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Using a new genetically engineered mouse model of\n                    <jats:italic>ZFTA<\/jats:italic>\n                    <jats:italic>\u2013RELA<\/jats:italic>\n                    ependymoma, a childhood brain tumor, we characterized an immune circuit between the tumor and antigen-presenting hematopoietic stem and progenitor cells (HSPCs) in the skull bone marrow. The presentation of antigens by HSPCs to CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells biased HSPC lineages toward myelopoiesis and polarized CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells to regulatory T cells, culminating in tumor immunotolerance. Remarkably, normalizing hematopoiesis with a single infusion of antibodies directed against cytokines enriched in the cerebrospinal fluid of mice bearing\n                    <jats:italic>ZFTA<\/jats:italic>\n                    <jats:italic>\u2013RELA<\/jats:italic>\n                    ependymomas, choroid plexus carcinomas or group 3 medulloblastoma\u2014all aggressive childhood brain tumors\u2014disrupted this process and caused profound tumor regression. These findings demonstrate the existence of a skull bone marrow\u2013tumor immunological interface and suggest that modulating the local supply of myeloid cells could represent a less toxic therapeutic strategy for aggressive childhood brain tumors.\n                  <\/jats:p>","DOI":"10.1038\/s41588-025-02499-2","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:02:57Z","timestamp":1770112977000},"page":"317-328","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Childhood brain tumors instruct cranial hematopoiesis and immunotolerance"],"prefix":"10.1038","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4719-7820","authenticated-orcid":false,"given":"Elizabeth","family":"Cooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Posner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-4917","authenticated-orcid":false,"given":"Colin Y. 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