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Here we demonstrate how untargeted nanoparticle-enriched mass spectrometry (MS)-based plasma proteomics delivers quantitatively and qualitatively different insights compared to two affinity-based assays in a sample of ~1,400 British South Asian individuals. We identify &gt;1,200 significant locus\u2013protein associations (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20098.7\u2009\u00d7\u200910\n                    <jats:sup>\u221212<\/jats:sup>\n                    ;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009895\n                    <jats:italic>cis<\/jats:italic>\n                    -protein quantitative trait loci (pQTLs)), more than half of which have not been reported previously. Cross-platform comparison demonstrated that multiple platforms are required to capture the full spectrum of pQTLs of blood proteins. We combine proteogenomic results with evidence from multiple biological domains to suggest a potential role of 21 proteins in the pathology of 44 diseases, including a previously uncharacterized role of immunoglobulin \u03bb variable 3-21 in the development of Graves\u2019 disease. Our results demonstrate the potential of MS-based blood proteomics in non-European ancestries for pQTL discovery and the need to consolidate proteogenomic evidence to confidently assign proteins to disease pathology.\n                  <\/jats:p>","DOI":"10.1038\/s41588-026-02697-6","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:02:04Z","timestamp":1784883724000},"page":"1866-1876","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease risk"],"prefix":"10.1038","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-9963","authenticated-orcid":false,"given":"Maik","family":"Pietzner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-9301","authenticated-orcid":false,"given":"Alice","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-4539","authenticated-orcid":false,"given":"Mine","family":"Koprulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4238-6602","authenticated-orcid":false,"given":"Leonhard","family":"Kohleick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Demircan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Genes & Health Research Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"van Heel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-4653","authenticated-orcid":false,"given":"Sarah","family":"Finer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-7505","authenticated-orcid":false,"given":"Julia","family":"Carrasco Zanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-2265","authenticated-orcid":false,"given":"David A.","family":"van Heel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-7344","authenticated-orcid":false,"given":"Claudia","family":"Langenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"2697_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41576-020-0268-2","volume":"22","author":"K Suhre","year":"2021","unstructured":"Suhre, K., McCarthy, M. 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