{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:42:38Z","timestamp":1793824958454,"version":"4.6.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1038\/s41588-018-0289-3","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T16:35:09Z","timestamp":1541522109000},"page":"1640-1641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Human disease mutations highlight the inhibitory function of TIM-3"],"prefix":"10.1038","volume":"50","author":[{"given":"Karen O.","family":"Dixon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Kuchroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,7]]},"reference":[{"key":"289_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0251-4","author":"T Gayden","year":"2018","unstructured":"Gayden, T. et al. Nat. Genet. \n                    https:\/\/doi.org\/10.1038\/s41588-018-0251-4\n                    \n                   (2018).","journal-title":"Nat. Genet."},{"key":"289_CR2","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/415536a","volume":"415","author":"L Monney","year":"2002","unstructured":"Monney, L. et al. Nature 415, 536\u2013541 (2002).","journal-title":"Nature"},{"key":"289_CR3","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/ni988","volume":"4","author":"CA Sabatos","year":"2003","unstructured":"Sabatos, C. A. et al. Nat. Immunol. 4, 1102\u20131110 (2003).","journal-title":"Nat. Immunol."},{"key":"289_CR4","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/ni.2376","volume":"13","author":"S Chiba","year":"2012","unstructured":"Chiba, S. et al. Nat. Immunol. 13, 832\u2013842 (2012).","journal-title":"Nat. Immunol."},{"key":"289_CR5","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1084\/jem.20100637","volume":"207","author":"J Fourcade","year":"2010","unstructured":"Fourcade, J. et al. J. Exp. Med. 207, 2175\u20132186 (2010).","journal-title":"J. Exp. Med."},{"key":"289_CR6","doi-asserted-by":"publisher","first-page":"14733","DOI":"10.1073\/pnas.1009731107","volume":"107","author":"HT Jin","year":"2010","unstructured":"Jin, H. T. et al. Proc. Natl. Acad. Sci. USA 107, 14733\u201314738 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"289_CR7","doi-asserted-by":"publisher","first-page":"e58006","DOI":"10.1371\/journal.pone.0058006","volume":"8","author":"J Yan","year":"2013","unstructured":"Yan, J. et al. PLoS One 8, e58006 (2013).","journal-title":"PLoS One"},{"key":"289_CR8","doi-asserted-by":"publisher","first-page":"e23849","DOI":"10.4161\/onci.23849","volume":"2","author":"K Sakuishi","year":"2013","unstructured":"Sakuishi, K. et al. OncoImmunology 2, e23849 (2013).","journal-title":"OncoImmunology"},{"key":"289_CR9","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.4049\/jimmunol.0903275","volume":"185","author":"V Dardalhon","year":"2010","unstructured":"Dardalhon, V. et al. J. Immunol. 185, 1383\u20131392 (2010).","journal-title":"J. Immunol."},{"key":"289_CR10","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1073\/pnas.1712107115","volume":"115","author":"L Avery","year":"2018","unstructured":"Avery, L., Filderman, J., Szymczak-Workman, A. L. & Kane, L. P. Proc. Natl. Acad. Sci. USA 115, 2455\u20132460 (2018).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"289_CR11","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1182\/blood-2008-10-185884","volume":"113","author":"M Nakayama","year":"2009","unstructured":"Nakayama, M. et al. Blood 113, 3821\u20133830 (2009).","journal-title":"Blood"},{"key":"289_CR12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nature17421","volume":"536","author":"YH Huang","year":"2016","unstructured":"Huang, Y. H. et al. Nature 536, 359 (2016).","journal-title":"Nature"},{"key":"289_CR13","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/ni1271","volume":"6","author":"C Zhu","year":"2005","unstructured":"Zhu, C. et al. Nat. Immunol. 6, 1245\u20131252 (2005).","journal-title":"Nat. Immunol."},{"key":"289_CR14","doi-asserted-by":"publisher","first-page":"e1003253","DOI":"10.1371\/journal.ppat.1003253","volume":"9","author":"J Leitner","year":"2013","unstructured":"Leitner, J. et al. PLoS Pathog. 9, e1003253 (2013).","journal-title":"PLoS Pathog."},{"key":"289_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0304-4165(99)00177-4","volume":"1473","author":"RC Hughes","year":"1999","unstructured":"Hughes, R. C. Biochim. Biophys. Acta 1473, 172\u2013185 (1999).","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41588-018-0289-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41588-018-0289-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41588-018-0289-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:20:51Z","timestamp":1684621251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41588-018-0289-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,7]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["289"],"URL":"https:\/\/doi.org\/10.1038\/s41588-018-0289-3","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,7]]},"assertion":[{"value":"7 November 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"V.K.K. has patents dealing with intellectual property that have been licensed to Novartis Pharmaceuticals by the Brigham and Women\u2019s Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}