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Commun."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41591-022-01891-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-022-01891-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-022-01891-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T06:05:37Z","timestamp":1660802737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41591-022-01891-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":92,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1891"],"URL":"https:\/\/doi.org\/10.1038\/s41591-022-01891-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-275591\/v1","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"25 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.B. and L.A.Lo. are employees of Regeneron Pharmaceuticals. R.D. has received grants from AstraZeneca, grants and non-financial support from Goldfinch Bio, is a scientific co-founder, consultant and equity holder for Pensieve Health and a consultant for Variant Bio. T.M.M. is an employee of the Healthcare Innovation Lab at BJC HealthCare\/Washington University School of Medicine, an advisor of Myia Labs, and a compensated director of the JF Maddox Foundation in New Mexico. S.Ka. is an employee of Verve Therapeutics, holds equity in Verve Therapeutics and Maze Therapeutics, and has served as a consultant for Acceleron, Eli Lilly, Novartis, Merck, Novo Nordisk, Novo Ventures, Ionis, Alnylam, Aegerion, Haug Partners, Noble Insights, Leerink Partners, Bayer Healthcare, Illumina, Color Genomics, MedGenome, Quest and Medscape. D.J.R. is on the Scientific Advisory Board of Alnylam, Novartis and Verve Therapeutics. M.D.R. is on the scientific advisory board for Goldfinch Bio and Cipherome. C.J.O. became an employee of Novartis after the initial submission of the manuscript. P.N. reports investigator-initiated grants from Amgen, Apple, AstraZeneca, Boston Scientific and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Invitae, Foresite Labs, Novartis and Roche\/Genentech, and is a co-founder of TenSixteen Bio, a shareholder of geneXwell, TenSixteen Bio and Vertex, a scientific advisory board member of geneXwell and TenSixteen Bio, and reports spousal employment at Vertex, all unrelated to the present work. S.M.D. receives research support from RenalytixAI to his institution and consulting fees from Calico Labs. A.G.B. is a scientific co-founder and equity holder in TenSixteen Bio. All other authors have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}