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B.W.J.H.P. has received research funding (unrelated to the work reported in this article) from Jansen Research and Boehringer Ingelheim. K.B.S is full-time employee of GlaxoSmithKline. G.S., D.F.G., I.J., H.H., P.S., U.T. and K.Stefansson are full time employees of deCODE genetics and Amgen. A.Y.C. is an employee of Merck & Co. W.Koenig received modest consultation fees for advisory board meetings from Amgen, DalCor Pharmaceuticals, Kowa, Novartis, Pfizer and Sanofi, and modest personal fees for lectures from Amgen, AstraZeneca, Novartis, Pfizer and Sanofi. D.C. is scientific consultant for Bio4Dreams. W.M. is employed by Synlab Services GmbH and holds shares of Synlab Holding Deutschland GmbH. M.A.N.\u2019s participation in this project is supported by a consulting contract between Data Tecnica International, the National Institute on Aging and NIH, and consults or has consulted during this time for Lysosomal Therapeutics, Neuron23, Illumina, the Michael J. Fox Foundation and the University of California Healthcare. O.P. is an owner of Gen-info. K.Ho has disclosed a research and financial relationship with Sanofi Genzyme. B.M.P. serves on the Data and Safety Monitoring Board of a clinical trial funded by the manufacturer (Zoll Lifecor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. A.S.B. received grants from MSD, Pfizer, Novartis, Biogen and Bioverativ and personal fees from Novartis. F.R. is a scientific consultant for ePhood. M.Scholz consults for and received grant support not related to this project from Merck Serono. A.K\u00f6ttgen received grant support not related to this project from Gr\u00fcnenthal. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}