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Genomic analysis of samples from 18 cases identified a lineage with limited internal diversity, closely related to a 2014 Ugandan case. Our findings suggest that the Rwandan lineage diverged decades ago from a common ancestor shared with diversity sampled from bats in Uganda. Our genomic data reveal limited genetic variation, consistent with a single zoonotic transmission event and limited human-to-human transmission. Investigations including contact tracing, clinical assessments, sequencing and serology, linked the index case to a mining cave inhabited by\n                    <jats:italic>Rousettus aegyptiacus<\/jats:italic>\n                    . Serology tests identified three individuals seropositive for immunoglobulin G and immunoglobulin M, further supporting the zoonotic origin of the outbreak through human\u2013animal interactions.\n                  <\/jats:p>","DOI":"10.1038\/s41591-024-03459-9","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T03:58:03Z","timestamp":1734321483000},"page":"422-426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Genomic and transmission dynamics of the 2024 Marburg virus outbreak in 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