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He serves on the scientific advisory boards for Skyhawk Therapeutics, Exo Therapeutics and Neomorph Therapeutics, none of which are directly related to the content of this paper. P.N. reports grant support from Amgen, Apple, AstraZeneca, Boston Scientific and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Genentech and Novartis and spousal employment at Vertex, all unrelated to the present work. G.K.G. reports affiliation to Moderna Therapeutics, which is unrelated to the present work. M.A. received consulting fees from German Accelerator Life Sciences and is a cofounder of iuvando Health and holds equity, all unrelated to the present work. All other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}