{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:31:09Z","timestamp":1793748669989,"version":"4.6.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["467697427"],"award-info":[{"award-number":["467697427"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1038\/s41591-023-02232-8","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T12:03:50Z","timestamp":1681301030000},"page":"846-858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Body composition and lung cancer-associated cachexia in TRACERx"],"prefix":"10.1038","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-0570","authenticated-orcid":false,"given":"Othman","family":"Al-Sawaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Skrzypski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-5029","authenticated-orcid":false,"given":"Jie Min","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-2360","authenticated-orcid":false,"given":"Takahiro","family":"Karasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Zambrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0341-7878","authenticated-orcid":false,"given":"Alexander M.","family":"Frankell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B. K.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-0565","authenticated-orcid":false,"given":"Carlos","family":"Mart\u00ednez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Puttick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R. M.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-4999","authenticated-orcid":false,"given":"Ariana","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-8332","authenticated-orcid":false,"given":"Maise Al","family":"Bakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Soka\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraju","family":"Veeriah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Magno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Naceur-Lombardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Prymas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Toncheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-5279","authenticated-orcid":false,"given":"Sophia","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Jayanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-3801","authenticated-orcid":false,"given":"Roberto","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-351X","authenticated-orcid":false,"given":"Christopher P.","family":"Bridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-0242","authenticated-orcid":false,"given":"David C.","family":"Christiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-0565","authenticated-orcid":false,"given":"Raymond H.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camden","family":"Bay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7970-3643","authenticated-orcid":false,"given":"Paul","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-1980","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-472X","authenticated-orcid":false,"given":"Norbert","family":"Perrimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karteek","family":"Popuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza Faisal","family":"Beg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"McGranahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-5070","authenticated-orcid":false,"given":"Allan","family":"Hackshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna M.","family":"Breen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-4449","authenticated-orcid":false,"given":"Stephen","family":"O\u2019Rahilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-9587","authenticated-orcid":false,"given":"Nicolai J.","family":"Birkbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-2003","authenticated-orcid":false,"given":"Hugo J. W. L.","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TRACERx Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B. K.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai J.","family":"Birkbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Jwl","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason F.","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Nakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmina","family":"Sodha-Ramdeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Tufail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Fiyaz","family":"Chowdhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Scotland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Boyles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Rathinam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenic","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Dulloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Fennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdeep","family":"Matharu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqui A.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Primrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterini","family":"Boleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Cheyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Cruickshank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Benafif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayleigh","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Lacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Langman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Shackleford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madava","family":"Djearaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Kadiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Leek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Davies","family":"Hodgkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Totten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eustace","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Granato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Doran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Novasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendadai","family":"Rammohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Crosbie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynsey","family":"Priest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R.","family":"Lindsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona H.","family":"Blackhall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Summers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Clipson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Tugwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic G.","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Kilgour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland F.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom L.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Van Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Szallasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Kisistok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Sokac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklos","family":"Diossy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Demeulemeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Bunkum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aengus","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Magness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Karamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Chain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany B.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Castignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Abbosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Weeden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentin","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crispin T.","family":"Hiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Karagianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruva","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Hoxha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Larose","family":"Cadieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia L.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Colliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Nye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felip","family":"G\u00e1lvez-Cancino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Athanasopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gimeno-Valiente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kassiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Stavrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Mastrokalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio Garcia","family":"Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacki","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Reading","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant K.","family":"Rane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Nicod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Hartley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl S.","family":"Peggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katey S. S.","family":"Enfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayalvizhi","family":"Selvaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Thol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Litchfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krijn","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiana","family":"Grigoriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupa","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Ensell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vasquez","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Litovchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Werner","family":"Sunderland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Dietzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Escudero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Angelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miljana","family":"Tani\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnennaya","family":"Kanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Chervova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Pich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Kevin","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bentham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Hynds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Vendramin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadegh","family":"Saghafinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saioa","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng Kuong Anakin","family":"Ung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Quezada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Vanloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Zaccaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Hessey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Boeing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supreet Kaur","family":"Bola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Denner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Marafioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanos P.","family":"Mourikis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Spanswick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Barb\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Kin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Ramsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Royle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Antoine","family":"Collins-Fekete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fraioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ashford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siow Ming","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Borg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Falzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysis","family":"Papadatos-Pastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander James","family":"Procter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali N.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Patrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Navani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky M.","family":"Thakrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam M.","family":"Janes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie Martinoni","family":"Hoogenboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Monk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Holding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junaid","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Bhakhri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Scarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Panagiotopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Khiroya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert CM.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yien Ning Sophia","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Bandula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjot Kaur","family":"Dhanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Pilotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Grapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"AbdulJabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairead","family":"MacKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Chee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Alzetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Cave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Scarlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papawadee","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Austin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"De Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilgardt","family":"Raubenheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshil","family":"Bhayani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hema","family":"Chavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofina","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silviu I.","family":"Buderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kaniu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mpho","family":"Malima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Proli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Hewish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Danson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Shackcloth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Blyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Le Quesne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Bilancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Kostoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-1259","authenticated-orcid":false,"given":"Mariam","family":"Jamal-Hanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-3018","authenticated-orcid":false,"given":"Charles","family":"Swanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"2232_CR1","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","author":"EE Calle","year":"2003","unstructured":"Calle, E. E., Rodriguez, C., Walker-Thurmond, K. & Thun, M. J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N. Engl. J. Med. 348, 1625\u20131638 (2003).","journal-title":"N. Engl. J. Med."},{"key":"2232_CR2","doi-asserted-by":"publisher","first-page":"e4225","DOI":"10.1097\/MD.0000000000004225","volume":"95","author":"Y Guo","year":"2016","unstructured":"Guo, Y. et al. Body mass index and mortality in chronic obstructive pulmonary disease: a dose-response meta-analysis. Medicine 95, e4225 (2016).","journal-title":"Medicine"},{"key":"2232_CR3","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.jacc.2014.01.022","volume":"63","author":"CJ Lavie","year":"2014","unstructured":"Lavie, C. J., McAuley, P. A., Church, T. S., Milani, R. V. & Blair, S. N. Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox. J. Am. Coll. Cardiol. 63, 1345\u20131354 (2014).","journal-title":"J. Am. Coll. Cardiol."},{"key":"2232_CR4","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","volume":"31","author":"L Martin","year":"2013","unstructured":"Martin, L. et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J. Clin. Oncol. 31, 1539\u20131547 (2013).","journal-title":"J. Clin. Oncol."},{"key":"2232_CR5","doi-asserted-by":"publisher","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"VE Baracos","year":"2018","unstructured":"Baracos, V. E., Martin, L., Korc, M., Guttridge, D. C. & Fearon, K. C. H. Cancer-associated cachexia. Nat. Rev. Dis. Primers 4, 17105 (2018).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2232_CR6","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon, K. et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 12, 489\u2013495 (2011).","journal-title":"Lancet Oncol."},{"key":"2232_CR7","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/jcsm.12305","volume":"9","author":"JC Brown","year":"2018","unstructured":"Brown, J. C. et al. The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I\u2013III colorectal cancer: a population-based cohort study (C-SCANS). J. Cachexia Sarcopenia Muscle 9, 664\u2013672 (2018).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2232_CR8","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1001\/jamaoncol.2018.0137","volume":"4","author":"BJ Caan","year":"2018","unstructured":"Caan, B. J. et al. Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer. JAMA Oncol. 4, 798\u2013804 (2018).","journal-title":"JAMA Oncol."},{"key":"2232_CR9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.juro.2018.01.069","volume":"200","author":"JS Lee","year":"2018","unstructured":"Lee, J. S. et al. Subcutaneous fat distribution is a prognostic biomarker for men with castration resistant prostate cancer. J. Urol. 200, 114\u2013120 (2018).","journal-title":"J. Urol."},{"key":"2232_CR10","doi-asserted-by":"publisher","first-page":"1133s","DOI":"10.3945\/ajcn.2010.28608C","volume":"91","author":"VE Baracos","year":"2010","unstructured":"Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I. & Antoun, S. Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis. Am. J. Clin. Nutr. 91, 1133s\u20131137s (2010).","journal-title":"Am. J. Clin. Nutr."},{"key":"2232_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.chest.2019.04.115","volume":"156","author":"M Yang","year":"2019","unstructured":"Yang, M., Shen, Y., Tan, L. & Li, W. Prognostic value of sarcopenia in lung cancer: a systematic review and meta-analysis. Chest 156, 101\u2013111 (2019).","journal-title":"Chest"},{"key":"2232_CR12","doi-asserted-by":"publisher","first-page":"e1580128","DOI":"10.1080\/2162402X.2019.1580128","volume":"8","author":"G Popinat","year":"2019","unstructured":"Popinat, G. et al. Subcutaneous fat mass measured on multislice computed tomography of pretreatment PET\/CT is a prognostic factor of stage IV non-small cell lung cancer treated by nivolumab. Oncoimmunology 8, e1580128 (2019).","journal-title":"Oncoimmunology"},{"key":"2232_CR13","doi-asserted-by":"publisher","first-page":"7429319","DOI":"10.1155\/2022\/7429319","volume":"2022","author":"H Tan","year":"2022","unstructured":"Tan, H. et al. Preoperative body composition combined with tumor metabolism analysis by PET\/CT is associated with disease-free survival in patients with NSCLC. Contrast Media Mol. Imaging 2022, 7429319 (2022).","journal-title":"Contrast Media Mol. Imaging"},{"key":"2232_CR14","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1139\/H08-075","volume":"33","author":"M Mourtzakis","year":"2008","unstructured":"Mourtzakis, M. et al. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl. Physiol. Nutr. Metab. 33, 997\u20131006 (2008).","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"2232_CR15","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1152\/japplphysiol.00744.2004","volume":"97","author":"W Shen","year":"2004","unstructured":"Shen, W. et al. Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J. Appl. Physiol. 97, 2333\u20132338 (2004).","journal-title":"J. Appl. Physiol."},{"key":"2232_CR16","doi-asserted-by":"publisher","first-page":"101776","DOI":"10.1016\/j.compmedimag.2020.101776","volume":"85","author":"S Dabiri","year":"2020","unstructured":"Dabiri, S. et al. Deep learning method for localization and segmentation of abdominal CT. Comput. Med. Imaging Graph 85, 101776 (2020).","journal-title":"Comput. Med. Imaging Graph"},{"key":"2232_CR17","unstructured":"Frankell, A. M. et al. The natural history of NSCLC and impact of subclonal selection in TRACERx. Nature (In press) (2023)."},{"key":"2232_CR18","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1056\/NEJMoa1616288","volume":"376","author":"M Jamal-Hanjani","year":"2017","unstructured":"Jamal-Hanjani, M. et al. Tracking the evolution of non-small-cell lung cancer. N. Engl. J. Med. 376, 2109\u20132121 (2017).","journal-title":"N. Engl. J. Med."},{"key":"2232_CR19","unstructured":"Christiani, D. B. Lung Cancer Study. https:\/\/sites.sph.harvard.edu\/blcs\/ (2022)."},{"key":"2232_CR20","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.1002\/jcsm.13080","volume":"13","author":"I Anyene","year":"2022","unstructured":"Anyene, I. et al. Body composition from single versus multi-slice abdominal computed tomography: concordance and associations with colorectal cancer survival. J. Cachexia Sarcopenia Muscle 13, 2974\u20132984 (2022).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2232_CR21","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/ng.686","volume":"42","author":"EK Speliotes","year":"2010","unstructured":"Speliotes, E. K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937\u2013948 (2010).","journal-title":"Nat. Genet."},{"key":"2232_CR22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature14177","volume":"518","author":"AE Locke","year":"2015","unstructured":"Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197\u2013206 (2015).","journal-title":"Nature"},{"key":"2232_CR23","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.1093\/hmg\/ddu248","volume":"23","author":"W Wen","year":"2014","unstructured":"Wen, W. et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum. Mol. Genet 23, 5492\u20135504 (2014).","journal-title":"Hum. Mol. Genet"},{"key":"2232_CR24","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1038\/ng.3951","volume":"49","author":"M Akiyama","year":"2017","unstructured":"Akiyama, M. et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat. Genet. 49, 1458\u20131467 (2017).","journal-title":"Nat. Genet."},{"key":"2232_CR25","doi-asserted-by":"publisher","first-page":"e1005378","DOI":"10.1371\/journal.pgen.1005378","volume":"11","author":"TW Winkler","year":"2015","unstructured":"Winkler, T. W. et al. The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PLoS Genet 11, e1005378 (2015).","journal-title":"PLoS Genet"},{"key":"2232_CR26","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/jcsm.12138","volume":"8","author":"N Johns","year":"2017","unstructured":"Johns, N. et al. New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss. J. Cachexia Sarcopenia Muscle 8, 122\u2013130 (2017).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2232_CR27","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1038\/bjc.2011.323","volume":"105","author":"TS Solheim","year":"2011","unstructured":"Solheim, T. S. et al. Is there a genetic cause for cancer cachexia? A clinical validation study in 1,797 patients. Br. J. Cancer 105, 1244\u20131251 (2011).","journal-title":"Br. J. Cancer"},{"key":"2232_CR28","doi-asserted-by":"publisher","first-page":"e1007222","DOI":"10.1371\/journal.pgen.1007222","volume":"14","author":"TJ Baranski","year":"2018","unstructured":"Baranski, T. J. et al. A high-throughput, functional screen of human body mass index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses. PLOS Genet. 14, e1007222 (2018).","journal-title":"PLOS Genet."},{"key":"2232_CR29","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1016\/j.devcel.2021.08.008","volume":"56","author":"W Lodge","year":"2021","unstructured":"Lodge, W. et al. Tumor-derived MMPs regulate cachexia in a Drosophila cancer model. Dev. Cell 56, 2664\u20132680 (2021).","journal-title":"Dev. Cell"},{"key":"2232_CR30","doi-asserted-by":"publisher","first-page":"109553","DOI":"10.1016\/j.celrep.2021.109553","volume":"36","author":"G Ding","year":"2021","unstructured":"Ding, G. et al. Coordination of tumor growth and host wasting by tumor-derived Upd3. Cell Rep. 36, 109553 (2021).","journal-title":"Cell Rep."},{"key":"2232_CR31","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.devcel.2015.02.012","volume":"33","author":"Y Kwon","year":"2015","unstructured":"Kwon, Y. et al. Systemic organ wasting induced by localized expression of the secreted insulin\/IGF antagonist ImpL2. Dev. Cell 33, 36\u201346 (2015).","journal-title":"Dev. Cell"},{"key":"2232_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.devcel.2018.12.003","volume":"48","author":"W Song","year":"2019","unstructured":"Song, W. et al. Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation. Dev. Cell 48, 277\u2013286 (2019).","journal-title":"Dev. Cell"},{"key":"2232_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18502-9","volume":"11","author":"H Newton","year":"2020","unstructured":"Newton, H. et al. Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Nat. Commun. 11, 4653 (2020).","journal-title":"Nat. Commun."},{"key":"2232_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.devcel.2015.03.001","volume":"33","author":"A Figueroa-Clarevega","year":"2015","unstructured":"Figueroa-Clarevega, A. & Bilder, D. Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting. Dev. Cell 33, 47\u201355 (2015).","journal-title":"Dev. Cell"},{"key":"2232_CR35","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1016\/j.devcel.2021.08.010","volume":"56","author":"J Kim","year":"2021","unstructured":"Kim, J. et al. Tumor-induced disruption of the blood\u2013brain barrier promotes host death. Dev. Cell 56, 2712\u20132721 (2021).","journal-title":"Dev. Cell"},{"key":"2232_CR36","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.cell.2018.12.009","volume":"176","author":"AA van der Klaauw","year":"2019","unstructured":"van der Klaauw, A. A. et al. Human semaphorin 3 variants link melanocortin circuit development and energy balance. Cell 176, 729\u2013742 (2019).","journal-title":"Cell"},{"key":"2232_CR37","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s13539-011-0043-5","volume":"2","author":"K Trobec","year":"2011","unstructured":"Trobec, K., von Haehling, S., Anker, S. D. & Lainscak, M. Growth hormone, insulin-like growth factor 1, and insulin signaling\u2014a pharmacological target in body wasting and cachexia. J. Cachexia Sarcopenia Muscle 2, 191\u2013200 (2011).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2232_CR38","doi-asserted-by":"crossref","unstructured":"Mermel, C.H., Schumacher, S.E., Hill, B. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011).","DOI":"10.1186\/gb-2011-12-4-r41"},{"key":"2232_CR39","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3390\/ijms18061321","volume":"18","author":"AE Achari","year":"2017","unstructured":"Achari, A. E. & Jain, S. K. Adiponectin, a therapeutic target for obesity, diabetes and endothelial dysfunction. Int J. Mol. Sci. 18, 1321 (2017).","journal-title":"Int J. Mol. Sci."},{"key":"2232_CR40","doi-asserted-by":"crossref","unstructured":"Bentham, R. et al. Using DNA sequencing data to quantify T cell fraction and therapy response. Nature 597, 555\u2013560 (2021).","DOI":"10.1038\/s41586-021-03894-5"},{"key":"2232_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0215-8","volume":"5","author":"P Danaher","year":"2017","unstructured":"Danaher, P. et al. Gene expression markers of tumor infiltrating leukocytes. J. Immunother. Cancer 5, 18 (2017).","journal-title":"J. Immunother. Cancer"},{"key":"2232_CR42","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman, A. M. et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol. 37, 773\u2013782 (2019).","journal-title":"Nat. Biotechnol."},{"key":"2232_CR43","doi-asserted-by":"publisher","first-page":"e95192","DOI":"10.1371\/journal.pone.0095192","volume":"9","author":"E Assarsson","year":"2014","unstructured":"Assarsson, E. et al. Homogenous 96-Plex PEA immunoassay exhibiting high sensitivity, specificity and excellent scalability. PLoS ONE 9, e95192 (2014).","journal-title":"PLoS ONE"},{"key":"2232_CR44","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/jcsm.12077","volume":"7","author":"L Lerner","year":"2016","unstructured":"Lerner, L. et al. MAP3K11\/GDF15 axis is a critical driver of cancer cachexia. J. Cachexia Sarcopenia Muscle 7, 467\u2013482 (2016).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2232_CR45","doi-asserted-by":"publisher","first-page":"bnaa007","DOI":"10.1210\/endrev\/bnaa007","volume":"41","author":"SM Lockhart","year":"2020","unstructured":"Lockhart, S. M., Saudek, V. & O\u2019Rahilly, S. GDF15: a hormone conveying somatic distress to the brain. Endocr. Rev. 41, bnaa007 (2020).","journal-title":"Endocr. Rev."},{"key":"2232_CR46","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1373\/jalm.2016.022376","volume":"1","author":"KC Wollert","year":"2017","unstructured":"Wollert, K. C. et al. An automated assay for growth differentiation factor 15. J. Appl. Lab. Med. 1, 510\u2013521 (2017).","journal-title":"J. Appl. Lab. Med."},{"key":"2232_CR47","doi-asserted-by":"publisher","first-page":"154868","DOI":"10.1016\/j.cyto.2019.154868","volume":"126","author":"D Cai","year":"2020","unstructured":"Cai, D. et al. Extensive serum biomarker analysis in patients with non-small-cell lung carcinoma. Cytokine 126, 154868 (2020).","journal-title":"Cytokine"},{"key":"2232_CR48","unstructured":"Roche. Elecsys GDF-15 datasheet. https:\/\/diagnostics.roche.com\/global\/en\/products\/params\/elecsys-gdf-15.html (2020)."},{"key":"2232_CR49","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1515\/cclm-2022-0135","volume":"60","author":"P Welsh","year":"2022","unstructured":"Welsh, P. et al. Reference ranges for GDF-15, and risk factors associated with GDF-15, in a large general population cohort. Clin. Chem. Lab. Med. 60, 1820\u20131829 (2022).","journal-title":"Clin. Chem. Lab. Med."},{"key":"2232_CR50","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/S1470-2045(14)70452-8","volume":"15","author":"SS Ramalingam","year":"2014","unstructured":"Ramalingam, S. S. et al. Dacomitinib versus erlotinib in patients with advanced-stage, previously treated non-small-cell lung cancer (ARCHER 1009): a randomised, double-blind, phase 3 trial. Lancet Oncol. 15, 1369\u20131378 (2014).","journal-title":"Lancet Oncol."},{"key":"2232_CR51","doi-asserted-by":"publisher","first-page":"111947","DOI":"10.1016\/j.celrep.2022.111947","volume":"42","author":"JY Kim-Muller","year":"2023","unstructured":"Kim-Muller, J. Y. et al. GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia. Cell Rep. 42, 111947 (2023).","journal-title":"Cell Rep."},{"key":"2232_CR52","doi-asserted-by":"publisher","first-page":"e11152","DOI":"10.1097\/MD.0000000000011152","volume":"97","author":"X He","year":"2018","unstructured":"He, X. et al. Age- and sex-related differences in body composition in healthy subjects aged 18 to 82 years. Medicine 97, e11152 (2018).","journal-title":"Medicine"},{"key":"2232_CR53","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/sj.ijo.0802697","volume":"28","author":"C Bamia","year":"2004","unstructured":"Bamia, C., Trichopoulou, A., Lenas, D. & Trichopoulos, D. Tobacco smoking in relation to body fat mass and distribution in a general population sample. Int. J. Obes. 28, 1091\u20131096 (2004).","journal-title":"Int. J. Obes."},{"key":"2232_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20123-1","volume":"12","author":"R Sartori","year":"2021","unstructured":"Sartori, R., Romanello, V. & Sandri, M. Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat. Commun. 12, 330 (2021).","journal-title":"Nat. Commun."},{"key":"2232_CR55","doi-asserted-by":"publisher","first-page":"18224","DOI":"10.18632\/oncotarget.24804","volume":"9","author":"LB Bindels","year":"2018","unstructured":"Bindels, L. B. et al. Increased gut permeability in cancer cachexia: mechanisms and clinical relevance. Oncotarget 9, 18224\u201318238 (2018).","journal-title":"Oncotarget"},{"key":"2232_CR56","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.matbio.2015.01.013","volume":"44-46","author":"S Cal","year":"2015","unstructured":"Cal, S. & L\u00f3pez-Ot\u00edn, C. ADAMTS proteases and cancer. Matrix Biol. 44-46, 77\u201385 (2015).","journal-title":"Matrix Biol."},{"key":"2232_CR57","first-page":"629","volume":"6","author":"EM de Matos-Neto","year":"2015","unstructured":"de Matos-Neto, E. M. et al. Systemic inflammation in cachexia\u2014is tumor cytokine expression profile the culprit? Front. Immunol. 6, 629 (2015).","journal-title":"Front. Immunol."},{"key":"2232_CR58","doi-asserted-by":"publisher","first-page":"597675","DOI":"10.3389\/fphys.2020.597675","volume":"11","author":"JM Webster","year":"2020","unstructured":"Webster, J. M., Kempen, L. J. A. P., Hardy, R. S. & Langen, R. C. J. Inflammation and skeletal muscle wasting during cachexia. Front. Physiol. 11, 597675 (2020).","journal-title":"Front. Physiol."},{"key":"2232_CR59","doi-asserted-by":"publisher","first-page":"C814","DOI":"10.1152\/ajpcell.00463.2021","volume":"322","author":"L Ying","year":"2022","unstructured":"Ying, L. et al. IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2\/STAT3 pathway. Am. J. Physiol. 322, C814\u2013C824 (2022).","journal-title":"Am. J. Physiol."},{"key":"2232_CR60","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nature13528","volume":"513","author":"S Kir","year":"2014","unstructured":"Kir, S. et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature 513, 100\u2013104 (2014).","journal-title":"Nature"},{"key":"2232_CR61","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.tem.2020.10.004","volume":"31","author":"L Rochette","year":"2020","unstructured":"Rochette, L., Zeller, M., Cottin, Y. & Vergely, C. Insights into mechanisms of GDF15 and receptor GFRAL: therapeutic targets. Trends Endocrinol. Metab. 31, 939\u2013951 (2020).","journal-title":"Trends Endocrinol. Metab."},{"key":"2232_CR62","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41586-021-04133-7","volume":"600","author":"L Mulderrig","year":"2021","unstructured":"Mulderrig, L. et al. Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature 600, 158\u2013163 (2021).","journal-title":"Nature"},{"key":"2232_CR63","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/ijo.2015.242","volume":"40","author":"VW Tsai","year":"2016","unstructured":"Tsai, V. W., Lin, S., Brown, D. A., Salis, A. & Breit, S. N. Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-\u03b2 superfamily cytokine MIC-1\/GDF15. Int J. Obes. 40, 193\u2013197 (2016).","journal-title":"Int J. Obes."},{"key":"2232_CR64","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/nm1677","volume":"13","author":"H Johnen","year":"2007","unstructured":"Johnen, H. et al. Tumor-induced anorexia and weight loss are mediated by the TGF-\u03b2 superfamily cytokine MIC-1. Nat. Med. 13, 1333\u20131340 (2007).","journal-title":"Nat. Med."},{"key":"2232_CR65","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/jcsm.12033","volume":"6","author":"L Lerner","year":"2015","unstructured":"Lerner, L. et al. Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients. J. Cachexia Sarcopenia Muscle 6, 317\u2013324 (2015).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2232_CR66","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/ijo.2017.258","volume":"42","author":"VW Tsai","year":"2018","unstructured":"Tsai, V. W. et al. Treatment with the TGF-\u03b2 superfamily cytokine MIC-1\/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity. Int J. Obes. 42, 561\u2013571 (2018).","journal-title":"Int J. Obes."},{"key":"2232_CR67","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1038\/nm.4393","volume":"23","author":"PJ Emmerson","year":"2017","unstructured":"Emmerson, P. J. et al. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat. Med. 23, 1215\u20131219 (2017).","journal-title":"Nat. Med."},{"key":"2232_CR68","doi-asserted-by":"publisher","unstructured":"Patel, S. et al. Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.06.08.495255 (2022).","DOI":"10.1101\/2022.06.08.495255"},{"key":"2232_CR69","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1172\/JCI44740","volume":"121","author":"K Schledzewski","year":"2011","unstructured":"Schledzewski, K. et al. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J. Clin. Invest 121, 703\u2013714 (2011).","journal-title":"J. Clin. Invest"},{"key":"2232_CR70","unstructured":"Dewys, W. D., Costa, G. & Henkin, R. I. Clinical parameters related to anorexia. Cancer Treat. Rep. 65, 49\u201352 (1981)."},{"key":"2232_CR71","doi-asserted-by":"crossref","unstructured":"Popuri, K., D. Cobzas, N. Esfandiari, et al. Body Composition Assessment in Axial CT Images Using FEM-Based Automatic Segmentation of Skeletal Muscle. IEEE Trans. Med. Imaging 35, 512\u2013520 (2016).","DOI":"10.1109\/TMI.2015.2479252"},{"key":"2232_CR72","unstructured":"Ma, D., V. Chow, K. Popuri, et al. Comprehensive Validation of Automated Whole Body Skeletal Muscle, Adipose Tissue, and Bone Segmentation from 3D CT images for Body Composition Analysis: Towards Extended Body Composition. Preprint at https:\/\/arxiv.org\/abs\/2106.00652 (2021)."},{"key":"2232_CR73","doi-asserted-by":"crossref","unstructured":"Cespedes Feliciano, E. M., Popuri, K., Cobzas, D. et al. Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients. J. Cachexia Sarcopenia Muscle 11, 1258\u20131269 (2020).","DOI":"10.1002\/jcsm.12573"},{"key":"2232_CR74","doi-asserted-by":"crossref","unstructured":"Arribas, L., Sabat\u00e9-Llobera, A., Domingo, M.C. et al. Assessing dynamic change in muscle during treatment of patients with cancer: Precision testing standards. Clin. Nutr. 41, 1059\u20131065 (2022).","DOI":"10.1016\/j.clnu.2022.03.016"},{"key":"2232_CR75","doi-asserted-by":"crossref","unstructured":"Bridge, C. P., Rosenthal, M., Wright, B. et al. In OR 2.0 Context-Aware Operating Theaters, Computer Assisted Robotic Endoscopy, Clinical Image-Based Procedures, and Skin Image Analysis. (eds. Stoyanov, D. et al.) Fully-Automated Analysis of Body Composition from CT in Cancer Patients Using Convolutional Neural Networks (Springer International Publishing, 2018).","DOI":"10.1007\/978-3-030-01201-4_22"},{"key":"2232_CR76","doi-asserted-by":"crossref","unstructured":"Magudia, K., Bridge, C. P., Bay, C. P. et al. Population-Scale CT-based Body Composition Analysis of a Large Outpatient Population Using Deep Learning to Derive Age-, Sex-, and Race-specific Reference Curves. Radiology 298, 319\u2013329 (2021).","DOI":"10.1148\/radiol.2020201640"},{"key":"2232_CR77","doi-asserted-by":"crossref","unstructured":"Martin, L., Senesse, P., Gioulbasanis, I. et al. Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss. J. Clin. Oncol. 33, 90\u201399 (2014).","DOI":"10.1200\/JCO.2014.56.1894"},{"key":"2232_CR78","doi-asserted-by":"crossref","unstructured":"Rosenthal, R., Cadieux, E. L., Salgado, R. et al. Neoantigen-directed immune escape in lung cancer evolution. Nature 567, 479\u2013485 (2019).","DOI":"10.1038\/s41586-019-1032-7"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41591-023-02232-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-023-02232-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-023-02232-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T11:07:46Z","timestamp":1681902466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41591-023-02232-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["2232"],"URL":"https:\/\/doi.org\/10.1038\/s41591-023-02232-8","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"20 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"O.A.S.: Advisory Board (AstraZeneca, AbbVie, Ascentage, Gilead, Janssen and Roche), speaker honoraria (Adaptive, AstraZeneca, AbbVie, BeiGene, Eli Lilly, Gilead, Janssen and Roche), research funding (BeiGene, AbbVie, Janssen and Roche). J.M.L. receives research funding from the NIHR. A.M.F. is a named inventor on a patent application to determine methods and systems for tumor monitoring (PCT\/EP2022\/077987). M.A.B. has consulted for Achilles Therapeutics. S.C.: employment (Pfizer). M.R. receives research funding from the NIH, Lustgarten Foundation, Stand Up to Cancer Foundation and the Hale Family Center for Pancreatic Cancer at DFCI. N.S.: consultancy and\/or speaker honoraria for Abbott Laboratories, Afimmune, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Hanmi Pharmaceuticals, Janssen, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Roche Diagnostics and Sanofi; research grants for AstraZeneca, Boehringer Ingelheim, Roche Diagnostics and Novartis. P.W.: grant income from Roche Diagnostics, AstraZeneca, Boehringer Ingelheim and Novartis and speaker\u2019s fees from Novo Nordisk outside the submitted work. K.P. and M.F.B. actively direct Voronoi Health Analytics Incorporated, a Canadian corporation that sells commercial licenses for the DAFS software. R.H.M.: Advisory Board (ViewRay, AstraZeneca), consulting (Varian Medical Systems, Sio Capital Management), honorarium (Novartis, Springer Nature), ownership (Health-AI) and research funding (ViewRay). N.M. has stock options in and has consulted for Achilles Therapeutics and holds a European patents relating to targeting neoantigens (PCT\/EP2016\/ 059401), identifying patient response to immune checkpoint blockade (PCT\/ EP2016\/071471), determining HLA LOH (PCT\/GB2018\/052004), predicting survival rates of patients with cancer (PCT\/GB2020\/050221). D.M.B.: employment (Pfizer). S.O.R.: consultancy (Pfizer, AstraZeneca, Northsea and Third Rock Ventures). N.J.B. is a co-inventor of a patent to identify responders to cancer treatment (PCT\/GB2018\/051912), and a patent to predict HRD deficiency (US10190160B2). H.J.W.J.A. is scientific advisor and shareholder of Onc.AI, Love Health, Health-AI and Sphera, and receives consulting fees from BMS and Editas Medicine (all outside the presented work). M.J.-H. is a CRUK Career Establishment Awardee and has received funding from CRUK, IASLC International Lung Cancer Foundation, Lung Cancer Research Foundation, Rosetrees Trust, UKI NETs, NIHR and NIHR UCLH Biomedical Research Centre. M.J.-H. has consulted and is a member of the Scientific Advisory Board and Steering Committee, for Achilles Therapeutics, has received speaker honoraria from Astex Pharmaceuticals, Oslo Cancer Cluster and Pfizer, and is co-inventor on a patent PCT\/US2017\/028013 relating to methods for lung cancer detection. C.S. acknowledges grant support from AstraZeneca, Boehringer-Ingelheim, Bristol Myers Squibb, Pfizer, Roche-Ventana, Invitae (previously Archer Dx Inc - collaboration in minimal residual disease sequencing technologies), and Ono Pharmaceutical. C.S. is an AstraZeneca Advisory Board member and Chief Investigator for the AZ MeRmaiD 1 and 2 clinical trials and is also Co-Chief Investigator of the NHS Galleri trial funded by GRAIL and a paid member of GRAIL\u2019s Scientific Advisory Board. He receives consultant fees from Achilles Therapeutics (also SAB member), Bicycle Therapeutics (also a SAB member), Genentech, Medicxi, Roche Innovation Centre \u2013 Shanghai, Metabomed (until July 2022), and the Sarah Cannon Research Institute. C.S. had stock options in Apogen Biotechnologies and GRAIL until June 2021, and currently has stock options in Epic Bioscience, Bicycle Therapeutics, and has stock options and is co-founder of Achilles Therapeutics. C.S. is an inventor on a European patent application relating to assay technology to detect tumour recurrence (PCT\/GB2017\/053289), the patent has been licensed to commercial entities and under his terms of employment with C.S due a revenue share of any revenue generated from such license(s). C.S. holds patents relating to targeting neoantigens (PCT\/EP2016\/059401), identifying patient response to immune checkpoint blockade (PCT\/EP2016\/071471), determining HLA LOH (PCT\/GB2018\/052004), predicting survival rates of patients with cancer (PCT\/GB2020\/050221), identifying patients who respond to cancer treatment (PCT\/GB2018\/051912), US patent relating to detecting tumour mutations (PCT\/US2017\/28013), methods for lung cancer detection (US20190106751A1) and both a European and US patent related to identifying insertion\/deletion mutation targets (PCT\/GB2018\/051892) and is co-inventor to a patent application to determine methods and systems for tumour monitoring (PCT\/EP2022\/077987). C.S. is a named inventor on a provisional patent protection related to a ctDNA detection algorithm.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}