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Here we identify a sleep function for peripheral macrophage-like cells (haemocytes) in the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    circulation, showing that haemocytes track to the brain during sleep and take up lipids accumulated in cortex glia due to wake-associated oxidative damage. Through a screen of phagocytic receptors expressed in haemocytes, we discovered that knockdown of\n                    <jats:italic>eater<\/jats:italic>\n                    \u2014a member of the Nimrod receptor family\u2014reduces sleep. Loss of\n                    <jats:italic>eater<\/jats:italic>\n                    also disrupts haemocyte localization to the brain and lipid uptake, which results in increased brain levels of acetyl-CoA and acetylated proteins, including mitochondrial proteins PGC1\u03b1 and DRP1. Dysregulation of mitochondria, reflected in high oxidation and reduced NAD\n                    <jats:sup>+<\/jats:sup>\n                    , is accompanied by impaired memory and lifespan. Thus, peripheral blood cells, which we suggest are precursors of mammalian microglia, perform a daily function of sleep to maintain brain function and fitness.\n                  <\/jats:p>","DOI":"10.1038\/s41586-025-10050-w","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:02:29Z","timestamp":1770825749000},"page":"720-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sleep-dependent clearance of brain lipids by peripheral blood cells"],"prefix":"10.1038","volume":"651","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0624","authenticated-orcid":false,"given":"Bumsik","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E.","family":"Youngstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Killiany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E.","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor H.","family":"Beveridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Saklani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-7898","authenticated-orcid":false,"given":"Gaurav","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-9641","authenticated-orcid":false,"given":"Amita","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"10050_CR1","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1534\/genetics.115.185157","volume":"205","author":"C Dubowy","year":"2017","unstructured":"Dubowy, C. & Sehgal, A. 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