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The laboratory of A.H.E. received funding from Emergent BioSolutions and AbbVie that is unrelated to the data presented in the current study. A.H.E. has received consulting and speaking fees from InBios International, Fimbrion Therapeutics, RGAX, Mubadala Investment Company, Moderna, Pfizer, GSK, Danaher, Third Rock Ventures, Goldman Sachs and Morgan Stanley and is the founder of ImmuneBio Consulting. A.J.S., J.S.T. and A.H.E. are recipients of a licensing agreement with Abbvie that is unrelated to the data presented in the current study. N.H.L., R.N. and R.P. are employees of and shareholders in Moderna. The Icahn School of Medicine at Mount Sinai has filed patent applications regarding influenza virus vaccines on which F.K. is listed as inventor and F.K. has received royalty payments from some of these patents. F.K. is co-founder and scientific advisory board member of Castlevax. F.K. has consulted for Merck, GSK, Sanofi, Curevac, Gritstone, Seqirus and Pfizer and is currently consulting for 3rd Rock Ventures and Avimex. The laboratory of F.K. is also collaborating with Dynavax on influenza vaccine development and with VIR on influenza virus therapeutics. J.D.B. is on the scientific advisory boards of Apriori Bio, Invivyd, Aerium Therapeutics and the Vaccine Company. J.D.B. consults for GlaxoSmithKline and Pfizer. J.D.B. receives royalty payments as inventors on Fred Hutch licensed patents related to incorporating barcodes into the influenza genome and viral deep mutational scanning. The other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}