{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:23:30Z","timestamp":1720571010675},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1038\/s41590-024-01870-5","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T16:02:28Z","timestamp":1719849748000},"page":"1140-1141","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic analysis of celiac disease treatment with transglutaminase 2 inhibitor"],"prefix":"10.1038","volume":"25","member":"297","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"1870_CR1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.tips.2023.09.006","volume":"44","author":"HA Besser","year":"2023","unstructured":"Besser, H. A. & Khosla, C. Celiac disease: mechanisms and emerging therapeutics. Trends Pharmacol. Sci. 44, 949\u2013962 (2023). A review article that presents current understanding of CeD pathogenesis and how this knowledge is being harnessed for therapeutic design and development.","journal-title":"Trends Pharmacol. Sci."},{"key":"1870_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jcmgh.2020.07.010","volume":"11","author":"V Dotsenko","year":"2021","unstructured":"Dotsenko, V. & Viiri, K. Genome-wide transcriptomic analysis of intestinal mucosa in celiac disease patients on a gluten-free diet and post gluten challenge. Cell Mol. Gastroenterol. Hepatol. 11, 13\u201332 (2021). This paper reports gluten challenge-induced duodenal biopsy transcriptomic changes and created a molecular morphometric tool to measure mucosal injury objectively.","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"1870_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1056\/NEJMoa2032441","volume":"385","author":"D Schuppan","year":"2021","unstructured":"Schuppan, D. & M\u00e4ki, M. A randomized trial of a transglutaminase 2 inhibitor for celiac disease. N. Engl. J. Med. 385, 35\u201345 (2021). This paper reports a proof-of-concept trial that treatment with ZED1227 attenuates gluten-induced mucosal damage in patients with CeD.","journal-title":"N. Engl. J. Med."},{"key":"1870_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nri3407","volume":"13","author":"LM Sollid","year":"2013","unstructured":"Sollid, L. M. & Jabri, B. Triggers and drivers of autoimmunity: lessons from coeliac disease. Nat. Rev. Immunol. 13, 294\u2013302 (2013). A review article that presents CeD as a model for autoimmunity in general.","journal-title":"Nat. Rev. Immunol."},{"key":"1870_CR5","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41591-019-0403-9","volume":"25","author":"A Christophersen","year":"2019","unstructured":"Christophersen, A. & Davis, M. M. Distinct phenotype of CD4+ cells driving celiac disease identified in multiple autoimmune conditions. Nat. Med. 25, 734\u2013737 (2019). This paper reports a way to identify CD4+ T cells specific for environmental disease-driving antigens in autoimmune conditions.","journal-title":"Nat. Med."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41590-024-01870-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-024-01870-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-024-01870-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T15:24:46Z","timestamp":1720538686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41590-024-01870-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["1870"],"URL":"https:\/\/doi.org\/10.1038\/s41590-024-01870-5","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"1 July 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}