{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:59:49Z","timestamp":1793721589178,"version":"4.6.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J006610\/1"],"award-info":[{"award-number":["MR\/J006610\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M003833\/1"],"award-info":[{"award-number":["MR\/M003833\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J006610\/1"],"award-info":[{"award-number":["MR\/J006610\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M003833\/1"],"award-info":[{"award-number":["MR\/M003833\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M003833\/1"],"award-info":[{"award-number":["MR\/M003833\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2020,6,1]]},"DOI":"10.1038\/s41590-020-0646-0","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T12:04:26Z","timestamp":1586174666000},"page":"615-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly"],"prefix":"10.1038","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-0867","authenticated-orcid":false,"given":"Roel P. H.","family":"De Maeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C.","family":"van de Merwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikah","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia V.","family":"Bracken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver P.","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-979X","authenticated-orcid":false,"given":"Daniel R.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-2657","authenticated-orcid":false,"given":"Mohib","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-9380","authenticated-orcid":false,"given":"Arne N.","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-0844","authenticated-orcid":false,"given":"Derek W.","family":"Gilroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"646_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","volume":"561","author":"L Partridge","year":"2018","unstructured":"Partridge, L., Deelen, J. & Slagboom, P. E. Facing up to the global challenges of ageing. Nature 561, 45\u201356 (2018).","journal-title":"Nature"},{"key":"646_CR2","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.vaccine.2005.08.105","volume":"24","author":"K Goodwin","year":"2006","unstructured":"Goodwin, K., Viboud, C. & Simonsen, L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24, 1159\u20131169 (2006).","journal-title":"Vaccine"},{"key":"646_CR3","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nri3547","volume":"13","author":"AC Shaw","year":"2013","unstructured":"Shaw, A. C., Goldstein, D. R. & Montgomery, R. R. Age-dependent dysregulation of innate immunity. Nat. Rev. Immunol. 13, 875\u2013887 (2013).","journal-title":"Nat. Rev. Immunol."},{"key":"646_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","volume":"908","author":"C Franceschi","year":"2000","unstructured":"Franceschi, C. et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908, 244\u2013254 (2000).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"646_CR5","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1172\/JCI113970","volume":"83","author":"J Savill","year":"1989","unstructured":"Savill, J. et al. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83, 865\u2013875 (1989).","journal-title":"J. Clin. Invest."},{"key":"646_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tem.2016.09.005","volume":"28","author":"C Franceschi","year":"2017","unstructured":"Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S. Inflammaging and \u2018garb-aging\u2019. Trends Endocrinol. Metab. 28, 199\u2013212 (2017).","journal-title":"Trends Endocrinol. Metab."},{"key":"646_CR7","first-page":"419","volume":"10","author":"C Pi\u00e9rard-Franchimont","year":"1988","unstructured":"Pi\u00e9rard-Franchimont, C. & Pi\u00e9rard, G. Cantharidin-induced acantholysis. Am. J. Dermatopathol. 10, 419\u2013423 (1988).","journal-title":"Am. J. Dermatopathol."},{"key":"646_CR8","doi-asserted-by":"publisher","first-page":"e89375","DOI":"10.1371\/journal.pone.0089375","volume":"9","author":"W Jenner","year":"2014","unstructured":"Jenner, W. et al. Characterisation of leukocytes in a human skin blister model of acute inflammation and resolution. PLoS ONE 9, e89375 (2014).","journal-title":"PLoS ONE"},{"key":"646_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-3-319-39406-0_2","volume":"930","author":"AM Fond","year":"2016","unstructured":"Fond, A. M. & Ravichandran, K. S. Clearance of dying cells by phagocytes: mechanisms and implications for disease pathogenesis. Adv. Exp. Med. Biol. 930, 25\u201349 (2016).","journal-title":"Adv. Exp. Med. Biol."},{"key":"646_CR10","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.tcb.2015.08.003","volume":"25","author":"K Segawa","year":"2015","unstructured":"Segawa, K. & Nagata, S. An apoptotic \u2018eat me\u2019 signal: phosphatidylserine exposure. Trends Cell Biol. 25, 639\u2013650 (2015).","journal-title":"Trends Cell Biol."},{"key":"646_CR11","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1128\/MCB.01394-13","volume":"34","author":"C Nishi","year":"2014","unstructured":"Nishi, C., Toda, S., Segawa, K. & Nagata, S. Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages. Mol. Cell. Biol. 34, 1512\u20131520 (2014).","journal-title":"Mol. Cell. Biol."},{"key":"646_CR12","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1074\/jbc.M706906200","volume":"283","author":"N Tibrewal","year":"2008","unstructured":"Tibrewal, N. et al. Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-\u03baB transcriptional activation. J. Biol. Chem. 283, 3618\u20133627 (2008).","journal-title":"J. Biol. Chem."},{"key":"646_CR13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nature06307","volume":"450","author":"M Miyanishi","year":"2007","unstructured":"Miyanishi, M. et al. Identification of Tim4 as a phosphatidylserine receptor. Nature 450, 435\u2013439 (2007).","journal-title":"Nature"},{"key":"646_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.cub.2009.01.042","volume":"19","author":"D Park","year":"2009","unstructured":"Park, D., Hochreiter-Hufford, A. & Ravichandran, K. S. The phosphatidylserine receptor TIM-4 does not mediate direct signaling. Curr. Biol. 19, 346\u2013351 (2009).","journal-title":"Curr. Biol."},{"key":"646_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13075-016-1084-0","volume":"18","author":"F Bonnefoy","year":"2016","unstructured":"Bonnefoy, F. et al. Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy. Arthritis Res. Ther. 18, 184 (2016).","journal-title":"Arthritis Res. Ther."},{"key":"646_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/nature18935","volume":"536","author":"Y Kojima","year":"2016","unstructured":"Kojima, Y. et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature 536, 86\u201390 (2016).","journal-title":"Nature"},{"key":"646_CR17","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1172\/JCI1112","volume":"101","author":"V Fadok","year":"1998","unstructured":"Fadok, V. et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101, 890\u2013898 (1998).","journal-title":"J. Clin. Invest."},{"key":"646_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1172\/JCI0211638","volume":"109","author":"M-LN Huynh","year":"2002","unstructured":"Huynh, M.-L. N., Fadok, V. A. & Henson, P. M. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-\u03b21 secretion and the resolution of inflammation. J. Clin. Invest. 109, 41\u201350 (2002).","journal-title":"J. Clin. Invest."},{"key":"646_CR19","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1182\/blood-2009-03-207522","volume":"114","author":"Z Yi","year":"2009","unstructured":"Yi, Z. et al. A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells. Blood 114, 3191\u20133198 (2009).","journal-title":"Blood"},{"key":"646_CR20","doi-asserted-by":"publisher","first-page":"24560","DOI":"10.1074\/jbc.M114.571620","volume":"289","author":"FN Soki","year":"2014","unstructured":"Soki, F. N. et al. Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis. J. Biol. Chem. 289, 24560\u201324572 (2014).","journal-title":"J. Biol. Chem."},{"key":"646_CR21","doi-asserted-by":"publisher","first-page":"e0158775","DOI":"10.1371\/journal.pone.0158775","volume":"11","author":"KL Hilligan","year":"2016","unstructured":"Hilligan, K. L., Connor, L. M., Schmidt, A. J. & Ronchese, F. Activation-induced TIM-4 expression identifies differential responsiveness of intestinal CD103+ CD11b+ dendritic cells to a mucosal adjuvant. PLoS ONE 11, e0158775 (2016).","journal-title":"PLoS ONE"},{"key":"646_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/srep21336","volume":"6","author":"B Yang","year":"2016","unstructured":"Yang, B. et al. Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells. Sci. Rep. 6, 21336 (2016).","journal-title":"Sci. Rep."},{"key":"646_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jaci.2008.04.036","volume":"122","author":"B-S Feng","year":"2008","unstructured":"Feng, B.-S. et al. Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1\/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. J. Allergy Clin. Immunol. 122, 55\u201361.e7 (2008).","journal-title":"J. Allergy Clin. Immunol."},{"key":"646_CR24","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/nar\/gks1312","volume":"41","author":"Q-E Wang","year":"2013","unstructured":"Wang, Q.-E. et al. p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair. Nucleic Acids Res. 41, 1722\u20131733 (2013).","journal-title":"Nucleic Acids Res."},{"key":"646_CR25","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1128\/MCB.25.7.2673-2687.2005","volume":"25","author":"C Poizat","year":"2005","unstructured":"Poizat, C., Puri, P. L., Bai, Y. & Kedes, L. Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol. Cell. Biol. 25, 2673\u20132687 (2005).","journal-title":"Mol. Cell. Biol."},{"key":"646_CR26","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","volume":"75","author":"J Campisi","year":"2013","unstructured":"Campisi, J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 75, 685\u2013705 (2013).","journal-title":"Annu. Rev. Physiol."},{"key":"646_CR27","doi-asserted-by":"publisher","first-page":"e0163139","DOI":"10.1371\/journal.pone.0163139","volume":"11","author":"MA Bewley","year":"2016","unstructured":"Bewley, M. A. et al. Differential effects of p38, MAPK, PI3K or Rho kinase inhibitors on bacterial phagocytosis and efferocytosis by macrophages in COPD. PLoS ONE 11, e0163139 (2016).","journal-title":"PLoS ONE"},{"key":"646_CR28","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrd.2016.39","volume":"15","author":"JN Fullerton","year":"2016","unstructured":"Fullerton, J. N. & Gilroy, D. W. Resolution of inflammation: a new therapeutic frontier. Nat. Rev. Drug Discov. 15, 551\u2013567 (2016).","journal-title":"Nat. Rev. Drug Discov."},{"key":"646_CR29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.smim.2015.05.003","volume":"27","author":"D Gilroy","year":"2015","unstructured":"Gilroy, D. & De Maeyer, R. New insights into the resolution of inflammation. Semin. Immunol. 27, 161\u2013168 (2015).","journal-title":"Semin. Immunol."},{"key":"646_CR30","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1016\/j.jid.2017.04.030","volume":"137","author":"P Laplante","year":"2017","unstructured":"Laplante, P. et al. MFG-E8 reprogramming of macrophages promotes wound healing by increased bFGF production and fibroblast functions. J. Invest. Dermatol. 137, 2005\u20132013 (2017).","journal-title":"J. Invest. Dermatol."},{"key":"646_CR31","doi-asserted-by":"publisher","first-page":"e9539","DOI":"10.1371\/journal.pone.0009539","volume":"5","author":"S Khanna","year":"2010","unstructured":"Khanna, S. et al. Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS ONE 5, e9539 (2010).","journal-title":"PLoS ONE"},{"key":"646_CR32","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1016\/j.celrep.2017.08.098","volume":"20","author":"J Newson","year":"2017","unstructured":"Newson, J. et al. Inflammatory resolution triggers a prolonged phase of immune suppression through COX-1\/mPGES-1-derived prostaglandin E2. Cell Rep. 20, 3162\u20133175 (2017).","journal-title":"Cell Rep."},{"key":"646_CR33","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1182\/blood-2014-03-562710","volume":"124","author":"J Newson","year":"2014","unstructured":"Newson, J. et al. Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Blood 124, 1748\u20131764 (2014).","journal-title":"Blood"},{"key":"646_CR34","first-page":"173","volume":"9","author":"US Gaipl","year":"2006","unstructured":"Gaipl, U. S. et al. Clearance of apoptotic cells in human SLE. Curr. Dir. Autoimmun. 9, 173\u2013187 (2006).","journal-title":"Curr. Dir. Autoimmun."},{"key":"646_CR35","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.cell.2010.02.014","volume":"140","author":"S Nagata","year":"2010","unstructured":"Nagata, S., Hanayama, R. & Kawane, K. Autoimmunity and the clearance of dead cells. Cell 140, 619\u2013630 (2010).","journal-title":"Cell"},{"key":"646_CR36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1474-9728.2004.00110.x","volume":"3","author":"T Fulop","year":"2004","unstructured":"Fulop, T. et al. Signal transduction and functional changes in neutrophils with aging. Aging Cell 3, 217\u2013226 (2004).","journal-title":"Aging Cell"},{"key":"646_CR37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1023\/A:1023286831246","volume":"18","author":"C Tortorella","year":"1998","unstructured":"Tortorella, C. et al. Spontaneous and Fas-induced apoptotic cell death in aged neutrophils. J. Clin. Immunol. 18, 321\u2013329 (1998).","journal-title":"J. Clin. Immunol."},{"key":"646_CR38","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.4049\/jimmunol.1401313","volume":"193","author":"HH Arnardottir","year":"2014","unstructured":"Arnardottir, H. H., Dalli, J., Colas, R. A., Shinohara, M. & Serhan, C. N. Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. J. Immunol. 193, 4235\u20134244 (2014).","journal-title":"J. Immunol."},{"key":"646_CR39","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/BF01488803","volume":"20","author":"D Biasi","year":"1996","unstructured":"Biasi, D. et al. Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects. Inflammation 20, 673\u2013681 (1996).","journal-title":"Inflammation"},{"key":"646_CR40","first-page":"742","volume":"74","author":"H Senn","year":"1969","unstructured":"Senn, H., Holland, J. F. & Banerjee, T. Kinetic and comparative studies on localized leukocyte mobilization in normal man. J. Lab. Clin. Med. 74, 742\u2013756 (1969).","journal-title":"J. Lab. Clin. Med."},{"key":"646_CR41","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1742-4933-2-6","volume":"2","author":"A Larbi","year":"2005","unstructured":"Larbi, A. et al. The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun. Ageing 2, 6 (2005).","journal-title":"Immun. Ageing"},{"key":"646_CR42","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1067\/msy.2001.115902","volume":"130","author":"K Sheth","year":"2001","unstructured":"Sheth, K., Friel, J., Nolan, B. & Bankey, P. Inhibition of p38 mitogen activated protein kinase increases lipopolysaccharide induced inhibition of apoptosis in neutrophils by activating extracellular signal-regulated kinase. Surgery 130, 242\u2013248 (2001).","journal-title":"Surgery"},{"key":"646_CR43","doi-asserted-by":"publisher","first-page":"8389","DOI":"10.1074\/jbc.273.14.8389","volume":"273","author":"CS Frasch","year":"1998","unstructured":"Frasch, C. S. et al. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J. Biol. Chem. 273, 8389\u20138397 (1998).","journal-title":"J. Biol. Chem."},{"key":"646_CR44","first-page":"L238","volume":"266","author":"SJ Smart","year":"1994","unstructured":"Smart, S. J. & Casale, T. B. TNF-alpha-induced transendothelial neutrophil migration is IL-8 dependent. Am. J. Physiol. 266, L238\u2013L245 (1994).","journal-title":"Am. J. Physiol."},{"key":"646_CR45","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1172\/JCI113903","volume":"83","author":"R Moser","year":"1989","unstructured":"Moser, R., Schleiffenbaum, B., Groscurth, P. & Fehr, J. Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. J. Clin. Invest. 83, 444\u2013455 (1989).","journal-title":"J. Clin. Invest."},{"key":"646_CR46","doi-asserted-by":"publisher","first-page":"e124213","DOI":"10.1172\/jci.insight.124213","volume":"4","author":"B Frisch","year":"2019","unstructured":"Frisch, B. et al. Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin1B. JCI Insight 4, e124213 (2019).","journal-title":"JCI Insight"},{"key":"646_CR47","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1161\/ATVBAHA.115.306860","volume":"36","author":"AC Foks","year":"2016","unstructured":"Foks, A. C. et al. Blockade of Tim-1 and Tim-4 enhances atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 36, 456\u2013465 (2016).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"646_CR48","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/mi.2012.100","volume":"6","author":"L Albacker","year":"2013","unstructured":"Albacker, L. et al. TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells. Mucosal Immunol. 6, 580\u2013590 (2013).","journal-title":"Mucosal Immunol."},{"key":"646_CR49","doi-asserted-by":"publisher","first-page":"8712","DOI":"10.1073\/pnas.0910929107","volume":"107","author":"K Wong","year":"2010","unstructured":"Wong, K. et al. Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages. Proc. Natl Acad. Sci. USA 107, 8712\u20138717 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"646_CR50","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.jaci.2017.10.032","volume":"142","author":"M Vukmanovic-Stejic","year":"2018","unstructured":"Vukmanovic-Stejic, M. et al. Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation. J. Allergy Clin. Immun. 142, 844\u2013856 (2018).","journal-title":"J. Allergy Clin. Immun."},{"key":"646_CR51","first-page":"cvd.2012.012009","volume":"1","author":"WJ Jenner","year":"2012","unstructured":"Jenner, W. J. & Gilroy, D. W. Assessment of leukocyte trafficking in humans using the cantharidin blister model. JRSM Cardiovasc. Dis. 1, cvd.2012.012009 (2012).","journal-title":"JRSM Cardiovasc. Dis."},{"key":"646_CR52","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/j.1365-2125.2011.04020.x","volume":"72","author":"PHD Dinh","year":"2011","unstructured":"Dinh, P. H. D. et al. Validation of the cantharidin-induced skin blister as an in vivo model of inflammation. Br. J. Clin. Pharmacol. 72, 912\u2013920 (2011).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"646_CR53","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S2213-2600(13)70200-5","volume":"2","author":"H Watz","year":"2014","unstructured":"Watz, H., Barnacle, H., Hartley, B. F. & Chan, R. Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial. Lancet Respir. Med. 2, 63\u201372 (2014).","journal-title":"Lancet Respir. Med."},{"key":"646_CR54","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1159\/000430188","volume":"36","author":"S Fehr","year":"2015","unstructured":"Fehr, S. et al. Impact of p38 MAP kinase inhibitors on LPS-induced release of TNF-\u03b1 in whole blood and primary cells from different species. Cell. Physiol. Biochem. 36, 2237\u20132249 (2015).","journal-title":"Cell. Physiol. Biochem."},{"key":"646_CR55","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1161\/CIRCRESAHA.111.241810","volume":"109","author":"B Pourcet","year":"2011","unstructured":"Pourcet, B. et al. LXR\u03b1 regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ. Res. 109, 492\u2013501 (2011).","journal-title":"Circ. Res."}],"updated-by":[{"DOI":"10.1038\/s41590-020-0686-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000}}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41590-020-0646-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-020-0646-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-020-0646-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:03:02Z","timestamp":1762455782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41590-020-0646-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,1]]}},"alternative-id":["646"],"URL":"https:\/\/doi.org\/10.1038\/s41590-020-0646-0","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737694582.793575506","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]},"assertion":[{"value":"15 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2020","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41590-020-0686-5","URL":"https:\/\/doi.org\/10.1038\/s41590-020-0686-5","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.U. is an employee of AstraZeneca and holds shares in the company. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}