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We conducted the largest genome-wide association study (GWAS) meta-analysis of BPD so far, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 cases and 107,750 controls (all participants of European ancestry). We identified 11 independent associated genomic loci and 9 risk genes in gene-based analyses. We observed a single-nucleotide polymorphism heritability of 17.3% and derived polygenic scores (PGS) that predicted 4.6% of the phenotypic variance in BPD on the liability scale. BPD showed the strongest positive genetic correlations with GWAS of post-traumatic stress disorder, depression, attention deficit hyperactivity disorder, antisocial behavior, and measures of suicide and self-harm. Phenome-wide analyses in Vanderbilt University Medical Center Biobank and UK Biobank using BPD-PGS confirmed these associations and also identified associations with other medical conditions, including obstructive pulmonary disease and diabetes. 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S.B. has ownerships in Hoba Therapeutics Aps, Novo Nordisk, Lundbeck and Eli Lilly and Company. J.L.K. is a Scientific Advisory Board member of Myriad Neuroscience. R.M. has received financial research support from B\u00f6hringer Ingelheim and Otsuka Pharmaceuticals. He has received speakers\u2019 honoraria from Otsuka Pharmaceuticals and Lundbeck and is a member of the advisory board of B\u00f6hringer Ingelheim. F.P. is a member of the Scientific Advisory Boards of Brainsway and Sooma. He has received speaker\u2019s honoraria from Mag&More and the neuroCare Group. J.A.R.-Q. was on the speakers\u2019 bureau and\/or acted as a consultant for Biogen, Idorsia, Casen-Recordati, Janssen-Cilag, Novartis, Takeda, Bial, Sincrolab, Neuraxpharm, BMS, Medice, Rubi\u00f3, Uriach, Technofarma and Raffo in the last 3\u2009years. He also received travel awards for taking part in psychiatric meetings from Idorsia, Janssen-Cilag, Rubi\u00f3, Takeda, Bial and Medice. The Department of Psychiatry, which he chaired, received unrestricted educational and research support from the following companies in the last 3\u2009years: Exeltis, Idorsia, Janssen-Cilag, Neuraxpharm, Oryzon, Roche, Probitas and Rubi\u00f3. C. Schilling received lecturer fees from Idorsia Pharmaceuticals (2024). M.M.N. has received fees for membership in an advisory board from HMG Systems Engineering, for membership in the Medical-Scientific Editorial Office of the Deutsches \u00c4rzteblatt, for review activities from the European Research Council (ERC) and for serving as a consultant for EVERIS Belgique SPRL in a project of the European Commission (REFORM\/SC2020\/029). M.M.N. receives salary payments from Life & Brain and holds shares in Life & Brain. A.O., A.S., H.S., G.B.W., T.E.T. and K.S. are employees of deCODE genetics\/Amgen. 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