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We conducted a long-term follow-up in a prospective cohort study of 312 patients\u2014247 home-isolated and 65 hospitalized\u2014comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189\/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32\/61) of home-isolated young adults, aged 16\u201330 years, had symptoms at 6 months, including loss of taste and\/or smell (28%, 17\/61), fatigue (21%, 13\/61), dyspnea (13%, 8\/61), impaired concentration (13%, 8\/61) and memory problems (11%, 7\/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.<\/jats:p>","DOI":"10.1038\/s41591-021-01433-3","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T06:06:11Z","timestamp":1624428371000},"page":"1607-1613","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":588,"title":["Long COVID in a prospective cohort of home-isolated patients"],"prefix":"10.1038","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-4297","authenticated-orcid":false,"given":"Bj\u00f8rn","family":"Blomberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-1719","authenticated-orcid":false,"given":"Kristin 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