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Y.N. has held leadership positions or advisory roles for Otsuka Pharmaceutical and Bristol Myers Squibb, and has received honoraria from Bristol Myers Squibb, Takeda Pharmaceuticals, Daiichi Sankyo, Kyowa Kirin, Novartis, Pfizer, Nippon Shinyaku, Otsuka Pharmaceutical, AstraZeneca, Astellas Pharma and AbbVie. S.\u00a0Kasahara has received honoraria from Daiichi Sankyo and AbbVie and funding for clinical trials from Astellas, Novartis and Incyte Biosciences Japan. J.K. has received honoraria from Daiichi Sankyo and Asahi Kasei Pharma. S.Y. has received honoraria from Bristol Myers Squibb, Janssen Pharmaceutical and Novartis. A.Y. was employed in an endowed department funded by Chordia Therapeutics. H.A. has served in an advisory role for and has received research funding from Konica Minolta, and has an endowed chair funded by Chugai Pharmaceutical. H.I.S. has received research funding from FUJIFILM. S.O. has received research funding from Chordia Therapeutics, Eisai and Otsuka Pharmaceutical, consulting fees from Chordia Therapeutics, Eisai and Montage Bio and owns stock in Asahi Genomics. The aforementioned companies were not involved in any aspect of this study. A patent application related to this work has been filed by Kyoto University. The remaining authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}