{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:55:00Z","timestamp":1792821300301,"version":"4.5.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421620\/2023-4"],"award-info":[{"award-number":["421620\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FAPEAM - Funda\u00e7\u00e3o de Amparo \u00c0 Pesquisa do Estado do Amazonas","id":[{"id":"https:\/\/ror.org\/026d6ma13","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1038\/s41591-024-03300-3","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T10:02:36Z","timestamp":1726653756000},"page":"3509-3521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region"],"prefix":"10.1038","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-1060","authenticated-orcid":false,"given":"Felipe Gomes","family":"Naveca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9086-8530","authenticated-orcid":false,"given":"Tatiana Amaral Pires de","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdinete","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejanane","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Silva de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natana","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Maito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1tia","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"F\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-2310","authenticated-orcid":false,"given":"Fernanda Sindeaux","family":"Camelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samyly Coutinho de Aguiar","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsandro Xavier de","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00edse Gomes","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Almeida de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Ruth","family":"Arcanjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Andr\u00e9 J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Lia Coragem de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosiane","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicil\u00e9ia","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Linhares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayn\u00e3","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francy","family":"Mariscal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Andr\u00e9a","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Marinho","family":"Presibella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Fernando Quallio","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deusilene","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson Alves da Silva","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Ma\u00edsa","family":"Passos-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Hugo","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Maria Pinto de","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cec\u00edlia Ribeiro","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Neves","family":"Casseb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannifer Oliveira","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Vinhal","family":"Frutuoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-0890","authenticated-orcid":false,"given":"Lucas","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00falio de Lima","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1419-5713","authenticated-orcid":false,"given":"Gabriel Luz","family":"Wallau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-8025","authenticated-orcid":false,"given":"Roberto Dias","family":"Lins Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura W.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Bispo de","family":"Filippis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-7975","authenticated-orcid":false,"given":"Tiago","family":"Gr\u00e4f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ighor","family":"Arantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-007X","authenticated-orcid":false,"given":"Ana I.","family":"Bento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Delatorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-2793","authenticated-orcid":false,"given":"Gonzalo","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"3300_CR1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4269\/ajtmh.16-0672","volume":"96","author":"JFT Da Rosa","year":"2017","unstructured":"Da Rosa, J. F. T. et al. Oropouche virus: clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus. Am. J. Trop. Med. Hyg. 96, 1019\u20131030 (2017).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"3300_CR2","doi-asserted-by":"crossref","first-page":"e0246932","DOI":"10.1371\/journal.pone.0246932","volume":"16","author":"JW Pereira-Silva","year":"2021","unstructured":"Pereira-Silva, J. W. et al. Distribution and diversity of mosquitoes and Oropouche-like virus infection rates in an Amazonian rural settlement. PLoS ONE 16, e0246932 (2021).","journal-title":"PLoS ONE"},{"key":"3300_CR3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1590\/0074-02760150123","volume":"110","author":"BF Cardoso","year":"2015","unstructured":"Cardoso, B. F. et al. Detection of Oropouche virus segment S in patients and in Culex quinquefasciatus in the state of Mato Grosso, Brazil. Mem. Inst. Oswaldo Cruz 110, 745\u2013754 (2015).","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"3300_CR4","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1126\/science.6800036","volume":"215","author":"FP Pinheiro","year":"1982","unstructured":"Pinheiro, F. P., Travassos Da Rosa, A. P. A., Gomes, M. L. C., LeDuc, J. W. & Hoch, A. L. Transmission of Oropouche virus from man to hamster by the midge Culicoides paraensis. Science 215, 1251\u20131253 (1982).","journal-title":"Science"},{"key":"3300_CR5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4269\/ajtmh.1981.30.165","volume":"30","author":"DR Roberts","year":"1981","unstructured":"Roberts, D. R., Hoch, A. L., Dixon, K. E. & Llewellyn, C. H. Oropouche virus. III. Entomological observations from three epidemics in Par\u00e1, Brazil, 1975. Am. J. Trop. Med. Hyg. 30, 165\u2013171 (1981).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"3300_CR6","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1016\/S1473-3099(23)00740-5","volume":"24","author":"KM Wesselmann","year":"2024","unstructured":"Wesselmann, K. M. et al. Emergence of Oropouche fever in Latin America: a narrative review. Lancet Infect. Dis. 24, e439\u2013e452 (2024).","journal-title":"Lancet Infect. Dis."},{"key":"3300_CR7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1590\/S0037-86822007000200016","volume":"40","author":"LTM Figueiredo","year":"2007","unstructured":"Figueiredo, L. T. M. Emergent arboviruses in Brazil. Rev. Soc. Bras. Med. Trop. 40, 224\u2013229 (2007).","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"3300_CR8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/v10040175","volume":"10","author":"H Sakkas","year":"2018","unstructured":"Sakkas, H., Bozidis, P., Franks, A. & Papadopoulou, C. Oropouche fever: a review. Viruses 10, 175 (2018).","journal-title":"Viruses"},{"key":"3300_CR9","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3201\/eid1512.090917","volume":"15","author":"MPG Mour\u00e3o","year":"2009","unstructured":"Mour\u00e3o, M. P. G. et al. Oropouche fever outbreak, Manaus, Brazil, 2007\u20132008. Emerg. Infect. Dis. 15, 2063\u20132064 (2009).","journal-title":"Emerg. Infect. Dis."},{"key":"3300_CR10","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1099\/vir.0.000108","volume":"96","author":"NL Tilston-Lunel","year":"2015","unstructured":"Tilston-Lunel, N. L. et al. Genetic analysis of members of the species Oropouche virus and identification of a novel M segment sequence. J. Gen. Virol. 96, 1636\u20131650 (2015).","journal-title":"J. Gen. Virol."},{"key":"3300_CR11","doi-asserted-by":"crossref","first-page":"105155","DOI":"10.1016\/j.jcv.2022.105155","volume":"150\u2013151","author":"VL Carvalho","year":"2022","unstructured":"Carvalho, V. L. et al. Arbovirus outbreak in a rural region of the Brazilian Amazon. J. Clin. Virol. 150\u2013151, 105155 (2022).","journal-title":"J. Clin. Virol."},{"key":"3300_CR12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jcv.2008.11.006","volume":"44","author":"HB Vasconcelos","year":"2009","unstructured":"Vasconcelos, H. B. et al. Oropouche fever epidemic in Northern Brazil: epidemiology and molecular characterization of isolates. J. Clin. Virol. 44, 129\u2013133 (2009).","journal-title":"J. Clin. Virol."},{"key":"3300_CR13","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3201\/eid1306.061114","volume":"13","author":"RDSDS Azevedo","year":"2007","unstructured":"Azevedo, R. D. S. D. S. et al. Reemergence of Oropouche fever, northern Brazil. Emerg. Infect. Dis. 13, 912\u2013915 (2007).","journal-title":"Emerg. Infect. Dis."},{"key":"3300_CR14","unstructured":"Naveca, F. G., Nascimento, V. A., Souza, V. C. & Figueiredo, R. M. P. D. Human Orthobunyavirus infections, Tef\u00e9, Amazonas, Brazil. PLoS Curr. 10, ecurrents.outbreaks.7d65e5eb6ef75664da68905c5582f7f7 (2018)."},{"key":"3300_CR15","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/jmv.23953","volume":"86","author":"MS Bastos","year":"2014","unstructured":"Bastos, M. S. et al. Detection of Herpesvirus, Enterovirus, and Arbovirus infection in patients with suspected central nervous system viral infection in the Western Brazilian Amazon. J. Med. Virol. 86, 1522\u20131527 (2014).","journal-title":"J. Med. Virol."},{"key":"3300_CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/tropicalmed7060111","volume":"7","author":"S Sciancalepore","year":"2022","unstructured":"Sciancalepore, S., Schneider, M. C., Kim, J., Galan, D. I. & Riviere-Cinnamond, A. Presence and multi-species spatial distribution of Oropouche virus in Brazil within the One Health framework. Trop. Med. Infect. Dis. 7, 111 (2022).","journal-title":"Trop. Med. Infect. Dis."},{"key":"3300_CR17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7883\/yoken.JJID.2019.296","volume":"73","author":"LMDS Fonseca","year":"2020","unstructured":"Fonseca, L. M. D. S., Carvalho, R. H., Bandeira, A. C., Sardi, S. I. & Campos, G. S. Oropouche virus detection in febrile patients\u2019 saliva and urine samples in Salvador, Bahia, Brazil. Jpn. J. Infect. Dis. 73, 164\u2013165 (2020).","journal-title":"Jpn. J. Infect. Dis."},{"key":"3300_CR18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.actatropica.2018.12.019","volume":"190","author":"MC De Souza Costa","year":"2019","unstructured":"De Souza Costa, M. C. et al. Arbovirus investigation in patients from Mato Grosso during Zika and Chikungunya virus introdution in Brazil, 2015\u20132016. Acta Trop. 190, 395\u2013402 (2019).","journal-title":"Acta Trop."},{"key":"3300_CR19","doi-asserted-by":"crossref","first-page":"732","DOI":"10.4269\/ajtmh.2012.11-0485","volume":"86","author":"RM Pinto De Figueiredo","year":"2012","unstructured":"Pinto De Figueiredo, R. M. et al. Identification of Oropouche Orthobunyavirus in the cerebrospinal fluid of three patients in the Amazonas, Brazil. Am. J. Trop. Med. Hyg. 86, 732\u2013735 (2012).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"3300_CR20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3201\/eid1502.080401","volume":"15","author":"ACB Terzian","year":"2009","unstructured":"Terzian, A. C. B. et al. Sporadic Oropouche infection, Acre, Brazil. Emerg. Infect. Dis. 15, 348\u2013350 (2009).","journal-title":"Emerg. Infect. Dis."},{"key":"3300_CR21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-100422-024648","author":"B De Thoisy","year":"2024","unstructured":"De Thoisy, B., Gr\u00e4f, T., Mansur, D. S., Delfraro, A. & Dos Santos, C. N. D. The risk of virus emergence in south america: a subtle balance between increasingly favorable conditions and a protective environment. Annu. Rev. Virol. https:\/\/doi.org\/10.1146\/annurev-virology-100422-024648 (2024).","journal-title":"Annu. Rev. Virol."},{"key":"3300_CR22","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1590\/0074-02760160062","volume":"112","author":"FG Naveca","year":"2017","unstructured":"Naveca, F. G. et al. Multiplexed reverse transcription real-time polymerase chain reaction for simultaneous detection of Mayaro, Oropouche, and Oropouche-like viruses. Mem. Inst. Oswaldo Cruz 112, 510\u2013513 (2017).","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"3300_CR23","doi-asserted-by":"crossref","unstructured":"Sah, R. et al. Oropouche fever outbreak in Brazil: an emerging concern in Latin America. Lancet Microbe https:\/\/doi.org\/10.1016\/S2666-5247(24)00136-8 (2024).","DOI":"10.1016\/S2666-5247(24)00136-8"},{"key":"3300_CR24","unstructured":"[Monitoring of arboviruses and closing balance of the Emergency Operations Committee (COE) Dengue and other Arboviruses 2024]. Epidemiological Bulletin 55 https:\/\/www.gov.br\/saude\/pt-br\/centrais-de-conteudo\/publicacoes\/boletins\/epidemiologicos\/edicoes\/2024\/boletim-epidemiologico-volume-55-no-11.pdf\/view (2024)."},{"key":"3300_CR25","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1080\/22221751.2022.2136536","volume":"11","author":"KA Ciuoderis","year":"2022","unstructured":"Ciuoderis, K. A. et al. Oropouche virus as an emerging cause of acute febrile illness in Colombia. Emerg. Microbes Infect. 11, 2645\u20132657 (2022).","journal-title":"Emerg. Microbes Infect."},{"key":"3300_CR26","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01127-19","volume":"94","author":"B Gutierrez","year":"2020","unstructured":"Gutierrez, B. et al. Evolutionary dynamics of Oropouche virus in South America. J. Virol. 94, e01127-19 (2020).","journal-title":"J. Virol."},{"key":"3300_CR27","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3201\/eid2710.204760","volume":"27","author":"M Gaillet","year":"2021","unstructured":"Gaillet, M. et al. Outbreak of Oropouche virus in French Guiana. Emerg. Infect. Dis. 27, 2711\u20132714 (2021).","journal-title":"Emerg. Infect. Dis."},{"key":"3300_CR28","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s13365-021-00987-9","volume":"27","author":"JO Chiang","year":"2021","unstructured":"Chiang, J. O. et al. Neurological disease caused by Oropouche virus in northern Brazil: should it be included in the scope of clinical neurological diseases? J. Neurovirol. 27, 626\u2013630 (2021).","journal-title":"J. Neurovirol."},{"key":"3300_CR29","doi-asserted-by":"crossref","first-page":"17104","DOI":"10.1073\/pnas.1918304117","volume":"117","author":"NF M\u00fcller","year":"2020","unstructured":"M\u00fcller, N. F., Stolz, U., Dudas, G., Stadler, T. & Vaughan, T. G. Bayesian inference of reassortment networks reveals fitness benefits of reassortment in human influenza viruses. Proc. Natl Acad. Sci. USA 117, 17104\u201317111 (2020).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"3300_CR30","first-page":"213","volume":"27","author":"FP Pinheiro","year":"1976","unstructured":"Pinheiro, F. P., Travassos da Rosa, A. P., Travassos da Rosa, J. F. & Bensabath, G. An outbreak of Oropouche virus diease in the vicinity of santarem, para, barzil. Tropenmed. Parasitol. 27, 213\u2013223 (1976).","journal-title":"Tropenmed. Parasitol."},{"key":"3300_CR31","first-page":"110","volume":"6","author":"AL Hoch","year":"1990","unstructured":"Hoch, A. L., Roberts, D. R. & Pinheiro, F. P. Host-seeking behavior and seasonal abundance of Culicoides paraensis (Diptera: Ceratopogonidae) in Brazil. J. Am. Mosq. Control Assoc. 6, 110\u2013114 (1990).","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"3300_CR32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2915.2009.00846.x","volume":"24","author":"CA Veggiani Aybar","year":"2010","unstructured":"Veggiani Aybar, C. A., Dantur Juri, M. J., Lizarralde De Grosso, M. S. & Spinelli, G. R. Species diversity and seasonal abundance of Culicoides biting midges in northwestern Argentina. Med. Vet. Entomol. 24, 95\u201398 (2010).","journal-title":"Med. Vet. Entomol."},{"key":"3300_CR33","doi-asserted-by":"crossref","first-page":"106928","DOI":"10.1016\/j.actatropica.2023.106928","volume":"243","author":"LHM Feitoza","year":"2023","unstructured":"Feitoza, L. H. M. et al. Influence of meteorological and seasonal parameters on the activity of Culicoides paraensis (Diptera: Ceratopogonidae), an annoying anthropophilic biting midge and putative vector of Oropouche Virus in Rond\u00f4nia, Brazilian Amazon. Acta Trop. 243, 106928 (2023).","journal-title":"Acta Trop."},{"key":"3300_CR34","first-page":"15","volume":"12","author":"FP Pinheiro","year":"1962","unstructured":"Pinheiro, F. P., Pinheiro, M., Bensabath, G., Causey, O. R. & Shope, R. E. Epidemia de virus Oropouche em Bel\u00e9m. Revista do Servi\u00e7o Especial de Sa\u00fade P\u00fablica 12, 15\u201323 (1962).","journal-title":"R"},{"key":"3300_CR35","doi-asserted-by":"crossref","first-page":"e0270294","DOI":"10.1371\/journal.pone.0270294","volume":"17","author":"HV Durango-Chavez","year":"2022","unstructured":"Durango-Chavez, H. V. et al. Oropouche virus infection in patients with acute febrile syndrome: is a predictive model based solely on signs and symptoms useful? PLoS ONE 17, e0270294 (2022).","journal-title":"PLoS ONE"},{"key":"3300_CR36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijid.2019.04.011","volume":"83","author":"W Silva-Caso","year":"2019","unstructured":"Silva-Caso, W. et al. First outbreak of Oropouche Fever reported in a non-endemic western region of the Peruvian Amazon: molecular diagnosis and clinical characteristics. Int. J. Infect. Dis. 83, 139\u2013144 (2019).","journal-title":"Int. J. Infect. Dis."},{"key":"3300_CR37","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1590\/S0037-86821996000600002","volume":"29","author":"APAT Rosa","year":"1996","unstructured":"Rosa, A. P. A. T. et al. Epidemia de febre do Oropouche em Serra Pelada, munic\u00edpio de Curion\u00f3polis, Par\u00e1, 1994. Rev. Soc. Bras. Med. Trop. 29, 537\u2013541 (1996).","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"3300_CR38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1590\/S0036-46651989000400011","volume":"31","author":"PFDC Vasconcelos","year":"1989","unstructured":"Vasconcelos, P. F. D. C. et al. Primeiro registro de epidemias causadas pelo v\u00edrus Oropouche nos Estados do Maranh\u00e3o e Goi\u00e1s, Brasil. Rev. Inst. Med. Trop. S\u00e3o Paulo 31, 271\u2013278 (1989).","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"3300_CR39","doi-asserted-by":"crossref","first-page":"e01629","DOI":"10.1128\/spectrum.01629-23","volume":"12","author":"HM Moreira","year":"2024","unstructured":"Moreira, H. M. et al. Outbreak of Oropouche virus in frontier regions in western Amazon. Microbiol. Spectr. 12, e01629\u201323 (2024).","journal-title":"Microbiol. Spectr."},{"key":"3300_CR40","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1099\/vir.0.061309-0","volume":"95","author":"JT Ladner","year":"2014","unstructured":"Ladner, J. T. et al. Genomic and phylogenetic characterization of viruses included in the Manzanilla and Oropouche species complexes of the genus Orthobunyavirus, family Bunyaviridae. J. Gen. Virol. 95, 1055\u20131066 (2014).","journal-title":"J. Gen. Virol."},{"key":"3300_CR41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001315","volume":"5","author":"PV Aguilar","year":"2011","unstructured":"Aguilar, P. V. et al. Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. PLoS Negl. Trop. Dis. 5, e1315 (2011).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"3300_CR42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0168-1702(01)00262-3","volume":"77","author":"MF Saeed","year":"2001","unstructured":"Saeed, M. F. et al. Jatobal virus is a reassortant containing the small RNA of Oropouche virus. Virus Res. 77, 25\u201330 (2001).","journal-title":"Virus Res."},{"key":"3300_CR43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.virol.2013.07.030","volume":"446","author":"T Briese","year":"2013","unstructured":"Briese, T., Calisher, C. H. & Higgs, S. Viruses of the family Bunyaviridae: are all available isolates reassortants? Virology 446, 207\u2013216 (2013).","journal-title":"Virology"},{"key":"3300_CR44","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s00705-008-0155-1","volume":"153","author":"J Matthijnssens","year":"2008","unstructured":"Matthijnssens, J. et al. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Arch. Virol. 153, 1621\u20131629 (2008).","journal-title":"Arch. Virol."},{"key":"3300_CR45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.1950.s1-30.301","volume":"30","author":"OR Causey","year":"1950","unstructured":"Causey, O. R., Laemmert, H. W. & Kumm, H. W. Dispersion of forest mosquitoes in Brazil: further studies. Am. J. Trop. Med. Hyg. 30, 301\u2013312 (1950).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"3300_CR46","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-ento-010814-020614","volume":"60","author":"BV Purse","year":"2015","unstructured":"Purse, B. V., Carpenter, S., Venter, G. J., Bellis, G. & Mullens, B. A. Bionomics of temperate and tropical Culicoides midges: knowledge gaps and consequences for transmission of Culicoides-borne viruses. Annu. Rev. Entomol. 60, 373\u2013392 (2015).","journal-title":"Annu. Rev. Entomol."},{"key":"3300_CR47","first-page":"343","volume":"44","author":"RJ Brenner","year":"1984","unstructured":"Brenner, R. J., Wargo, M. J., Stains, G. S. & Mulla, M. S. The dispersal of Culicoides mohave (Diptera: Ceratopogonidae) in the desert of Southern California. Mosquito News 44, 343\u2013350 (1984).","journal-title":"Mosquito News"},{"key":"3300_CR48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4039\/Ent113419-5","volume":"113","author":"TH Lillie","year":"1981","unstructured":"Lillie, T. H., Marquardt, W. C. & Jones, R. H. The flight range of Culicoides variipennis (Diptera: Ceratopogonidae). Can. Entomol. 113, 419\u2013426 (1981).","journal-title":"Can. Entomol."},{"key":"3300_CR49","doi-asserted-by":"crossref","first-page":"9967","DOI":"10.1128\/JVI.00588-10","volume":"84","author":"AJ Auguste","year":"2010","unstructured":"Auguste, A. J. et al. Yellow fever virus maintenance in Trinidad and its dispersal throughout the Americas. J. Virol. 84, 9967\u20139977 (2010).","journal-title":"J. Virol."},{"key":"3300_CR50","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/1365-2664.14031","volume":"59","author":"P Ribeiro Prist","year":"2022","unstructured":"Ribeiro Prist, P. et al. Roads and forest edges facilitate yellow fever virus dispersion. J. Appl. Ecol. 59, 4\u201317 (2022).","journal-title":"J. Appl. Ecol."},{"key":"3300_CR51","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3389\/fmicb.2019.01079","volume":"10","author":"E Delatorre","year":"2019","unstructured":"Delatorre, E. et al. Distinct YFV lineages co-circulated in the Central-Western and Southeastern Brazilian regions from 2015 to 2018. Front. Microbiol. 10, 1079 (2019).","journal-title":"Front. Microbiol."},{"key":"3300_CR52","volume":"16","author":"SC Hill","year":"2020","unstructured":"Hill, S. C. et al. Genomic surveillance of yellow fever virus epizootic in S\u00e3o Paulo, Brazil, 2016\u20132018. PLoS Pathog. 16, e1008699 (2020).","journal-title":"PLoS Pathog."},{"key":"3300_CR53","volume":"92","author":"JH Ellwanger","year":"2020","unstructured":"Ellwanger, J. H. et al. Beyond diversity loss and climate change: impacts of Amazon deforestation on infectious diseases and public health. Acad. Bras. Ci\u00eanc. 92, e20191375 (2020).","journal-title":"Acad. Bras. Ci\u00eanc."},{"key":"3300_CR54","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10393-014-0941-z","volume":"11","author":"NL Gottdenker","year":"2014","unstructured":"Gottdenker, N. L., Streicker, D. G., Faust, C. L. & Carroll, C. R. Anthropogenic land use change and infectious diseases: a review of the evidence. Ecohealth 11, 619\u2013632 (2014).","journal-title":"Ecohealth"},{"key":"3300_CR55","doi-asserted-by":"crossref","first-page":"m4385","DOI":"10.1136\/bmj.m4385","volume":"371","author":"R Lowe","year":"2020","unstructured":"Lowe, R. et al. Emerging arboviruses in the urbanized Amazon rainforest. BMJ 371, m4385 (2020).","journal-title":"BMJ"},{"key":"3300_CR56","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41579-024-01026-0","volume":"22","author":"WM De Souza","year":"2024","unstructured":"De Souza, W. M. & Weaver, S. C. Effects of climate change and human activities on vector-borne diseases. Nat. Rev. Microbiol. 22, 476\u2013491 (2024).","journal-title":"Nat. Rev. Microbiol."},{"key":"3300_CR57","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/S0140-6736(12)61151-9","volume":"380","author":"AM Kilpatrick","year":"2012","unstructured":"Kilpatrick, A. M. & Randolph, S. E. Drivers, dynamics, and control of emerging vector-borne zoonotic diseases. Lancet 380, 1946\u20131955 (2012).","journal-title":"Lancet"},{"key":"3300_CR58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1128\/MMBR.00004-08","volume":"72","author":"CR Parrish","year":"2008","unstructured":"Parrish, C. R. et al. Cross-species virus transmission and the emergence of new epidemic diseases. Microbiol. Mol. Biol. Rev. 72, 457\u2013470 (2008).","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"3300_CR59","doi-asserted-by":"publisher","unstructured":"Scachetti, G. C. et al. Reemergence of Oropouche virus between 2023 and 2024 in Brazil. Preprint at medRxiv https:\/\/doi.org\/10.1101\/2024.07.27.24310296 (2024).","DOI":"10.1101\/2024.07.27.24310296"},{"key":"3300_CR60","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1111\/ele.13335","volume":"22","author":"EA Mordecai","year":"2019","unstructured":"Mordecai, E. A. et al. Thermal biology of mosquito\u2010borne disease. Ecol. Lett. 22, 1690\u20131708 (2019).","journal-title":"Ecol. Lett."},{"key":"3300_CR61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/vetsci6020040","volume":"6","author":"AW Bartlow","year":"2019","unstructured":"Bartlow, A. W. et al. Forecasting zoonotic infectious disease response to climate change: mosquito vectors and a changing environment. Vet. Sci. 6, 40 (2019).","journal-title":"Vet. Sci."},{"key":"3300_CR62","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1289\/ehp.0901389","volume":"118","author":"JN Mills","year":"2010","unstructured":"Mills, J. N., Gage, K. L. & Khan, A. S. Potential influence of climate change on vector-borne and zoonotic diseases: a review and proposed research plan. Environ. Health Perspect. 118, 1507\u20131514 (2010).","journal-title":"Environ. Health Perspect."},{"key":"3300_CR63","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat8785","volume":"4","author":"J Barichivich","year":"2018","unstructured":"Barichivich, J. et al. Recent intensification of Amazon flooding extremes driven by strengthened Walker circulation. Sci. Adv. 4, eaat8785 (2018).","journal-title":"Sci. Adv."},{"key":"3300_CR64","doi-asserted-by":"crossref","first-page":"100406","DOI":"10.1016\/j.wace.2021.100406","volume":"35","author":"J-C Espinoza","year":"2022","unstructured":"Espinoza, J.-C., Marengo, J. A., Schongart, J. & Jimenez, J. C. The new historical flood of 2021 in the Amazon River compared to major floods of the 21st century: atmospheric features in the context of the intensification of floods. Weather Clim. Extrem. 35, 100406 (2022).","journal-title":"Weather Clim. Extrem."},{"key":"3300_CR65","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/joc.4420","volume":"36","author":"JA Marengo","year":"2016","unstructured":"Marengo, J. A. & Espinoza, J. C. Extreme seasonal droughts and floods in Amazonia: causes, trends and impacts. Int. J. Climatol. 36, 1033\u20131050 (2016).","journal-title":"Int. J. Climatol."},{"key":"3300_CR66","unstructured":"NOAA Research. Recent \u2018Triple-Dip\u2019 La Ni\u00f1a upends current understanding of ENSO. https:\/\/research.noaa.gov\/2023\/11\/07\/recent-triple-dip-la-nina-upends-current-understanding-of-enso\/ (2023)."},{"key":"3300_CR67","volume":"128","author":"X Li","year":"2023","unstructured":"Li, X., Hu, Z., McPhaden, M. J., Zhu, C. & Liu, Y. Triple\u2010Dip La Ni\u00f1as in 1998\u20132001 and 2020\u20132023: impact of mean state changes. J. Geophys. Res. Atmos. 128, e2023JD038843 (2023).","journal-title":"J. Geophys. Res. Atmos."},{"key":"3300_CR68","volume":"14","author":"J-C Espinoza","year":"2024","unstructured":"Espinoza, J.-C. et al. The new record of drought and warmth in the Amazon in 2023 related to regional and global climatic features. Sci. Rep. 14, 8107 (2024).","journal-title":"Sci. Rep."},{"key":"3300_CR69","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-023-06970-0","volume":"626","author":"BM Flores","year":"2024","unstructured":"Flores, B. M. et al. Critical transitions in the Amazon forest system. Nature 626, 555\u2013564 (2024).","journal-title":"Nature"},{"key":"3300_CR70","doi-asserted-by":"publisher","unstructured":"Gibb, R. et al. The anthropogenic fingerprint on emerging infectious diseases. Preprint at medRxiv https:\/\/doi.org\/10.1101\/2024.05.22.24307684 (2024).","DOI":"10.1101\/2024.05.22.24307684"},{"key":"3300_CR71","doi-asserted-by":"crossref","DOI":"10.1186\/s40249-023-01091-2","volume":"12","author":"D Romero-Alvarez","year":"2023","unstructured":"Romero-Alvarez, D., Escobar, L. E., Auguste, A. J., Del Valle, S. Y. & Manore, C. A. Transmission risk of Oropouche fever across the Americas. Infect. Dis. Poverty 12, 47 (2023).","journal-title":"Infect. Dis. Poverty"},{"key":"3300_CR72","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/0074-02760160415","volume":"112","author":"D Romero-Alvarez","year":"2017","unstructured":"Romero-Alvarez, D. & Escobar, L. E. Vegetation loss and the 2016 Oropouche fever outbreak in Peru. Mem. Inst. Oswaldo Cruz 112, 292\u2013298 (2017).","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"3300_CR73","unstructured":"IPAM. Amaz\u00f4nia em Chamas 9: O Novo e Alarmante Patamar do Desmatamento na Amaz\u00f4nia. https:\/\/ipam.org.br\/bibliotecas\/amazonia-em-chamas-9-o-novo-e-alarmante-patamar-do-desmatamento-na-amazonia\/ (2024)."},{"key":"3300_CR74","unstructured":"Santos, B. et al. Din\u00e2mica Do Desmatamento Na Regi\u00e3o Amacro Com O Sistema De Alerta De Desmatamento (Sad). In Anais do XX Simp\u00f3sio Brasileiro de Sensoriamento Remoto. https:\/\/proceedings.science\/sbsr-2023\/papers\/dinamica-do-desmatamento-na-regiao-amacro-com-o-sistema-de-alerta-de-desmatament?lang=en (INPE, 2023)."},{"key":"3300_CR75","unstructured":"INPE. TerraBrasilis: deforestation rates in the legal Amazon. https:\/\/terrabrasilis.dpi.inpe.br (2024)."},{"key":"3300_CR76","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1126\/science.abg9786","volume":"371","author":"L Ferrante","year":"2021","unstructured":"Ferrante, L. & Fearnside, P. M. Brazil\u2019s political upset threatens Amazonia. Science 371, 898\u2013898 (2021).","journal-title":"Science"},{"key":"3300_CR77","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41559-020-01368-x","volume":"5","author":"CHL Silva Junior","year":"2020","unstructured":"Silva Junior, C. H. L. et al. The Brazilian Amazon deforestation rate in 2020 is the greatest of the decade. Nat. Ecol. Evol. 5, 144\u2013145 (2020).","journal-title":"Nat. Ecol. Evol."},{"key":"3300_CR78","doi-asserted-by":"crossref","first-page":"108994","DOI":"10.1016\/j.biocon.2021.108994","volume":"255","author":"MM Vale","year":"2021","unstructured":"Vale, M. M. et al. The COVID-19 pandemic as an opportunity to weaken environmental protection in Brazil. Biol. Conserv. 255, 108994 (2021).","journal-title":"Biol. Conserv."},{"key":"3300_CR79","doi-asserted-by":"crossref","first-page":"064018","DOI":"10.1088\/1748-9326\/ab1e24","volume":"14","author":"B Brito","year":"2019","unstructured":"Brito, B., Barreto, P., Brand\u00e3o, A., Baima, S. & Gomes, P. H. Stimulus for land grabbing and deforestation in the Brazilian Amazon. Environ. Res. Lett. 14, 064018 (2019).","journal-title":"Environ. Res. Lett."},{"key":"3300_CR80","first-page":"93","volume":"22","author":"MED Chaves","year":"2024","unstructured":"Chaves, M. E. D. et al. AMACRO: the newer Amazonia deforestation hotspot and a potential setback for Brazilian agriculture. Perspect. Ecol. Conserv. 22, 93\u2013100 (2024).","journal-title":"Perspect. Ecol. Conserv."},{"key":"3300_CR81","unstructured":"Superintend\u00eancia do Desenvolvimento da Amaz\u00f4nia (SUDAM). Projeto Prev\u00ea A Cria\u00e7\u00e3o De Uma Zona Especial De Desenvolvimento Sustent\u00e1vel Na Amaz\u00f4nia. https:\/\/www.gov.br\/sudam\/pt-br\/release-amacro (2024)."},{"key":"3300_CR82","unstructured":"Superintend\u00eancia do Desenvolvimento da Amaz\u00f4nia (SUDAM). Zona de desenvolvimento sustent\u00e1vel dos Estados do Amazonas, Acre e Rond\u00f4nia 2021\u20132027: documento referencial. https:\/\/irp.cdn-website.com\/06e645c5\/files\/uploaded\/amacro.pdf (2021)."},{"key":"3300_CR83","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1126\/science.abd5942","volume":"369","author":"G De Oliveira","year":"2020","unstructured":"De Oliveira, G. et al. Smoke pollution\u2019s impacts in Amazonia. Science 369, 634\u2013635 (2020).","journal-title":"Science"},{"key":"3300_CR84","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1017\/S0376892921000084","volume":"48","author":"MB Andrade","year":"2021","unstructured":"Andrade, M. B., Ferrante, L. & Fearnside, P. M. Brazil\u2019s Highway BR-319 demonstrates a crucial lack of environmental governance in Amazonia. Environ. Conserv. 48, 161\u2013164 (2021).","journal-title":"Environ. Conserv."},{"key":"3300_CR85","doi-asserted-by":"crossref","first-page":"104548","DOI":"10.1016\/j.landusepol.2020.104548","volume":"94","author":"L Ferrante","year":"2020","unstructured":"Ferrante, L., Gomes, M. & Fearnside, P. M. Amazonian indigenous peoples are threatened by Brazil\u2019s Highway BR-319. Land Use Policy 94, 104548 (2020).","journal-title":"Land Use Policy"},{"key":"3300_CR86","first-page":"33","volume":"19","author":"GAV Mataveli","year":"2021","unstructured":"Mataveli, G. A. V., Chaves, M. E. D., Brunsell, N. A. & Arag\u00e3o, L. E. O. C. The emergence of a new deforestation hotspot in Amazonia. Perspect. Ecol. Conserv. 19, 33\u201336 (2021).","journal-title":"Perspect. Ecol. Conserv."},{"key":"3300_CR87","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1126\/science.abd6977","volume":"369","author":"L Ferrante","year":"2020","unstructured":"Ferrante, L. & Fearnside, P. M. The Amazon\u2019s road to deforestation. Science 369, 634 (2020).","journal-title":"Science"},{"key":"3300_CR88","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrmicro.2017.45","volume":"15","author":"RK Plowright","year":"2017","unstructured":"Plowright, R. K. et al. Pathways to zoonotic spillover. Nat. Rev. Microbiol. 15, 502\u2013510 (2017).","journal-title":"Nat. Rev. Microbiol."},{"key":"3300_CR89","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vead010","volume":"9","author":"M Layan","year":"2023","unstructured":"Layan, M. et al. Impact and mitigation of sampling bias to determine viral spread: evaluating discrete phylogeography through CTMC modeling and structured coalescent model approximations. Virus Evol. 9, vead010 (2023).","journal-title":"Virus Evol."},{"key":"3300_CR90","doi-asserted-by":"crossref","first-page":"e0000577","DOI":"10.1371\/journal.pgph.0000577","volume":"2","author":"P Liu","year":"2022","unstructured":"Liu, P., Song, Y., Colijn, C. & MacPherson, A. The impact of sampling bias on viral phylogeographic reconstruction. PLoS Glob. Public Health 2, e0000577 (2022).","journal-title":"PLoS Glob. Public Health"},{"key":"3300_CR91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1008561","volume":"17","author":"A Kalkauskas","year":"2021","unstructured":"Kalkauskas, A. et al. Sampling bias and model choice in continuous phylogeography: getting lost on a random walk. PLoS Comput. Biol. 17, e1008561 (2021).","journal-title":"PLoS Comput. Biol."},{"key":"3300_CR92","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1476-072X-9-54","volume":"9","author":"EF Lambin","year":"2010","unstructured":"Lambin, E. F., Tran, A., Vanwambeke, S. O., Linard, C. & Soti, V. Pathogenic landscapes: interactions between land, people, disease vectors, and their animal hosts. Int. J. Health Geogr. 9, 54 (2010).","journal-title":"Int. J. Health Geogr."},{"key":"3300_CR93","doi-asserted-by":"crossref","DOI":"10.1099\/mgen.0.000093","volume":"2","author":"S Argim\u00f3n","year":"2016","unstructured":"Argim\u00f3n, S. et al. Microreact: visualizing and sharing data for genomic epidemiology and phylogeography. Microb. Genomics 2, e000093 (2016).","journal-title":"Microb. Genomics"},{"key":"3300_CR94","doi-asserted-by":"publisher","unstructured":"C3S. ERA5 hourly data on single levels from 1940 to present. Copernicus Climate Change Service (C3S) Climate Data Store (CDS). https:\/\/doi.org\/10.24381\/CDS.ADBB2D47 (2018).","DOI":"10.24381\/CDS.ADBB2D47"},{"key":"3300_CR95","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nprot.2017.066","volume":"12","author":"J Quick","year":"2017","unstructured":"Quick, J. et al. Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples. Nat. Protoc. 12, 1261\u20131276 (2017).","journal-title":"Nat. Protoc."},{"key":"3300_CR96","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks596","volume":"40","author":"A Untergasser","year":"2012","unstructured":"Untergasser, A. et al. Primer3\u2014new capabilities and interfaces. Nucleic Acids Res. 40, e115 (2012).","journal-title":"Nucleic Acids Res."},{"key":"3300_CR97","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nmeth.2109","volume":"9","author":"D Darriba","year":"2012","unstructured":"Darriba, D., Taboada, G. L., Doallo, R. & Posada, D. jModelTest 2: more models, new heuristics and parallel computing. Nat. Methods 9, 772 (2012).","journal-title":"Nat. Methods"},{"key":"3300_CR98","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sysbio\/sys029","volume":"61","author":"F Ronquist","year":"2012","unstructured":"Ronquist, F. et al. MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Syst. Biol. 61, 539\u2013542 (2012).","journal-title":"Syst. Biol."},{"key":"3300_CR99","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/sysbio\/syy032","volume":"67","author":"A Rambaut","year":"2018","unstructured":"Rambaut, A., Drummond, A. J., Xie, D., Baele, G. & Suchard, M. A. Posterior summarization in Bayesian phylogenetics using Tracer 1.7. Syst. Biol. 67, 901\u2013904 (2018).","journal-title":"Syst. Biol."},{"key":"3300_CR100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/molbev\/msz240","volume":"37","author":"L-G Wang","year":"2020","unstructured":"Wang, L.-G. et al. Treeio: an R package for phylogenetic tree input and output with richly annotated and associated data. Mol. Biol. Evol. 37, 599\u2013603 (2020).","journal-title":"Mol. Biol. Evol."},{"key":"3300_CR101","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/2041-210X.12628","volume":"8","author":"G Yu","year":"2017","unstructured":"Yu, G., Smith, D. K., Zhu, H., Guan, Y. & Lam, T. T. ggtree: an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data. Methods Ecol. Evol. 8, 28\u201336 (2017).","journal-title":"Methods Ecol. Evol."},{"key":"3300_CR102","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/veaa087","volume":"7","author":"DP Martin","year":"2021","unstructured":"Martin, D. P. et al. RDP5: a computer program for analyzing recombination in, and removing signals of recombination from, nucleotide sequence datasets. Virus Evol. 7, veaa087 (2021).","journal-title":"Virus Evol."},{"key":"3300_CR103","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1093\/bioinformatics\/btx155","volume":"33","author":"TG Vaughan","year":"2017","unstructured":"Vaughan, T. G. IcyTree: rapid browser-based visualization for phylogenetic trees and networks. Bioinformatics 33, 2392\u20132394 (2017).","journal-title":"Bioinformatics"},{"key":"3300_CR104","doi-asserted-by":"crossref","first-page":"vew007","DOI":"10.1093\/ve\/vew007","volume":"2","author":"A Rambaut","year":"2016","unstructured":"Rambaut, A., Lam, T. T., Max Carvalho, L. & Pybus, O. G. Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen). Virus Evol. 2, vew007 (2016).","journal-title":"Virus Evol."},{"key":"3300_CR105","doi-asserted-by":"crossref","first-page":"vey016","DOI":"10.1093\/ve\/vey016","volume":"4","author":"MA Suchard","year":"2018","unstructured":"Suchard, M. A. et al. Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10. Virus Evol. 4, vey016 (2018).","journal-title":"Virus Evol."},{"key":"3300_CR106","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/sysbio\/syz020","volume":"68","author":"DL Ayres","year":"2019","unstructured":"Ayres, D. L. et al. BEAGLE 3: improved performance, scaling, and usability for a high-performance computing library for statistical phylogenetics. Syst. Biol. 68, 1052\u20131061 (2019).","journal-title":"Syst. Biol."},{"key":"3300_CR107","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/molbev\/msi103","volume":"22","author":"AJ Drummond","year":"2005","unstructured":"Drummond, A. J. Bayesian coalescent inference of past population dynamics from molecular sequences. Mol. Biol. Evol. 22, 1185\u20131192 (2005).","journal-title":"Mol. Biol. Evol."},{"key":"3300_CR108","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/cjs.5550360302","volume":"36","author":"MAR Ferreira","year":"2008","unstructured":"Ferreira, M. A. R. & Suchard, M. A. Bayesian analysis of elapsed times in continuous-time Markov chains. Can. J. Stat. Rev. Can. Stat. 36, 355\u2013368 (2008).","journal-title":"Can. J. Stat. Rev. Can. Stat."},{"key":"3300_CR109","doi-asserted-by":"crossref","first-page":"e1000520","DOI":"10.1371\/journal.pcbi.1000520","volume":"5","author":"P Lemey","year":"2009","unstructured":"Lemey, P., Rambaut, A., Drummond, A. J. & Suchard, M. A. Bayesian phylogeography finds its roots. PLoS Comput. Biol. 5, e1000520 (2009).","journal-title":"PLoS Comput. Biol."},{"key":"3300_CR110","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/molbev\/msq067","volume":"27","author":"P Lemey","year":"2010","unstructured":"Lemey, P., Rambaut, A., Welch, J. J. & Suchard, M. A. Phylogeography takes a relaxed random walk in continuous space and time. Mol. Biol. Evol. 27, 1877\u20131885 (2010).","journal-title":"Mol. Biol. Evol."},{"key":"3300_CR111","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/molbev\/mss265","volume":"30","author":"MS Gill","year":"2013","unstructured":"Gill, M. S. et al. Improving Bayesian population dynamics inference: a coalescent-based model for multiple loci. Mol. Biol. Evol. 30, 713\u2013724 (2013).","journal-title":"Mol. Biol. Evol."},{"key":"3300_CR112","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1093\/bioinformatics\/btr481","volume":"27","author":"F Bielejec","year":"2011","unstructured":"Bielejec, F., Rambaut, A., Suchard, M. A. & Lemey, P. SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics. Bioinformatics 27, 2910\u20132912 (2011).","journal-title":"Bioinformatics"},{"key":"3300_CR113","doi-asserted-by":"crossref","unstructured":"Wickham, H. ggplot2: Elegant Graphics for Data Analysis (Springer, 2016).","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"3300_CR114","doi-asserted-by":"crossref","first-page":"439","DOI":"10.32614\/RJ-2018-009","volume":"10","author":"E Pebesma","year":"2018","unstructured":"Pebesma, E. Simple features for R: standardized support for spatial vector data. R J. 10, 439 (2018).","journal-title":"R J."},{"key":"3300_CR115","doi-asserted-by":"crossref","unstructured":"Pereira, R. H. M. et al. geobr: Loads Shapefiles of Official Spatial Data Sets of Brazil. https:\/\/github.com\/ipeaGIT\/geobr (2019).","DOI":"10.32614\/CRAN.package.geobr"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03300-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03300-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03300-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T08:06:24Z","timestamp":1734077184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03300-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":115,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["3300"],"URL":"https:\/\/doi.org\/10.1038\/s41591-024-03300-3","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]},"assertion":[{"value":"30 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors declare that no conflicts of interest exist.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}