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To this end, host tissues increase their own oxidative stress resilience and repair capacity via adaptive redox signalling\n                    <jats:sup>4\u20136<\/jats:sup>\n                    . Here, using live zebrafish and human cells, we identify a metabolic redox signalling mechanism that integrates oxidative immune defence with tissue adaptation. We demonstrate that DHRS7, an orphan short-chain fatty acid dehydrogenase\u2013reductase, generates or consumes the pro-inflammatory lipid 5-oxoETE as a function of cytoplasmic NADP\n                    <jats:sup>+<\/jats:sup>\n                    \/NADPH ratio. At wounds, where oxidative stress and NADP\n                    <jats:sup>+<\/jats:sup>\n                    are high, 5-oxo-eicosatetraenoic acid (5-oxoETE) production by DHRS7 rapidly alerts antimicrobial white blood cells through the G-protein-coupled receptor OXER1. In undamaged tissue, where NADP\n                    <jats:sup>+<\/jats:sup>\n                    is low, DHRS7 quenches unnecessary inflammation. Notably, we find that 5-oxoETE also supports epithelial redox resilience; OXER1-deficient zebrafish exhibit intestinal apoptosis, barrier disruption and microbial inflammation. Mechanistically, 5-oxoETE induces the expression of NUDIX hydrolases, which protect the cytoplasmic nucleotide pool from oxidation and prevent apoptosis in zebrafish and human intestinal cells. Thus, our data reveal a conserved mode of redox sensing and signalling\u2014beyond classic thiol oxidation\u2014that leverages NADPH metabolism to orchestrate the antimicrobial and pro-resilience functions of oxidative stress.\n                  <\/jats:p>","DOI":"10.1038\/s41586-026-11121-2","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:03:27Z","timestamp":1791385407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["5-oxoETE links redox control of epithelial damage detection and resilience"],"prefix":"10.1038","author":[{"given":"Yanan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-6369","authenticated-orcid":false,"given":"Mikl\u00f3s","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King Lam","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes A.","family":"Ambaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-3916","authenticated-orcid":false,"given":"Zaza","family":"Gelashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-7828","authenticated-orcid":false,"given":"Leehyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchie","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2565-6452","authenticated-orcid":false,"given":"Siyang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-7661","authenticated-orcid":false,"given":"Meysoon","family":"Quraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-1327","authenticated-orcid":false,"given":"Tobias C.","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-2239","authenticated-orcid":false,"suffix":"Jr","given":"Robert V.","family":"Farese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-4012","authenticated-orcid":false,"given":"Philipp","family":"Niethammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"11121_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","volume":"20","author":"HJ Forman","year":"2021","unstructured":"Forman, H. 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