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Here we found that\n                    <jats:italic>Mtb<\/jats:italic>\n                    -specific T cells in RSTR were clonally expanded, confirming the priming of adaptive immune responses following\n                    <jats:italic>Mtb<\/jats:italic>\n                    exposure. RSTR CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells showed enrichment of T\n                    <jats:sub>H<\/jats:sub>\n                    17 and regulatory T cell-like functional programs compared to\n                    <jats:italic>Mtb<\/jats:italic>\n                    -specific T cells from individuals with latent\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection. Using public datasets, we showed that these T\n                    <jats:sub>H<\/jats:sub>\n                    17 cell-like functional programs were associated with lack of progression to active tuberculosis among South African adolescents with latent\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection and with bacterial control in nonhuman primates. Our findings suggested that RSTR may successfully control\n                    <jats:italic>Mtb<\/jats:italic>\n                    following exposure and immune priming and established a set of T cell biomarkers to facilitate further study of this clinical phenotype.\n                  <\/jats:p>","DOI":"10.1038\/s41590-024-01897-8","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T06:01:53Z","timestamp":1720764113000},"page":"1411-1421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Specific CD4+ T cell phenotypes associate with bacterial control in people who \u2018resist\u2019 infection with Mycobacterium tuberculosis"],"prefix":"10.1038","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-2775","authenticated-orcid":false,"given":"Meng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-868X","authenticated-orcid":false,"given":"Jolie M.","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan S.","family":"Kieswetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle K. 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