{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:29:21Z","timestamp":1794198561394,"version":"4.8.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["159188"],"award-info":[{"award-number":["159188"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["166500"],"award-info":[{"award-number":["166500"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["099897\/Z\/12\/A"],"award-info":[{"award-number":["099897\/Z\/12\/A"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["109965MA"],"award-info":[{"award-number":["109965MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007218","name":"Verein fur Krebsforschung","doi-asserted-by":"publisher","award":["KFS-4162-02-2017-R"],"award-info":[{"award-number":["KFS-4162-02-2017-R"]}],"id":[{"id":"10.13039\/100007218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1038\/s41590-021-00969-3","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T12:03:24Z","timestamp":1626350604000},"page":"1042-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells"],"prefix":"10.1038","volume":"22","author":[{"given":"Jovana","family":"Cupovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Onder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3337-2455","authenticated-orcid":false,"given":"Julia M.","family":"Colston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9011-5319","authenticated-orcid":false,"given":"Mechthild","family":"L\u00fctge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"De Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-2216","authenticated-orcid":false,"given":"Nicholas M.","family":"Provine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-2354","authenticated-orcid":false,"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Scandella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-6654","authenticated-orcid":false,"given":"Philippe","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-4701","authenticated-orcid":false,"given":"Daniel","family":"Engeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-9161","authenticated-orcid":false,"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7685-573X","authenticated-orcid":false,"given":"Burkhard","family":"Ludewig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"969_CR1","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/ni.3031","volume":"15","author":"JT Chang","year":"2014","unstructured":"Chang, J. T., Wherry, E. J. & Goldrath, A. W. Molecular regulation of effector and memory T cell differentiation. Nat. Immunol. 15, 1104\u20131115 (2014).","journal-title":"Nat. Immunol."},{"key":"969_CR2","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1086\/587993","volume":"46","author":"FH Priddy","year":"2008","unstructured":"Priddy, F. H. et al. Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag\/pol\/nef vaccine in healthy adults. Clin. Infect. Dis. 46, 1769\u20131781 (2008).","journal-title":"Clin. Infect. Dis."},{"key":"969_CR3","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1001\/jama.2021.3645","volume":"325","author":"KE Stephenson","year":"2021","unstructured":"Stephenson, K. E. et al. Immunogenicity of the Ad26.COV2.S vaccine for COVID-19. JAMA 325, 1535\u20131544 (2021).","journal-title":"JAMA"},{"key":"969_CR4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s40425-019-0576-2","volume":"7","author":"AE Snook","year":"2019","unstructured":"Snook, A. E. et al. Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. J. Immunother. Cancer 7, 104 (2019).","journal-title":"J. Immunother. Cancer"},{"key":"969_CR5","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1080\/21645515.2017.1383575","volume":"13","author":"K Ewer","year":"2017","unstructured":"Ewer, K. et al. Chimpanzee adenoviral vectors as vaccines for outbreak pathogens. Hum. Vaccin. Immunother. 13, 3020\u20133032 (2017).","journal-title":"Hum. Vaccin. Immunother."},{"key":"969_CR6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0140-6736(20)31604-4","volume":"396","author":"PM Folegatti","year":"2020","unstructured":"Folegatti, P. M. et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1\/2, single-blind, randomised controlled trial. Lancet 396, 467\u2013478 (2020).","journal-title":"Lancet"},{"key":"969_CR7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-020-01194-5","volume":"27","author":"KJ Ewer","year":"2021","unstructured":"Ewer, K. J. et al. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1\/2 clinical trial. Nat. Med. 27, 270\u2013278 (2021).","journal-title":"Nat. Med."},{"key":"969_CR8","doi-asserted-by":"publisher","first-page":"115ra111","DOI":"10.1126\/scitranslmed.3003155","volume":"4","author":"E Barnes","year":"2012","unstructured":"Barnes, E. et al. Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. Sci. Transl. Med. 4, 115ra111 (2012).","journal-title":"Sci. Transl. Med."},{"key":"969_CR9","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0140-6736(21)00234-8","volume":"397","author":"DY Logunov","year":"2021","unstructured":"Logunov, D. Y. et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet 397, 671\u2013681 (2021).","journal-title":"Lancet"},{"key":"969_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/imr.12653","volume":"283","author":"P Klenerman","year":"2018","unstructured":"Klenerman, P. The (gradual) rise of memory inflation. Immunol. Rev. 283, 99\u2013112 (2018).","journal-title":"Immunol. Rev."},{"key":"969_CR11","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.4049\/jimmunol.170.4.2022","volume":"170","author":"U Karrer","year":"2003","unstructured":"Karrer, U. et al. Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J. Immunol. 170, 2022\u20132029 (2003).","journal-title":"J. Immunol."},{"key":"969_CR12","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/eji.200425534","volume":"35","author":"S Sierro","year":"2005","unstructured":"Sierro, S., Rothkopf, R. & Klenerman, P. Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection. Eur. J. Immunol. 35, 1113\u20131123 (2005).","journal-title":"Eur. J. Immunol."},{"key":"969_CR13","doi-asserted-by":"publisher","first-page":"11495","DOI":"10.1128\/JVI.74.24.11495-11503.2000","volume":"74","author":"R Holtappels","year":"2000","unstructured":"Holtappels, R., Pahl-Seibert, M. F., Thomas, D. & Reddehase, M. J. Enrichment of immediate-early 1 (m123\/pp89) peptide-specific CD8 T cells in a pulmonary CD62Llo memory-effector cell pool during latent murine cytomegalovirus infection of the lungs. J. Virol. 74, 11495\u201311503 (2000).","journal-title":"J. Virol."},{"key":"969_CR14","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1128\/JVI.75.6.2692-2705.2001","volume":"75","author":"NK Grzimek","year":"2001","unstructured":"Grzimek, N. K., Dreis, D., Schmalz, S. & Reddehase, M. J. Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1\/3 and ie2 during murine cytomegalovirus latency in the lungs. J. Virol. 75, 2692\u20132705 (2001).","journal-title":"J. Virol."},{"key":"969_CR15","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.immuni.2008.07.017","volume":"29","author":"CM Snyder","year":"2008","unstructured":"Snyder, C. M. et al. Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. Immunity 29, 650\u2013659 (2008).","journal-title":"Immunity"},{"key":"969_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1046\/j.1365-2249.2003.02266.x","volume":"134","author":"H Komatsu","year":"2003","unstructured":"Komatsu, H., Sierro, S., Cuero, A. V. & Klenerman, P. Population analysis of antiviral T cell responses using MHC class I\u2013peptide tetramers. Clin. Exp. Immunol. 134, 9\u201312 (2003).","journal-title":"Clin. Exp. Immunol."},{"key":"969_CR17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nri.2016.38","volume":"16","author":"P Klenerman","year":"2016","unstructured":"Klenerman, P. & Oxenius, A. T cell responses to cytomegalovirus. Nat. Rev. Immunol. 16, 367\u2013377 (2016).","journal-title":"Nat. Rev. Immunol."},{"key":"969_CR18","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.4049\/jimmunol.1202665","volume":"190","author":"B Bolinger","year":"2013","unstructured":"Bolinger, B. et al. A new model for CD8+ T cell memory inflation based upon a recombinant adenoviral vector. J. Immunol. 190, 4162\u20134174 (2013).","journal-title":"J. Immunol."},{"key":"969_CR19","doi-asserted-by":"publisher","first-page":"e1006782","DOI":"10.1371\/journal.ppat.1006782","volume":"13","author":"LN Lee","year":"2017","unstructured":"Lee, L. N. et al. Adenoviral vaccine induction of CD8+ T cell memory inflation: impact of co-infection and infection order. PLoS Pathog. 13, e1006782 (2017).","journal-title":"PLoS Pathog."},{"key":"969_CR20","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1182\/blood-2010-03-272336","volume":"117","author":"JD Bassett","year":"2011","unstructured":"Bassett, J. D. et al. CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells. Blood 117, 1146\u20131155 (2011).","journal-title":"Blood"},{"key":"969_CR21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41590-020-0635-3","volume":"21","author":"AT Krishnamurty","year":"2020","unstructured":"Krishnamurty, A. T. & Turley, S. J. Lymph node stromal cells: cartographers of the immune system. Nat. Immunol. 21, 369\u2013380 (2020).","journal-title":"Nat. Immunol."},{"key":"969_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/imr.12748","volume":"289","author":"C Perez-Shibayama","year":"2019","unstructured":"Perez-Shibayama, C., Gil-Cruz, C. & Ludewig, B. Fibroblastic reticular cells at the nexus of innate and adaptive immune responses. Immunol. Rev. 289, 31\u201341 (2019).","journal-title":"Immunol. Rev."},{"key":"969_CR23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.4049\/jimmunol.2000914","volume":"206","author":"NB Pikor","year":"2021","unstructured":"Pikor, N. B., Cheng, H. W., Onder, L. & Ludewig, B. Development and immunological function of lymph node stromal cells. J. Immunol. 206, 257\u2013263 (2021).","journal-title":"J. Immunol."},{"key":"969_CR24","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1002\/eji.201041075","volume":"41","author":"N Torti","year":"2011","unstructured":"Torti, N., Walton, S. M., Murphy, K. M. & Oxenius, A. Batf3 transcription factor-dependent DC subsets in murine CMV infection: differential impact on T-cell priming and memory inflation. Eur. J. Immunol. 41, 2612\u20132618 (2011).","journal-title":"Eur. J. Immunol."},{"key":"969_CR25","doi-asserted-by":"publisher","first-page":"e1002313","DOI":"10.1371\/journal.ppat.1002313","volume":"7","author":"N Torti","year":"2011","unstructured":"Torti, N., Walton, S. M., Brocker, T., R\u00fclicke, T. & Oxenius, A. Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog. 7, e1002313 (2011).","journal-title":"PLoS Pathog."},{"key":"969_CR26","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.4049\/jimmunol.1200966","volume":"190","author":"A Busche","year":"2013","unstructured":"Busche, A. et al. Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation. J. Immunol. 190, 2767\u20132777 (2013).","journal-title":"J. Immunol."},{"key":"969_CR27","doi-asserted-by":"publisher","first-page":"e1006993","DOI":"10.1371\/journal.ppat.1006993","volume":"14","author":"NS Baumann","year":"2018","unstructured":"Baumann, N. S. et al. Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. PLoS Pathog. 14, e1006993 (2018).","journal-title":"PLoS Pathog."},{"key":"969_CR28","first-page":"167","volume":"12","author":"WP Rowe","year":"1954","unstructured":"Rowe, W. P. Studies on pathogenesis and immunity in lymphocytic choriomeningitis infection of the mouse. Navy Res. Rep. 12, 167\u2013220 (1954).","journal-title":"Navy Res. Rep."},{"key":"969_CR29","doi-asserted-by":"publisher","first-page":"7025","DOI":"10.1523\/JNEUROSCI.1954-08.2008","volume":"28","author":"D Atasoy","year":"2008","unstructured":"Atasoy, D., Aponte, Y., Su, H. H. & Sternson, S. M. A FLEX switch targets channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J. Neurosci. 28, 7025\u20137030 (2008).","journal-title":"J. Neurosci."},{"key":"969_CR30","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.immuni.2013.03.012","volume":"38","author":"Q Chai","year":"2013","unstructured":"Chai, Q. et al. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 38, 1013\u20131024 (2013).","journal-title":"Immunity"},{"key":"969_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09728-3","volume":"10","author":"HW Cheng","year":"2019","unstructured":"Cheng, H. W. et al. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat. Commun. 10, 1739 (2019).","journal-title":"Nat. Commun."},{"key":"969_CR32","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.immuni.2015.12.022","volume":"44","author":"J Cupovic","year":"2016","unstructured":"Cupovic, J. et al. Central nervous system stromal cells control local CD8+ T cell responses during virus-induced neuroinflammation. Immunity 44, 622\u2013633 (2016).","journal-title":"Immunity"},{"key":"969_CR33","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.jaci.2017.12.998","volume":"142","author":"HW Cheng","year":"2018","unstructured":"Cheng, H. W. et al. CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses. J. Allergy Clin. Immunol. 142, 1257\u20131271 (2018).","journal-title":"J. Allergy Clin. Immunol."},{"key":"969_CR34","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.1164206","volume":"322","author":"K Hildner","year":"2008","unstructured":"Hildner, K. et al. Batf3 deficiency reveals a critical role for CD8\u03b1+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097\u20131100 (2008).","journal-title":"Science"},{"key":"969_CR35","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.4049\/jimmunol.174.8.4559","volume":"174","author":"P Krebs","year":"2005","unstructured":"Krebs, P., Scandella, E., Odermatt, B. & Ludewig, B. Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus. J. Immunol. 174, 4559\u20134566 (2005).","journal-title":"J. Immunol."},{"key":"969_CR36","doi-asserted-by":"publisher","first-page":"e1002515","DOI":"10.1371\/journal.pbio.1002515","volume":"14","author":"M Novkovic","year":"2016","unstructured":"Novkovic, M. et al. Topological small-world organization of the fibroblastic reticular cell network determines lymph node functionality. PLoS Biol. 14, e1002515 (2016).","journal-title":"PLoS Biol."},{"key":"969_CR37","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.cell.2017.07.034","volume":"170","author":"JA Zepp","year":"2017","unstructured":"Zepp, J. A. et al. Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. Cell 170, 1134\u20131148 (2017).","journal-title":"Cell"},{"key":"969_CR38","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1016\/j.celrep.2018.03.010","volume":"22","author":"T Xie","year":"2018","unstructured":"Xie, T. et al. Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. Cell Rep. 22, 3625\u20133640 (2018).","journal-title":"Cell Rep."},{"key":"969_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15647-5","volume":"11","author":"T Tsukui","year":"2020","unstructured":"Tsukui, T. et al. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat. Commun. 11, 1920 (2020).","journal-title":"Nat. Commun."},{"key":"969_CR40","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","volume":"560","author":"G La Manno","year":"2018","unstructured":"La Manno, G. et al. RNA velocity of single cells. Nature 560, 494\u2013498 (2018).","journal-title":"Nature"},{"key":"969_CR41","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","volume":"36","author":"GJ van der Windt","year":"2012","unstructured":"van der Windt, G. J. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68\u201378 (2012).","journal-title":"Immunity"},{"key":"969_CR42","doi-asserted-by":"publisher","first-page":"14336","DOI":"10.1073\/pnas.1221740110","volume":"110","author":"GJ van der Windt","year":"2013","unstructured":"van der Windt, G. J. et al. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc. Natl Acad. Sci. USA 110, 14336\u201314341 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"969_CR43","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3390\/vaccines8030474","volume":"8","author":"GNA Rego","year":"2020","unstructured":"Rego, G. N. A. et al. Current clinical trials protocols and the global effort for immunization against SARS-CoV-2. Vaccines 8, 474 (2020).","journal-title":"Vaccines"},{"key":"969_CR44","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-020-2607-z","volume":"586","author":"NB Mercado","year":"2020","unstructured":"Mercado, N. B. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583\u2013588 (2020).","journal-title":"Nature"},{"key":"969_CR45","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.celrep.2015.10.034","volume":"13","author":"B Bolinger","year":"2015","unstructured":"Bolinger, B. et al. Adenoviral vector vaccination induces a conserved program of CD8+ T cell memory differentiation in mouse and man. Cell Rep. 13, 1578\u20131588 (2015).","journal-title":"Cell Rep."},{"key":"969_CR46","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.celrep.2018.03.074","volume":"23","author":"CL Gordon","year":"2018","unstructured":"Gordon, C. L. et al. Induction and maintenance of CX3CR1-intermediate peripheral memory CD8+ T cells by persistent viruses and vaccines. Cell Rep. 23, 768\u2013782 (2018).","journal-title":"Cell Rep."},{"key":"969_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9327","volume":"6","author":"ES Cohen","year":"2015","unstructured":"Cohen, E. S. et al. Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation. Nat. Commun. 6, 8327 (2015).","journal-title":"Nat. Commun."},{"key":"969_CR48","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1172\/JCI77347","volume":"125","author":"LF Mager","year":"2015","unstructured":"Mager, L. F. et al. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J. Clin. Invest. 125, 2579\u20132591 (2015).","journal-title":"J. Clin. Invest."},{"key":"969_CR49","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.4049\/jimmunol.1501399","volume":"198","author":"D Dominguez","year":"2017","unstructured":"Dominguez, D. et al. Exogenous IL-33 restores dendritic cell activation and maturation in established cancer. J. Immunol. 198, 1365\u20131375 (2017).","journal-title":"J. Immunol."},{"key":"969_CR50","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1126\/science.1215418","volume":"335","author":"WV Bonilla","year":"2012","unstructured":"Bonilla, W. V. et al. The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science 335, 984\u2013989 (2012).","journal-title":"Science"},{"key":"969_CR51","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3389\/fimmu.2019.01833","volume":"10","author":"C Baumann","year":"2019","unstructured":"Baumann, C. et al. Memory CD8+ T cell protection from viral reinfection depends on interleukin-33 alarmin signals. Front. Immunol. 10, 1833 (2019).","journal-title":"Front. Immunol."},{"key":"969_CR52","doi-asserted-by":"publisher","first-page":"943","DOI":"10.4049\/jimmunol.1701757","volume":"202","author":"JE McLaren","year":"2019","unstructured":"McLaren, J. E. et al. IL-33 augments virus-specific memory T cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccine. J. Immunol. 202, 943\u2013955 (2019).","journal-title":"J. Immunol."},{"key":"969_CR53","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41590-020-0672-y","volume":"21","author":"NB Pikor","year":"2020","unstructured":"Pikor, N. B. et al. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat. Immunol. 21, 649\u2013659 (2020).","journal-title":"Nat. Immunol."},{"key":"969_CR54","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.immuni.2019.05.008","volume":"50","author":"A Camara","year":"2019","unstructured":"Camara, A. et al. Lymph node mesenchymal and endothelial stromal cells cooperate via the RANK\u2013RANKL cytokine axis to shape the sinusoidal macrophage niche. Immunity 50, 1467\u20131481 (2019).","journal-title":"Immunity"},{"key":"969_CR55","first-page":"21","volume":"426","author":"A Silva-Sanchez","year":"2020","unstructured":"Silva-Sanchez, A. & Randall, T. D. Role of iBALT in respiratory immunity. Curr. Top. Microbiol. Immunol. 426, 21\u201343 (2020).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"969_CR56","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.immuni.2019.02.002","volume":"50","author":"MW Dahlgren","year":"2019","unstructured":"Dahlgren, M. W. et al. Adventitial stromal cells define group 2 innate lymphoid cell tissue niches. Immunity 50, 707\u2013722 (2019).","journal-title":"Immunity"},{"key":"969_CR57","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.1016\/j.vaccine.2017.05.032","volume":"35","author":"NK Alharbi","year":"2017","unstructured":"Alharbi, N. K. et al. ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice. Vaccine 35, 3780\u20133788 (2017).","journal-title":"Vaccine"},{"key":"969_CR58","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nprot.2008.245","volume":"4","author":"JC Grivel","year":"2009","unstructured":"Grivel, J. C. & Margolis, L. Use of human tissue explants to study human infectious agents. Nat. Protoc. 4, 256\u2013269 (2009).","journal-title":"Nat. Protoc."},{"key":"969_CR59","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/bioinformatics\/btw777","volume":"33","author":"DJ McCarthy","year":"2017","unstructured":"McCarthy, D. J., Campbell, K. R., Lun, A. T. & Wills, Q. F. Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R. Bioinformatics 33, 1179\u20131186 (2017).","journal-title":"Bioinformatics"},{"key":"969_CR60","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888\u20131902 (2019).","journal-title":"Cell"},{"key":"969_CR61","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L. G., Han, Y. & He, Q. Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284\u2013287 (2012).","journal-title":"OMICS"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00969-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00969-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00969-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:49:05Z","timestamp":1733939345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41590-021-00969-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["969"],"URL":"https:\/\/doi.org\/10.1038\/s41590-021-00969-3","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740482408.793587937","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"1 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"L.F. is a cofounder and shareholder of Hookipa Pharma. B.L., L.O. and H.-W.C. are cofounders and shareholders of Stromal Therapeutics. S.S.R. and H.-W.C. are part-time employees of Stromal Therapeutics. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}