{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:41:58Z","timestamp":1791495718676,"version":"4.3.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1179906"],"award-info":[{"award-number":["OPP1179906"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1179906"],"award-info":[{"award-number":["OPP1179906"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1179906"],"award-info":[{"award-number":["OPP1179906"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hospital for Sick Children Lap-Chee Tsui Postdoctoral Fellowship Canadian Institutes of Health Research (CIHR) fellowship"},{"name":"CIHR Canada Graduate Scholarship - Master's Award"},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1038\/s41591-020-0881-9","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T12:02:35Z","timestamp":1590408155000},"page":"1135-1145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs"],"prefix":"10.1038","volume":"26","author":[{"given":"Rajagopal","family":"Murugan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Scally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-5163","authenticated-orcid":false,"given":"Ghulam","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tizian","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-906X","authenticated-orcid":false,"given":"Elena A.","family":"Levashina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7602-3995","authenticated-orcid":false,"given":"Jean-Philippe","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-5933","authenticated-orcid":false,"given":"Hedda","family":"Wardemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"881_CR1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1084\/jem.177.5.1287","volume":"177","author":"U Frevert","year":"1993","unstructured":"Frevert, U. et al. Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes. J. Exp. Med. 177, 1287\u20131298 (1993).","journal-title":"J. Exp. Med."},{"key":"881_CR2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/385336a0","volume":"385","author":"R M\u00e9nard","year":"1997","unstructured":"M\u00e9nard, R. et al. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature 385, 336\u2013340 (1997).","journal-title":"Nature"},{"key":"881_CR3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1084\/jem.20101488","volume":"208","author":"A Coppi","year":"2011","unstructured":"Coppi, A. et al. The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. J. Exp. Med. 208, 341\u2013356 (2011).","journal-title":"J. Exp. Med."},{"key":"881_CR4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.6204383","volume":"225","author":"JB Dame","year":"1984","unstructured":"Dame, J. B. et al. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225, 593\u2013599 (1984).","journal-title":"Science"},{"key":"881_CR5","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.6204384","volume":"225","author":"V Enea","year":"1984","unstructured":"Enea, V. et al. DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope. Science 225, 628\u2013630 (1984).","journal-title":"Science"},{"key":"881_CR6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0166-6851(02)00216-5","volume":"125","author":"AA Escalante","year":"2002","unstructured":"Escalante, A. A. et al. A study of genetic diversity in the gene encoding the circumsporozoite protein (CSP) of Plasmodium falciparum from different transmission areas\u2014XVI. Asembo Bay Cohort Project. Mol. Biochem. Parasitol. 125, 83\u201390 (2002).","journal-title":"Mol. Biochem. Parasitol."},{"key":"881_CR7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/infdis\/jis329","volume":"206","author":"JA Bailey","year":"2012","unstructured":"Bailey, J. A. et al. Use of massively parallel pyrosequencing to evaluate the diversity of and selection on Plasmodium falciparum CSP T-cell epitopes in Lilongwe, Malawi. J. Infect. Dis. 206, 580\u2013587 (2012).","journal-title":"J. Infect. Dis."},{"key":"881_CR8","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1084\/jem.157.6.1947","volume":"157","author":"F Zavala","year":"1983","unstructured":"Zavala, F., Cochrane, A. H., Nardin, E. H., Nussenzweig, R. S. & Nussenzweig, V. Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. J. Exp. Med. 157, 1947\u20131957 (1983).","journal-title":"J. Exp. Med."},{"key":"881_CR9","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1084\/jem.151.6.1504","volume":"151","author":"P Potocnjak","year":"1980","unstructured":"Potocnjak, P., Yoshida, N., Nussenzweig, R. S. & Nussenzweig, V. Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection. J. Exp. Med. 151, 1504\u20131513 (1980).","journal-title":"J. Exp. Med."},{"key":"881_CR10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.6985745","volume":"207","author":"N Yoshida","year":"1980","unstructured":"Yoshida, N., Nussenzweig, R. S., Potocnjak, P., Nussenzweig, V. & Aikawa, M. Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. Science 207, 71\u201373 (1980).","journal-title":"Science"},{"key":"881_CR11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1084\/jem.156.1.20","volume":"156","author":"EH Nardin","year":"1982","unstructured":"Nardin, E. H. et al. Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax. J. Exp. Med. 156, 20\u201330 (1982).","journal-title":"J. Exp. Med."},{"key":"881_CR12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4161\/hv.6.1.9677","volume":"6","author":"J Cohen","year":"2010","unstructured":"Cohen, J., Nussenzweig, V., Nussenzweig, R., Vekemans, J. & Leach, A. From the circumsporozoite protein to the RTS, S\/AS candidate vaccine. Hum. Vaccin. 6, 90\u201396 (2010).","journal-title":"Hum. Vaccin."},{"key":"881_CR13","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1056\/NEJMoa1208394","volume":"367","author":"The RTS,S Clinical Trials Partnership et al.","year":"2012","unstructured":"The RTS,S Clinical Trials Partnership et al. A phase 3 trial of RTS,S\/AS01 malaria vaccine in African infants. N. Engl. J. Med. 367, 2284\u20132295 (2012).","journal-title":"N. Engl. J. Med."},{"key":"881_CR14","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJMoa1102287","volume":"365","author":"The RTS,S Clinical Trials Partnership et al.","year":"2011","unstructured":"The RTS,S Clinical Trials Partnership et al. First results of phase 3 trial of RTS,S\/AS01 malaria vaccine in African children. N. Engl. J. Med. 365, 1863\u20131875 (2011).","journal-title":"N. Engl. J. Med."},{"key":"881_CR15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(15)60721-8","volume":"386","author":"The RTS,S Clinical Trials Partnership et al.","year":"2015","unstructured":"The RTS,S Clinical Trials Partnership et al. Efficacy and safety of RTS,S\/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet 386, 31\u201345 (2015).","journal-title":"Lancet"},{"key":"881_CR16","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMoa1515257","volume":"374","author":"A Olotu","year":"2016","unstructured":"Olotu, A. et al. Seven-year efficacy of RTS,S\/AS01 malaria vaccine among young African children. N. Engl. J. Med. 374, 2519\u20132529 (2016).","journal-title":"N. Engl. J. Med."},{"key":"881_CR17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1172\/JCI70349","volume":"124","author":"L Foquet","year":"2014","unstructured":"Foquet, L. et al. Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J. Clin. Invest. 124, 140\u2013144 (2014).","journal-title":"J. Clin. Invest."},{"key":"881_CR18","doi-asserted-by":"crossref","first-page":"E10438","DOI":"10.1073\/pnas.1715812114","volume":"114","author":"D Oyen","year":"2017","unstructured":"Oyen, D. et al. Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proc. Natl Acad. Sci. USA 114, E10438\u2013E10445 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"881_CR19","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/j.immuni.2017.11.007","volume":"47","author":"G Triller","year":"2017","unstructured":"Triller, G. et al. Natural parasite exposure induces protective human anti-malarial antibodies. Immunity 47, e10 (2017).","journal-title":"Immunity"},{"key":"881_CR20","doi-asserted-by":"crossref","first-page":"eaap8029","DOI":"10.1126\/sciimmunol.aap8029","volume":"3","author":"R Murugan","year":"2018","unstructured":"Murugan, R. et al. Clonal selection drives protective memory B cell responses in controlled human malaria infection. Sci. Immunol. 3, eaap8029 (2018).","journal-title":"Sci. Immunol."},{"key":"881_CR21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.20170869","volume":"215","author":"SW Scally","year":"2018","unstructured":"Scally, S. W. et al. Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. J. Exp. Med. 215, 63\u201375 (2018).","journal-title":"J. Exp. Med."},{"key":"881_CR22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nm.4513","volume":"24","author":"J Tan","year":"2018","unstructured":"Tan, J. et al. A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein. Nat. Med. 24, 401\u2013407 (2018).","journal-title":"Nat. Med."},{"key":"881_CR23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nm.4512","volume":"24","author":"NK Kisalu","year":"2018","unstructured":"Kisalu, N. K. et al. A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nat. Med. 24, 408\u2013416 (2018).","journal-title":"Nat. Med."},{"key":"881_CR24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature21060","volume":"542","author":"B Mordm\u00fcller","year":"2017","unstructured":"Mordm\u00fcller, B. et al. Sterile protection against human malaria by chemoattenuated PfSPZ vaccine. Nature 542, 445\u2013449 (2017).","journal-title":"Nature"},{"key":"881_CR25","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.aar5304","volume":"360","author":"K Imkeller","year":"2018","unstructured":"Imkeller, K. et al. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science 360, 1358\u20131362 (2018).","journal-title":"Science"},{"key":"881_CR26","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1021\/bi00486a008","volume":"29","author":"HJ Dyson","year":"1990","unstructured":"Dyson, H. J., Satterthwait, A. C., Lerner, R. A. & Wright, P. E. Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by 1H NMR. Biochemistry 29, 7828\u20137837 (1990).","journal-title":"Biochemistry"},{"key":"881_CR27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1039\/B510812H","volume":"3","author":"A Ghasparian","year":"2006","unstructured":"Ghasparian, A., Moehle, K., Linden, A. & Robinson, J. A. Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum. Chem. Commun. 3, 174\u2013176 (2006).","journal-title":"Chem. Commun."},{"key":"881_CR28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1074-7613(00)80580-4","volume":"8","author":"FD Batista","year":"1998","unstructured":"Batista, F. D. & Neuberger, M. S. Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity 8, 751\u2013759 (1998).","journal-title":"Immunity"},{"key":"881_CR29","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.97.20.10679","volume":"97","author":"J Foote","year":"2000","unstructured":"Foote, J. & Eisen, H. N. Breaking the affinity ceiling for antibodies and T cell receptors. Proc. Natl Acad. Sci. USA 97, 10679\u201310681 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"881_CR30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","volume":"30","author":"GD Victora","year":"2012","unstructured":"Victora, G. D. & Nussenzweig, M. C. Germinal centers. Annu. Rev. Immunol. 30, 429\u2013457 (2012).","journal-title":"Annu. Rev. Immunol."},{"key":"881_CR31","doi-asserted-by":"crossref","first-page":"eaau8529","DOI":"10.1126\/sciadv.aau8529","volume":"4","author":"D Oyen","year":"2018","unstructured":"Oyen, D. et al. Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts. Sci. Adv. 4, eaau8529 (2018).","journal-title":"Sci. Adv."},{"key":"881_CR32","doi-asserted-by":"crossref","unstructured":"Julien, J.-P. & Wardemann, H. Antibodies against Plasmodium falciparum malaria at the molecular level. Nat. Rev. Immunol. 19, 761\u2013775 (2019).","DOI":"10.1038\/s41577-019-0209-5"},{"key":"881_CR33","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s41564-018-0254-z","volume":"3","author":"E Aliprandini","year":"2018","unstructured":"Aliprandini, E. et al. Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin. Nat. Microbiol. 3, 1224\u20131233 (2018).","journal-title":"Nat. Microbiol."},{"key":"881_CR34","doi-asserted-by":"crossref","unstructured":"Flores-Garcia, Y. et al. Antibody-mediated protection against Plasmodium sporozoites begins at the dermal inoculation site. MBio 9, e02194-18 (2018).","DOI":"10.1128\/mBio.02194-18"},{"key":"881_CR35","doi-asserted-by":"publisher","unstructured":"Hayley, A. et al. Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses. Preprint at https:\/\/doi.org\/10.1101\/808543 (2019).","DOI":"10.1101\/808543"},{"key":"881_CR36","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","volume":"98","author":"NA Baker","year":"2001","unstructured":"Baker, N. A., Sept, D., Joseph, S., Holst, M. J. & McCammon, J. A. Electrostatics of nanosystems: application to microtubules and the ribosome. Proc. Natl Acad. Sci. USA 98, 10037\u201310041 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"881_CR37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4269\/ajtmh.2006.74.708","volume":"74","author":"J Sattabongkot","year":"2006","unstructured":"Sattabongkot, J. et al. Establishment of a human hepatocyte line that supports in vitro development of the exo-erythrocytic stages of the malaria parasites Plasmodium falciparum and P. vivax. Am. J. Trop. Med. Hyg. 74, 708\u2013715 (2006).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"881_CR38","doi-asserted-by":"crossref","first-page":"e1001112","DOI":"10.1371\/journal.ppat.1001112","volume":"6","author":"C Harris","year":"2010","unstructured":"Harris, C. et al. Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum. PLoS Pathog. 6, e1001112 (2010).","journal-title":"PLoS Pathog."},{"key":"881_CR39","doi-asserted-by":"crossref","first-page":"e1002255","DOI":"10.1371\/journal.pbio.1002255","volume":"13","author":"J Pompon","year":"2015","unstructured":"Pompon, J. & Levashina, E. A. A new role of the mosquito complement-like cascade in male fertility in Anopheles gambiae. PLoS Biol. 13, e1002255 (2015).","journal-title":"PLoS Biol."},{"key":"881_CR40","doi-asserted-by":"crossref","unstructured":"Tiller, T. et al. Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J. Immunol. Methods 329, 112\u2013124 (2008).","DOI":"10.1016\/j.jim.2007.09.017"},{"key":"881_CR41","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jim.2008.02.010","volume":"334","author":"T Tiller","year":"2008","unstructured":"Tiller, T. et al. Corrigendum to\u2019Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning\u2019. J. Immunol. Methods 334, 142 (2008).","journal-title":"J. Immunol. Methods"},{"key":"881_CR42","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","volume":"301","author":"H Wardemann","year":"2003","unstructured":"Wardemann, H. et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374\u20131377 (2003).","journal-title":"Science"},{"key":"881_CR43","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jmb.2017.12.010","volume":"430","author":"J Ere\u00f1o-Orbea","year":"2018","unstructured":"Ere\u00f1o-Orbea, J. et al. Structural basis of enhanced crystallizability induced by a molecular chaperone for antibody antigen-binding fragments. J. Mol. Biol. 430, 322\u2013336 (2018).","journal-title":"J. Mol. Biol."},{"key":"881_CR44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","volume":"66","author":"W Kabsch","year":"2010","unstructured":"Kabsch, W. XDS. Acta Crystallogr. D. Biol. Crystallogr. 66, 125\u2013132 (2010).","journal-title":"Acta Crystallogr. D. Biol. Crystallogr."},{"key":"881_CR45","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"AJ McCoy","year":"2007","unstructured":"McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Cystallography 40, 658\u2013674 (2007).","journal-title":"J. Appl. Cystallography"},{"key":"881_CR46","doi-asserted-by":"crossref","unstructured":"Adams, P. D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. Sect. D Biol. Crystallogr. 66, 213\u2013221 (2010).","DOI":"10.1107\/S0907444909052925"},{"key":"881_CR47","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"P Emsley","year":"2010","unstructured":"Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr. D. Biol. Crystallogr. 66, 486\u2013501 (2010).","journal-title":"Acta Crystallogr. D. Biol. Crystallogr."},{"key":"881_CR48","doi-asserted-by":"crossref","first-page":"e01456","DOI":"10.7554\/eLife.01456","volume":"2","author":"A Morin","year":"2013","unstructured":"Morin, A. et al. Collaboration gets the most out of software. Elife 2, e01456 (2013).","journal-title":"Elife"},{"key":"881_CR49","doi-asserted-by":"crossref","first-page":"40ra49-40ra49","DOI":"10.1126\/scitranslmed.3001058","volume":"2","author":"J Friesen","year":"2010","unstructured":"Friesen, J. et al. Natural immunization against malaria: causal prophylaxis with antibiotics. Sci. Transl. Med. 2, 40ra49-40ra49 (2010).","journal-title":"Sci. Transl. Med."},{"key":"881_CR50","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41564-019-0414-9","volume":"4","author":"M Gildenhard","year":"2019","unstructured":"Gildenhard, M. et al. Mosquito microevolution drives Plasmodium falciparum dynamics. Nat. Microbiol. 4, 941\u2013947 (2019).","journal-title":"Nat. Microbiol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41591-020-0881-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41591-020-0881-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41591-020-0881-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T18:03:02Z","timestamp":1684605782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41591-020-0881-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["881"],"URL":"https:\/\/doi.org\/10.1038\/s41591-020-0881-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/798769","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]},"assertion":[{"value":"7 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.B., K.P. and G.M. declare no conflicts of interest. R.M., T.D. H.W., G.C., E.A.L., S.W.S., E.T. and J.-P.J. have filed a patent application related to mAb 4493 and mAb 2541.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}