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W.C., Y.-H.N., K.W.S. and C.H.H. filed a provisional patent application related to sensing accumbens activity to guide the treatment of obesity and related disorders. The laboratory of M.R.H. at the University of Pennsylvania receives research funding from Boehringer Ingelheim, Eli Lilly and Company, Pfizer, Gila Therapeutics and Coronation Bio, which was not used to support these studies. M.R.H. is a founding scientist of Coronation Bio, a Delaware corporation that pursues biological work unrelated to the current study. K.C.A. receives research funding from Novo Nordisk for a project that is unrelated to the scope of this study. A.A. receives research funding from Eli Lilly and Company, Novo Nordisk, Fractyl Laboratories and Altlmmune, which was not used in support of these studies. A.A. received consultant honoraria from Novo Nordisk and CVS Caremark, which is unrelated to the current study. 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