{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:38:33Z","timestamp":1765546713342,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1038\/s41590-021-00897-2","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T17:02:58Z","timestamp":1615395778000},"page":"545-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["ThymUS in times of stress"],"prefix":"10.1038","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-9955","authenticated-orcid":false,"given":"Susannah C.","family":"Shissler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-8372","authenticated-orcid":false,"given":"Avinash","family":"Bhandoola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"897_CR1","doi-asserted-by":"publisher","first-page":"eaay3224","DOI":"10.1126\/science.aay3224","volume":"367","author":"J-E Park","year":"2020","unstructured":"Park, J.-E. et al. Science 367, eaay3224 (2020).","journal-title":"Science"},{"key":"897_CR2","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.immuni.2020.03.019","volume":"52","author":"M Lavaert","year":"2020","unstructured":"Lavaert, M. et al. Immunity 52, 1088\u20131104.e6 (2020).","journal-title":"Immunity"},{"key":"897_CR3","doi-asserted-by":"publisher","first-page":"e2019655118","DOI":"10.1073\/pnas.2019655118","volume":"118","author":"B Shin","year":"2021","unstructured":"Shin, B. et al. Proc. Natl Acad. Sci. USA 118, e2019655118 (2021).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"897_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nri3667","volume":"14","author":"L Klein","year":"2014","unstructured":"Klein, L., Kyewski, B., Allen, P. M. & Hogquist, K. A. Nat. Rev. Immunol. 14, 377\u2013391 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"897_CR5","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.immuni.2020.10.024","volume":"53","author":"LB Chopp","year":"2020","unstructured":"Chopp, L. B. et al. Immunity 53, 1182\u20131201.e8 (2020).","journal-title":"Immunity"},{"key":"897_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20070-x","volume":"11","author":"M Watanabe","year":"2020","unstructured":"Watanabe, M., Lu, Y., Breen, M. & Hodes, R. J. Nat. Commun. 11, 6264 (2020).","journal-title":"Nat. Commun."},{"key":"897_CR7","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1073\/pnas.1010890108","volume":"108","author":"SD Barbee","year":"2011","unstructured":"Barbee, S. D. et al. Proc. Natl Acad. Sci. USA 108, 3330\u20133335 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"897_CR8","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1073\/pnas.1701237115","volume":"115","author":"P Vantourout","year":"2018","unstructured":"Vantourout, P. et al. Proc. Natl Acad. Sci. USA 115, 1039\u20131044 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"897_CR9","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s41577-020-0345-y","volume":"20","author":"DG Pellicci","year":"2020","unstructured":"Pellicci, D. G., Koay, H.-F. & Berzins, S. P. Nat. Rev. Immunol. 20, 756\u2013770 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"897_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05026-6","volume":"9","author":"KD Tuttle","year":"2018","unstructured":"Tuttle, K. D. et al. Nat. Commun. 9, 2650 (2018).","journal-title":"Nat. Commun."},{"key":"897_CR11","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/s41590-019-0518-7","volume":"20","author":"ELY Chen","year":"2019","unstructured":"Chen, E. L. Y., Thompson, P. K. & Z\u00fa\u00f1iga-Pfl\u00fccker, J. C. Nat. Immunol. 20, 1456\u20131468 (2019).","journal-title":"Nat. Immunol."},{"key":"897_CR12","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1016\/j.celrep.2019.10.079","volume":"29","author":"I Ohigashi","year":"2019","unstructured":"Ohigashi, I. et al. Cell Rep. 29, 2901\u20132916.e6 (2019).","journal-title":"Cell Rep."},{"key":"897_CR13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/ni.f.219","volume":"10","author":"KC Garcia","year":"2009","unstructured":"Garcia, K. C., Adams, J. J., Feng, D. & Ely, L. K. Nat. Immunol. 10, 143\u2013147 (2009).","journal-title":"Nat. Immunol."},{"key":"897_CR14","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.immuni.2016.09.007","volume":"45","author":"S Gras","year":"2016","unstructured":"Gras, S. et al. Immunity 45, 749\u2013760 (2016).","journal-title":"Immunity"},{"key":"897_CR15","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.1182\/blood-2006-02-004531","volume":"108","author":"DHD Gray","year":"2006","unstructured":"Gray, D. H. D. et al. Blood 108, 3777\u20133785 (2006).","journal-title":"Blood"},{"key":"897_CR16","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1084\/jem.20161864","volume":"214","author":"M Kozai","year":"2017","unstructured":"Kozai, M. et al. J. Exp. Med. 214, 1925\u20131935 (2017).","journal-title":"J. Exp. Med."},{"key":"897_CR17","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fimmu.2013.00316","volume":"4","author":"DB Palmer","year":"2013","unstructured":"Palmer, D. B. Front. Immunol. 4, 316 (2013).","journal-title":"Front. Immunol."},{"key":"897_CR18","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1073\/pnas.1714478115","volume":"115","author":"S Palmer","year":"2018","unstructured":"Palmer, S., Albergante, L., Blackburn, C. C. & Newman, T. J. Proc. Natl Acad. Sci. USA 115, 1883\u20131888 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"897_CR19","doi-asserted-by":"publisher","unstructured":"Palmer, S., Cunniffe, N. & Donnelly, R. Preprint at medRxiv https:\/\/doi.org\/10.1101\/2020.08.25.20181487 (2020).","DOI":"10.1101\/2020.08.25.20181487"},{"key":"897_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13465-y","volume":"10","author":"JE Cowan","year":"2019","unstructured":"Cowan, J. E. et al. Nat. Commun. 10, 5498 (2019).","journal-title":"Nat. Commun."},{"key":"897_CR21","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3389\/fimmu.2020.00830","volume":"11","author":"P Bhalla","year":"2020","unstructured":"Bhalla, P., Wysocki, C. A. & van Oers, N. S. C. Front. Immunol. 11, 830 (2020).","journal-title":"Front. Immunol."},{"key":"897_CR22","doi-asserted-by":"publisher","first-page":"4724","DOI":"10.1172\/JCI127565","volume":"129","author":"Q Du","year":"2019","unstructured":"Du, Q. et al. J. Clin. Invest. 129, 4724\u20134738 (2019).","journal-title":"J. Clin. Invest."},{"key":"897_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ajhg.2019.07.014","volume":"105","author":"M Bosticardo","year":"2019","unstructured":"Bosticardo, M. et al. Am. J. Hum. Genet. 105, 549\u2013561 (2019).","journal-title":"Am. J. Hum. Genet."},{"key":"897_CR24","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1182\/blood.2019000923","volume":"135","author":"OM Delmonte","year":"2020","unstructured":"Delmonte, O. M., Villa, A. & Notarangelo, L. D. Blood 135, 610\u2013619 (2020).","journal-title":"Blood"},{"key":"897_CR25","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.3389\/fimmu.2020.01837","volume":"11","author":"G Giardino","year":"2020","unstructured":"Giardino, G. et al. Front. Immunol. 11, 1837 (2020).","journal-title":"Front. Immunol."},{"key":"897_CR26","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nmeth.4237","volume":"14","author":"CS Seet","year":"2017","unstructured":"Seet, C. S. et al. Nat. Methods 14, 521\u2013530 (2017).","journal-title":"Nat. Methods"},{"key":"897_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.stem.2013.04.004","volume":"13","author":"AV Parent","year":"2013","unstructured":"Parent, A. V. et al. Cell Stem Cell 13, 219\u2013229 (2013).","journal-title":"Cell Stem Cell"},{"key":"897_CR28","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1182\/bloodadvances.2020001730","volume":"4","author":"M Bosticardo","year":"2020","unstructured":"Bosticardo, M. et al. Blood Adv. 4, 2611\u20132616 (2020).","journal-title":"Blood Adv."},{"key":"897_CR29","doi-asserted-by":"publisher","first-page":"108320","DOI":"10.1016\/j.celrep.2020.108320","volume":"33","author":"A Montel-Hagen","year":"2020","unstructured":"Montel-Hagen, A. et al. Cell Rep. 33, 108320 (2020).","journal-title":"Cell Rep."},{"key":"897_CR30","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/372100a0","volume":"372","author":"CD Surh","year":"1994","unstructured":"Surh, C. D. & Sprent, J. Nature 372, 100\u2013103 (1994).","journal-title":"Nature"},{"key":"897_CR31","doi-asserted-by":"publisher","first-page":"11671","DOI":"10.1073\/pnas.0603466103","volume":"103","author":"M Kovar","year":"2006","unstructured":"Kovar, M. et al. Proc. Natl Acad. Sci. USA 103, 11671\u201311676 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00897-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00897-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00897-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T22:48:46Z","timestamp":1733957326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00897-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,10]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["897"],"URL":"https:\/\/doi.org\/10.1038\/s41590-021-00897-2","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"type":"print","value":"1529-2908"},{"type":"electronic","value":"1529-2916"}],"subject":[],"published":{"date-parts":[[2021,3,10]]},"assertion":[{"value":"10 March 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}