{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:49:19Z","timestamp":1793875759059,"version":"4.7.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["15977"],"award-info":[{"award-number":["15977"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["15049"],"award-info":[{"award-number":["15049"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["152536"],"award-info":[{"award-number":["152536"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["152977"],"award-info":[{"award-number":["152977"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["AI144462"],"award-info":[{"award-number":["AI144462"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["AI126620"],"award-info":[{"award-number":["AI126620"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AI124414-01A1"],"award-info":[{"award-number":["1P30AI124414-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI-129795"],"award-info":[{"award-number":["R01AI-129795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["AI-144462"],"award-info":[{"award-number":["AI-144462"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019546","name":"Einstein-Rockefeller-CUNY Center for AIDS Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019546","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1092074"],"award-info":[{"award-number":["OPP1092074"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1124068"],"award-info":[{"award-number":["OPP1124068"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1038\/s41591-019-0747-1","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T12:04:21Z","timestamp":1580731461000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-1924","authenticated-orcid":false,"given":"Julia","family":"Niessl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda Z.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Dub\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Shimeliovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Gruell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1376-1792","authenticated-orcid":false,"given":"Florian","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Caskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel C.","family":"Nussenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-136X","authenticated-orcid":false,"given":"Daniel E.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"747_CR1","doi-asserted-by":"publisher","first-page":"13193","DOI":"10.1073\/pnas.94.24.13193","volume":"94","author":"TW Chun","year":"1997","unstructured":"Chun, T. W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl Acad. Sci. USA 94, 13193\u201313197 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"747_CR2","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","volume":"278","author":"D Finzi","year":"1997","unstructured":"Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295\u20131300 (1997).","journal-title":"Science"},{"key":"747_CR3","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41591-019-0412-8","volume":"25","author":"M Caskey","year":"2019","unstructured":"Caskey, M., Klein, F. & Nussenzweig, M. C. Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic. Nat. Med. 25, 547\u2013553 (2019).","journal-title":"Nat. Med."},{"key":"747_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41586-018-0531-2","volume":"561","author":"P Mendoza","year":"2018","unstructured":"Mendoza, P. et al. Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature 561, 479\u2013484 (2018).","journal-title":"Nature"},{"key":"747_CR5","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1128\/JVI.68.7.4650-4655.1994","volume":"68","author":"RA Koup","year":"1994","unstructured":"Koup, R. A. et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68, 4650\u20134655 (1994).","journal-title":"J. Virol."},{"key":"747_CR6","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1084\/jem.20090365","volume":"206","author":"N Goonetilleke","year":"2009","unstructured":"Goonetilleke, N. et al. The first T cell response to transmitted\/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med. 206, 1253 (2009).","journal-title":"J. Exp. Med."},{"key":"747_CR7","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1126\/science.278.5342.1447","volume":"278","author":"ES Rosenberg","year":"1997","unstructured":"Rosenberg, E. S. et al. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 278, 1447\u20131450 (1997).","journal-title":"Science"},{"key":"747_CR8","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1086\/526786","volume":"197","author":"F Pereyra","year":"2008","unstructured":"Pereyra, F. et al. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J. Infectious Dis. 197, 563\u2013571 (2008).","journal-title":"J. Infectious Dis."},{"key":"747_CR9","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1182\/blood-2005-12-4818","volume":"107","author":"MR Betts","year":"2006","unstructured":"Betts, M. R. et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107, 4781\u20134789 (2006).","journal-title":"Blood"},{"key":"747_CR10","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1126\/science.aaf1279","volume":"352","author":"C-L Lu","year":"2016","unstructured":"Lu, C.-L. et al. Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo. Science 352, 1001\u20131004 (2016).","journal-title":"Science"},{"key":"747_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature21435","volume":"543","author":"Y Nishimura","year":"2017","unstructured":"Nishimura, Y. et al. Early antibody therapy can induce long-lasting immunity to SHIV. Nature 543, 559\u2013563 (2017).","journal-title":"Nature"},{"key":"747_CR12","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/nature18929","volume":"535","author":"JF Scheid","year":"2016","unstructured":"Scheid, J. F. et al. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535, 556\u2013560 (2016).","journal-title":"Nature"},{"key":"747_CR13","doi-asserted-by":"publisher","first-page":"e82","DOI":"10.1016\/S2352-3018(15)00026-0","volume":"2","author":"CJ Achenbach","year":"2015","unstructured":"Achenbach, C. J. et al. Effect of therapeutic intensification followed by HIV DNA prime and rAd5 boost vaccination on HIV-specific immunity and HIV reservoir (EraMune 02): a multicentre randomised clinical trial. Lancet HIV 2, e82\u2013e91 (2015).","journal-title":"Lancet HIV"},{"key":"747_CR14","doi-asserted-by":"publisher","first-page":"e0176527","DOI":"10.1371\/journal.pone.0176527","volume":"12","author":"C Prebensen","year":"2017","unstructured":"Prebensen, C. et al. Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: an exploratory clinical trial. PLoS ONE 12, e0176527 (2017).","journal-title":"PLoS ONE"},{"key":"747_CR15","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.4049\/jimmunol.162.3.1780","volume":"162","author":"CM Gray","year":"1999","unstructured":"Gray, C. M. et al. Frequency of class I HLA-Restricted Anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J. Immunol. 162, 1780 (1999).","journal-title":"J. Immunol."},{"key":"747_CR16","doi-asserted-by":"publisher","first-page":"13747","DOI":"10.1073\/pnas.202372199","volume":"99","author":"A Oxenius","year":"2002","unstructured":"Oxenius, A. et al. Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection. Proc. Natl Acad. Sci. USA 99, 13747\u201313752 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"747_CR17","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1084\/jem.20070784","volume":"204","author":"JR Almeida","year":"2007","unstructured":"Almeida, J. R. et al. Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J. Exp. Med. 204, 2473\u20132485 (2007).","journal-title":"J. Exp. Med."},{"key":"747_CR18","doi-asserted-by":"publisher","first-page":"4998","DOI":"10.1128\/JVI.00138-10","volume":"84","author":"SA Freel","year":"2010","unstructured":"Freel, S. A. et al. Phenotypic and functional profile of HIV-inhibitory CD8+ T cells elicited by natural infection and heterologous prime\/boost vaccination. J. Virol. 84, 4998\u20135006 (2010).","journal-title":"J. Virol."},{"key":"747_CR19","doi-asserted-by":"publisher","first-page":"e0186998","DOI":"10.1371\/journal.pone.0186998","volume":"12","author":"S Reiss","year":"2017","unstructured":"Reiss, S. et al. Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4+ T cells. PLoS ONE 12, e0186998 (2017).","journal-title":"PLoS ONE"},{"key":"747_CR20","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/s41590-019-0418-x","volume":"20","author":"A Morou","year":"2019","unstructured":"Morou, A. et al. Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease. Nat. Immunol. 20, 1059\u20131070 (2019).","journal-title":"Nat. Immunol."},{"key":"747_CR21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/312496a0","volume":"312","author":"R Patarca","year":"1984","unstructured":"Patarca, R. & Haseltine, W. A. Similarities among retrovirus proteins. Nature 312, 496 (1984).","journal-title":"Nature"},{"key":"747_CR22","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nprot.2010.73","volume":"5","author":"A Saez-Cirion","year":"2010","unstructured":"Saez-Cirion, A., Shin, S. Y., Versmisse, P., Barre-Sinoussi, F. & Pancino, G. Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T cell responses. Nat. Protoc. 5, 1033\u20131041 (2010).","journal-title":"Nat. Protoc."},{"key":"747_CR23","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1126\/science.8096089","volume":"259","author":"MJ Piatak","year":"1993","unstructured":"Piatak, M. J. et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259, 1749\u20131754 (1993).","journal-title":"Science"},{"key":"747_CR24","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41586-018-0600-6","volume":"563","author":"EN Borducchi","year":"2018","unstructured":"Borducchi, E. N. et al. Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys. Nature 563, 360\u2013364 (2018).","journal-title":"Nature"},{"key":"747_CR25","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1001\/archinte.163.10.1220","volume":"163","author":"C Fagard","year":"2003","unstructured":"Fagard, C. et al. A prospective trial of structured treatment interruptions in human immunodeficiency virus infection. Arch. Intern. Med. 163, 1220\u20131226 (2003).","journal-title":"Arch. Intern. Med."},{"key":"747_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/imr.12343","volume":"268","author":"S Bournazos","year":"2015","unstructured":"Bournazos, S. & Ravetch, J. V. Fc\u03b3 receptor pathways during active and passive immunization. Immunol. Rev. 268, 88\u2013103 (2015).","journal-title":"Immunol. Rev."},{"key":"747_CR27","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.jhep.2010.05.013","volume":"53","author":"S Pelletier","year":"2010","unstructured":"Pelletier, S. et al. Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses. J. Hepatol. 53, 805\u2013816 (2010).","journal-title":"J. Hepatol."},{"key":"747_CR28","doi-asserted-by":"publisher","first-page":"E11341","DOI":"10.1073\/pnas.1813512115","volume":"115","author":"C-L Lu","year":"2018","unstructured":"Lu, C.-L. et al. Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption. Proc. Natl Acad. Sci. USA 115, E11341\u2013E11348 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"747_CR29","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1128\/JVI.02660-07","volume":"82","author":"JF Salazar-Gonzalez","year":"2008","unstructured":"Salazar-Gonzalez, J. F. et al. Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. J. Virol. 82, 3952\u20133970 (2008).","journal-title":"J. Virol."},{"key":"747_CR30","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","volume":"23","author":"MA Larkin","year":"2007","unstructured":"Larkin, M. A. et al. Clustal W and Clustal X version 2.0. Bioinformatics 23, 2947\u20132948 (2007).","journal-title":"Bioinformatics"},{"key":"747_CR31","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","volume":"30","author":"A Stamatakis","year":"2014","unstructured":"Stamatakis, A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30, 1312\u20131313 (2014).","journal-title":"Bioinformatics"},{"key":"747_CR32","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.3014648","volume":"233","author":"S Gartner","year":"1986","unstructured":"Gartner, S. et al. The role of mononuclear phagocytes in HTLV-III\/LAV infection. Science 233, 215\u2013219 (1986).","journal-title":"Science"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41591-019-0747-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-019-0747-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-019-0747-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:42:20Z","timestamp":1733942540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41591-019-0747-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["747"],"URL":"https:\/\/doi.org\/10.1038\/s41591-019-0747-1","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"24 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There are patents on 3BNC117 (PTC\/US2012\/038400) and 10-1074 (PTC\/US2013\/065696) that list M.C.N. as an inventor. M.C.N. is a member of the Scientific Advisory Board of Frontier Bioscience. Gilead has the rights to develop the 3BNC117 and 10-1074 antibody combination for clinical use.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}