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We identified five genetic loci linked to PPH in a meta-analysis. Functional annotation analysis indicated candidate genes<jats:italic>HAND2<\/jats:italic>,<jats:italic>TBX3<\/jats:italic>and<jats:italic>RAP2C<\/jats:italic>\/<jats:italic>FRMD7<\/jats:italic>at three loci and showed that at each locus, associated variants were located within binding sites for progesterone receptors. There were strong genetic correlations with birth weight, gestational duration and uterine fibroids. Bleeding in early pregnancy yielded no genome-wide association signals but showed strong genetic correlation with various human traits, suggesting a potentially complex, polygenic etiology. 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