{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:39Z","timestamp":1792809519462,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"DOI":"10.1038\/s41586-026-11064-8","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:03:22Z","timestamp":1790780602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal clonal architecture of the newborn mouse forebrain"],"prefix":"10.1038","author":[{"given":"Guohua","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4159-8056","authenticated-orcid":false,"given":"Michael","family":"Kunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-4776","authenticated-orcid":false,"given":"Marilyn R.","family":"Steyert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-4546","authenticated-orcid":false,"given":"Cindy T. J.","family":"van Velthoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-4424","authenticated-orcid":false,"given":"Delissa","family":"McMillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-4183","authenticated-orcid":false,"given":"Jack","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6737-8370","authenticated-orcid":false,"given":"Yasmin","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kazerounian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Alvarez-Buylla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-5878","authenticated-orcid":false,"given":"Hongkui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-4964","authenticated-orcid":false,"given":"Tomasz J.","family":"Nowakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"11064_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41586-021-03775-x","volume":"596","author":"G La Manno","year":"2021","unstructured":"La Manno, G. et al. Molecular architecture of the developing mouse brain. Nature 596, 92\u201396 (2021).","journal-title":"Nature"},{"key":"11064_CR2","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41586-021-04237-0","volume":"601","author":"RC Bandler","year":"2022","unstructured":"Bandler, R. C. et al. Single-cell delineation of lineage and genetic identity in the mouse brain. Nature 601, 404\u2013409 (2022).","journal-title":"Nature"},{"key":"11064_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41586-018-0654-5","volume":"563","author":"B Tasic","year":"2018","unstructured":"Tasic, B. et al. Shared and distinct transcriptomic cell types across neocortical areas. Nature 563, 72\u201378 (2018).","journal-title":"Nature"},{"key":"11064_CR4","doi-asserted-by":"publisher","first-page":"e23013","DOI":"10.1371\/journal.pone.0023013","volume":"6","author":"TJ Nowakowski","year":"2011","unstructured":"Nowakowski, T. J., Mysiak, K. S., Pratt, T. & Price, D. J. Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS ONE 6, e23013 (2011).","journal-title":"PLoS ONE"},{"key":"11064_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","volume":"32","author":"A Kriegstein","year":"2009","unstructured":"Kriegstein, A. & Alvarez-Buylla, A. The glial nature of embryonic and adult neural stem cells. Annu. Rev. Neurosci. 32, 149\u2013184 (2009).","journal-title":"Annu. Rev. Neurosci."},{"key":"11064_CR6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/35055553","volume":"409","author":"SC Noctor","year":"2001","unstructured":"Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S. & Kriegstein, A. R. Neurons derived from radial glial cells establish radial units in neocortex. Nature 409, 714\u2013720 (2001).","journal-title":"Nature"},{"key":"11064_CR7","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0896-6273(04)00140-0","volume":"41","author":"TE Anthony","year":"2004","unstructured":"Anthony, T. E., Klein, C., Fishell, G. & Heintz, N. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41, 881\u2013890 (2004).","journal-title":"Neuron"},{"key":"11064_CR8","doi-asserted-by":"publisher","first-page":"5253","DOI":"10.1242\/dev.127.24.5253","volume":"127","author":"P Malatesta","year":"2000","unstructured":"Malatesta, P., Hartfuss, E. & G\u00f6tz, M. Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development 127, 5253\u20135263 (2000).","journal-title":"Development"},{"key":"11064_CR9","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1111\/j.1460-9568.2010.07267.x","volume":"31","author":"DM Gelman","year":"2010","unstructured":"Gelman, D. M. & Mar\u00edn, O. Generation of interneuron diversity in the mouse cerebral cortex. Eur. J. Neurosci. 31, 2136\u20132141 (2010).","journal-title":"Eur. J. Neurosci."},{"key":"11064_CR10","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1146\/annurev-cellbio-100814-125353","volume":"31","author":"S Lodato","year":"2015","unstructured":"Lodato, S. & Arlotta, P. Generating neuronal diversity in the mammalian cerebral cortex. Annu. Rev. Cell Dev. Biol. 31, 699\u2013720 (2015).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"11064_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nn1620","volume":"9","author":"N Kessaris","year":"2006","unstructured":"Kessaris, N. et al. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat. Neurosci. 9, 173\u2013179 (2006).","journal-title":"Nat. Neurosci."},{"key":"11064_CR12","doi-asserted-by":"publisher","first-page":"17528","DOI":"10.1073\/pnas.0407893101","volume":"101","author":"FT Merkle","year":"2004","unstructured":"Merkle, F. T., Tramontin, A. D., Garc\u00eda-Verdugo, J. M. & Alvarez-Buylla, A. Radial glia give rise to adult neural stem cells in the subventricular zone. Proc. Natl Acad. Sci. USA 101, 17528\u201317532 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"11064_CR13","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.cell.2015.05.041","volume":"161","author":"LC Fuentealba","year":"2015","unstructured":"Fuentealba, L. C. et al. Embryonic origin of postnatal neural stem cells. Cell 161, 1644\u20131655 (2015).","journal-title":"Cell"},{"key":"11064_CR14","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.stem.2012.05.012","volume":"10","author":"LC Fuentealba","year":"2012","unstructured":"Fuentealba, L. C., Obernier, K. & Alvarez-Buylla, A. Adult neural stem cells bridge their niche. Cell Stem Cell 10, 698\u2013708 (2012).","journal-title":"Cell Stem Cell"},{"key":"11064_CR15","doi-asserted-by":"publisher","first-page":"708","DOI":"10.3390\/biom14060708","volume":"14","author":"L Puelles","year":"2024","unstructured":"Puelles, L. & Nieuwenhuys, R. Can we explain thousands of molecularly identified mouse neuronal types? From knowing to understanding. Biomolecules 14, 708 (2024).","journal-title":"Biomolecules"},{"key":"11064_CR16","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1002\/1873-3468.12906","volume":"591","author":"R Beattie","year":"2017","unstructured":"Beattie, R. & Hippenmeyer, S. Mechanisms of radial glia progenitor cell lineage progression. FEBS Lett. 591, 3993\u20134008 (2017).","journal-title":"FEBS Lett."},{"key":"11064_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005211","volume":"16","author":"SZH Wong","year":"2018","unstructured":"Wong, S. Z. H. et al. In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis. PLoS Biol. 16, e2005211 (2018).","journal-title":"PLoS Biol."},{"key":"11064_CR18","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nn.4519","volume":"20","author":"W Shi","year":"2017","unstructured":"Shi, W. et al. Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus. Nat. Neurosci. 20, 516\u2013528 (2017).","journal-title":"Nat. Neurosci."},{"key":"11064_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108853","volume":"34","author":"Z Shen","year":"2021","unstructured":"Shen, Z. et al. Distinct progenitor behavior underlying neocortical gliogenesis related to tumorigenesis. Cell Rep. 34, 108853 (2021).","journal-title":"Cell Rep."},{"key":"11064_CR20","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2014.10.027","volume":"159","author":"P Gao","year":"2014","unstructured":"Gao, P. et al. Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell 159, 775\u2013788 (2014).","journal-title":"Cell"},{"key":"11064_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0896-6273(88)90163-8","volume":"1","author":"MB Luskin","year":"1988","unstructured":"Luskin, M. B., Pearlman, A. L. & Sanes, J. R. Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a recombinant retrovirus. Neuron 1, 635\u2013647 (1988).","journal-title":"Neuron"},{"key":"11064_CR22","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/0076-6879(93)25059-B","volume":"225","author":"CL Cepko","year":"1993","unstructured":"Cepko, C. L., Ryder, E. F., Austin, C. P., Walsh, C. & Fekete, D. M. Lineage analysis using retrovirus vectors. Methods Enzymol. 225, 933\u2013960 (1993).","journal-title":"Methods Enzymol."},{"key":"11064_CR23","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1038\/s41593-024-01827-9","volume":"27","author":"I Adameyko","year":"2024","unstructured":"Adameyko, I. et al. Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system. Nat. Neurosci. 27, 2278\u20132291 (2024).","journal-title":"Nat. Neurosci."},{"key":"11064_CR24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41593-022-01011-x","volume":"25","author":"M Ratz","year":"2022","unstructured":"Ratz, M. et al. Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics. Nat. Neurosci. 25, 285\u2013294 (2022).","journal-title":"Nat. Neurosci."},{"key":"11064_CR25","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.neuron.2015.07.011","volume":"87","author":"C Mayer","year":"2015","unstructured":"Mayer, C. et al. Clonally related forebrain interneurons disperse broadly across both functional areas and structural boundaries. Neuron 87, 989\u2013998 (2015).","journal-title":"Neuron"},{"key":"11064_CR26","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.neuron.2015.07.030","volume":"87","author":"CC Harwell","year":"2015","unstructured":"Harwell, C. C. et al. Wide dispersion and diversity of clonally related inhibitory interneurons. Neuron 87, 999\u20131007 (2015).","journal-title":"Neuron"},{"key":"11064_CR27","doi-asserted-by":"publisher","unstructured":"Puche-Aroca, L. et al. Early lineage divergence segregates sensory and non-sensory thalamic circuits. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2025.07.17.665342 (2025).","DOI":"10.1101\/2025.07.17.665342"},{"key":"11064_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04230-7","author":"RN Delgado","year":"2021","unstructured":"Delgado, R. N. et al. Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature https:\/\/doi.org\/10.1038\/s41586-021-04230-7 (2021).","journal-title":"Nature"},{"key":"11064_CR29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41586-025-09644-1","volume":"647","author":"Y Gao","year":"2025","unstructured":"Gao, Y. et al. Continuous cell-type diversification in mouse visual cortex development. Nature 647, 127\u2013142 (2025).","journal-title":"Nature"},{"key":"11064_CR30","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1016\/j.cell.2022.09.004","volume":"185","author":"EE Crouch","year":"2022","unstructured":"Crouch, E. E. et al. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell 185, 3753\u20133769.e18 (2022).","journal-title":"Cell"},{"key":"11064_CR31","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","volume":"50","author":"TR Hammond","year":"2019","unstructured":"Hammond, T. R. et al. Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes. Immunity 50, 253\u2013271.e6 (2019).","journal-title":"Immunity"},{"key":"11064_CR32","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/nn1511","volume":"8","author":"F Bielle","year":"2005","unstructured":"Bielle, F. et al. Multiple origins of Cajal\u2013Retzius cells at the borders of the developing pallium. Nat. Neurosci. 8, 1002\u20131012 (2005).","journal-title":"Nat. Neurosci."},{"key":"11064_CR33","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","volume":"330","author":"F Ginhoux","year":"2010","unstructured":"Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841\u2013845 (2010).","journal-title":"Science"},{"key":"11064_CR34","doi-asserted-by":"publisher","first-page":"9484","DOI":"10.1073\/pnas.1508545112","volume":"112","author":"GJ Sun","year":"2015","unstructured":"Sun, G. J. et al. Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain. Proc. Natl Acad. Sci. USA 112, 9484\u20139489 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"11064_CR35","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ydbio.2006.06.040","volume":"298","author":"O Britanova","year":"2006","unstructured":"Britanova, O. et al. A novel mode of tangential migration of cortical projection neurons. Dev. Biol. 298, 299\u2013311 (2006).","journal-title":"Dev. Biol."},{"key":"11064_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.04.003","author":"N Baumann","year":"2025","unstructured":"Baumann, N. et al. Regional differences in progenitor metabolism shape brain growth during development. Cell https:\/\/doi.org\/10.1016\/j.cell.2025.04.003 (2025).","journal-title":"Cell"},{"key":"11064_CR37","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrn2463","volume":"9","author":"JM H\u00e9bert","year":"2008","unstructured":"H\u00e9bert, J. M. & Fishell, G. The genetics of early telencephalon patterning: some assembly required. Nat. Rev. Neurosci. 9, 678\u2013685 (2008).","journal-title":"Nat. Rev. Neurosci."},{"key":"11064_CR38","doi-asserted-by":"publisher","first-page":"E909","DOI":"10.3390\/brainsci10120909","volume":"10","author":"AM Bond","year":"2020","unstructured":"Bond, A. M. et al. Differential timing and coordination of neurogenesis and astrogenesis in developing mouse hippocampal subregions. Brain Sci. 10, E909 (2020).","journal-title":"Brain Sci."},{"key":"11064_CR39","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/ar.1092120215","volume":"212","author":"RW Young","year":"1985","unstructured":"Young, R. W. Cell differentiation in the retina of the mouse. Anat. Rec. 212, 199\u2013205 (1985).","journal-title":"Anat. Rec."},{"key":"11064_CR40","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/cne.901390407","volume":"139","author":"P Rakic","year":"1970","unstructured":"Rakic, P. & Sidman, R. L. Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J. Comp. Neurol. 139, 473\u2013500 (1970).","journal-title":"J. Comp. Neurol."},{"key":"11064_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-6-12","volume":"6","author":"E Winpenny","year":"2011","unstructured":"Winpenny, E. et al. Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells. Neural Dev. 6, 12 (2011).","journal-title":"Neural Dev."},{"key":"11064_CR42","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1016\/j.celrep.2018.02.030","volume":"22","author":"V Donega","year":"2018","unstructured":"Donega, V. et al. Transcriptional dysregulation in postnatal glutamatergic progenitors contributes to closure of the cortical neurogenic period. Cell Rep. 22, 2567\u20132574 (2018).","journal-title":"Cell Rep."},{"key":"11064_CR43","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature25999","volume":"555","author":"C Mayer","year":"2018","unstructured":"Mayer, C. et al. Developmental diversification of cortical inhibitory interneurons. Nature 555, 457\u2013462 (2018).","journal-title":"Nature"},{"key":"11064_CR44","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuron.2018.06.021","volume":"99","author":"SM Kelly","year":"2018","unstructured":"Kelly, S. M. et al. Radial glial lineage progression and differential intermediate progenitor amplification underlie striatal compartments and circuit organization. Neuron 99, 345\u2013361.e4 (2018).","journal-title":"Neuron"},{"key":"11064_CR45","doi-asserted-by":"publisher","first-page":"100153","DOI":"10.1016\/j.addicn.2024.100153","volume":"11","author":"E Andraka","year":"2024","unstructured":"Andraka, E., Phillips, R. A. 3rd, Brida, K. L. & Day, J. J. Chst9 marks a spatially and transcriptionally unique population of Oprm1-expressing neurons in the nucleus accumbens. Addict. Neurosci. 11, 100153 (2024).","journal-title":"Addict. Neurosci."},{"key":"11064_CR46","doi-asserted-by":"publisher","first-page":"eadf9941","DOI":"10.1126\/science.adf9941","volume":"382","author":"CN Kim","year":"2023","unstructured":"Kim, C. N., Shin, D., Wang, A. & Nowakowski, T. J. Spatiotemporal molecular dynamics of the developing human thalamus. Science 382, eadf9941 (2023).","journal-title":"Science"},{"key":"11064_CR47","doi-asserted-by":"publisher","first-page":"e59272","DOI":"10.7554\/eLife.59272","volume":"10","author":"P Jager","year":"2021","unstructured":"Jager, P. et al. Dual midbrain and forebrain origins of thalamic inhibitory interneurons. eLife 10, e59272 (2021).","journal-title":"eLife"},{"key":"11064_CR48","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41586-023-06564-w","volume":"622","author":"X Meng","year":"2023","unstructured":"Meng, X. et al. Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment. Nature 622, 359\u2013366 (2023).","journal-title":"Nature"},{"key":"11064_CR49","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/s41588-022-01104-0","volume":"54","author":"JM Fu","year":"2022","unstructured":"Fu, J. M. et al. Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. Nat. Genet. 54, 1320\u20131331 (2022).","journal-title":"Nat. Genet."},{"key":"11064_CR50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67436","volume":"10","author":"A Cebrian-Silla","year":"2021","unstructured":"Cebrian-Silla, A. et al. Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis. eLife 10, e67436 (2021).","journal-title":"eLife"},{"key":"11064_CR51","doi-asserted-by":"publisher","first-page":"115264","DOI":"10.1016\/j.celrep.2025.115264","volume":"44","author":"A Cebrian-Silla","year":"2025","unstructured":"Cebrian-Silla, A. et al. Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone. Cell Rep. 44, 115264 (2025).","journal-title":"Cell Rep."},{"key":"11064_CR52","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.conb.2020.10.017","volume":"66","author":"Y Lin","year":"2021","unstructured":"Lin, Y. et al. Behavior and lineage progression of neural progenitors in the mammalian cortex. Curr. Opin. Neurobiol. 66, 144\u2013157 (2021).","journal-title":"Curr. Opin. Neurobiol."},{"key":"11064_CR53","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/s41593-024-01611-9","volume":"27","author":"E Dvoretskova","year":"2024","unstructured":"Dvoretskova, E. et al. Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development. Nat. Neurosci. 27, 862\u2013872 (2024).","journal-title":"Nat. Neurosci."},{"key":"11064_CR54","doi-asserted-by":"publisher","unstructured":"Varela-Mart\u00ednez, I., Villalba, A., Garc\u00eda-Marqu\u00e9s, J., Hippenmeyer, S. & Nieto, M. Early emergence of projection-subtype fate-restricted Radial glial progenitors orchestrates neocortical neurogenesis. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2025.05.07.652665 (2025).","DOI":"10.1101\/2025.05.07.652665"},{"key":"11064_CR55","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1222381","volume":"337","author":"H-H Tsai","year":"2012","unstructured":"Tsai, H.-H. et al. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science 337, 358\u2013362 (2012).","journal-title":"Science"},{"key":"11064_CR56","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuron.2018.10.009","volume":"100","author":"L Lim","year":"2018","unstructured":"Lim, L., Mi, D., Llorca, A. & Mar\u00edn, O. Development and functional diversification of cortical interneurons. Neuron 100, 294\u2013313 (2018).","journal-title":"Neuron"},{"key":"11064_CR57","unstructured":"Allen Institute. Allen Reference Atlas \u2013 Mouse Brain [brain atlas] https:\/\/atlas.brain-map.org (accessed 10 August 2023)."},{"key":"11064_CR58","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.celrep.2014.07.042","volume":"8","author":"P Squarzoni","year":"2014","unstructured":"Squarzoni, P. et al. Microglia modulate wiring of the embryonic forebrain. Cell Rep. 8, 1271\u20131279 (2014).","journal-title":"Cell Rep."},{"key":"11064_CR59","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/12186","volume":"2","author":"N Gaiano","year":"1999","unstructured":"Gaiano, N., Kohtz, J. D., Turnbull, D. H. & Fishell, G. A method for rapid gain-of-function studies in the mouse embryonic nervous system. Nat. Neurosci. 2, 812\u2013819 (1999).","journal-title":"Nat. Neurosci."},{"key":"11064_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25","volume":"10","author":"B Langmead","year":"2009","unstructured":"Langmead, B., Trapnell, C., Pop, M. & Salzberg, S. L. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).","journal-title":"Genome Biol."},{"key":"11064_CR61","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1101\/gr.209601.116","volume":"27","author":"T Smith","year":"2017","unstructured":"Smith, T., Heger, A. & Sudbery, I. UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy. Genome Res. 27, 491\u2013499 (2017).","journal-title":"Genome Res."},{"key":"11064_CR62","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1038\/s41592-022-01663-4","volume":"19","author":"M Pachitariu","year":"2022","unstructured":"Pachitariu, M. & Stringer, C. Cellpose 2.0: how to train your own model. Nat. Methods 19, 1634\u20131641 (2022).","journal-title":"Nat. Methods"},{"key":"11064_CR63","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cels.2020.05.010","volume":"11","author":"NJ Bernstein","year":"2020","unstructured":"Bernstein, N. J. et al. Solo: doublet identification in single-cell RNA-seq via semi-supervised deep learning. Cell Syst. 11, 95\u2013101.e5 (2020).","journal-title":"Cell Syst."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-11064-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-11064-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-11064-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:03:25Z","timestamp":1792807405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-11064-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":63,"alternative-id":["11064"],"URL":"https:\/\/doi.org\/10.1038\/s41586-026-11064-8","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"8 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}