{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:26:16Z","timestamp":1794281176245,"version":"4.9.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1038\/s41588-019-0351-9","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T12:04:17Z","timestamp":1549886657000},"page":"606-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":344,"title":["Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration"],"prefix":"10.1038","volume":"51","author":[{"given":"Rinki","family":"Ratnapriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olukayode A.","family":"Sosina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Starostik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Kwicklis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Kapphahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-1690","authenticated-orcid":false,"given":"Lars G.","family":"Fritsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Walton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Arvanitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Gieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pietraszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra R.","family":"Montezuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-627X","authenticated-orcid":false,"given":"Alexis","family":"Battle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo R.","family":"Abecasis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-7464","authenticated-orcid":false,"given":"Deborah A.","family":"Ferrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-008X","authenticated-orcid":false,"given":"Nilanjan","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-1141","authenticated-orcid":false,"given":"Anand","family":"Swaroop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"351_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-genom-090413-025610","volume":"15","author":"LG Fritsche","year":"2014","unstructured":"Fritsche, L. G. et al. Age-related macular degeneration: genetics and biology coming together. Annu. Rev. Genomics Hum. Genet. 15, 151\u2013171 (2014).","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"351_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-vision-082114-035609","volume":"1","author":"F Grassmann","year":"2015","unstructured":"Grassmann, F., Ach, T., Brandl, C., Heid, I. M. & Weber, B. H. F. What does genetics tell us about age-related macular degeneration? Annu. Rev. Vis. Sci. 1, 73\u201396 (2015).","journal-title":"Annu. Rev. Vis. Sci."},{"key":"351_CR3","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","volume":"48","author":"LG Fritsche","year":"2016","unstructured":"Fritsche, L. G. et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat. Genet. 48, 134\u2013143 (2016).","journal-title":"Nat. Genet."},{"key":"351_CR4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/ng1011-1040c","volume":"43","author":"KS Small","year":"2011","unstructured":"Small, K. S. et al. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat. Genet. 43, 561\u2013564 (2011).","journal-title":"Nat. Genet."},{"key":"351_CR5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature24277","volume":"550","author":"A Battle","year":"2017","unstructured":"Battle, A., Brown, C. D., Engelhardt, B. E. & Montgomery, S. B. Genetic effects on gene expression across human tissues. Nature 550, 204\u2013213 (2017).","journal-title":"Nature"},{"key":"351_CR6","doi-asserted-by":"publisher","first-page":"4484","DOI":"10.1167\/iovs.04-0342","volume":"45","author":"TW Olsen","year":"2004","unstructured":"Olsen, T. W. & Feng, X. The Minnesota Grading System of eye bank eyes for age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 45, 4484\u20134490 (2004).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"351_CR7","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1001\/archopht.123.11.1570","volume":"123","author":"FL Ferris","year":"2005","unstructured":"Ferris, F. L. et al. A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch. Ophthalmol. 123, 1570\u20131574 (2005).","journal-title":"Arch. Ophthalmol."},{"key":"351_CR8","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1093\/nar\/gkw486","volume":"44","author":"M Pinelli","year":"2016","unstructured":"Pinelli, M. et al. An atlas of gene expression and gene co-regulation in the human retina. Nucleic Acids Res. 44, 5773\u20135784 (2016).","journal-title":"Nucleic Acids Res."},{"key":"351_CR9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1017\/S0952523802194028","volume":"19","author":"QV Hoang","year":"2002","unstructured":"Hoang, Q. V., Linsenmeier, R. A., Chung, C. K. & Curcio, C. A. Photoreceptor inner segments in monkey and human retina: mitochondrial density, optics, and regional variation. Vis. Neurosci. 19, 395\u2013407 (2002).","journal-title":"Vis. Neurosci."},{"key":"351_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.902920402","volume":"292","author":"CA Curcio","year":"1990","unstructured":"Curcio, C. A., Sloan, K. R., Kalina, R. E. & Hendrickson, A. E. Human photoreceptor topography. J. Comp. Neurol. 292, 497\u2013523 (1990).","journal-title":"J. Comp. Neurol."},{"key":"351_CR11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41588-018-0081-4","volume":"50","author":"HK Finucane","year":"2018","unstructured":"Finucane, H. K. et al. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat. Genet. 50, 621\u2013629 (2018).","journal-title":"Nat. Genet."},{"key":"351_CR12","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1038\/s41588-018-0154-4","volume":"50","author":"ER Gamazon","year":"2018","unstructured":"Gamazon, E. R. et al. Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation. Nat. Genet. 50, 956\u2013967 (2018).","journal-title":"Nat. Genet."},{"key":"351_CR13","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.ajhg.2016.10.003","volume":"99","author":"F Hormozdiari","year":"2016","unstructured":"Hormozdiari, F. et al. Colocalization of GWAS and eQTL signals detects target genes. Am. J. Hum. Genet. 99, 1245\u20131260 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"351_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","volume":"48","author":"A Gusev","year":"2016","unstructured":"Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245\u2013252 (2016).","journal-title":"Nat. Genet."},{"key":"351_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24219-z","volume":"8","author":"T Strunz","year":"2018","unstructured":"Strunz, T. et al. A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver. Sci. Rep 8, 5865 (2018).","journal-title":"Sci. Rep"},{"key":"351_CR16","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1038\/nn.4399","volume":"19","author":"M Fromer","year":"2016","unstructured":"Fromer, M. et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat. Neurosci. 19, 1442\u20131453 (2016).","journal-title":"Nat. Neurosci."},{"key":"351_CR17","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1126\/science.aad6469","volume":"359","author":"MJ Gandal","year":"2018","unstructured":"Gandal, M. J. et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359, 693\u2013697 (2018).","journal-title":"Science"},{"key":"351_CR18","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/ejhg.2013.274","volume":"22","author":"T Beck","year":"2014","unstructured":"Beck, T., Hastings, R. K., Gollapudi, S., Free, R. C. & Brookes, A. J. GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies. Eur. J. Hum. Genet. 22, 949\u2013952 (2014).","journal-title":"Eur. J. Hum. Genet."},{"key":"351_CR19","doi-asserted-by":"publisher","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","volume":"45","author":"J MacArthur","year":"2017","unstructured":"MacArthur, J. et al. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res. 45, D896\u2013D901 (2017).","journal-title":"Nucleic Acids Res."},{"key":"351_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2013.09.001","volume":"155","author":"A Chakravarti","year":"2013","unstructured":"Chakravarti, A., Clark, A. G. & Mootha, V. K. Distilling pathophysiology from complex disease genetics. Cell 155, 21\u201326 (2013).","journal-title":"Cell"},{"key":"351_CR21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.ajhg.2018.04.002","volume":"102","author":"MD Gallagher","year":"2018","unstructured":"Gallagher, M. D. & Chen-Plotkin, A. S. The post-GWAS era: from association to function. Am. J. Hum. Genet. 102, 717\u2013730 (2018).","journal-title":"Am. J. Hum. Genet."},{"key":"351_CR22","doi-asserted-by":"publisher","first-page":"e1003649","DOI":"10.1371\/journal.pgen.1003649","volume":"9","author":"CD Brown","year":"2013","unstructured":"Brown, C. D., Mangravite, L. M. & Engelhardt, B. E. Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. PLoS Genet. 9, e1003649 (2013).","journal-title":"PLoS Genet."},{"key":"351_CR23","doi-asserted-by":"publisher","first-page":"36742","DOI":"10.1074\/jbc.M605912200","volume":"281","author":"K Kozma","year":"2006","unstructured":"Kozma, K. et al. Identification and characterization of a\u03b21,3-glucosyltransferase that synthesizes the Glc-\u03b21,3-Fuc disaccharide on thrombospondin type 1 repeats. J. Biol. Chem. 281, 36742\u201336751 (2006).","journal-title":"J. Biol. Chem."},{"key":"351_CR24","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1086\/507567","volume":"79","author":"SA Lesnik Oberstein","year":"2006","unstructured":"Lesnik Oberstein, S. A. et al. Peters Plus syndrome is caused by mutations in B3GALTL, a putative glycosyltransferase. Am. J. Hum. Genet. 79, 562\u2013566 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"351_CR25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.devcel.2015.04.008","volume":"33","author":"L Langemeyer","year":"2015","unstructured":"Langemeyer, L. & Ungermann, C. BORC and BLOC-1: shared subunits in trafficking complexes. Dev. Cell 33, 121\u2013122 (2015).","journal-title":"Dev. Cell"},{"key":"351_CR26","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1523\/JNEUROSCI.3542-14.2015","volume":"35","author":"AP Mullin","year":"2015","unstructured":"Mullin, A. P. et al. Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. J. Neurosci. 35, 325\u2013338 (2015).","journal-title":"J. Neurosci."},{"key":"351_CR27","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41588-018-0148-2","volume":"50","author":"F Hormozdiari","year":"2018","unstructured":"Hormozdiari, F. et al. Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nat. Genet. 50, 1041\u20131047 (2018).","journal-title":"Nat. Genet."},{"key":"351_CR28","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ajo.2006.12.006","volume":"143","author":"A Decanini","year":"2007","unstructured":"Decanini, A., Nordgaard, C. L., Feng, X., Ferrington, D. A. & Olsen, T. W. Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration. Am. J. Ophthalmol. 143, 607\u2013615 (2007).","journal-title":"Am. J. Ophthalmol."},{"key":"351_CR29","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/biostatistics\/kxr034","volume":"13","author":"JA Gagnon-Bartsch","year":"2012","unstructured":"Gagnon-Bartsch, J. A. & Speed, T. P. Using control genes to correct for unwanted variation in microarray data. Biostatistics 13, 539\u2013552 (2012).","journal-title":"Biostatistics"},{"key":"351_CR30","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1093\/nar\/gku864","volume":"42","author":"JT Leek","year":"2014","unstructured":"Leek, J. T. svaseq: removing batch effects and other unwanted noise from sequencing data. Nucleic Acids Res. 42, e161 (2014).","journal-title":"Nucleic Acids Res."},{"key":"351_CR31","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882\u2013883 (2012).","journal-title":"Bioinformatics"},{"key":"351_CR32","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.tig.2013.05.010","volume":"29","author":"E Eisenberg","year":"2013","unstructured":"Eisenberg, E. & Levanon, E. Y. Human housekeeping genes, revisited. Trends Genet. 29, 569\u2013574 (2013).","journal-title":"Trends Genet."},{"key":"351_CR33","volume-title":"Batch Effects and Noise in Microarray Experiments: Sources and Solutions","year":"2009","unstructured":"Scherer, A. (ed.) Batch Effects and Noise in Microarray Experiments: Sources and Solutions (Wiley, West Sussex, UK, 2009)."},{"key":"351_CR34","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1126\/science.aaa0355","volume":"348","author":"M Mel\u00e9","year":"2015","unstructured":"Mel\u00e9, M. et al. The human transcriptome across tissues and individuals. Science 348, 660\u2013665 (2015).","journal-title":"Science"},{"key":"351_CR35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M. et al. Gene ontology: tool for the unification of biology. Nat. Genet. 25, 25\u201329 (2000).","journal-title":"Nat. Genet."},{"key":"351_CR36","doi-asserted-by":"publisher","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","volume":"45","author":"The Gene Ontology Consortium.","year":"2017","unstructured":"The Gene Ontology Consortium. Expansion of the Gene Ontology knowledgebase and resources. Nucleic Acids Res. 45, D331\u2013D338 (2017).","journal-title":"Nucleic Acids Res."},{"key":"351_CR37","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L. G., Han, Y. & He, Q. Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284\u2013287 (2012).","journal-title":"OMICS"},{"key":"351_CR38","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","volume":"28","author":"C Trapnell","year":"2010","unstructured":"Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511\u2013515 (2010).","journal-title":"Nat. Biotechnol."},{"key":"351_CR39","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1093\/bioinformatics\/btr355","volume":"27","author":"A Roberts","year":"2011","unstructured":"Roberts, A., Pimentel, H., Trapnell, C. & Pachter, L. Identification of novel transcripts in annotated genomes using RNA-Seq. Bioinformatics 27, 2325\u20132329 (2011).","journal-title":"Bioinformatics"},{"key":"351_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15452","volume":"8","author":"O Delaneau","year":"2017","unstructured":"Delaneau, O. et al. A complete tool set for molecular QTL discovery and analysis. Nat. Commun. 8, 15452 (2017).","journal-title":"Nat. Commun."},{"key":"351_CR41","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey, J. D. & Tibshirani, R. Statistical significance for genomewide studies. Proc. Natl Acad. Sci. USA 100, 9440\u20139445 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"351_CR42","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","volume":"28","author":"AA Shabalin","year":"2012","unstructured":"Shabalin, A. A. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics 28, 1353\u20131358 (2012).","journal-title":"Bioinformatics"},{"key":"351_CR43","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1007\/s10519-009-9281-0","volume":"39","author":"TM Beasley","year":"2009","unstructured":"Beasley, T. M., Erickson, S. & Allison, D. B. Rank-based inverse normal transformations are increasingly used, but are they merited? Behav. Genet. 39, 580\u2013595 (2009).","journal-title":"Behav. Genet."},{"key":"351_CR44","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).","journal-title":"PLoS Genet."},{"key":"351_CR45","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904\u2013909 (2006).","journal-title":"Nat. Genet."},{"key":"351_CR46","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","volume":"27","author":"P Danecek","year":"2011","unstructured":"Danecek, P. et al. The variant call format and VCFtools. Bioinformatics 27, 2156\u20132158 (2011).","journal-title":"Bioinformatics"},{"key":"351_CR47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","volume":"88","author":"J Yang","year":"2011","unstructured":"Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76\u201382 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"351_CR48","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."},{"key":"351_CR49","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"351_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9, 559 (2008).","journal-title":"BMC Bioinformatics"},{"key":"351_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/gm315","volume":"4","author":"AM Newman","year":"2012","unstructured":"Newman, A. M. et al. Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Med. 4, 16 (2012).","journal-title":"Genome Med."},{"key":"351_CR52","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."}],"updated-by":[{"DOI":"10.1038\/s41588-019-0430-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000}}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41588-019-0351-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41588-019-0351-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41588-019-0351-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T18:21:29Z","timestamp":1684606889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41588-019-0351-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["351"],"URL":"https:\/\/doi.org\/10.1038\/s41588-019-0351-9","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,11]]},"assertion":[{"value":"24 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the version of this article initially published, in Supplementary Data 5, the logFC, FC, <i>P<\/i> value and adjusted <i>P<\/i> value for advanced AMD versus control (DE 4\/1) without age correction did not correspond to the correct gene IDs. The errors have been corrected in the HTML version of the article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"G.R.A. is now employed by Regeneron Pharmaceuticals. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}