{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:24:44Z","timestamp":1790231084543,"version":"4.1.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS055349"],"award-info":[{"award-number":["R01NS055349"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01NS105910"],"award-info":[{"award-number":["1R01NS105910"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01AI165946"],"award-info":[{"award-number":["R01AI165946"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"U.S. Department of Health & Human Services | NIH | Fogarty International Center","doi-asserted-by":"publisher","award":["D43 TW010928"],"award-info":[{"award-number":["D43 TW010928"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI148525"],"award-info":[{"award-number":["R01AI148525"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI148525"],"award-info":[{"award-number":["R01AI148525"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002531"],"award-info":[{"award-number":["TL1TR002531"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["3R01HL150145-02S1"],"award-info":[{"award-number":["3R01HL150145-02S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL150145"],"award-info":[{"award-number":["1R01HL150145"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH R21AI151349"],"award-info":[{"award-number":["NIH R21AI151349"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH R21AI151349"],"award-info":[{"award-number":["NIH R21AI151349"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5T32DK120524-05"],"award-info":[{"award-number":["5T32DK120524-05"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1038\/s41591-024-03430-8","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T10:03:04Z","timestamp":1737712984000},"page":"777-787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria"],"prefix":"10.1038","volume":"31","author":[{"given":"Caitlin","family":"Bond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-8461","authenticated-orcid":false,"given":"Olivia J.","family":"Bednarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibyadyuti","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Namazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Opoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Lima-Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Batte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthi","family":"Udumula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Balasubramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Vasquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Liepmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bangirana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hwi","family":"Schwantes-An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-5934","authenticated-orcid":false,"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-3614","authenticated-orcid":false,"given":"Tarek M.","family":"El-Achkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7325-4536","authenticated-orcid":false,"given":"Nathan W.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-1411","authenticated-orcid":false,"given":"Chandy C.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-6511","authenticated-orcid":false,"given":"Andrea L.","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"3430_CR1","unstructured":"World Health Organization. World malaria report 2023. www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2023 (2023)."},{"key":"3430_CR2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJMoa2101746","volume":"385","author":"B Balikagala","year":"2021","unstructured":"Balikagala, B. et al. Evidence of artemisinin-resistant malaria in Africa. N. Engl. J. Med. 385, 1163\u20131171 (2021).","journal-title":"N. Engl. J. Med."},{"key":"3430_CR3","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3201\/eid2804.212269","volume":"28","author":"W Van Loon","year":"2022","unstructured":"Van Loon, W. et al. In vitro confirmation of artemisinin resistance in Plasmodium falciparum from patient isolates, Southern Rwanda, 2019. Emerg. Infect. Dis. 28, 852\u2013855 (2022).","journal-title":"Emerg. Infect. Dis."},{"key":"3430_CR4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pt.2009.10.007","volume":"26","author":"NJ White","year":"2010","unstructured":"White, N. J., Turner, G. D., Medana, I. M., Dondorp, A. M. & Day, N. P. The murine cerebral malaria phenomenon. Trends Parasitol. 26, 11\u201315 (2010).","journal-title":"Trends Parasitol."},{"key":"3430_CR5","doi-asserted-by":"crossref","first-page":"e46424","DOI":"10.1371\/journal.pone.0046424","volume":"7","author":"TM Lopera-Mesa","year":"2012","unstructured":"Lopera-Mesa, T. M. et al. Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. PLoS ONE 7, e46424 (2012).","journal-title":"PLoS ONE"},{"key":"3430_CR6","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2875-9-36","volume":"9","author":"NB Quashie","year":"2010","unstructured":"Quashie, N. B., Ranford-Cartwright, L. C. & de Koning, H. P. Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human equilibrative nucleoside transporter and the human facilitative nucleobase transporter. Malar. J. 9, 36 (2010).","journal-title":"Malar. J."},{"key":"3430_CR7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm.3197","volume":"19","author":"P Guermonprez","year":"2013","unstructured":"Guermonprez, P. et al. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat. Med. 19, 730\u2013738 (2013).","journal-title":"Nat. Med."},{"key":"3430_CR8","doi-asserted-by":"crossref","first-page":"e55584","DOI":"10.1371\/journal.pone.0055584","volume":"8","author":"DL Van de Hoef","year":"2013","unstructured":"Van de Hoef, D. L. et al. Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells. PLoS ONE 8, e55584 (2013).","journal-title":"PLoS ONE"},{"key":"3430_CR9","doi-asserted-by":"crossref","first-page":"e1000013","DOI":"10.1371\/journal.ppat.1000013","volume":"4","author":"JM Orengo","year":"2008","unstructured":"Orengo, J. M. et al. Plasmodium-induced inflammation by uric acid. PLoS Pathog. 4, e1000013 (2008).","journal-title":"PLoS Pathog."},{"key":"3430_CR10","doi-asserted-by":"crossref","first-page":"e5194","DOI":"10.1371\/journal.pone.0005194","volume":"4","author":"JM Orengo","year":"2009","unstructured":"Orengo, J. M. et al. Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. PLoS ONE 4, e5194 (2009).","journal-title":"PLoS ONE"},{"key":"3430_CR11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5005\/japi-11001-0110","volume":"70","author":"J Mishra","year":"2022","unstructured":"Mishra, J. & Jatav, J. K. To study the correlation or association of serum uric acid level with morbidities and mortality in sepsis patient and its prognostic significance. J. Assoc. Physicians India 70, 11\u201312 (2022).","journal-title":"J. Assoc. Physicians India"},{"key":"3430_CR12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5005\/japi-11001-0110","volume":"70","author":"Sreekanth","year":"2022","unstructured":"Sreekanth & Maldar, A. Hyperuricemia as an early marker in predicting mortality and morbidity in patients with Sepsis. J. Assoc. Physicians India 70, 11\u201312 (2022).","journal-title":"J. Assoc. Physicians India"},{"key":"3430_CR13","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.7754\/Clin.Lab.2018.180334","volume":"64","author":"M Pehlivanlar-Kucuk","year":"2018","unstructured":"Pehlivanlar-Kucuk, M., Kucuk, A. O., Ozturk, C. E., Er, M. C. & Ulger, F. The association between serum uric acid level and prognosis in critically Ill patients, uric acid as a prognosis predictor. Clin. Lab. 64, 1491\u20131500 (2018).","journal-title":"Clin. Lab."},{"key":"3430_CR14","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1542\/peds.2007-3709","volume":"122","author":"CC John","year":"2008","unstructured":"John, C. C. et al. Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics 122, e92\u2013e99 (2008).","journal-title":"Pediatrics"},{"key":"3430_CR15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/cid\/ciu293","volume":"59","author":"P Bangirana","year":"2014","unstructured":"Bangirana, P. et al. Severe malarial anemia is associated with long-term neurocognitive impairment. Clin. Infect. Dis. 59, 336\u2013344 (2014).","journal-title":"Clin. Infect. Dis."},{"key":"3430_CR16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/BOR.0000000000000472","volume":"30","author":"A Latourte","year":"2018","unstructured":"Latourte, A., Bardin, T. & Richette, P. Uric acid and cognitive decline: a double-edge sword? Curr. Opin. Rheumatol. 30, 183\u2013187 (2018).","journal-title":"Curr. Opin. Rheumatol."},{"key":"3430_CR17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3390\/nu10080975","volume":"10","author":"C Tana","year":"2018","unstructured":"Tana, C., Ticinesi, A., Prati, B., Nouvenne, A. & Meschi, T. Uric acid and cognitive function in older individuals. Nutrients 10, 975 (2018).","journal-title":"Nutrients"},{"key":"3430_CR18","volume":"13","author":"M Vasquez","year":"2023","unstructured":"Vasquez, M. et al. Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria. Sci. Rep. 13, 14720 (2023).","journal-title":"Sci. Rep."},{"key":"3430_CR19","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1097\/CCM.0b013e3182373157","volume":"40","author":"AL Conroy","year":"2012","unstructured":"Conroy, A. L. et al. Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study. Crit. Care Med. 40, 952\u2013959 (2012).","journal-title":"Crit. Care Med."},{"key":"3430_CR20","doi-asserted-by":"crossref","first-page":"e4912","DOI":"10.1371\/journal.pone.0004912","volume":"4","author":"FE Lovegrove","year":"2009","unstructured":"Lovegrove, F. E. et al. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS ONE 4, e4912 (2009).","journal-title":"PLoS ONE"},{"key":"3430_CR21","volume":"3","author":"AL Conroy","year":"2016","unstructured":"Conroy, A. L. et al. Host biomarkers are associated with response to therapy and long-term mortality in pediatric severe malaria. Open Forum Infect. Dis. 3, ofw134 (2016).","journal-title":"Open Forum Infect. Dis."},{"key":"3430_CR22","volume":"4","author":"BA Charles","year":"2011","unstructured":"Charles, B. A. et al. A genome-wide association study of serum uric acid in African Americans. BMC Med. Genet. 4, 17 (2011).","journal-title":"BMC Med. Genet."},{"key":"3430_CR23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/hmg\/ddz272","volume":"29","author":"G Chen","year":"2020","unstructured":"Chen, G. et al. Refining genome-wide associated loci for serum uric acid in individuals with African ancestry. Hum. Mol. Genet. 29, 506\u2013514 (2020).","journal-title":"Hum. Mol. Genet."},{"key":"3430_CR24","unstructured":"Ensembl. Human (CRCh38.p14), variant: rs12498742. useast.ensembl.org\/Homo_sapiens\/Variation\/Population?r=4:9941928-9942928;v=rs12498742;vdb=variation;vf=261683788#gnomadgenomesv3.1.2_table (accessed 15 August 2023)."},{"key":"3430_CR25","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/art.1780080429","volume":"8","author":"LB Sorensen","year":"1965","unstructured":"Sorensen, L. B. Role of the intestinal tract in the elimination of uric acid. Arthritis Rheum. 8, 694\u2013706 (1965).","journal-title":"Arthritis Rheum."},{"key":"3430_CR26","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/cid\/ciac229","volume":"75","author":"R Namazzi","year":"2022","unstructured":"Namazzi, R. et al. Acute kidney injury interacts with coma, acidosis, and impaired perfusion to significantly increase risk of death in children with severe malaria. Clin. Infect. Dis. 75, 1511\u20131519 (2022).","journal-title":"Clin. Infect. Dis."},{"key":"3430_CR27","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01325-22","volume":"13","author":"ML Sarangam","year":"2022","unstructured":"Sarangam, M. L. et al. Intestinal injury biomarkers predict mortality in pediatric severe malaria. mBio 13, e0132522 (2022).","journal-title":"mBio"},{"key":"3430_CR28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cyto.2007.12.008","volume":"41","author":"CC John","year":"2008","unstructured":"John, C. C., Park, G. S., Sam-Agudu, N., Opoka, R. O. & Boivin, M. J. Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease. Cytokine 41, 204\u2013208 (2008).","journal-title":"Cytokine"},{"key":"3430_CR29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn5040","volume":"14","author":"JA Watson","year":"2022","unstructured":"Watson, J. A. et al. Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations. Sci. Transl. Med. 14, eabn5040 (2022).","journal-title":"Sci. Transl. Med."},{"key":"3430_CR30","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2023.1177242","volume":"17","author":"AL Conroy","year":"2023","unstructured":"Conroy, A. L. et al. Cerebrospinal fluid biomarkers provide evidence for kidney\u2013brain axis involvement in cerebral malaria pathogenesis. Front. Hum. Neurosci. 17, 1177242 (2023).","journal-title":"Front. Hum. Neurosci."},{"key":"3430_CR31","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/cid\/ciz325","volume":"70","author":"D Datta","year":"2020","unstructured":"Datta, D. et al. Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria. Clin. Infect. Dis. 70, 1161\u20131168 (2020).","journal-title":"Clin. Infect. Dis."},{"key":"3430_CR32","unstructured":"Labcorp. Albumin, cerebrospinal fluid. www.labcorp.com\/tests\/012229\/albumin-cerebrospinal-fluid (accessed 1 September 2023)."},{"key":"3430_CR33","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-013-0401-8","volume":"16","author":"J Gallego-Delgado","year":"2014","unstructured":"Gallego-Delgado, J., Ty, M., Orengo, J. M., van de Hoef, D. & Rodriguez, A. A surprising role for uric acid: the inflammatory malaria response. Curr. Rheumatol. Rep. 16, 401 (2014).","journal-title":"Curr. Rheumatol. Rep."},{"key":"3430_CR34","volume":"13","author":"H Yin","year":"2022","unstructured":"Yin, H., Liu, N. & Chen, J. The role of the intestine in the development of hyperuricemia. Front. Immunol. 13, 845684 (2022).","journal-title":"Front. Immunol."},{"key":"3430_CR35","volume":"18","author":"X Xu","year":"2017","unstructured":"Xu, X. et al. Hyperuricemia increases the risk of acute kidney injury: a systematic review and meta-analysis. BMC Nephrol. 18, 27 (2017).","journal-title":"BMC Nephrol."},{"key":"3430_CR36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12882-023-03129-x","volume":"24","author":"YX Jiang","year":"2023","unstructured":"Jiang, Y. X. et al. Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis. BMC Nephrol. 24, 128 (2023).","journal-title":"BMC Nephrol."},{"key":"3430_CR37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10157-014-1012-z","volume":"19","author":"D Bayram","year":"2015","unstructured":"Bayram, D. et al. The effects of allopurinol on metabolic acidosis and endothelial functions in chronic kidney disease patients. Clin. Exp. Nephrol. 19, 443\u2013449 (2015).","journal-title":"Clin. Exp. Nephrol."},{"key":"3430_CR38","first-page":"3292","volume":"20","author":"Y Guo","year":"2019","unstructured":"Guo, Y. et al. Impaired intestinal barrier function in a mouse model of hyperuricemia. Mol. Med. Rep. 20, 3292\u20133300 (2019).","journal-title":"Mol. Med. Rep."},{"key":"3430_CR39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.amjmed.2011.06.021","volume":"125","author":"V Lapsia","year":"2012","unstructured":"Lapsia, V. et al. Elevated uric acid increases the risk for acute kidney injury. Am. J. Med. 125, 302 (2012).","journal-title":"Am. J. Med."},{"key":"3430_CR40","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00467-013-2549-x","volume":"29","author":"SA Fathallah-Shaykh","year":"2014","unstructured":"Fathallah-Shaykh, S. A. & Cramer, M. T. Uric acid and the kidney. Pediatr. Nephrol. 29, 999\u20131008 (2014).","journal-title":"Pediatr. Nephrol."},{"key":"3430_CR41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1758-5996-4-12","volume":"4","author":"EP De Oliveira","year":"2012","unstructured":"De Oliveira, E. P. & Burini, R. C. High plasma uric acid concentration: causes and consequences. Diabetol. Metab. Syndr. 4, 12 (2012).","journal-title":"Diabetol. Metab. Syndr."},{"key":"3430_CR42","volume":"2021","author":"T Zheng","year":"2021","unstructured":"Zheng, T. et al. Laboratory predictors of COVID-19 mortality: a retrospective analysis from Tongji Hospital in Wuhan. Mediators Inflamm. 2021, 6687412 (2021).","journal-title":"Mediators Inflamm."},{"key":"3430_CR43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3121\/cmr.2023.1782","volume":"21","author":"I Feldman","year":"2023","unstructured":"Feldman, I., Natsheh, A. & Breuer, G. S. Hyperuricemia and adverse outcomes in patients hospitalized for COVID-19 disease. Clin. Med. Res. 21, 87\u201394 (2023).","journal-title":"Clin. Med. Res."},{"key":"3430_CR44","volume":"12","author":"S Liu","year":"2022","unstructured":"Liu, S., Zhong, Z. & Liu, F. Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit. Sci. Rep. 12, 1070 (2022).","journal-title":"Sci. Rep."},{"key":"3430_CR45","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1177\/0885066617698911","volume":"34","author":"HW Lee","year":"2019","unstructured":"Lee, H. W. et al. Serum uric acid level as a prognostic marker in patients with acute respiratory distress syndrome. J. Intensive Care Med. 34, 404\u2013410 (2019).","journal-title":"J. Intensive Care Med."},{"key":"3430_CR46","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.3389\/fmicb.2018.02233","volume":"9","author":"Y Yu","year":"2018","unstructured":"Yu, Y., Liu, Q., Li, H., Wen, C. & He, Z. Alterations of the gut microbiome associated with the treatment of hyperuricaemia in male rats. Front. Microbiol. 9, 2233 (2018).","journal-title":"Front. Microbiol."},{"key":"3430_CR47","doi-asserted-by":"crossref","first-page":"524236","DOI":"10.3389\/fphys.2020.524236","volume":"11","author":"Q Lv","year":"2020","unstructured":"Lv, Q. et al. Association of hyperuricemia with immune disorders and intestinal barrier dysfunction. Front. Physiol. 11, 524236 (2020).","journal-title":"Front. Physiol."},{"key":"3430_CR48","doi-asserted-by":"crossref","first-page":"S368","DOI":"10.1093\/cid\/cix101","volume":"64","author":"AJ Driscoll","year":"2017","unstructured":"Driscoll, A. J. et al. The effect of antibiotic exposure and specimen volume on the detection of bacterial pathogens in children with pneumonia. Clin. Infect. Dis. 64, S368\u2013S377 (2017).","journal-title":"Clin. Infect. Dis."},{"key":"3430_CR49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/1751-2980.13249","volume":"25","author":"X Liu","year":"2024","unstructured":"Liu, X. et al. Commensal Enterococcus faecalis W5 ameliorates hyperuricemia and maintains the epithelial barrier in a hyperuricemia mouse model. J. Dig. Dis. 25, 44\u201360 (2024).","journal-title":"J. Dig. Dis."},{"key":"3430_CR50","volume":"112","author":"Y Sun","year":"2024","unstructured":"Sun, Y. et al. Wild-type Escherichia coli Nissle 1917 improves hyperuricemia by anaerobically degrading uric acid and maintaining gut microbiota profile of mice. J. Funct. Foods 112, 105935 (2024).","journal-title":"J. Funct. Foods"},{"key":"3430_CR51","first-page":"e41","volume":"6","author":"RO Opoka","year":"2017","unstructured":"Opoka, R. O. et al. High postdischarge morbidity in Ugandan children with severe malarial anemia or cerebral malaria. J. Pediatr. Infect. Dis. Soc. 6, e41\u2013e48 (2017).","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"3430_CR52","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/S2214-109X(23)00492-8","volume":"12","author":"KS Phiri","year":"2024","unstructured":"Phiri, K. S. et al. Post-discharge malaria chemoprevention in children admitted with severe anaemia in malaria-endemic settings in Africa: a systematic review and individual patient data meta-analysis of randomised controlled trials. Lancet Glob. Health 12, e33\u2013e44 (2024).","journal-title":"Lancet Glob. Health"},{"key":"3430_CR53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.14802\/jmd.18037","volume":"11","author":"HR Lee","year":"2018","unstructured":"Lee, H. R., Park, J. H., Han, S. W. & Baik, J. S. Cognition, olfaction and uric acid in early de novo Parkinson\u2019s disease. J. Mov. Disord. 11, 139\u2013144 (2018).","journal-title":"J. Mov. Disord."},{"key":"3430_CR54","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.parkreldis.2007.11.001","volume":"14","author":"T Annanmaki","year":"2008","unstructured":"Annanmaki, T., Pessala-Driver, A., Hokkanen, L. & Murros, K. Uric acid associates with cognition in Parkinson\u2019s disease. Parkinsonism Relat. Disord. 14, 576\u2013578 (2008).","journal-title":"Parkinsonism Relat. Disord."},{"key":"3430_CR55","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/gps.1469","volume":"21","author":"TS Kim","year":"2006","unstructured":"Kim, T. S. et al. Decreased plasma antioxidants in patients with Alzheimer\u2019s disease. Int. J. Geriatr. Psychiatry 21, 344\u2013348 (2006).","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"3430_CR56","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1096\/fasebj.14.5.691","volume":"14","author":"DC Hooper","year":"2000","unstructured":"Hooper, D. C. et al. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood\u2013CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J. 14, 691\u2013698 (2000).","journal-title":"FASEB J."},{"key":"3430_CR57","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3233\/JAD-2010-1330","volume":"19","author":"GL Bowman","year":"2010","unstructured":"Bowman, G. L., Shannon, J., Frei, B., Kaye, J. A. & Quinn, J. F. Uric acid as a CNS antioxidant. J. Alzheimers Dis. 19, 1331\u20131336 (2010).","journal-title":"J. Alzheimers Dis."},{"key":"3430_CR58","doi-asserted-by":"crossref","first-page":"10990","DOI":"10.1523\/JNEUROSCI.1480-16.2016","volume":"36","author":"X Shao","year":"2016","unstructured":"Shao, X. et al. Uric acid induces cognitive dysfunction through hippocampal inflammation in rodents and humans. J. Neurosci. 36, 10990\u201311005 (2016).","journal-title":"J. Neurosci."},{"key":"3430_CR59","volume":"11","author":"T Tian","year":"2021","unstructured":"Tian, T. et al. Detrimental effects of long-term elevated serum uric acid on cognitive function in rats. Sci. Rep. 11, 6732 (2021).","journal-title":"Sci. Rep."},{"key":"3430_CR60","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/SHK.0000000000001708","volume":"56","author":"S L\u2019Ecuyer","year":"2021","unstructured":"L\u2019Ecuyer, S. et al. Targeting uric acid prevents brain injury and anxiety in a rat model of hemorrhagic shock. Shock 56, 298\u2013307 (2021).","journal-title":"Shock"},{"key":"3430_CR61","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fphys.2018.00476","volume":"9","author":"A Ruiz","year":"2018","unstructured":"Ruiz, A., Gautschi, I., Schild, L. & Bonny, O. Human mutations in SLC2A9 (Glut9) affect transport capacity for urate. Front. Physiol. 9, 476 (2018).","journal-title":"Front. Physiol."},{"key":"3430_CR62","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4269\/ajtmh.1998.58.454","volume":"58","author":"PS Sarma","year":"1998","unstructured":"Sarma, P. S., Mandal, A. K. & Khamis, H. J. Allopurinol as an additive to quinine in the treatment of acute complicated falciparum malaria. Am. J. Trop. Med. Hyg. 58, 454\u2013457 (1998).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"3430_CR63","unstructured":"World Health Organization. Uric acid: optical methods; automated chemistry analyser if available. edl.who-healthtechnologies.org\/recommendations\/2350uric (2020; accessed 8 April 2024)"},{"key":"3430_CR64","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13075-018-1585-0","volume":"20","author":"S Fabre","year":"2018","unstructured":"Fabre, S. et al. Accuracy of the HumaSens(plus) point-of-care uric acid meter using capillary blood obtained by fingertip puncture. Arthritis Res. Ther. 20, 78 (2018).","journal-title":"Arthritis Res. Ther."},{"key":"3430_CR65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/tmi.12313_2","volume":"19","author":"World Health Organization.","year":"2014","unstructured":"World Health Organization. Severe malaria. Trop. Med. Int. Health 19, 7\u2013131 (2014).","journal-title":"Trop. Med. Int. Health"},{"key":"3430_CR66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"KDIGO.","year":"2012","unstructured":"KDIGO. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. Suppl. 2, 1\u2013138 (2012).","journal-title":"Kidney Int. Suppl."},{"key":"3430_CR67","doi-asserted-by":"crossref","first-page":"101292","DOI":"10.1016\/j.eclinm.2022.101292","volume":"44","author":"R Namazzi","year":"2022","unstructured":"Namazzi, R. et al. Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: a prospective cohort study. EClinicalMedicine 44, 101292 (2022).","journal-title":"EClinicalMedicine"},{"key":"3430_CR68","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12882-020-02076-1","volume":"21","author":"A Batte","year":"2020","unstructured":"Batte, A. et al. Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study. BMC Nephrol. 21, 417 (2020).","journal-title":"BMC Nephrol."},{"key":"3430_CR69","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mimet.2018.09.019","volume":"154","author":"AE Schriefer","year":"2018","unstructured":"Schriefer, A. E. et al. A multi-amplicon 16S rRNA sequencing and analysis method for improved taxonomic profiling of bacterial communities. J. Microbiol. Methods 154, 6\u201313 (2018).","journal-title":"J. Microbiol. Methods"},{"key":"3430_CR70","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42235-0","volume":"14","author":"RK Mandal","year":"2023","unstructured":"Mandal, R. K. et al. Gut bacteroides act in a microbial consortium to cause susceptibility to severe malaria. Nat. Commun. 14, 6465 (2023).","journal-title":"Nat. Commun."},{"key":"3430_CR71","doi-asserted-by":"crossref","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","volume":"8","author":"PJ McMurdie","year":"2013","unstructured":"McMurdie, P. J. & Holmes, S. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE 8, e61217 (2013).","journal-title":"PLoS ONE"},{"key":"3430_CR72","first-page":"94","volume":"14","author":"DM Bryan","year":"2020","unstructured":"Bryan, D. M., Daniela, W. & Amy, D. W. Modeling microbial abundances and dysbiosis with \u03b2-binomial regression. Ann. Appl. Stat. 14, 94\u2013115 (2020).","journal-title":"Ann. Appl. Stat."},{"key":"3430_CR73","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.21105\/joss.03201","volume":"6","author":"D Barnett","year":"2021","unstructured":"Barnett, D., Arts, I. & Penders, J. microViz: an R package for microbiome data visualization and statistics. J. Open Source Softw. 6, 3201 (2021).","journal-title":"J. Open Source Softw."},{"key":"3430_CR74","doi-asserted-by":"crossref","DOI":"10.1186\/s13742-015-0047-8","volume":"4","author":"CC Chang","year":"2015","unstructured":"Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. GigaScience 4, 7 (2015).","journal-title":"GigaScience"},{"key":"3430_CR75","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1093\/bioinformatics\/bts606","volume":"28","author":"X Zheng","year":"2012","unstructured":"Zheng, X. et al. A high-performance computing toolset for relatedness and principal component analysis of SNP data. Bioinformatics 28, 3326\u20133328 (2012).","journal-title":"Bioinformatics"},{"key":"3430_CR76","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-03205-y","volume":"590","author":"D Taliun","year":"2021","unstructured":"Taliun, D. et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed program. Nature 590, 290\u2013299 (2021).","journal-title":"Nature"},{"key":"3430_CR77","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","volume":"48","author":"S Das","year":"2016","unstructured":"Das, S. et al. Next-generation genotype imputation service and methods. Nat. Genet. 48, 1284\u20131287 (2016).","journal-title":"Nat. Genet."},{"key":"3430_CR78","unstructured":"Mullen E. Mullen Scales of Early Learning (American Guidance Services Inc., 1995)."},{"key":"3430_CR79","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/09297040601100430","volume":"14","author":"CM Jordan","year":"2008","unstructured":"Jordan, C. M., Johnson, A. L., Hughes, S. J. & Shapiro, E. G. The Color Object Association Test (COAT): the development of a new measure of declarative memory for 18- to 36-month-old toddlers. Child Neuropsychol. 14, 21\u201341 (2008).","journal-title":"Child Neuropsychol."},{"key":"3430_CR80","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1207\/s15326942dn2503_1","volume":"25","author":"DZ Goldman","year":"2004","unstructured":"Goldman, D. Z., Shapiro, E. G. & Nelson, C. A. Measurement of vigilance in 2-year-old children. Dev. Neuropsychol. 25, 227\u2013250 (2004).","journal-title":"Dev. Neuropsychol."},{"key":"3430_CR81","unstructured":"Kaufman A. S. & Kaufman, N. L. Kaufman Assessment Battery for Children Manual. Second Edition (American Guidance Service, 2004)."},{"key":"3430_CR82","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1469-7610.1993.tb01105.x","volume":"34","author":"LM Greenberg","year":"1993","unstructured":"Greenberg, L. M. & Waldmant, I. D. Developmental normative data on the Test of Variables of Attention (T.O.V.A.). J. Child Psychol. Psychiatry 34, 1019\u20131030 (1993).","journal-title":"J. Child Psychol. Psychiatry"},{"key":"3430_CR83","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","volume":"51","author":"RM Baron","year":"1986","unstructured":"Baron, R. M. & Kenny, D. A. The moderator\u2013mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51, 1173\u20131182 (1986).","journal-title":"J. Pers. Soc. Psychol."},{"key":"3430_CR84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Methodol. 57, 289\u2013300 (1995).","journal-title":"J. R. Stat. Soc. Ser. B Methodol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03430-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03430-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03430-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:25:49Z","timestamp":1742387149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41591-024-03430-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":84,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3430"],"URL":"https:\/\/doi.org\/10.1038\/s41591-024-03430-8","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"8 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}