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A.-D.A. and C.M.S. are employees of Bayer US LLC (a subsidiary of Bayer AG), and may own stock in Bayer AG. D.J. is supported by grants from Genentech, Eisai, EMD Serono, Takeda, Amgen, Celgene, Placon Therapeutics, Syros, Petra Pharma, InventisBio, Infinity Pharmaceuticals and Novartis. D.J. has also received personal fees from Genentech, Eisai, EMD Serono, Ipsen, Syros, Relay Therapeutics, MapKure, Vibliome, Petra Pharma and Novartis. A.A.P. is employed as a Venture Partner at GV; he is also supported by a grant from Bayer AG to the Broad Institute focused on machine learning for clinical trial design. J.E.H. is supported by a grant from Bayer AG focused on machine learning and cardiovascular disease and a research grant from Gilead Sciences. J.E.H. has received research supplies from EcoNugenics. P.B. is supported by grants from Bayer AG and IBM applying machine learning in cardiovascular disease. P.T.E. is supported by a grant from Bayer AG to the Broad Institute focused on the genetics and therapeutics of cardiovascular diseases. P.T.E. has also served on advisory boards or consulted for Bayer AG, Quest Diagnostics, MyoKardia and Novartis. S.A.L. receives sponsored research support from Bristol Myers Squibb\/Pfizer, Bayer AG, Boehringer Ingelheim and Fitbit, and has consulted for Bristol Myers Squibb\/Pfizer and Bayer AG, and participates in a research collaboration with IBM. The Broad Institute has filed for a patent on an invention from P.T.E., M.E.L. and J.P.P. related to a genetic risk predictor for aortic disease.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}