{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:49:55Z","timestamp":1792784995483,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key Research and Development Program of China"},{"DOI":"10.13039\/501100007202","name":"Gouvernement du Canada | Instituts de Recherche en Sant\u00e9 du Canada | CIHR Skin Research Training Centre","doi-asserted-by":"publisher","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}],"id":[{"id":"10.13039\/501100007202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972287"],"award-info":[{"award-number":["31972287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["BINDS; JP20am0101080j0004"],"award-info":[{"award-number":["BINDS; JP20am0101080j0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI; 19H03404"],"award-info":[{"award-number":["KAKENHI; 19H03404"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007202","name":"Gouvernement du Canada | Instituts de Recherche en Sant\u00e9 du Canada | CIHR Skin Research Training Centre","doi-asserted-by":"publisher","award":["PJT-159601"],"award-info":[{"award-number":["PJT-159601"]}],"id":[{"id":"10.13039\/501100007202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Chem Biol"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1038\/s41589-020-0627-5","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:04:56Z","timestamp":1597665896000},"page":"1246-1254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Structural basis for diamide modulation of ryanodine receptor"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-2240","authenticated-orcid":false,"given":"Ruifang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Haji-Ghassemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-5938","authenticated-orcid":false,"given":"Arthur","family":"Samurkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-6685","authenticated-orcid":false,"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-6594","authenticated-orcid":false,"given":"Shian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-0631","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-2980","authenticated-orcid":false,"given":"Takashi","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2854-9500","authenticated-orcid":false,"given":"Bernard","family":"Moussian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-8537","authenticated-orcid":false,"given":"Filip","family":"Van Petegem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-9106","authenticated-orcid":false,"given":"Zhiguang","family":"Yuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"627_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1085\/jgp.92.1.1","volume":"92","author":"JS Smith","year":"1988","unstructured":"Smith, J. S. et al. Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum. J. Gen. Physiol. 92, 1\u201326 (1988).","journal-title":"J. Gen. Physiol."},{"key":"627_CR2","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0006-291X(85)91699-7","volume":"128","author":"IN Pessah","year":"1985","unstructured":"Pessah, I. N., Waterhouse, A. L. & Casida, J. E. The calcium-ryanodine receptor complex of skeletal and cardiac muscle. Biochem. Biophys. Res. Commun. 128, 449\u2013456 (1985).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"627_CR3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/med.2610150405","volume":"15","author":"G Giannini","year":"1995","unstructured":"Giannini, G. & Sorrentino, V. Molecular structure and tissue distribution of ryanodine receptors calcium channels. Res. Rev. 15, 313\u2013323 (1995).","journal-title":"Res. Rev."},{"key":"627_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10158-008-0076-4","volume":"8","author":"DB Sattelle.","year":"2008","unstructured":"Sattelle., D. B., Cordova, D. & Cheek, T. R. Insect ryanodine receptors: molecular targets for novel pest control chemicals. Invert. Neurosci. 8, 107\u2013119 (2008).","journal-title":"Invert. Neurosci."},{"key":"627_CR5","doi-asserted-by":"publisher","first-page":"C682","DOI":"10.1152\/ajpcell.00150.2012","volume":"303","author":"P Maura","year":"2012","unstructured":"Maura, P. et al. Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2, Mg2, and ATP. Am. J. Physiol. Cell Physiol. 303, C682\u2013C697 (2012).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"627_CR6","doi-asserted-by":"publisher","first-page":"20144","DOI":"10.1074\/jbc.M010771200","volume":"276","author":"DM Balshaw","year":"2001","unstructured":"Balshaw, D. M., Xu, L., Yamaguchi, N., Pasek, D. A. & Meissner, G. Calmodulin binding and inhibition of cardiac muscle calcium release channel (Ryanodine Receptor). J. Biol. Chem. 276, 20144\u201320153 (2001).","journal-title":"J. Biol. Chem."},{"key":"627_CR7","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.281.5378.818","volume":"281","author":"SO Marx","year":"1998","unstructured":"Marx, S. O., Ondrias, K. & Marks, A. R. Coupled gating between individual skeletal muscle Ca2+ release channels (Ryanodine Receptors). Science 281, 818\u2013821 (1998).","journal-title":"Science"},{"key":"627_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jmb.2014.08.004","volume":"427","author":"FV Petegem","year":"2015","unstructured":"Petegem, F. V. Ryanodine receptors: allosteric ion channel giants. J. Mol. Biol. 427, 31\u201353 (2015).","journal-title":"J. Mol. Biol."},{"key":"627_CR9","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1039\/C7TX00198C","volume":"6","author":"JE Casida","year":"2017","unstructured":"Casida, J. E. & Bryant, R. J. The ABCs of pesticide toxicology: amounts, biology, and chemistry. Toxicol. Res. 6, 755\u2013763 (2017).","journal-title":"Toxicol. Res."},{"key":"627_CR10","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/ps.1254","volume":"62","author":"R Nauen","year":"2006","unstructured":"Nauen, R. Insecticide mode of action: return of the ryanodine receptor. Pest. Manag. Sci. 62, 690\u2013692 (2006).","journal-title":"Pest. Manag. Sci."},{"key":"627_CR11","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1584\/jpestics.30.354","volume":"30","author":"M Tohnishi","year":"2005","unstructured":"Tohnishi, M. et al. Flubendiamide, a novel insecticide highly active against lepidopterous insect pests. J. Pestic. Sci. 30, 354\u2013360 (2005).","journal-title":"J. Pestic. Sci."},{"key":"627_CR12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.pestbp.2005.07.005","volume":"84","author":"D Cordova","year":"2006","unstructured":"Cordova, D. et al. Anthranilic diamides: a new class of insecticides with a novel mode of action, ryanodine receptor activation. Pestic. Biochem. Physiol. 84, 196\u2013214 (2006).","journal-title":"Pestic. Biochem. Physiol."},{"key":"627_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ibmb.2016.11.003","volume":"80","author":"E Roditakis","year":"2016","unstructured":"Roditakis, E. et al. Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae). Insect Biochem. Mol. Biol. 80, 11\u201320 (2016).","journal-title":"Insect Biochem. Mol. Biol."},{"key":"627_CR14","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/1744-7917.12695","volume":"27","author":"Y Zuo","year":"2019","unstructured":"Zuo, Y. et al. Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide resistance in Spodoptera exigua (Lepidoptera: Noctuidae). Insect Sci. 27, 791\u2013800 (2019).","journal-title":"Insect Sci."},{"key":"627_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/srep06924","volume":"4","author":"L Guo","year":"2014","unstructured":"Guo, L., Liang, P., Zhou, X. & Gao, X. Novel mutations and mutation combinations of ryanodine receptor in a chlorantraniliprole resistant population of Plutella xylostella (L.). Sci. Rep. 4, 6924 (2014).","journal-title":"Sci. Rep."},{"key":"627_CR16","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1002\/ps.4824","volume":"74","author":"Y Sun","year":"2018","unstructured":"Sun, Y. et al. Chlorantraniliprole resistance and its biochemical and new molecular target mechanisms in laboratory and field strains of Chilo suppressalis (Walker). Pest Manag. Sci. 74, 1416\u20131423 (2018).","journal-title":"Pest Manag. Sci."},{"key":"627_CR17","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.ibmb.2012.09.001","volume":"42","author":"B Troczka","year":"2012","unstructured":"Troczka, B. et al. Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae) is associated with a mutation in the membrane-spanning domain of the ryanodine receptor. Insect Biochem. Mol. Biol. 42, 873\u2013880 (2012).","journal-title":"Insect Biochem. Mol. Biol."},{"key":"627_CR18","doi-asserted-by":"crossref","unstructured":"Nauen, R. & Steinbach, D. in Resistance to Diamide Insecticides in Lepidopteran Pests (eds Rami Horowitz, A. & Ishaaya, I.) 219\u2013240 (Springer, 2016).","DOI":"10.1007\/978-3-319-31800-4_12"},{"key":"627_CR19","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.bbrc.2018.11.180","volume":"508","author":"J Chen","year":"2019","unstructured":"Chen, J., Xue, L., Wei, R., Liu, S. & Yin, C. The insecticide chlorantraniliprole is a weak activator of mammalian skeletal ryanodine receptor\/Ca2+ release channel. Biochem. Biophys. Res. Commun. 508, 633\u2013639 (2019).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"627_CR20","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/toxsci\/kfy256","volume":"167","author":"KM Truong","year":"2019","unstructured":"Truong, K. M. & Pessah, I. N. Comparison of chlorantraniliprole and flubendiamide activity toward wild-type and malignant hyperthermia-susceptible ryanodine receptors and heat stress intolerance. Toxicol. Sci. 167, 509\u2013523 (2019).","journal-title":"Toxicol. Sci."},{"key":"627_CR21","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/26758","volume":"395","author":"XM Xia","year":"1998","unstructured":"Xia, X. M., Fakler, B., Rivard, A., Wayman, G. & Adelman, J. P. Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature 395, 503\u2013507 (1998).","journal-title":"Nature"},{"key":"627_CR22","doi-asserted-by":"publisher","first-page":"145\u2013157","DOI":"10.1016\/j.cell.2016.08.075","volume":"167","author":"A des Georges","year":"2016","unstructured":"des Georges, A. et al. Structural basis for gating and activation of RyR1. Cell 167, 145\u2013157 (2016).","journal-title":"Cell"},{"key":"627_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/srep14680","volume":"5","author":"BJ Troczka","year":"2015","unstructured":"Troczka, B. J. et al. Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides. Sci. Rep. 5, 14680 (2015).","journal-title":"Sci. Rep."},{"key":"627_CR24","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1124\/mol.117.111468","volume":"94","author":"T Murayama","year":"2018","unstructured":"Murayama, T. et al. Efficient high-throughput screening by endoplasmic reticulum Ca2+ measurement to identify inhibitors of Ryanodine receptor Ca2+-release channels. Mol. Pharmacol. 94, 722\u2013730 (2018).","journal-title":"Mol. Pharmacol."},{"key":"627_CR25","doi-asserted-by":"publisher","first-page":"103367","DOI":"10.1016\/j.ibmb.2020.103367","volume":"121","author":"JM Huang","year":"2020","unstructured":"Huang, J. M. et al. Multiple target-site mutations occurring in lepidopterans confer resistance to diamide insecticides. Insect Biochem. Mol. Biol. 121, 103367 (2020).","journal-title":"Insect Biochem. Mol. Biol."},{"key":"627_CR26","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s10340-020-01220-y","volume":"93","author":"EB Richardson","year":"2020","unstructured":"Richardson, E. B., Troczka, B. J., Gutbrod, O., Davies, T. G. E. & Nauen, R. Diamide resistance: 10 years of lessons from lepidopteran pests. J. Pest Sci. 93, 911\u2013928 (2020).","journal-title":"J. Pest Sci."},{"key":"627_CR27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.pestbp.2013.09.004","volume":"107","author":"S Qi","year":"2013","unstructured":"Qi, S. & Casida, J. E. Species differences in chlorantraniliprole and flubendiamide insecticide binding sites in the ryanodine receptor. Pestic. Biochem. Physiol. 107, 321\u2013326 (2013).","journal-title":"Pestic. Biochem. Physiol."},{"key":"627_CR28","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1021\/jf501236h","volume":"62","author":"S Qi","year":"2014","unstructured":"Qi, S., L\u00fcmmen, P., Nauen, R. & Casida, J. E. Diamide insecticide target site specificity in the Heliothis and musca Ryanodine receptors relative to toxicity. J. Agric. Food Chem. 62, 4077\u20134082 (2014).","journal-title":"J. Agric. Food Chem."},{"key":"627_CR29","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1093\/nar\/gkt1113","volume":"42","author":"MJ Landrum","year":"2014","unstructured":"Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res. 42, 980\u2013985 (2014).","journal-title":"Nucleic Acids Res."},{"key":"627_CR30","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1093\/hmg\/10.22.2581","volume":"10","author":"M Nicole","year":"2001","unstructured":"Nicole, M. et al. Familial and sporadic forms of central core disease are associated with mutations in the C-terminal domain of the skeletal muscle ryanodine receptor. Hum. Mol. Genet. 10, 2581\u20132592 (2001).","journal-title":"Hum. Mol. Genet."},{"key":"627_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0960-8966(02)00218-3","volume":"3","author":"MR Davisa","year":"2003","unstructured":"Davisa, M. R. et al. Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene. Neuromuscul. Disord. 3, 151\u2013157 (2003).","journal-title":"Neuromuscul. Disord."},{"key":"627_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1085\/jgp.200308791","volume":"121","author":"G Avila","year":"2003","unstructured":"Avila, G., O\u2019Connell, K. M. & Dirksen, R. T. The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation\u2013contraction uncoupling in central core disease. J. Gen. Physiol. 121, 277\u2013286 (2003).","journal-title":"J. Gen. Physiol."},{"key":"627_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-117","volume":"8","author":"K Amburgey","year":"2013","unstructured":"Amburgey, K. et al. Genotype\u2013phenotype correlations in recessive RYR1-related myopathies. Orphanet J. Rare Dis. 8, 117 (2013).","journal-title":"Orphanet J. Rare Dis."},{"key":"627_CR34","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1093\/hmg\/ddz105","volume":"28","author":"S Brennan","year":"2019","unstructured":"Brennan, S. et al. Mouse model of severe recessive RYR1-related myopathy. Hum. Mol. Genet. 28, 3024\u20133036 (2019).","journal-title":"Hum. Mol. Genet."},{"key":"627_CR35","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1042\/BJ20040580","volume":"382","author":"GG Du","year":"2004","unstructured":"Du, G. G., Khanna, V. K., Guo, X. & MacLENNAN, D. H. Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release. Biochem. J. 382, 557\u2013564 (2004).","journal-title":"Biochem. J."},{"key":"627_CR36","first-page":"61","volume":"12","author":"H Rosenberg","year":"2015","unstructured":"Rosenberg, H., Pollock, N., Schiemann, A., Bulger, T. & Stowell, K. Malignant hyperthermia: a review. Orphanet J. Rare. Dis. 12, 61\u201371 (2015).","journal-title":"Orphanet J. Rare. Dis."},{"key":"627_CR37","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<410::AID-HUMU2>3.0.CO;2-D","volume":"15","author":"TV Mccarthy","year":"2000","unstructured":"Mccarthy, T. V., Quane, K. A. & Lynch, P. J. Ryanodine receptor mutations in malignant hyperthermia and central core disease. Hum. Mutat. 15, 410\u2013417 (2000).","journal-title":"Hum. Mutat."},{"key":"627_CR38","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1161\/01.RES.0000192146.85173.4b","volume":"97","author":"D Jiang","year":"2005","unstructured":"Jiang, D. et al. Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. Circ. Res. 97, 1173\u20131181 (2005).","journal-title":"Circ. Res."},{"key":"627_CR39","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1161\/01.CIR.103.2.196","volume":"103","author":"SG Priori","year":"2001","unstructured":"Priori, S. G. et al. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation 103, 1996\u20132000 (2001).","journal-title":"Circulation"},{"key":"627_CR40","first-page":"550","volume":"2","author":"K Yl\u00e4nen","year":"2010","unstructured":"Yl\u00e4nen, K., Poutanen, T., Hiippala, A., Swan, H. & Korppi, M. Catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2, 550\u2013554 (2010).","journal-title":"Heart Rhythm"},{"key":"627_CR41","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-019-1377-y","volume":"572","author":"D Gong","year":"2019","unstructured":"Gong, D. et al. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature 572, 347\u2013351 (2019).","journal-title":"Nature"},{"key":"627_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bej.2017.01.013","volume":"121","author":"T Sindhu","year":"2017","unstructured":"Sindhu, T., Venkatesan, T., Gracy, G. R., Jalali, S. K. & Rai, A. Exploring the resistance-developing mutations on Ryanodine receptor in diamondback moth and binding mechanism of its activators using computational study. Biochem. Eng. J. 121, 59\u201372 (2017).","journal-title":"Biochem. Eng. J."},{"key":"627_CR43","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/ps.5640","volume":"76","author":"L Lin","year":"2019","unstructured":"Lin, L., Hao, Z., Cao, P. & Yuchi, Z. Homology modeling and docking study of diamondback moth ryanodine receptor reveals the mechanisms for channel activation, insecticide binding and resistance. Pest Manag Sci. 76, 1291\u20131303 (2019).","journal-title":"Pest Manag Sci."},{"key":"627_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39193-3","volume":"9","author":"A Kadala","year":"2019","unstructured":"Kadala, A., Charreton, M., Charnet, P. & Collet, C. Honey bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations. Sci. Rep. 9, 2153 (2019).","journal-title":"Sci. Rep."},{"key":"627_CR45","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.str.2012.04.015","volume":"20","author":"Z Yuchi","year":"2012","unstructured":"Yuchi, Z., Lau, K. & Van Petegem, F. Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain. Structure 20, 1201\u20131211 (2012).","journal-title":"Structure"},{"key":"627_CR46","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nmeth.4169","volume":"14","author":"A Punjani","year":"2017","unstructured":"Punjani, A., Rubinstein, J. L., Fleet, D. J. & Brubaker, M. A. cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Nat. Methods 14, 290\u2013297 (2017).","journal-title":"Nat. Methods"},{"key":"627_CR47","doi-asserted-by":"crossref","first-page":"e42166","DOI":"10.7554\/eLife.42166","volume":"7","author":"J Zivanov","year":"2018","unstructured":"Zivanov, J. et al. New tools for automated high-resolution cryo-EM structure determination in RELION-3. eLife 7, e42166 (2018).","journal-title":"eLife"},{"key":"627_CR48","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nmeth.4193","volume":"14","author":"SQ Zheng","year":"2017","unstructured":"Zheng, S. Q. et al. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Nat. Methods 14, 331\u2013332 (2017).","journal-title":"Nat. Methods"},{"key":"627_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jsb.2015.11.003","volume":"193","author":"K Zhang","year":"2016","unstructured":"Zhang, K. Gctf: real-time CTF determination and correction. J. Struct. Biol. 193, 1\u201312 (2016).","journal-title":"J. Struct. Biol."},{"key":"627_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-019-0437-z","volume":"2","author":"T Wagner","year":"2019","unstructured":"Wagner, T. et al. SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM. Commun. Biol. 2, 1\u201313 (2019).","journal-title":"Commun. Biol."},{"key":"627_CR51","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nature13950","volume":"517","author":"R Zalk","year":"2015","unstructured":"Zalk, R. et al. Structure of a mammalian ryanodine receptor. Nature 517, 44\u201349 (2015).","journal-title":"Nature"},{"key":"627_CR52","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1107\/S2059798318004655","volume":"74","author":"TC Terwilliger","year":"2018","unstructured":"Terwilliger, T. C., Sobolev, O. V., Afonine, P. V. & Adams, P. D. Automated map sharpening by maximization of detail and connectivity. Acta Crystallogr. D Struct. Biol. 74, 545\u2013559 (2018).","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"627_CR53","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/pro.3740","volume":"29","author":"TC Terwilliger","year":"2019","unstructured":"Terwilliger, T. C., Adams, P. D., Afonine, P. V. & Sobolev, O. V. Cryo-EM map interpretation and protein model-building using iterative map segmentation. Protein Sci. 29, 87\u201399 (2019).","journal-title":"Protein Sci."},{"key":"627_CR54","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S0263-7855(97)00009-X","volume":"14","author":"OS Smart","year":"1996","unstructured":"Smart, O. S., Neduvelil, J. G., Wang, X., Wallace, B. & Sansom, M. S. HOLE: a program for the analysis of the pore dimensions of ion channel structural models. J. Mol. Graph. Model. 14, 354\u2013360 (1996).","journal-title":"J. Mol. Graph. Model."},{"key":"627_CR55","doi-asserted-by":"publisher","first-page":"26332","DOI":"10.1074\/jbc.272.42.26332","volume":"272","author":"J Tong","year":"1997","unstructured":"Tong, J. et al. Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and\/or central core disease. J. Biol. Chem. 272, 26332\u201326339 (1997).","journal-title":"J. Biol. Chem."},{"key":"627_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5153","volume":"5","author":"J Suzuki","year":"2014","unstructured":"Suzuki, J. et al. Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA. Nat. Commun. 5, 4153 (2014).","journal-title":"Nat. Commun."},{"key":"627_CR57","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/humu.23072","volume":"37","author":"T Murayama","year":"2016","unstructured":"Murayama, T. et al. Genotype\u2013phenotype correlations of malignant hyperthermia and central core disease mutations in the central region of the RYR1 channel. Hum. Mutat. 37, 1231\u20131241 (2016).","journal-title":"Hum. Mutat."}],"container-title":["Nature Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41589-020-0627-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-020-0627-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-020-0627-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:01:45Z","timestamp":1629144105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41589-020-0627-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["627"],"URL":"https:\/\/doi.org\/10.1038\/s41589-020-0627-5","relation":{},"ISSN":["1552-4450","1552-4469"],"issn-type":[{"value":"1552-4450","type":"print"},{"value":"1552-4469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]},"assertion":[{"value":"17 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}