{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:22:27Z","timestamp":1794486147779,"version":"4.9.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1038\/s41590-026-02682-5","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:01:50Z","timestamp":1792659710000},"page":"2252-2266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serine protease inhibitor A3 is a soluble SIRP\u03b1 ligand that suppresses inflammation and antitumor immunity"],"prefix":"10.1038","volume":"27","author":[{"given":"Yufei","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0056-1136","authenticated-orcid":false,"given":"Yongxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7162-255X","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qina","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zicheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naicui","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-7173","authenticated-orcid":false,"given":"Wentao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-1247","authenticated-orcid":false,"given":"Yong-Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"2682_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.coi.2021.09.004","volume":"73","author":"JT Greene","year":"2021","unstructured":"Greene, J. T., Brian, B. F. T., Senevirathne, S. E. & Freedman, T. S. Regulation of myeloid-cell activation. Curr. Opin. Immunol. 73, 34\u201342 (2021).","journal-title":"Curr. Opin. Immunol."},{"key":"2682_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14102-4","volume":"11","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice. Nat. Commun. 11, 581 (2020).","journal-title":"Nat. Commun."},{"key":"2682_CR3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41571-022-00620-6","volume":"19","author":"MJ Pittet","year":"2022","unstructured":"Pittet, M. J., Michielin, O. & Migliorini, D. Clinical relevance of tumour-associated macrophages. Nat. Rev. Clin. Oncol. 19, 402\u2013421 (2022).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"2682_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115039","volume":"43","author":"L Zhao","year":"2024","unstructured":"Zhao, L. et al. IL-17A\/CEBPbeta\/OPN\/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages. Cell Rep. 43, 115039 (2024).","journal-title":"Cell Rep."},{"key":"2682_CR5","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","volume":"138","author":"R Majeti","year":"2009","unstructured":"Majeti, R. et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138, 286\u2013299 (2009).","journal-title":"Cell"},{"key":"2682_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S0962-8924(00)01906-1","volume":"11","author":"EJ Brown","year":"2001","unstructured":"Brown, E. J. & Frazier, W. A. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11, 130\u2013135 (2001).","journal-title":"Trends Cell Biol."},{"key":"2682_CR7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","volume":"138","author":"S Jaiswal","year":"2009","unstructured":"Jaiswal, S. et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271\u2013285 (2009).","journal-title":"Cell"},{"key":"2682_CR8","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1126\/science.288.5473.2051","volume":"288","author":"PA Oldenborg","year":"2000","unstructured":"Oldenborg, P. A. et al. Role of CD47 as a marker of self on red blood cells. Science 288, 2051\u20132054 (2000).","journal-title":"Science"},{"key":"2682_CR9","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.immuni.2020.04.011","volume":"52","author":"MEW Logtenberg","year":"2020","unstructured":"Logtenberg, M. E. W., Scheeren, F. A. & Schumacher, T. N. The CD47-SIRPalpha immune checkpoint. Immunity 52, 742\u2013752 (2020).","journal-title":"Immunity"},{"key":"2682_CR10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41392-023-01365-z","volume":"8","author":"Y Liu","year":"2023","unstructured":"Liu, Y. et al. Emerging phagocytosis checkpoints in cancer immunotherapy. Signal. Transduct. Target. Ther. 8, 104 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"2682_CR11","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.trecan.2023.04.006","volume":"9","author":"K Huntoon","year":"2023","unstructured":"Huntoon, K. et al. Targeting phagocytosis to enhance antitumor immunity. Trends Cancer 9, 650\u2013665 (2023).","journal-title":"Trends Cancer"},{"key":"2682_CR12","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1056\/NEJMoa1807315","volume":"379","author":"R Advani","year":"2018","unstructured":"Advani, R. et al. CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin\u2019s lymphoma. N. Engl. J. Med. 379, 1711\u20131721 (2018).","journal-title":"N. Engl. J. Med."},{"key":"2682_CR13","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41591-021-01625-x","volume":"28","author":"J Theruvath","year":"2022","unstructured":"Theruvath, J. et al. Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. Nat. Med. 28, 333\u2013344 (2022).","journal-title":"Nat. Med."},{"key":"2682_CR14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41590-018-0292-y","volume":"20","author":"M Liu","year":"2019","unstructured":"Liu, M. et al. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated \u2018don\u2019t-eat-me\u2019 signal. Nat. Immunol. 20, 265\u2013275 (2019).","journal-title":"Nat. Immunol."},{"key":"2682_CR15","doi-asserted-by":"crossref","unstructured":"Huang, C. et al. Sirpalpha on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47. Nat. Cancer 5, 500\u2013516 (2024).","DOI":"10.1038\/s43018-023-00691-z"},{"key":"2682_CR16","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.4049\/jimmunol.0901550","volume":"184","author":"H Wang","year":"2010","unstructured":"Wang, H., Wu, X., Wang, Y., Oldenborg, P. A. & Yang, Y. G. CD47 is required for suppression of allograft rejection by donor-specific transfusion. J. Immunol. 184, 3401\u20133407 (2010).","journal-title":"J. Immunol."},{"key":"2682_CR17","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/nm.3931","volume":"21","author":"X Liu","year":"2015","unstructured":"Liu, X. et al. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat. Med. 21, 1209\u20131215 (2015).","journal-title":"Nat. Med."},{"key":"2682_CR18","doi-asserted-by":"crossref","unstructured":"Deuse, T. et al. The SIRP\u03b1-CD47 immune checkpoint in NK cells. J. Exp. Med. 218, e20200839 (2021).","DOI":"10.1084\/jem.20200839"},{"key":"2682_CR19","doi-asserted-by":"publisher","first-page":"E5434","DOI":"10.1073\/pnas.1521069113","volume":"113","author":"Z Bian","year":"2016","unstructured":"Bian, Z. et al. Cd47-Sirpalpha interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proc. Natl Acad. Sci. USA 113, E5434\u2013E5443 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2682_CR20","doi-asserted-by":"crossref","unstructured":"de Mezer, M. et al. SERPINA3: stimulator or inhibitor of pathological changes. Biomedicines 11, 156 (2023).","DOI":"10.3390\/biomedicines11010156"},{"key":"2682_CR21","doi-asserted-by":"publisher","first-page":"13744","DOI":"10.1073\/pnas.0702881104","volume":"104","author":"H Wang","year":"2007","unstructured":"Wang, H. et al. Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc. Natl Acad. Sci. USA 104, 13744\u201313749 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2682_CR22","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1164\/rccm.200711-1661oc","volume":"178","author":"WJ Janssen","year":"2008","unstructured":"Janssen, W. J. et al. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am. J. Respir. Crit. Care Med. 178, 158\u2013167 (2008).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2682_CR23","doi-asserted-by":"publisher","first-page":"7781","DOI":"10.4049\/jimmunol.175.12.7781","volume":"175","author":"EM van Beek","year":"2005","unstructured":"van Beek, E. M., Cochrane, F., Barclay, A. N. & van den Berg, T. K. Signal regulatory proteins in the immune system. J. Immunol. 175, 7781\u20137787 (2005).","journal-title":"J. Immunol."},{"key":"2682_CR24","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adv5085","volume":"10","author":"Z Tang","year":"2025","unstructured":"Tang, Z. et al. Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPalpha. Sci. Immunol. 10, eadv5085 (2025).","journal-title":"Sci. Immunol."},{"key":"2682_CR25","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1182\/blood-2011-04-345330","volume":"118","author":"MJ Stables","year":"2011","unstructured":"Stables, M. J. et al. Transcriptomic analyses of murine resolution-phase macrophages. Blood 118, e192\u2013e208 (2011).","journal-title":"Blood"},{"key":"2682_CR26","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1007\/s00262-022-03207-3","volume":"71","author":"K Zilionyte","year":"2022","unstructured":"Zilionyte, K. et al. Correction to: Functional antigen processing and presentation mechanism as a prerequisite factor of response to treatment with dendritic cell vaccines and anti-PD-1 in preclinical murine LLC1 and GL261 tumor models. Cancer Immunol. Immunother. 71, 2701 (2022).","journal-title":"Cancer Immunol. Immunother."},{"key":"2682_CR27","doi-asserted-by":"publisher","first-page":"e2250234","DOI":"10.1002\/eji.202250234","volume":"53","author":"M Diebold","year":"2023","unstructured":"Diebold, M., Fehrenbacher, L., Frosch, M. & Prinz, M. How myeloid cells shape experimental autoimmune encephalomyelitis: at the crossroads of outside-in immunity. Eur. J. Immunol. 53, e2250234 (2023).","journal-title":"Eur. J. Immunol."},{"key":"2682_CR28","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/JLB.3MR0620-035R","volume":"108","author":"WN Brandao","year":"2020","unstructured":"Brandao, W. N. et al. Neuroinflammation at single cell level: what is new?. J. Leukoc. Biol. 108, 1129\u20131137 (2020).","journal-title":"J. Leukoc. Biol."},{"key":"2682_CR29","first-page":"C106","volume":"320","author":"A Sanchez-Navarro","year":"2021","unstructured":"Sanchez-Navarro, A., Gonzalez-Soria, I., Caldino-Bohn, R. & Bobadilla, N. A. An integrative view of serpins in health and disease: the contribution of SerpinA3. Am. J. Physiol. Cell Physiol. 320, C106\u2013C118 (2021).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2682_CR30","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.jmb.2007.10.085","volume":"375","author":"A Nakaishi","year":"2008","unstructured":"Nakaishi, A. et al. Structural insight into the specific interaction between murine SHPS-1\/SIRP alpha and its ligand CD47. J. Mol. Biol. 375, 650\u2013660 (2008).","journal-title":"J. Mol. Biol."},{"key":"2682_CR31","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s40425-019-0772-0","volume":"7","author":"E Voets","year":"2019","unstructured":"Voets, E. et al. Functional characterization of the selective pan-allele anti-SIRPalpha antibody ADU-1805 that blocks the SIRPalpha-CD47 innate immune checkpoint. J. Immunother. Cancer 7, 340 (2019).","journal-title":"J. Immunother. Cancer"},{"key":"2682_CR32","first-page":"80","volume":"3","author":"AR Jalil","year":"2020","unstructured":"Jalil, A. R., Andrechak, J. C. & Discher, D. E. Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRP\u03b1 structure-function. Antib. Ther. 3, 80\u201394 (2020).","journal-title":"Antib. Ther."},{"key":"2682_CR33","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.molcel.2008.05.026","volume":"31","author":"D Hatherley","year":"2008","unstructured":"Hatherley, D. et al. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol. Cell 31, 266\u2013277 (2008).","journal-title":"Mol. Cell"},{"key":"2682_CR34","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/s43018-021-00254-0","volume":"2","author":"F Klemm","year":"2021","unstructured":"Klemm, F. et al. Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis. Nat. Cancer 2, 1086\u20131101 (2021).","journal-title":"Nat. Cancer"},{"key":"2682_CR35","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s12026-022-09330-8","volume":"71","author":"S Yadav","year":"2023","unstructured":"Yadav, S., Priya, A., Borade, D. R. & Agrawal-Rajput, R. Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance. Immunol. Res. 71, 130\u2013152 (2023).","journal-title":"Immunol. Res."},{"key":"2682_CR36","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1097\/SHK.0000000000002106","volume":"59","author":"W Xie","year":"2023","unstructured":"Xie, W. et al. Silencing m6a reader Ythdc1 reduces inflammatory response in sepsis-induced cardiomyopathy by inhibiting Serpina3n expression. Shock 59, 791\u2013802 (2023).","journal-title":"Shock"},{"key":"2682_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34412-4","volume":"13","author":"H Kim","year":"2022","unstructured":"Kim, H. et al. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat. Commun. 13, 6581 (2022).","journal-title":"Nat. Commun."},{"key":"2682_CR38","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1182\/blood-2005-11-4388","volume":"108","author":"P Lan","year":"2006","unstructured":"Lan, P., Tonomura, N., Shimizu, A., Wang, S. & Yang, Y. G. Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus\/liver and CD34+ cell transplantation. Blood 108, 487\u2013492 (2006).","journal-title":"Blood"},{"key":"2682_CR39","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1182\/blood-2007-11-121319","volume":"111","author":"N Tonomura","year":"2008","unstructured":"Tonomura, N., Habiro, K., Shimizu, A., Sykes, M. & Yang, Y. G. Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 111, 4293\u20134296 (2008).","journal-title":"Blood"},{"key":"2682_CR40","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.4049\/jimmunol.161.4.1853","volume":"161","author":"S Adams","year":"1998","unstructured":"Adams, S. et al. Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J. Immunol. 161, 1853\u20131859 (1998).","journal-title":"J. Immunol."},{"key":"2682_CR41","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1182\/blood.V94.11.3633","volume":"94","author":"M Seiffert","year":"1999","unstructured":"Seiffert, M. et al. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood 94, 3633\u20133643 (1999).","journal-title":"Blood"},{"key":"2682_CR42","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1074\/jbc.274.3.1821","volume":"274","author":"SR Hwang","year":"1999","unstructured":"Hwang, S. R., Steineckert, B., Kohn, A., Palkovits, M. & Hook, V. Y. Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer\u2019s disease brains. Comparison of act in hippocampus and liver. J. Biol. Chem. 274, 1821\u20131827 (1999).","journal-title":"J. Biol. Chem."},{"key":"2682_CR43","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s42003-021-02095-0","volume":"4","author":"MG Ferrarini","year":"2021","unstructured":"Ferrarini, M. G. et al. Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis. Commun. Biol. 4, 590 (2021).","journal-title":"Commun. Biol."},{"key":"2682_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198408","volume":"300","author":"S Abbasi","year":"2021","unstructured":"Abbasi, S. et al. Impact of human rhinoviruses on gene expression in pediatric patients with severe acute respiratory infection. Virus Res. 300, 198408 (2021).","journal-title":"Virus Res."},{"key":"2682_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.652799","volume":"12","author":"K Suvarna","year":"2021","unstructured":"Suvarna, K. et al. Proteomics and machine learning approaches reveal a set of prognostic markers for COVID-19 severity with drug repurposing potential. Front. Physiol. 12, 652799 (2021).","journal-title":"Front. Physiol."},{"key":"2682_CR46","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1128\/IAI.01900-06","volume":"75","author":"CF Flach","year":"2007","unstructured":"Flach, C. F. et al. Broad up-regulation of innate defense factors during acute cholera. Infect. Immun. 75, 2343\u20132350 (2007).","journal-title":"Infect. Immun."},{"key":"2682_CR47","doi-asserted-by":"crossref","unstructured":"Fissolo, N. et al. CSF SERPINA3 levels are elevated in patients with progressive MS. Neurol. Neuroimmunol. Neuroinflamm. 8, e941 (2021).","DOI":"10.1212\/NXI.0000000000000983"},{"key":"2682_CR48","doi-asserted-by":"crossref","unstructured":"Shiratori-Aso, S. et al. CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps. JCI Insight 8, e167486 (2023).","DOI":"10.1172\/jci.insight.167486"},{"key":"2682_CR49","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jaut.2016.03.002","volume":"69","author":"Q Gao","year":"2016","unstructured":"Gao, Q. et al. Blockade of CD47 ameliorates autoimmune inflammation in CNS by suppressing IL-1-triggered infiltration of pathogenic Th17 cells. J. Autoimmun. 69, 74\u201385 (2016).","journal-title":"J. Autoimmun."},{"key":"2682_CR50","doi-asserted-by":"publisher","first-page":"188760","DOI":"10.1016\/j.bbcan.2022.188760","volume":"1877","author":"A Soman","year":"2022","unstructured":"Soman, A. & Asha Nair, S. Unfolding the cascade of SERPINA3: inflammation to cancer. Biochim. Biophys. Acta Rev. Cancer 1877, 188760 (2022).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"2682_CR51","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1016\/j.immuni.2023.06.012","volume":"56","author":"Q Luo","year":"2023","unstructured":"Luo, Q. et al. An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression. Immunity 56, 2006\u20132020 (2023).","journal-title":"Immunity"},{"key":"2682_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36468-2","volume":"14","author":"S Zhang","year":"2023","unstructured":"Zhang, S. et al. Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice. Nat. Commun. 14, 817 (2023).","journal-title":"Nat. Commun."},{"key":"2682_CR53","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41590-024-02068-5","volume":"26","author":"J He","year":"2025","unstructured":"He, J. et al. The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer. Nat. Immunol. 26, 391\u2013403 (2025).","journal-title":"Nat. Immunol."},{"key":"2682_CR54","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1038\/s41590-025-02321-5","volume":"26","author":"CH Weng","year":"2025","unstructured":"Weng, C. H. et al. Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer. Nat. Immunol. 26, 2296\u20132311 (2025).","journal-title":"Nat. Immunol."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41590-026-02682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-026-02682-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41590-026-02682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:34:07Z","timestamp":1794483247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41590-026-02682-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2682"],"URL":"https:\/\/doi.org\/10.1038\/s41590-026-02682-5","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"13 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}