{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:46:59Z","timestamp":1793256419894,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Methods"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1038\/s41592-024-02292-9","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:04:10Z","timestamp":1718359450000},"page":"1288-1297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity"],"prefix":"10.1038","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-2686","authenticated-orcid":false,"given":"Brenda C.","family":"Shields","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-8865","authenticated-orcid":false,"given":"Haidun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-6275","authenticated-orcid":false,"given":"Shaun S. X.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-1365","authenticated-orcid":false,"given":"Sasha C. V.","family":"Burwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine M.","family":"Cammarata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-7121","authenticated-orcid":false,"given":"S. Aryana","family":"Yousefzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-0735","authenticated-orcid":false,"given":"Victoria Z.","family":"Goldenshtein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Kahuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purav P.","family":"Vagadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie H.","family":"Loughran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhiquan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0158-5170","authenticated-orcid":false,"given":"Miranda L.","family":"Scalabrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mishek","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-3580","authenticated-orcid":false,"given":"Tammy M.","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-2679","authenticated-orcid":false,"given":"Greg D.","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Court","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-5051","authenticated-orcid":false,"given":"Gary E.","family":"Schiltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-2235","authenticated-orcid":false,"given":"Lindsey L.","family":"Glickfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-4044","authenticated-orcid":false,"given":"Allen B.","family":"Reitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-6380","authenticated-orcid":false,"given":"Michael R.","family":"Tadross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"2292_CR1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nrn.2015.21","volume":"17","author":"NX Tritsch","year":"2016","unstructured":"Tritsch, N. X., Granger, A. J. & Sabatini, B. L. Mechanisms and functions of GABA co-release. Nat. Rev. Neurosci. 17, 139\u2013145 (2016).","journal-title":"Nat. Rev. Neurosci."},{"key":"2292_CR2","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/s41593-022-01113-6","volume":"25","author":"BR Rost","year":"2022","unstructured":"Rost, B. R., Wietek, J., Yizhar, O. & Schmitz, D. Optogenetics at the presynapse. Nat. Neurosci. 25, 984\u2013998 (2022).","journal-title":"Nat. Neurosci."},{"key":"2292_CR3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2161","volume":"356","author":"BC Shields","year":"2017","unstructured":"Shields, B. C. et al. Deconstructing behavioral neuropharmacology with cellular specificity. Science 356, eaaj2161 (2017).","journal-title":"Science"},{"key":"2292_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/ilar.47.2.124","volume":"47","author":"KR Bailey","year":"2006","unstructured":"Bailey, K. R., Rustay, N. R. & Crawley, J. N. Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfalls. ILAR J. 47, 124\u2013131 (2006).","journal-title":"ILAR J."},{"key":"2292_CR5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.molcel.2020.01.010","volume":"77","author":"R Verma","year":"2020","unstructured":"Verma, R., Mohl, D. & Deshaies, R. J. Harnessing the power of proteolysis for targeted protein inactivation. Mol. Cell 77, 446\u2013460 (2020).","journal-title":"Mol. Cell"},{"key":"2292_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nmeth.3894","volume":"13","author":"GG Gross","year":"2016","unstructured":"Gross, G. G. et al. An E3-ligase-based method for ablating inhibitory synapses. Nat. Methods 13, 673\u2013678 (2016).","journal-title":"Nat. Methods"},{"key":"2292_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature15257","volume":"525","author":"A Hayashi-Takagi","year":"2015","unstructured":"Hayashi-Takagi, A. et al. Labelling and optical erasure of synaptic memory traces in the motor cortex. Nature 525, 333\u2013338 (2015).","journal-title":"Nature"},{"key":"2292_CR8","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/nn1356","volume":"7","author":"M Banghart","year":"2004","unstructured":"Banghart, M., Borges, K., Isacoff, E., Trauner, D. & Kramer, R. H. Light-activated ion channels for remote control of neuronal firing. Nat. Neurosci. 7, 1381\u20131386 (2004).","journal-title":"Nat. Neurosci."},{"key":"2292_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nchembio756","volume":"2","author":"M Volgraf","year":"2006","unstructured":"Volgraf, M. et al. Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat. Chem. Biol. 2, 47\u201352 (2006).","journal-title":"Nat. Chem. Biol."},{"key":"2292_CR10","doi-asserted-by":"publisher","first-page":"102196","DOI":"10.1016\/j.coph.2022.102196","volume":"63","author":"J Broichhagen","year":"2022","unstructured":"Broichhagen, J. & Levitz, J. Advances in tethered photopharmacology for precise optical control of signaling proteins. Curr. Opin. Pharmacol. 63, 102196 (2022).","journal-title":"Curr. Opin. Pharmacol."},{"key":"2292_CR11","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.neuron.2007.05.010","volume":"54","author":"S Szobota","year":"2007","unstructured":"Szobota, S. et al. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron 54, 535\u2013545 (2007).","journal-title":"Neuron"},{"key":"2292_CR12","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nature08323","volume":"461","author":"C Wyart","year":"2009","unstructured":"Wyart, C. et al. Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature 461, 407\u2013410 (2009).","journal-title":"Nature"},{"key":"2292_CR13","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.neuron.2015.10.026","volume":"88","author":"WC Lin","year":"2015","unstructured":"Lin, W. C. et al. A comprehensive optogenetic pharmacology toolkit for in vivo control of GABA(A) receptors and synaptic inhibition. Neuron 88, 879\u2013891 (2015).","journal-title":"Neuron"},{"key":"2292_CR14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.coph.2014.10.011","volume":"20","author":"F Gardoni","year":"2015","unstructured":"Gardoni, F. & Di Luca, M. Targeting glutamatergic synapses in Parkinson\u2019s disease. Curr. Opin. Pharmacol. 20, 24\u201328 (2015).","journal-title":"Curr. Opin. Pharmacol."},{"key":"2292_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41586-021-04220-9","volume":"601","author":"AA Sadybekov","year":"2022","unstructured":"Sadybekov, A. A. et al. Synthon-based ligand discovery in virtual libraries of over 11 billion compounds. Nature 601, 452\u2013459 (2022).","journal-title":"Nature"},{"key":"2292_CR16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1021\/cb800025k","volume":"3","author":"GV Los","year":"2008","unstructured":"Los, G. V. et al. HaloTag: a novel protein labeling technology for cell imaging and protein analysis. ACS Chem. Biol. 3, 373\u2013382 (2008).","journal-title":"ACS Chem. Biol."},{"key":"2292_CR17","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1021\/cb400569k","volume":"8","author":"TK Neklesa","year":"2013","unstructured":"Neklesa, T. K. et al. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. ACS Chem. Biol. 8, 2293\u20132300 (2013).","journal-title":"ACS Chem. Biol."},{"key":"2292_CR18","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4","volume":"41","author":"VV Rostovtsev","year":"2002","unstructured":"Rostovtsev, V. V., Green, L. G., Fokin, V. V. & Sharpless, K. B. A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective \u2018ligation\u2019 of azides and terminal alkynes. Angew. Chem. Int. Ed. Engl. 41, 2596\u20132599 (2002).","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"2292_CR19","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1113\/jphysiol.1969.sp008820","volume":"202","author":"D Marr","year":"1969","unstructured":"Marr, D. A theory of cerebellar cortex. J. Physiol. 202, 437\u2013470 (1969).","journal-title":"J. Physiol."},{"key":"2292_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0025-5564(71)90051-4","volume":"10","author":"JS Albus","year":"1971","unstructured":"Albus, J. S. A theory of cerebellar function. Math. Biosci. 10, 25\u201361 (1971).","journal-title":"Math. Biosci."},{"key":"2292_CR21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/BF00235211","volume":"1","author":"JC Eccles","year":"1966","unstructured":"Eccles, J. C., Llinas, R. & Sasaki, K. The mossy fibre-granule cell relay of the cerebellum and its inhibitory control by Golgi cells. Exp. Brain Res. 1, 82\u2013101 (1966).","journal-title":"Exp. Brain Res."},{"key":"2292_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/gene.10204","volume":"36","author":"MI Aller","year":"2003","unstructured":"Aller, M. I. et al. Cerebellar granule cell Cre recombinase expression. Genesis 36, 97\u2013103 (2003).","journal-title":"Genesis"},{"key":"2292_CR23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1113\/jphysiol.1996.sp021806","volume":"497","author":"SG Brickley","year":"1996","unstructured":"Brickley, S. G., Cull-Candy, S. G. & Farrant, M. Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J. Physiol. 497, 753\u2013759 (1996).","journal-title":"J. Physiol."},{"key":"2292_CR24","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature12354","volume":"499","author":"TW Chen","year":"2013","unstructured":"Chen, T. W. et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 499, 295\u2013300 (2013).","journal-title":"Nature"},{"key":"2292_CR25","doi-asserted-by":"publisher","first-page":"11132","DOI":"10.1523\/JNEUROSCI.0460-12.2012","volume":"32","author":"I Duguid","year":"2012","unstructured":"Duguid, I., Branco, T., London, M., Chadderton, P. & Hausser, M. Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex. J. Neurosci. 32, 11132\u201311143 (2012).","journal-title":"J. Neurosci."},{"key":"2292_CR26","doi-asserted-by":"crossref","unstructured":"Fleming, E. A., Field, G. D., Tadross, M. R. & Hull, C. Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations. Nat. Neurosci. 27, 689\u2013701 (2024).","DOI":"10.1038\/s41593-023-01565-4"},{"key":"2292_CR27","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1021\/acs.biochem.1c00258","volume":"60","author":"J Wilhelm","year":"2021","unstructured":"Wilhelm, J. et al. Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry 60, 2560\u20132575 (2021).","journal-title":"Biochemistry"},{"key":"2292_CR28","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2. Sci. Transl. Med. 4, 147ra111 (2012).","journal-title":"Sci. Transl. Med."},{"key":"2292_CR29","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.neuron.2017.08.014","volume":"95","author":"H Adesnik","year":"2017","unstructured":"Adesnik, H. Synaptic mechanisms of feature coding in the visual cortex of awake mice. Neuron 95, 1147\u20131159 e1144 (2017).","journal-title":"Neuron"},{"key":"2292_CR30","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nature11312","volume":"488","author":"SH Lee","year":"2012","unstructured":"Lee, S. H. et al. Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature 488, 379\u2013383 (2012).","journal-title":"Nature"},{"key":"2292_CR31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/s41586-018-0832-5","volume":"565","author":"S Masiulis","year":"2019","unstructured":"Masiulis, S. et al. GABAA receptor signalling mechanisms revealed by structural pharmacology. Nature 565, 454\u2013459 (2019).","journal-title":"Nature"},{"key":"2292_CR32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/417245a","volume":"417","author":"Y Sun","year":"2002","unstructured":"Sun, Y. et al. Mechanism of glutamate receptor desensitization. Nature 417, 245\u2013253 (2002).","journal-title":"Nature"},{"key":"2292_CR33","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1124\/mol.110.070243","volume":"80","author":"DE Timm","year":"2011","unstructured":"Timm, D. E., Benveniste, M., Weeks, A. M., Nisenbaum, E. S. & Partin, K. M. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol. Pharmacol. 80, 267\u2013280 (2011).","journal-title":"Mol. Pharmacol."},{"key":"2292_CR34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev.neuro.23.1.249","volume":"23","author":"RH Masland","year":"2000","unstructured":"Masland, R. H. & Raviola, E. Confronting complexity: strategies for understanding the microcircuitry of the retina. Annu. Rev. Neurosci. 23, 249\u2013284 (2000).","journal-title":"Annu. Rev. Neurosci."},{"key":"2292_CR35","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/0024-3205(79)90402-8","volume":"25","author":"J Arnt","year":"1979","unstructured":"Arnt, J. & Scheel-Kruger, J. GABA in the ventral tegmental area: differential regional effects on locomotion, aggression and food intake after microinjection of GABA agonists and antagonists. Life Sci. 25, 1351\u20131360 (1979).","journal-title":"Life Sci."},{"key":"2292_CR36","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0028-3908(79)90067-4","volume":"18","author":"T Tanner","year":"1979","unstructured":"Tanner, T. GABA-induced locomotor activity in the rat, after bilateral injection into the ventral tegmental area. Neuropharmacology 18, 441\u2013446 (1979).","journal-title":"Neuropharmacology"},{"key":"2292_CR37","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/nature11740","volume":"493","author":"KM Tye","year":"2013","unstructured":"Tye, K. M. et al. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493, 537\u2013541 (2013).","journal-title":"Nature"},{"key":"2292_CR38","doi-asserted-by":"publisher","first-page":"109684","DOI":"10.1016\/j.celrep.2021.109684","volume":"36","author":"W-X Pan","year":"2021","unstructured":"Pan, W.-X., Coddington, L. T. & Dudman, J. T. Dissociable contributions of phasic dopamine activity to reward and prediction. Cell Rep. 36, 109684 (2021).","journal-title":"Cell Rep."},{"key":"2292_CR39","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41593-022-01021-9","volume":"25","author":"SS Bolkan","year":"2022","unstructured":"Bolkan, S. S. et al. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state. Nat. Neurosci. 25, 345\u2013357 (2022).","journal-title":"Nat. Neurosci."},{"key":"2292_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroscience.2011.08.023","volume":"198","author":"H Morikawa","year":"2011","unstructured":"Morikawa, H. & Paladini, C. A. Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience 198, 95\u2013111 (2011).","journal-title":"Neuroscience"},{"key":"2292_CR41","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s40259-017-0248-z","volume":"31","author":"WM Pardridge","year":"2017","unstructured":"Pardridge, W. M. Delivery of biologics across the blood-brain barrier with molecular Trojan Horse technology. BioDrugs 31, 503\u2013519 (2017).","journal-title":"BioDrugs"},{"key":"2292_CR42","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.neuron.2019.10.036","volume":"105","author":"A Acosta-Ruiz","year":"2020","unstructured":"Acosta-Ruiz, A. et al. Branched photoswitchable tethered ligands enable ultra-efficient optical control and detection of G protein-coupled receptors in vivo. Neuron 105, 446\u2013463 e413 (2020).","journal-title":"Neuron"},{"key":"2292_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25003-w","volume":"12","author":"P Donthamsetti","year":"2021","unstructured":"Donthamsetti, P. et al. Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors. Nat. Commun. 12, 4775 (2021).","journal-title":"Nat. Commun."},{"key":"2292_CR44","doi-asserted-by":"publisher","first-page":"11522","DOI":"10.1021\/jacs.9b02895","volume":"141","author":"PC Donthamsetti","year":"2019","unstructured":"Donthamsetti, P. C. et al. Genetically targeted optical control of an endogenous G protein-coupled receptor. J. Am. Chem. Soc. 141, 11522\u201311530 (2019).","journal-title":"J. Am. Chem. Soc."},{"key":"2292_CR45","doi-asserted-by":"publisher","unstructured":"Veres, J. M., Nagy, G. A. & Hajos, N. Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks. eLife https:\/\/doi.org\/10.7554\/eLife.20721 (2017).","DOI":"10.7554\/eLife.20721"},{"key":"2292_CR46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nmeth.1784","volume":"9","author":"J Kim","year":"2012","unstructured":"Kim, J. et al. mGRASP enables mapping mammalian synaptic connectivity with light microscopy. Nat. Methods 9, 96\u2013102 (2012).","journal-title":"Nat. Methods"},{"key":"2292_CR47","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cell.2010.02.037","volume":"141","author":"V Gradinaru","year":"2010","unstructured":"Gradinaru, V. et al. Molecular and cellular approaches for diversifying and extending optogenetics. Cell 141, 154\u2013165 (2010).","journal-title":"Cell"},{"key":"2292_CR48","doi-asserted-by":"publisher","first-page":"e38173","DOI":"10.7554\/eLife.38173","volume":"8","author":"A Giovannucci","year":"2019","unstructured":"Giovannucci, A. et al. CaImAn: an open source tool for scalable calcium imaging data analysis. eLife 8, e38173 (2019).","journal-title":"eLife"},{"key":"2292_CR49","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/jn.00758.2019","volume":"124","author":"M Jin","year":"2020","unstructured":"Jin, M. & Glickfeld, L. L. Magnitude, time course, and specificity of rapid adaptation across mouse visual areas. J. Neurophysiol. 124, 245\u2013258 (2020).","journal-title":"J. Neurophysiol."}],"container-title":["Nature Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41592-024-02292-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41592-024-02292-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41592-024-02292-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T23:03:44Z","timestamp":1720739024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41592-024-02292-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["2292"],"URL":"https:\/\/doi.org\/10.1038\/s41592-024-02292-9","relation":{},"ISSN":["1548-7091","1548-7105"],"issn-type":[{"value":"1548-7091","type":"print"},{"value":"1548-7105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"30 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.R.T., B.C.S., A.B.R., M.H.L. and M.E.M. are on patent applications describing HTL.2 and its applications. A.B.R., M.H.L. and M.E.M. are employees of Fox Chase Chemical Diversity Center. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}