\u2013230 (2016).","journal-title":"Nature"},{"key":"8440_CR18","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1126\/science.aaf1648","volume":"351","author":"MR Howitt","year":"2016","unstructured":"Howitt, M. R. et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351, 1329\u20131333 (2016).","journal-title":"Science"},{"key":"8440_CR19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.immuni.2018.06.016","volume":"49","author":"MS Nadjsombati","year":"2018","unstructured":"Nadjsombati, M. S. et al. Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49, 33\u201341 (2018).","journal-title":"Immunity"},{"key":"8440_CR20","doi-asserted-by":"crossref","first-page":"eaaw6433","DOI":"10.1126\/science.aaw6433","volume":"365","author":"U Gowthaman","year":"2019","unstructured":"Gowthaman, U. et al. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science 365, eaaw6433 (2019).","journal-title":"Science"},{"key":"8440_CR21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaci.2012.11.032","volume":"131","author":"LM Bartnikas","year":"2013","unstructured":"Bartnikas, L. M. et al. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J. Allergy Clin. Immunol. 131, 451\u2013460 (2013).","journal-title":"J. Allergy Clin. Immunol."},{"key":"8440_CR22","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.aaa9420","volume":"349","author":"E Sefik","year":"2015","unstructured":"Sefik, E. et al. Individual intestinal symbionts induce a distinct population of ROR\u03b3+ regulatory T cells. Science 349, 993\u2013997 (2015).","journal-title":"Science"},{"key":"8440_CR23","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.immuni.2020.10.002","volume":"53","author":"JA Turner","year":"2020","unstructured":"Turner, J. A. et al. Regulatory T cell-derived TGF-\u03b21 controls multiple checkpoints governing allergy and autoimmunity. Immunity 53, 1202\u20131214 (2020).","journal-title":"Immunity"},{"key":"8440_CR24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.aac4263","volume":"349","author":"C Ohnmacht","year":"2015","unstructured":"Ohnmacht, C. et al. The microbiota regulates type 2 immunity through ROR\u03b3+ T cells. Science 349, 989\u2013993 (2015).","journal-title":"Science"},{"key":"8440_CR25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature25500","volume":"554","author":"M Xu","year":"2018","unstructured":"Xu, M. et al. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature 554, 373\u2013377 (2018).","journal-title":"Nature"},{"key":"8440_CR26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.immuni.2022.05.010","volume":"55","author":"J van der Veeken","year":"2022","unstructured":"van der Veeken, J. et al. Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity 55, 1173\u20131184 (2022).","journal-title":"Immunity"},{"key":"8440_CR27","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/mi.2015.140","volume":"9","author":"V Morampudi","year":"2016","unstructured":"Morampudi, V. et al. The goblet cell-derived mediator RELM-\u03b2 drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis. Mucosal Immunol. 9, 1218\u20131233 (2016).","journal-title":"Mucosal Immunol."},{"key":"8440_CR28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","volume":"39","author":"T Zelante","year":"2013","unstructured":"Zelante, T. et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39, 372\u2013385 (2013).","journal-title":"Immunity"},{"key":"8440_CR29","doi-asserted-by":"crossref","first-page":"R257","DOI":"10.1016\/j.cub.2022.02.023","volume":"32","author":"GA Kuziel","year":"2022","unstructured":"Kuziel, G. A. & Rakoff-Nahoum, S. The gut microbiome. Curr. Biol. 32, R257\u2013R264 (2022).","journal-title":"Curr. Biol."},{"key":"8440_CR30","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","volume":"308","author":"PB Eckburg","year":"2005","unstructured":"Eckburg, P. B. et al. Diversity of the human intestinal microbial flora. Science 308, 1635\u20131638 (2005).","journal-title":"Science"},{"key":"8440_CR31","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3389\/fimmu.2020.00906","volume":"11","author":"BJ Parker","year":"2020","unstructured":"Parker, B. J., Wearsch, P. A., Veloo, A. C. M. & Rodriguez-Palacios, A. The genus Alistipes: gut bacteria with emerging implications to inflammation, cancer, and mental health. Front. Immunol. 11, 906 (2020).","journal-title":"Front. Immunol."},{"key":"8440_CR32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.chom.2016.10.021","volume":"20","author":"AS Devlin","year":"2016","unstructured":"Devlin, A. S. et al. Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota. Cell Host Microbe 20, 709\u2013715 (2016).","journal-title":"Cell Host Microbe"},{"key":"8440_CR33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","volume":"453","author":"FJ Quintana","year":"2008","unstructured":"Quintana, F. J. et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65\u201371 (2008).","journal-title":"Nature"},{"key":"8440_CR34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2017.12.012","volume":"48","author":"C Gutierrez-Vazquez","year":"2018","unstructured":"Gutierrez-Vazquez, C. & Quintana, F. J. Regulation of the immune response by the aryl hydrocarbon receptor. Immunity 48, 19\u201333 (2018).","journal-title":"Immunity"},{"key":"8440_CR35","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.celrep.2017.10.114","volume":"21","author":"J Ye","year":"2017","unstructured":"Ye, J. et al. The aryl hydrocarbon receptor preferentially marks and promotes gut regulatory T cells. Cell Rep. 21, 2277\u20132290 (2017).","journal-title":"Cell Rep."},{"key":"8440_CR36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","volume":"141","author":"SH Sicherer","year":"2018","unstructured":"Sicherer, S. H. & Sampson, H. A. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J. Allergy Clin. Immunol. 141, 41\u201358 (2018).","journal-title":"J. Allergy Clin. Immunol."},{"key":"8440_CR37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaci.2020.10.039","volume":"147","author":"K Kanchan","year":"2021","unstructured":"Kanchan, K., Clay, S., Irizar, H., Bunyavanich, S. & Mathias, R. A. Current insights into the genetics of food allergy. J. Allergy Clin. Immunol. 147, 15\u201328 (2021).","journal-title":"J. Allergy Clin. Immunol."},{"key":"8440_CR38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jaci.2020.12.624","volume":"147","author":"R Rachid","year":"2021","unstructured":"Rachid, R., Stephen-Victor, E. & Chatila, T. A. The microbial origins of food allergy. J. Allergy Clin. Immunol. 147, 808\u2013813 (2021).","journal-title":"J. Allergy Clin. Immunol."},{"key":"8440_CR39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41577-020-00420-y","volume":"21","author":"H Renz","year":"2021","unstructured":"Renz, H. & Skevaki, C. Early life microbial exposures and allergy risks: opportunities for prevention. Nat. Rev. Immunol. 21, 177\u2013191 (2021).","journal-title":"Nat. Rev. Immunol."},{"key":"8440_CR40","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.immuni.2019.02.014","volume":"50","author":"Z Al Nabhani","year":"2019","unstructured":"Al Nabhani, Z. et al. A weaning reaction to microbiota is required for resistance to immunopathologies in the adult. Immunity 50, 1276\u20131288 (2019).","journal-title":"Immunity"},{"key":"8440_CR41","doi-asserted-by":"crossref","first-page":"eaao1314","DOI":"10.1126\/sciimmunol.aao1314","volume":"2","author":"KA Knoop","year":"2017","unstructured":"Knoop, K. A. et al. Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria. Sci. Immunol. 2, eaao1314 (2017).","journal-title":"Sci. Immunol."},{"key":"8440_CR42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41385-020-0257-y","volume":"13","author":"Z Al Nabhani","year":"2020","unstructured":"Al Nabhani, Z. & Eberl, G. Imprinting of the immune system by the microbiota early in life. Mucosal Immunol. 13, 183\u2013189 (2020).","journal-title":"Mucosal Immunol."},{"key":"8440_CR43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jaci.2012.10.026","volume":"131","author":"M Noval Rivas","year":"2013","unstructured":"Noval Rivas, M. et al. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J. Allergy Clin. Immunol. 131, 201\u2013212 (2013).","journal-title":"J. Allergy Clin. Immunol."},{"key":"8440_CR44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.immuni.2014.05.017","volume":"41","author":"OT Burton","year":"2014","unstructured":"Burton, O. T. et al. Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity 41, 141\u2013151 (2014).","journal-title":"Immunity"},{"key":"8440_CR45","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/dvdy.20551","volume":"234","author":"V Matei","year":"2005","unstructured":"Matei, V. et al. Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev. Dyn. 234, 633\u2013650 (2005).","journal-title":"Dev. Dyn."},{"key":"8440_CR46","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.immuni.2021.04.002","volume":"54","author":"H Harb","year":"2021","unstructured":"Harb, H. et al. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity 54, 1186\u20131199 (2021).","journal-title":"Immunity"},{"key":"8440_CR47","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27901-5","volume":"13","author":"D Zeve","year":"2022","unstructured":"Zeve, D. et al. Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nat. Commun. 13, 261 (2022).","journal-title":"Nat. Commun."},{"key":"8440_CR48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41586-021-03241-8","volume":"591","author":"C Rao","year":"2021","unstructured":"Rao, C. et al. Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Nature 591, 633\u2013638 (2021).","journal-title":"Nature"},{"key":"8440_CR49","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403\u2013410 (1990).","journal-title":"J. Mol. Biol."},{"key":"8440_CR50","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/nar\/7.6.1513","volume":"7","author":"HC Birnboim","year":"1979","unstructured":"Birnboim, H. C. & Doly, J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 7, 1513\u20131523 (1979).","journal-title":"Nucleic Acids Res."},{"key":"8440_CR51","first-page":"e00607-17","volume":"200","author":"S Zhang","year":"2018","unstructured":"Zhang, S., Oh, J. H., Alexander, L. M., Ozcam, M. & van Pijkeren, J. P. d-Alanyl-d-alanine ligase as a broad-host-range counterselection marker in vancomycin-resistant lactic acid bacteria. J. Bacteriol. 200, e00607-17 (2018).","journal-title":"J. Bacteriol."},{"key":"8440_CR52","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","volume":"6","author":"DG Gibson","year":"2009","unstructured":"Gibson, D. G. et al. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 6, 343\u2013345 (2009).","journal-title":"Nat. Methods"},{"key":"8440_CR53","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2022.01.002","volume":"185","author":"SY Park","year":"2022","unstructured":"Park, S. Y. et al. Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Cell 185, 513\u2013529 (2022).","journal-title":"Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08440-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08440-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08440-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T09:16:57Z","timestamp":1739956617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-024-08440-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":53,"journal-issue":{"issue":"8051","published-print":{"date-parts":[[2025,2,20]]}},"alternative-id":["8440"],"URL":"https:\/\/doi.org\/10.1038\/s41586-024-08440-7","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"16 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"T.A.C., E.C., E.S.-V. and A.A.-G. have a pending patent application related to methods or compositions for treating or preventing allergy or anaphylaxis (US17\/801,238). T.A.C. has a provisional patent application related to RELM\u03b2\u00a0regulation of oral tolerance (US\u00a063\/722,176).\u00a0G.A.K. has financial interests in Hasana Biosciences and Matoi Therapeutics. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}