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S.A.L. is a full-time employee of Novartis Institutes of BioMedical Research as of 18 July 2022. S.A.L. previously received sponsored research support from Bristol Myers Squibb, Pfizer, Boehringer Ingelheim, Fitbit, Medtronic, Premier and IBM and has consulted for Bristol Myers Squibb, Pfizer, Blackstone Life Sciences and Invitae. B.M.P. serves on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. M.H.C. has received grant funding from GSK and Bayer, and speaking or consulting fees from AstraZeneca, Illumina and Genentech. C.M.H. receives research support from Tempus Labs, outside the scope of the present work. S.M.D. receives in kind research support from Novo Nordisk and personal consulting fees, outside the scope of the current research. D.C. receives consulting fees from Roche Diagnostics and Trimedics, and speaker fees from Servier and BMS\/Pfizer. M.K. receives consulting fees from Roche Diagnostics. N.A.M. reports involvement in clinical trials with Amgen, Ionis, Pfizer, Novartis and AstraZeneca without personal fees, payments or increase in salary. C.T.R. provides consultancies with Anthos, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo, Janssen and Pfizer. M.S.S. provides Consultancies with Amgen, Anthos Therapeutics, AstraZeneca, Bristol Myers Squibb, DalCor, Dr. Reddy\u2019s Laboratories, IFM Therapeutics, Intarcia, Merck, Moderna, Novo Nordisk and Silence Therapeutics. R.S. has received lecture fees and advisory board fees from BMS\/Pfizer outside this work. L.M.R. is a consultant for the TOPMed Administrative Coordinating Center through WeStat. M.K. reports personal fees from Bayer, B\u00f6hringer Ingelheim, Pfizer BMS, Daiichi Sankyo, Medtronic, Biotronik, Boston Scientific, Johnson & Johnson and Roche, and grants from Bayer, Pfizer, Boston Scientific, BMS, Biotronik and Daiichi Sankyo. L.-C.W. has received research support from IBM to the Broad Institute. C.R. is supported by a grant from Bayer to the Broad Institute focused on the development of therapeutics for cardiovascular disease. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}