{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T09:22:38Z","timestamp":1794648158813,"version":"4.9.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Methods"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1038\/s41592-018-0054-7","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T10:31:07Z","timestamp":1531305067000},"page":"595-597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":254,"title":["A synthetic-diploid benchmark for accurate variant-calling evaluation"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4874-2874","authenticated-orcid":false,"given":"Heng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-1434","authenticated-orcid":false,"given":"Jonathan M.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-2868","authenticated-orcid":false,"given":"Yossi","family":"Farjoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fleharty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-6077","authenticated-orcid":false,"given":"Benjamin","family":"Neale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-2290","authenticated-orcid":false,"given":"Daniel","family":"MacArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"54_CR1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/nbt.2835","volume":"32","author":"JM Zook","year":"2014","unstructured":"Zook, J. M. et al. Nat. Biotechnol. 32, 246\u2013251 (2014).","journal-title":"Nat. Biotechnol."},{"key":"54_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1101\/gr.210500.116","volume":"27","author":"MA Eberle","year":"2017","unstructured":"Eberle, M. A. et al. Genome Res. 27, 157\u2013164 (2017).","journal-title":"Genome Res."},{"key":"54_CR3","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1093\/bioinformatics\/btu356","volume":"30","author":"H Li","year":"2014","unstructured":"Li, H. Bioinformatics 30, 2843\u20132851 (2014).","journal-title":"Bioinformatics"},{"key":"54_CR4","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nmeth.4035","volume":"13","author":"CS Chin","year":"2016","unstructured":"Chin, C. S. et al. Nat. Methods 13, 1050\u20131054 (2016).","journal-title":"Nat. Methods"},{"key":"54_CR5","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nmeth.2474","volume":"10","author":"CS Chin","year":"2013","unstructured":"Chin, C. S. et al. Nat. Methods 10, 563\u2013569 (2013).","journal-title":"Nat. Methods"},{"key":"54_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature20098","volume":"538","author":"JS Seo","year":"2016","unstructured":"Seo, J. S. et al. Nature 538, 243\u2013247 (2016).","journal-title":"Nature"},{"key":"54_CR7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1101\/gr.214007.116","volume":"27","author":"J Huddleston","year":"2017","unstructured":"Huddleston, J. et al. Genome Res. 27, 677\u2013685 (2017).","journal-title":"Genome Res."},{"key":"54_CR8","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1101\/gr.213611.116","volume":"27","author":"VA Schneider","year":"2017","unstructured":"Schneider, V. A. et al. Genome Res. 27, 849\u2013864 (2017).","journal-title":"Genome Res."},{"key":"54_CR9","unstructured":"Li, H. arXiv Preprint at https:\/\/arxiv.org\/abs\/1303.3997 (2013)."},{"key":"54_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B. & Salzberg, S. L. Nat. Methods 9, 357\u2013359 (2012).","journal-title":"Nat. Methods"},{"key":"54_CR11","doi-asserted-by":"publisher","unstructured":"Li, H. Bioinformatics https:\/\/doi.org\/10.1093\/bioinformatics\/bty191 (2018).","DOI":"10.1093\/bioinformatics\/bty191"},{"key":"54_CR12","unstructured":"Garrison, E. & Marth, G. arXiv Preprint at https:\/\/arxiv.org\/abs\/1207.3907 (2012)."},{"key":"54_CR13","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/ng.3036","volume":"46","author":"A Rimmer","year":"2014","unstructured":"Rimmer, A. et al. Nat. Genet. 46, 912\u2013918 (2014).","journal-title":"Nat. Genet."},{"key":"54_CR14","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1093\/bioinformatics\/btr509","volume":"27","author":"H Li","year":"2011","unstructured":"Li, H. Bioinformatics 27, 2987\u20132993 (2011).","journal-title":"Bioinformatics"},{"key":"54_CR15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.806","volume":"43","author":"MA DePristo","year":"2011","unstructured":"DePristo, M. A. et al. Nat. Genet. 43, 491\u2013498 (2011).","journal-title":"Nat. Genet."},{"key":"54_CR16","unstructured":"Cleary, J.G. et al. bioRxiv Preprint at https:\/\/www.biorxiv.org\/content\/early\/2015\/08\/03\/023754 (2015)."},{"key":"54_CR17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"Auton, A. et al. Nature 526, 68\u201374 (2015).","journal-title":"Nature"},{"key":"54_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson, J. T. et al. Nat. Biotechnol. 29, 24\u201326 (2011).","journal-title":"Nat. Biotechnol."},{"key":"54_CR19","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1089\/cmb.2006.13.1028","volume":"13","author":"A Morgulis","year":"2006","unstructured":"Morgulis, A., Gertz, E. M., Sch\u00e4ffer, A. A. & Agarwala, R. J. Comput. Biol. 13, 1028\u20131040 (2006).","journal-title":"J. Comput. Biol."},{"key":"54_CR20","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature18964","volume":"538","author":"S Mallick","year":"2016","unstructured":"Mallick, S. et al. Nature 538, 201\u2013206 (2016).","journal-title":"Nature"},{"key":"54_CR21","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1093\/bioinformatics\/btv440","volume":"31","author":"H Li","year":"2015","unstructured":"Li, H. Bioinformatics 31, 3694\u20133696 (2015).","journal-title":"Bioinformatics"}],"container-title":["Nature Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41592-018-0054-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41592-018-0054-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41592-018-0054-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:20:11Z","timestamp":1693747211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41592-018-0054-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["54"],"URL":"https:\/\/doi.org\/10.1038\/s41592-018-0054-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/223297","asserted-by":"object"}]},"ISSN":["1548-7091","1548-7105"],"issn-type":[{"value":"1548-7091","type":"print"},{"value":"1548-7105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,16]]},"assertion":[{"value":"22 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}