{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:29:20Z","timestamp":1786613360245,"version":"build-2736575974"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000052","name":"U.S. Department of Health & Human Services | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD036363"],"award-info":[{"award-number":["S10OD036363"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM150765"],"award-info":[{"award-number":["R35GM150765"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Chem Biol"],"DOI":"10.1038\/s41589-026-02284-0","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:02:17Z","timestamp":1786611737000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photoproximity labeling of c-Myc reveals SLK as a cancer-specific co-regulator"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-0175","authenticated-orcid":false,"given":"Ryan R.","family":"Milione","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-3517","authenticated-orcid":false,"given":"Kelsey L.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron J.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara B.","family":"Linker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmeng Jasmine","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V.","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Nager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8592-5146","authenticated-orcid":false,"given":"Michalina","family":"Janiszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-128X","authenticated-orcid":false,"given":"Ciaran P.","family":"Seath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2284_CR1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41568-019-0196-7","volume":"19","author":"JH Bushweller","year":"2019","unstructured":"Bushweller, J. H. Targeting transcription factors in cancer\u2014from undruggable to reality. Nat. Rev. Cancer 19, 611\u2013624 (2019).","journal-title":"Nat. Rev. Cancer"},{"key":"2284_CR2","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41573-021-00199-0","volume":"20","author":"MJ Henley","year":"2021","unstructured":"Henley, M. J. & Koehler, A. N. Advances in targeting \u2018undruggable\u2019 transcription factors with small molecules. Nat. Rev. Drug Discov. 20, 669\u2013688 (2021).","journal-title":"Nat. Rev. Drug Discov."},{"key":"2284_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.chembiol.2020.09.001","volume":"28","author":"L Boike","year":"2021","unstructured":"Boike, L. et al. Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC. Cell Chem. Biol. 28, 4\u201313 (2021).","journal-title":"Cell Chem. Biol."},{"key":"2284_CR4","doi-asserted-by":"publisher","first-page":"e202508518","DOI":"10.1002\/anie.202508518","volume":"64","author":"HT Rosen","year":"2025","unstructured":"Rosen, H. T. et al. Sulfinyl aziridines as stereoselective covalent destabilizing degraders of the oncogenic transcription factor MYC. Angew. Chem. Int. Ed. 64, e202508518 (2025).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2284_CR5","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","volume":"172","author":"SA Lambert","year":"2018","unstructured":"Lambert, S. A. et al. The human transcription factors. Cell 172, 650\u2013665 (2018).","journal-title":"Cell"},{"key":"2284_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.biocel.2017.12.020","volume":"95","author":"J Bennett","year":"2018","unstructured":"Bennett, J. et al. NF-\u03baB in the crosshairs: rethinking an old riddle. Int. J. Biochem. Cell Biol. 95, 108\u2013112 (2018).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2284_CR7","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/jmcb\/mjz075","volume":"11","author":"G Sanz","year":"2019","unstructured":"Sanz, G., Singh, M., Peuget, S. & Selivanova, G. Inhibition of p53 inhibitors: progress, challenges and perspectives. J. Mol. Cell Biol. 11, 586\u2013599 (2019).","journal-title":"J. Mol. Cell Biol."},{"key":"2284_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14356","volume":"8","author":"Z Li","year":"2017","unstructured":"Li, Z. et al. The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Nat. Commun. 8, 14356 (2017).","journal-title":"Nat. Commun."},{"key":"2284_CR9","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.cell.2021.02.020","volume":"184","author":"WC Hahn","year":"2021","unstructured":"Hahn, W. C. et al. An expanded universe of cancer targets. Cell 184, 1142\u20131155 (2021).","journal-title":"Cell"},{"key":"2284_CR10","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1158\/1078-0432.CCR-12-0977","volume":"18","author":"DM Miller","year":"2012","unstructured":"Miller, D. M., Thomas, S. D., Islam, A., Muench, D. & Sedoris, K. c-Myc and cancer metabolism. Clin. Cancer Res. 18, 5546\u20135553 (2012).","journal-title":"Clin. Cancer Res."},{"key":"2284_CR11","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41568-021-00367-9","volume":"21","author":"C Lourenco","year":"2021","unstructured":"Lourenco, C. et al. MYC protein interactors in gene transcription and cancer. Nat. Rev. Cancer 21, 579\u2013591 (2021).","journal-title":"Nat. Rev. Cancer"},{"key":"2284_CR12","doi-asserted-by":"publisher","first-page":"103756","DOI":"10.1016\/j.ebiom.2021.103756","volume":"75","author":"V Llombart","year":"2022","unstructured":"Llombart, V. & Mansour, M. R. Therapeutic targeting of \u2018undruggable\u2019 MYC. EBioMedicine 75, 103756 (2022).","journal-title":"EBioMedicine"},{"key":"2284_CR13","doi-asserted-by":"publisher","first-page":"eaar5012","DOI":"10.1126\/scitranslmed.aar5012","volume":"11","author":"M-E Beaulieu","year":"2019","unstructured":"Beaulieu, M.-E. et al. Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy. Sci. Transl. Med. 11, eaar5012 (2019).","journal-title":"Sci. Transl. Med."},{"key":"2284_CR14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.molcel.2016.09.016","volume":"64","author":"D Xiao","year":"2016","unstructured":"Xiao, D. et al. Polo-like Kinase-1 regulates Myc stabilization and activates a feedforward circuit promoting tumor cell survival. Mol. Cell 64, 493\u2013506 (2016).","journal-title":"Mol. Cell"},{"key":"2284_CR15","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1200\/JCO.2015.62.1474","volume":"34","author":"E Pujade-Lauraine","year":"2016","unstructured":"Pujade-Lauraine, E. et al. Volasertib versus chemotherapy in platinum-resistant or -refractory ovarian cancer: a randomized phase II Groupe des Investigateurs Nationaux pour l\u2019Etude des Cancers de l\u2019Ovaire Study. J. Clin. Oncol. 34, 706\u2013713 (2016).","journal-title":"J. Clin. Oncol."},{"key":"2284_CR16","doi-asserted-by":"publisher","first-page":"1709388","DOI":"10.1080\/23723556.2019.1709388","volume":"7","author":"LR Thomas","year":"2020","unstructured":"Thomas, L. R., Adams, C. M., Fesik, S. W., Eischen, C. M. & Tansey, W. P. Targeting MYC through WDR5. Mol. Cell. Oncol. 7, 1709388 (2020).","journal-title":"Mol. Cell. Oncol."},{"key":"2284_CR17","doi-asserted-by":"publisher","first-page":"25260","DOI":"10.1073\/pnas.1910391116","volume":"116","author":"LR Thomas","year":"2019","unstructured":"Thomas, L. R. et al. Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance. Proc. Natl Acad. Sci. USA 116, 25260\u201325268 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2284_CR18","doi-asserted-by":"publisher","first-page":"11232","DOI":"10.1021\/acs.jmedchem.9b01411","volume":"62","author":"JD Macdonald","year":"2019","unstructured":"Macdonald, J. D. et al. Discovery and optimization of salicylic acid-derived sulfonamide inhibitors of the WD repeat-containing protein 5-MYC protein-protein interaction. J. Med. Chem. 62, 11232\u201311259 (2019).","journal-title":"J. Med. Chem."},{"key":"2284_CR19","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.chembiol.2024.12.006","volume":"32","author":"J Tang","year":"2025","unstructured":"Tang, J. et al. Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem. Biol. 32, 352\u2013362 (2025).","journal-title":"Cell Chem. Biol."},{"key":"2284_CR20","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nm.4107","volume":"22","author":"D Dauch","year":"2016","unstructured":"Dauch, D. et al. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med. 22, 744\u2013753 (2016).","journal-title":"Nat. Med."},{"key":"2284_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ccr.2013.05.005","volume":"24","author":"M Brockmann","year":"2013","unstructured":"Brockmann, M. et al. Small molecule inhibitors of Aurora-A induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell 24, 75\u201389 (2013).","journal-title":"Cancer Cell"},{"key":"2284_CR22","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.molcel.2018.09.031","volume":"72","author":"M Kalkat","year":"2018","unstructured":"Kalkat, M. et al. MYC protein interactome profiling reveals functionally distinct regions that cooperate to drive tumorigenesis. Mol. Cell 72, 836\u2013848 (2018).","journal-title":"Mol. Cell"},{"key":"2284_CR23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jprot.2014.09.029","volume":"118","author":"D Dingar","year":"2015","unstructured":"Dingar, D. et al. BioID identifies novel c-Myc interacting partners in cultured cells and xenograft tumors. J. Proteomics 118, 95\u2013111 (2015).","journal-title":"J. Proteomics"},{"key":"2284_CR24","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.4161\/cc.9.24.14199","volume":"9","author":"P Agrawal","year":"2010","unstructured":"Agrawal, P., Yu, K., Salomon, A. R. & Sedivy, J. M. Proteomic profiling of Myc-associated proteins. Cell Cycle 9, 4908\u20134921 (2010).","journal-title":"Cell Cycle"},{"key":"2284_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4161\/cc.6.2.3742","volume":"6","author":"HB Koch","year":"2007","unstructured":"Koch, H. B. et al. Large-scale identification of c-Myc-associated proteins using a combined TAP\/MudPIT approach. Cell Cycle 6, 205\u2013217 (2007).","journal-title":"Cell Cycle"},{"key":"2284_CR26","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41586-023-05914-y","volume":"616","author":"CP Seath","year":"2023","unstructured":"Seath, C. P. et al. Tracking chromatin state changes using nanoscale photo-proximity labelling. Nature 616, 574\u2013580 (2023).","journal-title":"Nature"},{"key":"2284_CR27","doi-asserted-by":"publisher","first-page":"e2203027119","DOI":"10.1073\/pnas.2203027119","volume":"119","author":"JV Oakley","year":"2022","unstructured":"Oakley, J. V. et al. Radius measurement via super-resolution microscopy enables the development of a variable radii proximity labeling platform. Proc. Natl Acad. Sci. USA 119, e2203027119 (2022).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2284_CR28","doi-asserted-by":"publisher","unstructured":"Douglas, C. J. et al. Mesoscale proximity labeling to study macro changes to chromatin occupancy. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2025.03.13.643041 (2025).","DOI":"10.1101\/2025.03.13.643041"},{"key":"2284_CR29","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0092-8674(00)81479-8","volume":"94","author":"SB McMahon","year":"1998","unstructured":"McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T. D. & Cole, M. D. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94, 363\u2013374 (1998).","journal-title":"Cell"},{"key":"2284_CR30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.09.010","volume":"143","author":"J Kim","year":"2010","unstructured":"Kim, J. et al. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143, 313\u2013324 (2010).","journal-title":"Cell"},{"key":"2284_CR31","doi-asserted-by":"publisher","unstructured":"Luo, Y. et al. mRNA interactions with disordered regions control protein activity. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2023.02.18.529068 (2023).","DOI":"10.1101\/2023.02.18.529068"},{"key":"2284_CR32","doi-asserted-by":"publisher","first-page":"109598","DOI":"10.1016\/j.celrep.2021.109598","volume":"36","author":"V Fischer","year":"2021","unstructured":"Fischer, V. et al. The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. Cell Rep. 36, 109598 (2021).","journal-title":"Cell Rep."},{"key":"2284_CR33","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1111\/febs.16580","volume":"290","author":"A Kotekar","year":"2023","unstructured":"Kotekar, A., Singh, A. K. & Devaiah, B. N. BRD4 and MYC: power couple in transcription and disease. FEBS J. 290, 4820\u20134842 (2023).","journal-title":"FEBS J."},{"key":"2284_CR34","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrc4016","volume":"15","author":"PA Watson","year":"2015","unstructured":"Watson, P. A., Arora, V. K. & Sawyers, C. L. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat. Rev. Cancer 15, 701\u2013711 (2015).","journal-title":"Nat. Rev. Cancer"},{"key":"2284_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27077-y","volume":"12","author":"H Guo","year":"2021","unstructured":"Guo, H. et al. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat. Commun. 12, 7308 (2021).","journal-title":"Nat. Commun."},{"key":"2284_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30257-z","volume":"13","author":"X Qiu","year":"2022","unstructured":"Qiu, X. et al. MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets. Nat. Commun. 13, 2559 (2022).","journal-title":"Nat. Commun."},{"key":"2284_CR37","doi-asserted-by":"publisher","first-page":"9085","DOI":"10.1073\/pnas.0402770101","volume":"101","author":"M Welcker","year":"2004","unstructured":"Welcker, M. et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl Acad. Sci. USA 101, 9085\u20139090 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2284_CR38","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.4161\/cc.3.9.1145","volume":"3","author":"RC Sears","year":"2004","unstructured":"Sears, R. C. The life cycle of c-Myc: from synthesis to degradation. Cell Cycle 3, 1133\u20131137 (2004).","journal-title":"Cell Cycle"},{"key":"2284_CR39","doi-asserted-by":"publisher","first-page":"679445","DOI":"10.3389\/fonc.2021.679445","volume":"11","author":"X-X Sun","year":"2021","unstructured":"Sun, X.-X., Li, Y., Sears, R. C. & Dai, M.-S. Targeting the MYC ubiquitination-proteasome degradation pathway for cancer therapy. Front. Oncol. 11, 679445 (2021).","journal-title":"Front. Oncol."},{"key":"2284_CR40","doi-asserted-by":"publisher","first-page":"4746","DOI":"10.3390\/ijms24054746","volume":"24","author":"D Boi","year":"2023","unstructured":"Boi, D., Rubini, E., Breccia, S., Guarguaglini, G. & Paiardini, A. When just one phosphate is one too many: the multifaceted interplay between Myc and kinases. Int. J. Mol. Sci. 24, 4746 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"2284_CR41","doi-asserted-by":"publisher","first-page":"37685","DOI":"10.1074\/jbc.M205899200","volume":"277","author":"S Wagner","year":"2002","unstructured":"Wagner, S., Flood, T. A., O\u2019Reilly, P., Hume, K. & Sabourin, L. A. Association of the STE20-like kinase (SLK) with the microtubule. Role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading. J. Biol. Chem. 277, 37685\u201337692 (2002).","journal-title":"J. Biol. Chem."},{"key":"2284_CR42","doi-asserted-by":"publisher","first-page":"e1868","DOI":"10.1371\/journal.pone.0001868","volume":"3","author":"S Wagner","year":"2008","unstructured":"Wagner, S. et al. FAK\/src-family dependent activation of the STE20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLOS ONE 3, e1868 (2008).","journal-title":"PLOS ONE"},{"key":"2284_CR43","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1038\/onc.2012.488","volume":"32","author":"JL Quizi","year":"2013","unstructured":"Quizi, J. L. et al. SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration. Oncogene 32, 4656\u20134663 (2013).","journal-title":"Oncogene"},{"key":"2284_CR44","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1016\/j.bbagen.2013.06.007","volume":"1830","author":"S Chen","year":"2013","unstructured":"Chen, S. et al. Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-Myc transcription. Biochim. Biophys. Acta 1830, 4769\u20134777 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"2284_CR45","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1093\/nar\/gkn919","volume":"37","author":"RK Thakur","year":"2009","unstructured":"Thakur, R. K. et al. Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-Myc promoter nuclease hypersensitive element induces c-Myc expression. Nucleic Acids Res. 37, 172\u2013183 (2009).","journal-title":"Nucleic Acids Res."},{"key":"2284_CR46","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/emboj.2008.8","volume":"27","author":"ACW Pike","year":"2008","unstructured":"Pike, A. C. W. et al. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 27, 704\u2013714 (2008).","journal-title":"EMBO J."},{"key":"2284_CR47","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1038\/onc.2008.123","volume":"27","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y., Wang, Z., Li, X. & Magnuson, N. S. Pim kinase-dependent inhibition of c-Myc degradation. Oncogene 27, 4809\u20134819 (2008).","journal-title":"Oncogene"},{"key":"2284_CR48","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1158\/0008-5472.CAN-13-0615","volume":"73","author":"G Civenni","year":"2013","unstructured":"Civenni, G. et al. RNAi-mediated silencing of Myc transcription inhibits stem-like cell maintenance and tumorigenicity in prostate cancer. Cancer Res. 73, 6816\u20136827 (2013).","journal-title":"Cancer Res."},{"key":"2284_CR49","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1158\/0008-5472.CAN-25-0523","volume":"85","author":"Z Chen","year":"2025","unstructured":"Chen, Z. et al. Exon skipping of STE20-like kinase enhances glycolysis and tumor progression by activating enolase 1-mediated phosphoenolpyruvate production. Cancer Res. 85, 3930\u20133948 (2025).","journal-title":"Cancer Res."},{"key":"2284_CR50","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1038\/onc.2013.50","volume":"33","author":"C Braeutigam","year":"2014","unstructured":"Braeutigam, C. et al. The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion. Oncogene 33, 1082\u20131092 (2014).","journal-title":"Oncogene"},{"key":"2284_CR51","doi-asserted-by":"publisher","first-page":"F554","DOI":"10.1152\/ajprenal.00062.2011","volume":"301","author":"S Delarosa","year":"2011","unstructured":"Delarosa, S. et al. Activity of the STE20-like kinase, SLK, is enhanced by homodimerization. Am. J. Physiol. Renal Physiol. 301, F554\u201364 (2011).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2284_CR52","doi-asserted-by":"publisher","first-page":"e47678","DOI":"10.7554\/eLife.47678","volume":"8","author":"J Munkley","year":"2019","unstructured":"Munkley, J. et al. Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. eLife 8, e47678 (2019).","journal-title":"eLife"},{"key":"2284_CR53","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1038\/emboj.2010.195","volume":"29","author":"CC Warzecha","year":"2010","unstructured":"Warzecha, C. C. et al. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J 29, 3286\u20133300 (2010).","journal-title":"EMBO J"},{"key":"2284_CR54","doi-asserted-by":"publisher","unstructured":"Yang, Y.-Q. et al. Extensive dysregulation of SLK splicing in cancers impacts metastasis. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.10.28.514146 (2022).","DOI":"10.1101\/2022.10.28.514146"},{"key":"2284_CR55","doi-asserted-by":"publisher","first-page":"e1010065","DOI":"10.1371\/journal.pcbi.1010065","volume":"18","author":"DO Holland","year":"2022","unstructured":"Holland, D. O. et al. Characterization and clustering of kinase isoform expression in metastatic melanoma. PLOS Comput. Biol. 18, e1010065 (2022).","journal-title":"PLOS Comput. Biol."},{"key":"2284_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63251-2","volume":"16","author":"UV Chembazhi","year":"2025","unstructured":"Chembazhi, U. V. et al. Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease. Nat. Commun. 16, 8049 (2025).","journal-title":"Nat. Commun."},{"key":"2284_CR57","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nbt.3772","volume":"35","author":"J Vivian","year":"2017","unstructured":"Vivian, J. et al. Toil enables reproducible, open source, big biomedical data analyses. Nat. Biotechnol. 35, 314\u2013316 (2017).","journal-title":"Nat. Biotechnol."},{"key":"2284_CR58","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","volume":"38","author":"MJ Goldman","year":"2020","unstructured":"Goldman, M. J. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat. Biotechnol. 38, 675\u2013678 (2020).","journal-title":"Nat. Biotechnol."},{"key":"2284_CR59","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ccell.2017.06.001","volume":"32","author":"Y Gu","year":"2017","unstructured":"Gu, Y. et al. Stabilization of the c-Myc protein by CAMKII\u03b3 promotes T cell lymphoma. Cancer Cell 32, 115\u2013128 (2017).","journal-title":"Cancer Cell"},{"key":"2284_CR60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41568-024-00763-x","volume":"25","author":"R Arafeh","year":"2025","unstructured":"Arafeh, R., Shibue, T., Dempster, J. M., Hahn, W. C. & Vazquez, F. The present and future of the Cancer Dependency Map. Nat. Rev. Cancer 25, 59\u201373 (2025).","journal-title":"Nat. Rev. Cancer"},{"key":"2284_CR61","doi-asserted-by":"publisher","unstructured":"Ashmore, J. et al. nf-core\/rnasplice: nf-core\/rnasplice 1.0.4. Zenodo https:\/\/doi.org\/10.5281\/zenodo.8424632 (2024).","DOI":"10.5281\/zenodo.8424632"},{"key":"2284_CR62","doi-asserted-by":"publisher","unstructured":"Patel, H. et al. nf-core\/rnaseq: nf-core\/rnaseq v3.12.0 - Osmium Octopus. Zenodo https:\/\/doi.org\/10.5281\/zenodo.7998767 (2023).","DOI":"10.5281\/zenodo.7998767"},{"key":"2284_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-10-r69","volume":"4","author":"KI Zeller","year":"2003","unstructured":"Zeller, K. I., Jegga, A. G., Aronow, B. J., O\u2019Donnell, K. A. & Dang, C. V. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 4, R69 (2003).","journal-title":"Genome Biol."},{"key":"2284_CR64","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1021\/acs.jproteome.8b00217","volume":"17","author":"J Navarrete-Perea","year":"2018","unstructured":"Navarrete-Perea, J., Yu, Q., Gygi, S. P. & Paulo, J. A. Streamlined tandem mass tag (SL-TMT) protocol: an efficient strategy for quantitative (phospho)proteome profiling using tandem mass tag-synchronous precursor selection-MS3. J. Proteome Res. 17, 2226\u20132236 (2018).","journal-title":"J. Proteome Res."},{"key":"2284_CR65","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/nmeth.1714","volume":"8","author":"L Ting","year":"2011","unstructured":"Ting, L., Rad, R., Gygi, S. P. & Haas, W. MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics. Nat. Methods 8, 937\u2013940 (2011).","journal-title":"Nat. Methods"},{"key":"2284_CR66","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1126\/science.ade3925","volume":"380","author":"J Zecha","year":"2023","unstructured":"Zecha, J. et al. Decrypting drug actions and protein modifications by dose- and time-resolved proteomics. Science 380, 93\u2013101 (2023).","journal-title":"Science"},{"key":"2284_CR67","doi-asserted-by":"publisher","first-page":"7566","DOI":"10.1021\/acs.analchem.4c00424","volume":"96","author":"H Ye","year":"2024","unstructured":"Ye, H. et al. Carbene footprinting directs design of genetically encoded proximity-reactive protein binders. Anal. Chem. 96, 7566\u20137576 (2024).","journal-title":"Anal. Chem."},{"key":"2284_CR68","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1038\/nprot.2013.143","volume":"8","author":"FA Ran","year":"2013","unstructured":"Ran, F. A. et al. Genome engineering using the CRISPR\u2013Cas9 system. Nat. Protoc. 8, 2281\u20132308 (2013).","journal-title":"Nat. Protoc."}],"container-title":["Nature Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02284-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02284-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02284-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:02:19Z","timestamp":1786611739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02284-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":68,"alternative-id":["2284"],"URL":"https:\/\/doi.org\/10.1038\/s41589-026-02284-0","relation":{},"ISSN":["1552-4450","1552-4469"],"issn-type":[{"value":"1552-4450","type":"print"},{"value":"1552-4469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"14 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}