{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:57:56Z","timestamp":1792205876510,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Chem Biol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1038\/s41589-025-01902-7","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:14:15Z","timestamp":1747721655000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals"],"prefix":"10.1038","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6642-1559","authenticated-orcid":false,"given":"Yinghui","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-6157","authenticated-orcid":false,"given":"Guoling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangpu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zujiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5714-9090","authenticated-orcid":false,"given":"Kun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-0181","authenticated-orcid":false,"given":"Zhaowei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-1344","authenticated-orcid":false,"given":"Xiaolong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"1902_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41579-019-0299-x","volume":"18","author":"KS Makarova","year":"2020","unstructured":"Makarova, K. S. et al. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. Nat. Rev. Microbiol. 18, 67\u201383 (2020).","journal-title":"Nat. Rev. Microbiol."},{"key":"1902_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature15386","volume":"526","author":"LA Marraffini","year":"2015","unstructured":"Marraffini, L. A. CRISPR-Cas immunity in prokaryotes. Nature 526, 55\u201361 (2015).","journal-title":"Nature"},{"key":"1902_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cell.2015.12.035","volume":"164","author":"AV Wright","year":"2016","unstructured":"Wright, A. V., Nu\u00f1ez, J. K. & Doudna, J. A. Biology and applications of CRISPR systems: harnessing nature\u2019s toolbox for genome engineering. Cell 164, 29\u201344 (2016).","journal-title":"Cell"},{"key":"1902_CR4","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41586-021-04058-1","volume":"599","author":"T Karvelis","year":"2021","unstructured":"Karvelis, T. et al. Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Nature 599, 692\u2013696 (2021).","journal-title":"Nature"},{"key":"1902_CR5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41586-023-05826-x","volume":"616","author":"G Sasnauskas","year":"2023","unstructured":"Sasnauskas, G. et al. TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature 616, 384\u2013389 (2023).","journal-title":"Nature"},{"key":"1902_CR6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/s41586-023-05933-9","volume":"616","author":"R Nakagawa","year":"2023","unstructured":"Nakagawa, R. et al. Cryo-EM structure of the transposon-associated TnpB enzyme. Nature 616, 390\u2013397 (2023).","journal-title":"Nature"},{"key":"1902_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41586-023-06597-1","volume":"622","author":"C Meers","year":"2023","unstructured":"Meers, C. et al. Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Nature 622, 863\u2013871 (2023).","journal-title":"Nature"},{"key":"1902_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1126\/science.abj6856","volume":"374","author":"H Altae-Tran","year":"2021","unstructured":"Altae-Tran, H. et al. The widespread IS200\/IS605 transposon family encodes diverse programmable RNA-guided endonucleases. Science 374, 57\u201365 (2021).","journal-title":"Science"},{"key":"1902_CR9","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1126\/science.abq7220","volume":"376","author":"G Schuler","year":"2022","unstructured":"Schuler, G., Hu, C. & Ke, A. Structural basis for RNA-guided DNA cleavage by IscB-omegaRNA and mechanistic comparison with Cas9. Science 376, 1476\u20131481 (2022).","journal-title":"Science"},{"key":"1902_CR10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-022-05324-6","volume":"610","author":"S Hirano","year":"2022","unstructured":"Hirano, S. et al. Structure of the OMEGA nickase IsrB in complex with omegaRNA and target DNA. Nature 610, 575\u2013581 (2022).","journal-title":"Nature"},{"key":"1902_CR11","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/s41586-023-06356-2","volume":"620","author":"M Saito","year":"2023","unstructured":"Saito, M. et al. Fanzor is a eukaryotic programmable RNA-guided endonuclease. Nature 620, 660\u2013668 (2023).","journal-title":"Nature"},{"key":"1902_CR12","doi-asserted-by":"publisher","first-page":"eadk0171","DOI":"10.1126\/sciadv.adk0171","volume":"9","author":"K Jiang","year":"2023","unstructured":"Jiang, K. et al. Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses. Sci. Adv. 9, eadk0171 (2023).","journal-title":"Sci. Adv."},{"key":"1902_CR13","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1016\/j.cell.2024.07.050","volume":"187","author":"P Xu","year":"2024","unstructured":"Xu, P. et al. Structural insights into the diversity and DNA cleavage mechanism of Fanzor. Cell 187, 5238\u20135252.e5220 (2024).","journal-title":"Cell"},{"key":"1902_CR14","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","volume":"163","author":"B Zetsche","year":"2015","unstructured":"Zetsche, B. et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell 163, 759\u2013771 (2015).","journal-title":"Cell"},{"key":"1902_CR15","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nature17945","volume":"532","author":"I Fonfara","year":"2016","unstructured":"Fonfara, I., Richter, H., Bratovi\u010d, M., Le Rhun, A. & Charpentier, E. The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA. Nature 532, 517\u2013521 (2016).","journal-title":"Nature"},{"key":"1902_CR16","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1126\/science.aav4294","volume":"362","author":"LB Harrington","year":"2018","unstructured":"Harrington, L. B. et al. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science 362, 839\u2013842 (2018).","journal-title":"Science"},{"key":"1902_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/1759-8753-4-12","volume":"4","author":"W Bao","year":"2013","unstructured":"Bao, W. & Jurka, J. Homologues of bacterial TnpB_IS605 are widespread in diverse eukaryotic transposable elements. Mob. DNA 4, 12 (2013).","journal-title":"Mob. DNA"},{"key":"1902_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45197-z","volume":"15","author":"Z Li","year":"2024","unstructured":"Li, Z. et al. Engineering a transposon-associated TnpB-\u03c9RNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model. Nat. Commun. 15, 831 (2024).","journal-title":"Nat. Commun."},{"key":"1902_CR19","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1038\/s41592-024-02418-z","volume":"21","author":"KF Marquart","year":"2024","unstructured":"Marquart, K. F. et al. Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted \u03c9RNAs. Nat. Methods 21, 2084\u20132093 (2024).","journal-title":"Nat. Methods"},{"key":"1902_CR20","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41587-023-01857-x","volume":"42","author":"G Xiang","year":"2024","unstructured":"Xiang, G. et al. Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors. Nat. Biotechnol. 42, 745\u2013757 (2024).","journal-title":"Nat. Biotechnol."},{"key":"1902_CR21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41589-023-01420-4","volume":"20","author":"M Su","year":"2024","unstructured":"Su, M. et al. Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity. Nat. Chem. Biol. 20, 180\u2013189 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"1902_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37829-7","volume":"14","author":"X Kong","year":"2023","unstructured":"Kong, X. et al. Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing. Nat. Commun. 14, 2046 (2023).","journal-title":"Nat. Commun."},{"key":"1902_CR23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41587-021-01009-z","volume":"40","author":"DY Kim","year":"2022","unstructured":"Kim, D. Y. et al. Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virus. Nat. Biotechnol. 40, 94\u2013102 (2022).","journal-title":"Nat. Biotechnol."},{"key":"1902_CR24","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s41592-023-01898-9","volume":"20","author":"D Han","year":"2023","unstructured":"Han, D. et al. Development of miniature base editors using engineered IscB nickase. Nat. Methods 20, 1029\u20131036 (2023).","journal-title":"Nat. Methods"},{"key":"1902_CR25","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.molcel.2023.06.014","volume":"83","author":"W Chen","year":"2023","unstructured":"Chen, W. et al. Cas12n nucleases, early evolutionary intermediates of type V CRISPR, comprise a distinct family of miniature genome editors. Mol. Cell 83, 2768\u20132780.e6 (2023).","journal-title":"Mol. Cell"},{"key":"1902_CR26","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41929-023-00995-4","volume":"6","author":"Z Wu","year":"2023","unstructured":"Wu, Z. et al. Structure and engineering of miniature Acidibacillus sulfuroxidans Cas12f1. Nat. Catal. 6, 695\u2013709 (2023).","journal-title":"Nat. Catal."},{"key":"1902_CR27","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1126\/science.aas9129","volume":"361","author":"H Nishimasu","year":"2018","unstructured":"Nishimasu, H. et al. Engineered CRISPR-Cas9 nuclease with expanded targeting space. Science 361, 1259\u20131262 (2018).","journal-title":"Science"},{"key":"1902_CR28","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1126\/science.aba8853","volume":"368","author":"RT Walton","year":"2020","unstructured":"Walton, R. T., Christie, K. A., Whittaker, M. N. & Kleinstiver, B. P. Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants. Science 368, 290\u2013296 (2020).","journal-title":"Science"},{"key":"1902_CR29","first-page":"538","volume":"14","author":"H Zhang","year":"2023","unstructured":"Zhang, H. et al. An engineered xCas12i with high activity, high specificity, and broad PAM range. Protein Cell 14, 538\u2013543 (2023).","journal-title":"Protein Cell"},{"key":"1902_CR30","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s12010-016-2122-8","volume":"180","author":"Y Yang","year":"2016","unstructured":"Yang, Y. et al. Highly efficient and rapid detection of the cleavage activity of Cas9\/gRNA via a fluorescent reporter. Appl. Biochem. Biotechnol. 180, 655\u2013667 (2016).","journal-title":"Appl. Biochem. Biotechnol."},{"key":"1902_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.molcel.2016.02.031","volume":"62","author":"RT Leenay","year":"2016","unstructured":"Leenay, R. T. et al. Identifying and visualizing functional PAM diversity across CRISPR-Cas systems. Mol. Cell 62, 137\u2013147 (2016).","journal-title":"Mol. Cell"},{"key":"1902_CR32","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1093\/bioinformatics\/btu048","volume":"30","author":"S Bae","year":"2014","unstructured":"Bae, S., Park, J. & Kim, J. S. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases. Bioinformatics 30, 1473\u20131475 (2014).","journal-title":"Bioinformatics"},{"key":"1902_CR33","doi-asserted-by":"publisher","first-page":"101088","DOI":"10.1016\/j.xpro.2021.101088","volume":"3","author":"Y Liu","year":"2022","unstructured":"Liu, Y. et al. PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair. STAR Protoc. 3, 101088 (2022).","journal-title":"STAR Protoc."},{"key":"1902_CR34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004840117","volume":"118","author":"EN Olson","year":"2021","unstructured":"Olson, E. N. Toward the correction of muscular dystrophy by gene editing. Proc. Natl Acad. Sci. USA 118, e2004840117 (2021).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1902_CR35","doi-asserted-by":"publisher","first-page":"eaav4324","DOI":"10.1126\/sciadv.aav4324","volume":"5","author":"YL Min","year":"2019","unstructured":"Min, Y. L. et al. CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells. Sci. Adv. 5, eaav4324 (2019).","journal-title":"Sci. Adv."},{"key":"1902_CR36","doi-asserted-by":"publisher","first-page":"eaap9004","DOI":"10.1126\/sciadv.aap9004","volume":"4","author":"C Long","year":"2018","unstructured":"Long, C. et al. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci. Adv. 4, eaap9004 (2018).","journal-title":"Sci. Adv."},{"key":"1902_CR37","doi-asserted-by":"publisher","first-page":"21848","DOI":"10.1073\/pnas.0911354106","volume":"106","author":"M Boyer","year":"2009","unstructured":"Boyer, M. et al. Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms. Proc. Natl Acad. Sci. USA 106, 21848\u201321853 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1902_CR38","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.1016\/j.molcel.2021.08.008","volume":"81","author":"X Xu","year":"2021","unstructured":"Xu, X. et al. Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing. Mol. Cell 81, 4333\u20134345.e4 (2021).","journal-title":"Mol. Cell"},{"key":"1902_CR39","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1038\/s41589-024-01670-w","volume":"20","author":"L Han","year":"2024","unstructured":"Han, L. et al. Engineering miniature IscB nickase for robust base editing with broad targeting range. Nat. Chem. Biol. 20, 1629\u20131639 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"1902_CR40","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/s41589-024-01669-3","volume":"20","author":"H Yan","year":"2024","unstructured":"Yan, H. et al. Assessing and engineering the IscB-\u03c9RNA system for programmed genome editing. Nat. Chem. Biol. 20, 1617\u20131628 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"1902_CR41","doi-asserted-by":"publisher","first-page":"111418","DOI":"10.1016\/j.celrep.2022.111418","volume":"40","author":"Y Wang","year":"2022","unstructured":"Wang, Y. et al. Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease. Cell Rep. 40, 111418 (2022).","journal-title":"Cell Rep."},{"key":"1902_CR42","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cell.2020.03.023","volume":"181","author":"D Wang","year":"2020","unstructured":"Wang, D., Zhang, F. & Gao, G. CRISPR-based therapeutic genome editing: strategies and in vivo delivery by AAV vectors. Cell 181, 136\u2013150 (2020).","journal-title":"Cell"},{"key":"1902_CR43","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1016\/j.cell.2022.03.045","volume":"185","author":"A Raguram","year":"2022","unstructured":"Raguram, A., Banskota, S. & Liu, D. R. Therapeutic in vivo delivery of gene editing agents. Cell 185, 2806\u20132827 (2022).","journal-title":"Cell"},{"key":"1902_CR44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/nature17946","volume":"533","author":"AC Komor","year":"2016","unstructured":"Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533, 420\u2013424 (2016).","journal-title":"Nature"},{"key":"1902_CR45","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/nature24644","volume":"551","author":"NM Gaudelli","year":"2017","unstructured":"Gaudelli, N. M. et al. Programmable base editing of A\u2022T to G\u2022C in genomic DNA without DNA cleavage. Nature 551, 464\u2013471 (2017).","journal-title":"Nature"},{"key":"1902_CR46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","volume":"576","author":"AV Anzalone","year":"2019","unstructured":"Anzalone, A. V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576, 149\u2013157 (2019).","journal-title":"Nature"},{"key":"1902_CR47","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s13238-021-00862-7","volume":"12","author":"X Kong","year":"2021","unstructured":"Kong, X. et al. Precise genome editing without exogenous donor DNA via retron editing system in human cells. Protein Cell 12, 899\u2013902 (2021).","journal-title":"Protein Cell"},{"key":"1902_CR48","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1016\/j.cell.2021.03.025","volume":"184","author":"JK Nu\u00f1ez","year":"2021","unstructured":"Nu\u00f1ez, J. K. et al. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell 184, 2503\u20132519.e2517 (2021).","journal-title":"Cell"},{"key":"1902_CR49","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41587-019-0032-3","volume":"37","author":"K Clement","year":"2019","unstructured":"Clement, K. et al. CRISPResso2 provides accurate and rapid genome editing sequence analysis. Nat. Biotechnol. 37, 224\u2013226 (2019).","journal-title":"Nat. Biotechnol."},{"key":"1902_CR50","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41421-019-0088-8","volume":"5","author":"J Yin","year":"2019","unstructured":"Yin, J. et al. Optimizing genome editing strategy by primer-extension-mediated sequencing. Cell Discov. 5, 18 (2019).","journal-title":"Cell Discov."}],"container-title":["Nature Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41589-025-01902-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-025-01902-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-025-01902-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:19:10Z","timestamp":1766503150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41589-025-01902-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1902"],"URL":"https:\/\/doi.org\/10.1038\/s41589-025-01902-7","relation":{},"ISSN":["1552-4450","1552-4469"],"issn-type":[{"value":"1552-4450","type":"print"},{"value":"1552-4469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"17 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Y.W., X.W. and K.X. have filed a patent application related to this work through NWAFU (patent no. 202411627205.2). The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}