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R.S.R. reports research funding to his institution from Amgen, Arrowhead, Eli Lilly, Merck, NIH, Novartis, Novo Nordisk, Regeneron and 89Bio, consulting fees from Amgen, Avilar, CRISPER Therapeutics, Editas, Eli Lilly, Lipigon, New Amsterdam, Novartis, Precision Biosciences, Regeneron, UltraGenyx, Verve Therapeutics, nonpromotional honoraria from Meda Pharma, royalties from Wolters Kluwer (UpToDate) and stock holding in MediMergent, LLC. He reports patent applications on: methods and systems for biocellular marker detection and diagnosis using a microfluidic profiling device. EFS ID: 32278349. application no. (PCT\/US2019\/026364) (provisional); all unrelated to this study. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}