{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:58:54Z","timestamp":1793289534647,"version":"4.5.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["I01BX003364"],"award-info":[{"award-number":["I01BX003364"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["IK6BX005233"],"award-info":[{"award-number":["IK6BX005233"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["I01BX004189"],"award-info":[{"award-number":["I01BX004189"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["I01BX004557"],"award-info":[{"award-number":["I01BX004557"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1038\/s41588-024-01764-0","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:01:53Z","timestamp":1733115713000},"page":"2659-2671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries"],"prefix":"10.1038","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-4672","authenticated-orcid":false,"given":"Bryan R.","family":"Gorman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-632X","authenticated-orcid":false,"given":"Georgios","family":"Voloudakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-1993","authenticated-orcid":false,"suffix":"Jr.","given":"Robert P.","family":"Igo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Kinzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Halladay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim B.","family":"Bigdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanan","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-8702","authenticated-orcid":false,"given":"Jessica N.","family":"Cooke Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6437-6248","authenticated-orcid":false,"given":"Dana C.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-6014","authenticated-orcid":false,"given":"Kyriacos","family":"Markianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-2642","authenticated-orcid":false,"given":"Patrick A.","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"VA Million Veteran Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"International AMD Genomics Consortium (IAMDGC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars G.","family":"Fritsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmar","family":"Igl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N.","family":"Cooke Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Grassman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebanti","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Bragg-Gresham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn P.","family":"Burdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hebring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Gorski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana K.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Zack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Souied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik P. N.","family":"Scholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Sardell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Merriam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara T. E.","family":"Lechanteur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn H.","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingda","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe M.","family":"Stanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabri\u00eblle H. S.","family":"Buitendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Boleda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Gieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinki","family":"Ratnapriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari E.","family":"Branham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna R.","family":"Foerster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Heckenlively","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad I.","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"Vote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Hai","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Souzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian L.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Mackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Constable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie","family":"Kitchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiquang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouyang","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Flagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Ferreyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Nvon","family":"Strachwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Brandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenther","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Olden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux A.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniste J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Schu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeeyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia E.","family":"Tsironi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Orlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Brucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Curcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saddek","family":"Mohand-Sa\u00efd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Audo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Benchaboune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J.","family":"Cree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Rennie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas V.","family":"Goverdhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Grunin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Hagbi-Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Campochiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Katsanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Blond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Blanch\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Deleuze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert P.","family":"Igo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Truitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy M.","family":"Meuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea E.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Postel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique D.","family":"Courtenay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn L.","family":"Kovach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava G.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamini","family":"Gopinath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Merriam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Theodore","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humma","family":"Shahidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Allie","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u00e9","family":"Laux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Milam A.","family":"Brantley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lebriz","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Caramoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Langmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole T. M.","family":"Saksens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko K.","family":"deJohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carel B.","family":"Hoyng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda S.","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blangero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Weeks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"van Duijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly F.","family":"Doheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Romm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline C. W.","family":"Klaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Gorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke I.","family":"den Hollander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R. W.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rando","family":"Allikmets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Schaumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E. K.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Hagstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Chowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lotery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"L\u00e9veillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray H.","family":"Brilliant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex W.","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Swaroop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight","family":"Stambolian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha K.","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard H. F.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo R.","family":"Abecasis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris M.","family":"Heid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Anger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Stockwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Melles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-8667","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Choquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-3201","authenticated-orcid":false,"given":"Rebecca","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Patasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-4067","authenticated-orcid":false,"given":"Praveen J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-2510","authenticated-orcid":false,"given":"Brian L.","family":"Yaspan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-8191","authenticated-orcid":false,"given":"Eric","family":"Jorgenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-2510","authenticated-orcid":false,"given":"Pirro G.","family":"Hysi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-4305","authenticated-orcid":false,"given":"Andrew J.","family":"Lotery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Fliesler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-2024","authenticated-orcid":false,"given":"Wen-Chih","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-0009","authenticated-orcid":false,"given":"Themistocles L.","family":"Assimes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-3762","authenticated-orcid":false,"given":"Saiju","family":"Pyarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-6239","authenticated-orcid":false,"given":"Panos","family":"Roussos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-7226","authenticated-orcid":false,"given":"Neal S.","family":"Peachey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7488-250X","authenticated-orcid":false,"given":"Sudha K.","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"1764_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","volume":"7","author":"M Fleckenstein","year":"2021","unstructured":"Fleckenstein, M. et al. Age-related macular degeneration. Nat. Rev. Dis. Primers 7, 31 (2021).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"1764_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ajo.2011.02.004","volume":"152","author":"BL Vanderbeek","year":"2011","unstructured":"Vanderbeek, B. L. et al. Racial differences in age-related macular degeneration rates in the United States: a longitudinal analysis of a managed care network. Am. J. Ophthalmol. 152, 273\u2013282.e3 (2011).","journal-title":"Am. J. Ophthalmol."},{"key":"1764_CR3","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.oret.2018.05.005","volume":"2","author":"MA Mahr","year":"2018","unstructured":"Mahr, M. A., Hodge, D. O. & Erie, J. C. Racial differences in age-related macular degeneration and associated anti-vascular endothelial growth factor intravitreal injections among Medicare beneficiaries. Ophthalmol. Retina 2, 1188\u20131195 (2018).","journal-title":"Ophthalmol. Retina"},{"key":"1764_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1080\/02713683.2019.1576907","volume":"44","author":"D Wang","year":"2019","unstructured":"Wang, D., Jiang, Y., He, M., Scheetz, J. & Wang, W. Disparities in the global burden of age-related macular degeneration: An analysis of trends from 1990 to 2015. Curr. Eye Res. 44, 657\u2013663 (2019).","journal-title":"Curr. Eye Res."},{"key":"1764_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.1110359","volume":"308","author":"JL Haines","year":"2005","unstructured":"Haines, J. L. et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419\u2013421 (2005).","journal-title":"Science"},{"key":"1764_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","volume":"308","author":"RJ Klein","year":"2005","unstructured":"Klein, R. J. et al. Complement factor H polymorphism in age-related macular degeneration. Science 308, 385\u2013389 (2005).","journal-title":"Science"},{"key":"1764_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1110189","volume":"308","author":"AO Edwards","year":"2005","unstructured":"Edwards, A. O. et al. Complement factor H polymorphism and age-related macular degeneration. Science 308, 421\u2013424 (2005).","journal-title":"Science"},{"key":"1764_CR8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","volume":"48","author":"LG Fritsche","year":"2016","unstructured":"Fritsche, L. G. et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat. Genet. 48, 134\u2013143 (2016).","journal-title":"Nat. Genet."},{"key":"1764_CR9","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jclinepi.2015.09.016","volume":"70","author":"JM Gaziano","year":"2016","unstructured":"Gaziano, J. M. et al. Million Veteran Program: a mega-biobank to study genetic influences on health and disease. J. Clin. Epidemiol. 70, 214\u2013223 (2016).","journal-title":"J. Clin. Epidemiol."},{"key":"1764_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5","volume":"10","author":"T Ge","year":"2019","unstructured":"Ge, T., Chen, C.-Y., Ni, Y., Feng, Y.-C. A. & Smoller, J. W. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat. Commun. 10, 1776 (2019).","journal-title":"Nat. Commun."},{"key":"1764_CR11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291\u2013295 (2015).","journal-title":"Nat. Genet."},{"key":"1764_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19996-z","volume":"11","author":"M Pietzner","year":"2020","unstructured":"Pietzner, M. et al. Genetic architecture of host proteins involved in SARS-CoV-2 infection. Nat. Commun. 11, 6397 (2020).","journal-title":"Nat. Commun."},{"key":"1764_CR13","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","volume":"4","author":"P Kumar","year":"2009","unstructured":"Kumar, P., Henikoff, S. & Ng, P. C. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4, 1073\u20131081 (2009).","journal-title":"Nat. Protoc."},{"key":"1764_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei, I. A. et al. A method and server for predicting damaging missense mutations. Nat. Methods 7, 248\u2013249 (2010).","journal-title":"Nat. Methods"},{"key":"1764_CR15","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1038\/nm1324","volume":"11","author":"M Komatsu","year":"2005","unstructured":"Komatsu, M. & Ruoslahti, E. R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat. Med. 11, 1346\u20131350 (2005).","journal-title":"Nat. Med."},{"key":"1764_CR16","doi-asserted-by":"publisher","first-page":"8133","DOI":"10.1074\/jbc.M114.591511","volume":"290","author":"J Sawada","year":"2015","unstructured":"Sawada, J., Li, F. & Komatsu, M. R-Ras protein inhibits autophosphorylation of vascular endothelial growth factor receptor 2 in endothelial cells and suppresses receptor activation in tumor vasculature. J. Biol. Chem. 290, 8133\u20138145 (2015).","journal-title":"J. Biol. Chem."},{"key":"1764_CR17","doi-asserted-by":"publisher","first-page":"4898","DOI":"10.1167\/iovs.16-19212","volume":"57","author":"M V\u00e4h\u00e4tupa","year":"2016","unstructured":"V\u00e4h\u00e4tupa, M. et al. Lack of R-Ras leads to increased vascular permeability in ischemic retinopathy. Invest. Ophthalmol. Vis. Sci. 57, 4898\u20134909 (2016).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"1764_CR18","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/ng.3654","volume":"48","author":"P Surendran","year":"2016","unstructured":"Surendran, P. et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat. Genet. 48, 1151\u20131161 (2016).","journal-title":"Nat. Genet."},{"key":"1764_CR19","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1182\/blood.2020009021","volume":"138","author":"RA Campbell","year":"2021","unstructured":"Campbell, R. A. et al. Placental HTRA1 cleaves \u03b11-antitrypsin to generate a NET-inhibitory peptide. Blood 138, 977\u2013988 (2021).","journal-title":"Blood"},{"key":"1764_CR20","doi-asserted-by":"publisher","first-page":"00049","DOI":"10.1183\/23120541.00049-2021","volume":"7","author":"KA Fawcett","year":"2021","unstructured":"Fawcett, K. A. et al. Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank. ERJ Open Res. 7, 00049\u20132021 (2021).","journal-title":"ERJ Open Res."},{"key":"1764_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29143-5","volume":"13","author":"X Yin","year":"2022","unstructured":"Yin, X. et al. Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci. Nat. Commun. 13, 1644 (2022).","journal-title":"Nat. Commun."},{"key":"1764_CR22","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ophtha.2022.01.005","volume":"129","author":"MJ Simcoe","year":"2022","unstructured":"Simcoe, M. J. et al. Genome-wide association study identifies two common loci associated with pigment dispersion syndrome\/pigmentary glaucoma and implicates myopia in its development. Ophthalmology 129, 626\u2013636 (2022).","journal-title":"Ophthalmology"},{"key":"1764_CR23","doi-asserted-by":"publisher","first-page":"eabd1239","DOI":"10.1126\/sciadv.abd1239","volume":"7","author":"M Simcoe","year":"2021","unstructured":"Simcoe, M. et al. Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color. Sci. Adv. 7, eabd1239 (2021).","journal-title":"Sci. Adv."},{"key":"1764_CR24","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41588-018-0100-5","volume":"50","author":"PG Hysi","year":"2018","unstructured":"Hysi, P. G. et al. Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability. Nat. Genet. 50, 652\u2013656 (2018).","journal-title":"Nat. Genet."},{"key":"1764_CR25","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1093\/hmg\/ddz121","volume":"28","author":"UE Liyanage","year":"2019","unstructured":"Liyanage, U. E. et al. Combined analysis of keratinocyte cancers identifies novel genome-wide loci. Hum. Mol. Genet. 28, 3148\u20133160 (2019).","journal-title":"Hum. Mol. Genet."},{"key":"1764_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04086-y","volume":"9","author":"A Visconti","year":"2018","unstructured":"Visconti, A. et al. Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. Nat. Commun. 9, 1684 (2018).","journal-title":"Nat. Commun."},{"key":"1764_CR27","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"S Burgess","year":"2017","unstructured":"Burgess, S. & Thompson, S. G. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur. J. Epidemiol. 32, 377\u2013389 (2017).","journal-title":"Eur. J. Epidemiol."},{"key":"1764_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1177\/002215549704500306","volume":"45","author":"S Lundgren","year":"1997","unstructured":"Lundgren, S. et al. Tissue distribution of human gp330\/megalin, a putative Ca2+-sensing protein. J. Histochem. Cytochem. 45, 383\u2013392 (1997).","journal-title":"J. Histochem. Cytochem."},{"key":"1764_CR29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00441-014-1919-4","volume":"358","author":"T Storm","year":"2014","unstructured":"Storm, T., Heegaard, S., Christensen, E. I. & Nielsen, R. Megalin-deficiency causes high myopia, retinal pigment epithelium-macromelanosomes and abnormal development of the ciliary body in mice. Cell Tissue Res. 358, 99\u2013107 (2014).","journal-title":"Cell Tissue Res."},{"key":"1764_CR30","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.survophthal.2020.04.005","volume":"65","author":"NCL Noel","year":"2020","unstructured":"Noel, N. C. L. & MacDonald, I. M. RP1L1 and inherited photoreceptor disease: A review. Surv. Ophthalmol. 65, 725\u2013739 (2020).","journal-title":"Surv. Ophthalmol."},{"key":"1764_CR31","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.ajhg.2011.04.014","volume":"88","author":"B Han","year":"2011","unstructured":"Han, B. & Eskin, E. Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am. J. Hum. Genet. 88, 586\u2013598 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR32","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/bioinformatics\/btw018","volume":"32","author":"C Benner","year":"2016","unstructured":"Benner, C. et al. FINEMAP: efficient variable selection using summary data from genome-wide association studies. Bioinformatics 32, 1493\u20131501 (2016).","journal-title":"Bioinformatics"},{"key":"1764_CR33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41588-021-00987-9","volume":"54","author":"B Zeng","year":"2022","unstructured":"Zeng, B. et al. Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits. Nat. Genet. 54, 161\u2013169 (2022).","journal-title":"Nat. Genet."},{"key":"1764_CR34","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.ajhg.2016.10.003","volume":"99","author":"F Hormozdiari","year":"2016","unstructured":"Hormozdiari, F. et al. Colocalization of GWAS and eQTL signals detects target genes. Am. J. Hum. Genet. 99, 1245\u20131260 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR35","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ajhg.2013.06.020","volume":"93","author":"BK Maples","year":"2013","unstructured":"Maples, B. K., Gravel, S., Kenny, E. E. & Bustamante, C. D. RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference. Am. J. Hum. Genet. 93, 278\u2013288 (2013).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41588-020-00766-y","volume":"53","author":"EG Atkinson","year":"2021","unstructured":"Atkinson, E. G. et al. Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power. Nat. Genet. 53, 195\u2013204 (2021).","journal-title":"Nat. Genet."},{"key":"1764_CR37","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ng1890","volume":"38","author":"AE Hughes","year":"2006","unstructured":"Hughes, A. E. et al. A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat. Genet. 38, 1173\u20131177 (2006).","journal-title":"Nat. Genet."},{"key":"1764_CR38","doi-asserted-by":"publisher","first-page":"e25598","DOI":"10.1371\/journal.pone.0025598","volume":"6","author":"TA Sivakumaran","year":"2011","unstructured":"Sivakumaran, T. A. et al. A 32\u2009kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. PLoS ONE 6, e25598 (2011).","journal-title":"PLoS ONE"},{"key":"1764_CR39","doi-asserted-by":"publisher","first-page":"e60352","DOI":"10.1371\/journal.pone.0060352","volume":"8","author":"LV Holmes","year":"2013","unstructured":"Holmes, L. V. et al. Determining the population frequency of the CFHR3\/CFHR1 deletion at 1q32. PLoS ONE 8, e60352 (2013).","journal-title":"PLoS ONE"},{"key":"1764_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14499-3","volume":"11","author":"V Cipriani","year":"2020","unstructured":"Cipriani, V. et al. Increased circulating levels of factor H-related protein 4 are strongly associated with age-related macular degeneration. Nat. Commun. 11, 778 (2020).","journal-title":"Nat. Commun."},{"key":"1764_CR41","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s40246-021-00359-8","volume":"15","author":"CM Pappas","year":"2021","unstructured":"Pappas, C. M. et al. Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2\/HTRA1 loci. Hum. Genomics 15, 60 (2021).","journal-title":"Hum. Genomics"},{"key":"1764_CR42","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.ajhg.2021.05.015","volume":"108","author":"V Cipriani","year":"2021","unstructured":"Cipriani, V. et al. Beyond factor H: the impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations. Am. J. Hum. Genet. 108, 1385\u20131400 (2021).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR43","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/tpj.2013.18","volume":"14","author":"X Zheng","year":"2014","unstructured":"Zheng, X. et al. HIBAG\u2013HLA genotype imputation with attribute bagging. Pharmacogenomics J. 14, 192\u2013200 (2014).","journal-title":"Pharmacogenomics J."},{"key":"1764_CR44","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1423-0127-19-88","volume":"19","author":"F Megiorni","year":"2012","unstructured":"Megiorni, F. & Pizzuti, A. HLA-DQA1 and HLA-DQB1 in celiac disease predisposition: practical implications of the HLA molecular typing. J. Biomed. Sci. 19, 88 (2012).","journal-title":"J. Biomed. Sci."},{"key":"1764_CR45","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.3324\/haematol.2017.168211","volume":"102","author":"N Kutszegi","year":"2017","unstructured":"Kutszegi, N. et al. HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia. Haematologica 102, 1578\u20131586 (2017).","journal-title":"Haematologica"},{"key":"1764_CR46","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1182\/blood-2014-03-563742","volume":"124","author":"CA Fernandez","year":"2014","unstructured":"Fernandez, C. A. et al. HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies. Blood 124, 1266\u20131276 (2014).","journal-title":"Blood"},{"key":"1764_CR47","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1111\/bcp.14664","volume":"87","author":"N Kutszegi","year":"2021","unstructured":"Kutszegi, N. et al. Two tagging single-nucleotide polymorphisms to capture HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype associated with asparaginase hypersensitivity. Br. J. Clin. Pharmacol. 87, 2542\u20132548 (2021).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"1764_CR48","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","volume":"14","author":"RF Mullins","year":"2000","unstructured":"Mullins, R. F., Russell, S. R., Anderson, D. H. & Hageman, G. S. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 14, 835\u2013846 (2000).","journal-title":"FASEB J."},{"key":"1764_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11874-7","volume":"10","author":"W Zhang","year":"2019","unstructured":"Zhang, W. et al. Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits. Nat. Commun. 10, 3834 (2019).","journal-title":"Nat. Commun."},{"key":"1764_CR50","doi-asserted-by":"publisher","first-page":"eaat8127","DOI":"10.1126\/science.aat8127","volume":"362","author":"MJ Gandal","year":"2018","unstructured":"Gandal, M. J. et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 362, eaat8127 (2018).","journal-title":"Science"},{"key":"1764_CR51","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/s41588-019-0351-9","volume":"51","author":"R Ratnapriya","year":"2019","unstructured":"Ratnapriya, R. et al. Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration. Nat. Genet. 51, 606\u2013610 (2019).","journal-title":"Nat. Genet."},{"key":"1764_CR52","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","volume":"369","author":"GTEx Consortium.","year":"2020","unstructured":"GTEx Consortium. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science 369, 1318\u20131330 (2020).","journal-title":"Science"},{"key":"1764_CR53","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1126\/science.aad6970","volume":"353","author":"O Franz\u00e9n","year":"2016","unstructured":"Franz\u00e9n, O. et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science 353, 827\u2013830 (2016).","journal-title":"Science"},{"key":"1764_CR54","doi-asserted-by":"crossref","unstructured":"Liu, Y. et al. ACAT: a fast and powerful p value combination method for rare-variant analysis in sequencing studies. Am. J. Hum. Genet. 104, 410\u2013421 (2019).","DOI":"10.1016\/j.ajhg.2019.01.002"},{"key":"1764_CR55","doi-asserted-by":"publisher","first-page":"eaay5947","DOI":"10.1126\/science.aay5947","volume":"367","author":"E Sj\u00f6stedt","year":"2020","unstructured":"Sj\u00f6stedt, E. et al. An atlas of the protein-coding genes in the human, pig, and mouse brain. Science 367, eaay5947 (2020).","journal-title":"Science"},{"key":"1764_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58510-9","volume":"10","author":"T Strunz","year":"2020","unstructured":"Strunz, T. et al. A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration. Sci. Rep. 10, 1584 (2020).","journal-title":"Sci. Rep."},{"key":"1764_CR57","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ajhg.2020.03.004","volume":"106","author":"H Hunter-Zinck","year":"2020","unstructured":"Hunter-Zinck, H. et al. Genotyping array design and data quality control in the Million Veteran Program. Am. J. Hum. Genet. 106, 535\u2013548 (2020).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR58","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cell.2016.09.025","volume":"167","author":"Y N\u00e9d\u00e9lec","year":"2016","unstructured":"N\u00e9d\u00e9lec, Y. et al. Genetic ancestry and natural selection drive population differences in immune responses to pathogens. Cell 167, 657\u2013669 (2016).","journal-title":"Cell"},{"key":"1764_CR59","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1126\/science.abg0928","volume":"374","author":"HE Randolph","year":"2021","unstructured":"Randolph, H. E. et al. Genetic ancestry effects on the response to viral infection are pervasive but cell type specific. Science 374, 1127\u20131133 (2021).","journal-title":"Science"},{"key":"1764_CR60","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.1167\/iovs.14-14602","volume":"55","author":"BEK Klein","year":"2014","unstructured":"Klein, B. E. K. et al. Sunlight exposure, pigmentation, and incident age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 55, 5855\u20135861 (2014).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"1764_CR61","first-page":"153","volume":"2019","author":"CW Halladay","year":"2019","unstructured":"Halladay, C. W. et al. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl. Sci. Proc. 2019, 153\u2013162 (2019).","journal-title":"AMIA Jt Summits Transl. Sci. Proc."},{"key":"1764_CR62","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.ajhg.2019.08.012","volume":"105","author":"H Fang","year":"2019","unstructured":"Fang, H. et al. Harmonizing genetic ancestry and self-identified race\/ethnicity in genome-wide association studies. Am. J. Hum. Genet. 105, 763\u2013772 (2019).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR63","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/ng.3643","volume":"48","author":"S McCarthy","year":"2016","unstructured":"McCarthy, S. et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat. Genet. 48, 1279\u20131283 (2016).","journal-title":"Nat. Genet."},{"key":"1764_CR64","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41588-021-00870-7","volume":"53","author":"J Mbatchou","year":"2021","unstructured":"Mbatchou, J. et al. Computationally efficient whole-genome regression for quantitative and binary traits. Nat. Genet. 53, 1097\u20131103 (2021).","journal-title":"Nat. Genet."},{"key":"1764_CR65","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/ng.2876","volume":"46","author":"J Yang","year":"2014","unstructured":"Yang, J., Zaitlen, N. A., Goddard, M. E., Visscher, P. M. & Price, A. L. Advantages and pitfalls in the application of mixed-model association methods. Nat. Genet. 46, 100\u2013106 (2014).","journal-title":"Nat. Genet."},{"key":"1764_CR66","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/ng.3190","volume":"47","author":"P-R Loh","year":"2015","unstructured":"Loh, P.-R. et al. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat. Genet. 47, 284\u2013290 (2015).","journal-title":"Nat. Genet."},{"key":"1764_CR67","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.ajhg.2016.02.012","volume":"98","author":"H Chen","year":"2016","unstructured":"Chen, H. et al. Control for population structure and relatedness for binary traits in genetic association studies via logistic mixed models. Am. J. Hum. Genet. 98, 653\u2013666 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR68","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.1167\/iovs.15-16533","volume":"56","author":"L Shen","year":"2015","unstructured":"Shen, L. et al. Differences in the genetic susceptibility to age-related macular degeneration clinical subtypes. Invest. Ophthalmol. Vis. Sci. 56, 4290\u20134299 (2015).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"1764_CR69","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/ejhg.2015.247","volume":"24","author":"E Jorgenson","year":"2016","unstructured":"Jorgenson, E. et al. Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration. Eur. J. Hum. Genet. 24, 1049\u20131055 (2016).","journal-title":"Eur. J. Hum. Genet."},{"key":"1764_CR70","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"1764_CR71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of genetic associations with FUMA. Nat. Commun. 8, 1826 (2017).","journal-title":"Nat. Commun."},{"key":"1764_CR72","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","volume":"88","author":"J Yang","year":"2011","unstructured":"Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76\u201382 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR73","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/sim.1047","volume":"21","author":"G Heinze","year":"2002","unstructured":"Heinze, G. & Schemper, M. A solution to the problem of separation in logistic regression. Stat. Med. 21, 2409\u20132419 (2002).","journal-title":"Stat. Med."},{"key":"1764_CR74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13225-y","volume":"10","author":"O Delaneau","year":"2019","unstructured":"Delaneau, O., Zagury, J.-F., Robinson, M. R., Marchini, J. L. & Dermitzakis, E. T. Accurate, scalable and integrative haplotype estimation. Nat. Commun. 10, 5436 (2019).","journal-title":"Nat. Commun."},{"key":"1764_CR75","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1086\/518564","volume":"80","author":"X Mao","year":"2007","unstructured":"Mao, X. et al. A genomewide admixture mapping panel for Hispanic\/Latino populations. Am. J. Hum. Genet. 80, 1171\u20131178 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR76","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.ajhg.2017.03.004","volume":"100","author":"AR Martin","year":"2017","unstructured":"Martin, A. R. et al. Human demographic history impacts genetic risk prediction across diverse populations. Am. J. Hum. Genet. 100, 635\u2013649 (2017).","journal-title":"Am. J. Hum. Genet."},{"key":"1764_CR77","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8","volume":"4","author":"CC Chang","year":"2015","unstructured":"Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).","journal-title":"Gigascience"},{"key":"1764_CR78","doi-asserted-by":"crossref","unstructured":"McInnes, L., Healy, J., Saul, N. & Gro\u00dfberger, L. UMAP: uniform manifold approximation and projection. J. Open Source Softw. 3, 861 (2018).","DOI":"10.21105\/joss.00861"},{"key":"1764_CR79","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/ng.3656","volume":"48","author":"S Das","year":"2016","unstructured":"Das, S. et al. Next-generation genotype imputation service and methods. Nat. Genet. 48, 1284\u20131287 (2016).","journal-title":"Nat. Genet."},{"key":"1764_CR80","doi-asserted-by":"crossref","unstructured":"Mizrahi-Man, O. et al. Novel genotyping algorithms for rare variants significantly improve the accuracy of Applied BiosystemsTM AxiomTM array genotyping calls: Retrospective evaluation of UK Biobank array data. PLoS ONE 17, e0277680 (2022).","DOI":"10.1371\/journal.pone.0277680"},{"key":"1764_CR81","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14288-y","volume":"11","author":"ET Cirulli","year":"2020","unstructured":"Cirulli, E. T. et al. Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts. Nat. Commun. 11, 542 (2020).","journal-title":"Nat. Commun."},{"key":"1764_CR82","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","volume":"26","author":"A Manichaikul","year":"2010","unstructured":"Manichaikul, A. et al. Robust relationship inference in genome-wide association studies. Bioinformatics 26, 2867\u20132873 (2010).","journal-title":"Bioinformatics"},{"key":"1764_CR83","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481\u2013487 (2016).","journal-title":"Nat. Genet."},{"key":"1764_CR84","doi-asserted-by":"crossref","unstructured":"Hemani, G. et al. The MR-Base platform supports systematic causal inference across the human phenome. eLife 7, e34408 (2018).","DOI":"10.7554\/eLife.34408"},{"key":"1764_CR85","doi-asserted-by":"crossref","unstructured":"Brown, B. C., Asian Genetic Epidemiology Network Type 2 Diabetes Consortium, Ye, C. J., Price, A. L. & Zaitlen, N. Transethnic genetic-correlation estimates from summary statistics. Am. J. Hum. Genet. 99, 76\u201388 (2016).","DOI":"10.1016\/j.ajhg.2016.05.001"},{"key":"1764_CR86","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/bioinformatics\/btu197","volume":"30","author":"RJ Carroll","year":"2014","unstructured":"Carroll, R. J., Bastarache, L. & Denny, J. C. R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment. Bioinformatics 30, 2375\u20132376 (2014).","journal-title":"Bioinformatics"},{"key":"1764_CR87","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00933-8","volume":"13","author":"JF Fullard","year":"2021","unstructured":"Fullard, J. F. et al. Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19. Genome Med. 13, 118 (2021).","journal-title":"Genome Med."},{"key":"1764_CR88","doi-asserted-by":"publisher","first-page":"eaat8464","DOI":"10.1126\/science.aat8464","volume":"362","author":"D Wang","year":"2018","unstructured":"Wang, D. et al. Comprehensive functional genomic resource and integrative model for the human brain. Science 362, eaat8464 (2018).","journal-title":"Science"},{"key":"1764_CR89","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/ng.3367","volume":"47","author":"ER Gamazon","year":"2015","unstructured":"Gamazon, E. R. et al. A gene-based association method for mapping traits using reference transcriptome data. Nat. Genet. 47, 1091\u20131098 (2015).","journal-title":"Nat. Genet."},{"key":"1764_CR90","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03621-1","volume":"9","author":"AN Barbeira","year":"2018","unstructured":"Barbeira, A. N. et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat. Commun. 9, 1825 (2018).","journal-title":"Nat. Commun."},{"key":"1764_CR91","doi-asserted-by":"crossref","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289\u2013300 (1995).","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"1764_CR92","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1764_CR93","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25\u201329 (2000).","journal-title":"Nat. Genet."},{"key":"1764_CR94","unstructured":"Gene Ontology Consortium. The Gene Ontology resource: enriching a GOld mine. Nucleic Acids Res. 49, D325\u2013D334 (2021)."},{"key":"1764_CR95","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33219-y","volume":"8","author":"C Zhao","year":"2018","unstructured":"Zhao, C. & Wang, Z. GOGO: An improved algorithm to measure the semantic similarity between gene ontology terms. Sci. Rep. 8, 15107 (2018).","journal-title":"Sci. Rep."},{"key":"1764_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v061.i06","volume":"61","author":"M Charrad","year":"2014","unstructured":"Charrad, M., Ghazzali, N., Boiteau, V. & Niknafs, A. NbClust: an R package for determining the relevant number of clusters in a data set. J. Stat. Softw. 61, 1\u201336 (2014).","journal-title":"J. Stat. Softw."},{"key":"1764_CR97","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s00357-014-9161-z","volume":"31","author":"F Murtagh","year":"2014","unstructured":"Murtagh, F. & Legendre, P. Ward\u2019s hierarchical agglomerative clustering method: which algorithms implement ward\u2019s criterion? J. Classif. 31, 274\u2013295 (2014).","journal-title":"J. Classif."},{"key":"1764_CR98","doi-asserted-by":"crossref","unstructured":"Rousseeuw, P. J. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J. Comput. Appl. Math. 20, 53\u201365 (1987).","DOI":"10.1016\/0377-0427(87)90125-7"},{"key":"1764_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v025.i05","volume":"25","author":"I Feinerer","year":"2008","unstructured":"Feinerer, I., Hornik, K. & Meyer, D. Text mining infrastructure in R. J. Stat. Softw. 25, 1\u201354 (2008).","journal-title":"J. Stat. Softw."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41588-024-01764-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41588-024-01764-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41588-024-01764-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:39:56Z","timestamp":1733873996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41588-024-01764-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":99,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1764"],"URL":"https:\/\/doi.org\/10.1038\/s41588-024-01764-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.08.16.22278855","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.S. and B.L.Y. are employees of Genentech\/Roche and hold stock and stock options in Roche. E.J. is an employee and a stockholder of Regeneron Genetics Center. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}