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Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters\n                    <jats:sup>5\u20137<\/jats:sup>\n                    and nonhuman primates\n                    <jats:sup>8\u201310<\/jats:sup>\n                    have generally reported mild clinical disease, and preclinical SARS-CoV-2 vaccine studies have demonstrated reduction of viral replication in the upper and lower respiratory tracts in nonhuman primates\n                    <jats:sup>11\u201313<\/jats:sup>\n                    . Here we show that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals. A single immunization with an adenovirus serotype 26 vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein elicited binding and neutralizing antibody responses and protected against SARS-CoV-2-induced weight loss, pneumonia and mortality. These data demonstrate vaccine protection against SARS-CoV-2 clinical disease. This model should prove useful for preclinical studies of SARS-CoV-2 vaccines, therapeutics and pathogenesis.\n                  <\/jats:p>","DOI":"10.1038\/s41591-020-1070-6","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T06:04:10Z","timestamp":1599113050000},"page":"1694-1700","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":293,"title":["Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-5684","authenticated-orcid":false,"given":"Lisa 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