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H.J. and J.C. are scientific consultants for Site Tx. A.M. is a cofounder of Site Tx, Arsenal Biosciences and Survey Genomics, serves on the boards of directors at Site Tx and Survey Genomics, is a member of the scientific advisory boards of Network Bio, Site Tx, Arsenal Biosciences, Cellanome, Survey Genomics, NewLimit, Amgen and Tenaya, owns stock in Network Bio, Arsenal Biosciences, Site Tx, Cellanome, NewLimit, Survey Genomics, Tenaya and Lightcast and has received fees from Network Bio, Site Tx, Arsenal Biosciences, Cellanome, Survey Genomics, Spotlight Therapeutics, NewLimit, Abbvie, Gilead, Pfizer, 23andMe, PACT Pharma, Juno Therapeutics, Tenaya, Lightcast, Trizell, Vertex, Merck, Amgen, Genentech, GLG, ClearView Healthcare, AlphaSights and Rupert Case Management. A.M. is an investor in and informal advisor to Offline Ventures and a client of EPIQ. The A.M. laboratory has received research support from the Parker Institute for Cancer Immunotherapy, CZI\/Biohub, the Emerson Collective, Arc Institute, Juno Therapeutics, Epinomics, Sanofi, GlaxoSmithKline, Gilead and Anthem and reagents from 10x, Ultima, Genscript, Illumina and Cellanome. J.E. owns stock in Mnemo Therapeutics, Azalea Therapeutics and Cytovia Therapeutics. J.E. has received a consulting fee from Casdin Capital, Resolution Therapeutics and Treefrog Therapeutics. The Regents of the University of California have patents issued and\/or pending for CRISPR technologies (on which J.A.D. is an inventor) and delivery technologies (on which J.A.D. and W.N. are coinventors). J.A.D. is a cofounder of Azalea Therapeutics, Caribou Biosciences, Editas Medicine, Scribe Therapeutics, Intellia Therapeutics and Mammoth Biosciences. J.A.D. is a scientific advisory board member at Azalea, Caribou Biosciences, Scribe Therapeutics, The Column Group and Inari. J.A.D. is chief science advisor to Sixth Street, is a director at Johnson & Johnson, Altos and Tempus and has a research project sponsored by AppleTree Partners. D.R.L. is a cofounder of Beam Therapeutics, Prime Medicine, Editas Medicine, Pairwise Plants and nChroma Bio, companies that use or deliver genome-editing or epigenome-modifying agents. M.A. and D.R.L. are coinventors on patent applications on eVLPs. The other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}