{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:56:49Z","timestamp":1790665009867,"version":"4.1.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Chem Biol"],"DOI":"10.1038\/s41589-026-02345-4","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:31:24Z","timestamp":1790616684000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytochrome P450 enzymes that form allenes and alkynes from prenyl groups"],"prefix":"10.1038","member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2345_CR1","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1002\/anie.200300628","volume":"43","author":"A Hoffmann-R\u00f6der","year":"2004","unstructured":"Hoffmann-R\u00f6der, A. & Krause, N. Synthesis and properties of allenic natural products and pharmaceuticals. Angew. Chem. Int. Ed. 43, 1196\u20131216 (2004). A review article that presents an overview of the synthesis and properties of allenic natural products and pharmaceuticals.","journal-title":"Angew. Chem. Int. Ed."},{"key":"2345_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1039\/D0CB00190B","volume":"2","author":"X Li","year":"2021","unstructured":"Li, X., Lv, J.-M., Hu, D. & Abe, I. Biosynthesis of alkyne-containing natural products. RSC Chem. Biol. 2, 166\u2013180 (2021). A review that summarizes progress in the biosynthesis of alkyne-containing natural products.","journal-title":"RSC Chem. Biol."},{"key":"2345_CR3","doi-asserted-by":"publisher","first-page":"6573","DOI":"10.1021\/acs.chemrev.8b00031","volume":"118","author":"FP Guengerich","year":"2018","unstructured":"Guengerich, F. P. & Yoshimoto, F. K. Formation and cleavage of C\u2013C bonds by enzymatic oxidation\u2013reduction reactions. Chem. Rev. 118, 6573\u20136655 (2018). A comprehensive review of C\u2013C bond formation and cleavage catalyzed by redox enzymes.","journal-title":"Chem. Rev."},{"key":"2345_CR4","unstructured":"Walsh, C. T. & Tang, Y. Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery 2nd edn (The Royal Society of Chemistry, 2023). A textbook that summarizes the chemical logic and enzymatic mechanisms underlying natural product biosynthesis."},{"key":"2345_CR5","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1246\/cl.1988.855","volume":"17","author":"S Hokama","year":"1988","unstructured":"Hokama, S. et al. Ginamallene, a new norditerpene with allene functionality from four gorgonians of the genus Acalycigorgia. Chem. Lett. 17, 855\u2013856 (1988). An early report of ginamallene isolation.","journal-title":"Chem. Lett."}],"container-title":["Nature Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02345-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02345-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02345-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:03:32Z","timestamp":1790661812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41589-026-02345-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":5,"alternative-id":["2345"],"URL":"https:\/\/doi.org\/10.1038\/s41589-026-02345-4","relation":{},"ISSN":["1552-4450","1552-4469"],"issn-type":[{"value":"1552-4450","type":"print"},{"value":"1552-4469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"28 September 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}