{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:57:46Z","timestamp":1793314666668,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1038\/s41593-017-0010-3","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T10:25:52Z","timestamp":1510223152000},"page":"1752-1760","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":977,"title":["Social stress induces neurovascular pathology promoting depression"],"prefix":"10.1038","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-7378","authenticated-orcid":false,"given":"Caroline","family":"Menard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline L.","family":"Pfau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia E.","family":"Hodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Kana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"Flanigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Aleyasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine B.","family":"LeClair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Labont\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Parise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-9287","authenticated-orcid":false,"given":"Zachary S.","family":"Lorsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-2272","authenticated-orcid":false,"given":"Sam A.","family":"Golden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Heshmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Tamminga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A.","family":"Fayad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk Ying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Merad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-1805","authenticated-orcid":false,"given":"Scott J.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"10_CR1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/npp.2016.90","volume":"42","author":"C M\u00e9nard","year":"2017","unstructured":"M\u00e9nard, C., Pfau, M. L., Hodes, G. E. & Russo, S. J. Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology 42, 62\u201380 (2017).","journal-title":"Neuropsychopharmacology"},{"key":"10_CR2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler, R. C., Chiu, W. T., Demler, O., Merikangas, K. R. & Walters, E. E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey replication. Arch. Gen. Psychiatry 62, 617\u2013627 (2005).","journal-title":"Arch. Gen. Psychiatry"},{"key":"10_CR3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/nyas.12738","volume":"1345","author":"F Seligman","year":"2015","unstructured":"Seligman, F. & Nemeroff, C. B. The interface of depression and cardiovascular disease: therapeutic implications. Ann. NY Acad. Sci. 1345, 25\u201335 (2015).","journal-title":"Ann. NY Acad. Sci."},{"key":"10_CR4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrcardio.2016.181","volume":"14","author":"RM Carney","year":"2017","unstructured":"Carney, R. M. & Freedland, K. E. Depression and coronary heart disease. Nat. Rev. Cardiol. 14, 145\u2013155 (2017).","journal-title":"Nat. Rev. Cardiol."},{"key":"10_CR5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/1570159X11666131120224413","volume":"12","author":"SK Wood","year":"2014","unstructured":"Wood, S. K. Individual differences in the neurobiology of social stress: implications for depression-cardiovascular disease comorbidity. Curr. Neuropharmacol. 12, 205\u2013211 (2014).","journal-title":"Curr. Neuropharmacol."},{"key":"10_CR6","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/695925","volume":"2013","author":"JC Huffman","year":"2013","unstructured":"Huffman, J. C., Celano, C. M., Beach, S. R., Motiwala, S. R. & Januzzi, J. L. Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. Cardiovasc. Psychiatry Neurol. 2013, 695925 (2013).","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"10_CR7","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nn.4113","volume":"18","author":"GE Hodes","year":"2015","unstructured":"Hodes, G. E., Kana, V., Menard, C., Merad, M. & Russo, S. J. Neuroimmune mechanisms of depression. Nat. Neurosci. 18, 1386\u20131393 (2015).","journal-title":"Nat. Neurosci."},{"key":"10_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/npp.2016.169","volume":"42","author":"J Barnes","year":"2017","unstructured":"Barnes, J., Mondelli, V. & Pariante, C. M. Genetic contributions of inflammation to depression. Neuropsychopharmacology 42, 81\u201398 (2017).","journal-title":"Neuropsychopharmacology"},{"key":"10_CR9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.iac.2009.02.002","volume":"29","author":"R Dantzer","year":"2009","unstructured":"Dantzer, R. Cytokine, sickness behavior, and depression. Immunol. Allergy Clin. North Am. 29, 247\u2013264 (2009).","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10_CR10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","volume":"16","author":"AH Miller","year":"2016","unstructured":"Miller, A. H. & Raison, C. L. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat. Rev. Immunol. 16, 22\u201334 (2016).","journal-title":"Nat. Rev. Immunol."},{"key":"10_CR11","doi-asserted-by":"crossref","first-page":"16136","DOI":"10.1073\/pnas.1415191111","volume":"111","author":"GE Hodes","year":"2014","unstructured":"Hodes, G. E. et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc. Natl. Acad. Sci. USA 111, 16136\u201316141 (2014).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10_CR12","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1073\/pnas.1310655110","volume":"110","author":"ND Powell","year":"2013","unstructured":"Powell, N. D. et al. Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via \u03b2-adrenergic induction of myelopoiesis. Proc. Natl. Acad. Sci. USA 110, 16574\u201316579 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10_CR13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","volume":"20","author":"T Heidt","year":"2014","unstructured":"Heidt, T. et al. Chronic variable stress activates hematopoietic stem cells. Nat. Med. 20, 754\u2013758 (2014).","journal-title":"Nat. Med."},{"key":"10_CR14","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1523\/JNEUROSCI.1671-13.2013","volume":"33","author":"ES Wohleb","year":"2013","unstructured":"Wohleb, E. S., Powell, N. D., Godbout, J. P. & Sheridan, J. F. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 33, 13820\u201313833 (2013).","journal-title":"J. Neurosci."},{"key":"10_CR15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/npp.2016.102","volume":"42","author":"MD Weber","year":"2017","unstructured":"Weber, M. D., Godbout, J. P. & Sheridan, J. F. Repeated social defeat, neuroinflammation, and behavior: monocytes carry the signal. Neuropsychopharmacology 42, 46\u201361 (2017).","journal-title":"Neuropsychopharmacology"},{"key":"10_CR16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(00)03026-2","volume":"888","author":"P Esposito","year":"2001","unstructured":"Esposito, P. et al. Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells. Brain Res. 888, 117\u2013127 (2001).","journal-title":"Brain Res."},{"key":"10_CR17","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2015.00088","volume":"8","author":"P S\u00e1ntha","year":"2016","unstructured":"S\u00e1ntha, P. et al. Restraint stress-induced morphological changes at the blood-brain barrier in adult rats. Front. Mol. Neurosci. 8, 88 (2016).","journal-title":"Front. Mol. Neurosci."},{"key":"10_CR18","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/nm1296-1382","volume":"2","author":"A Friedman","year":"1996","unstructured":"Friedman, A. et al. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nat. Med. 2, 1382\u20131385 (1996).","journal-title":"Nat. Med."},{"key":"10_CR19","first-page":"111","volume":"25","author":"HS Sharma","year":"1981","unstructured":"Sharma, H. S. & Dey, P. K. Impairment of blood-brain barrier (BBB) in rat by immobilization stress: role of serotonin (5-HT). Indian J. Physiol. Pharmacol. 25, 111\u2013122 (1981).","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"10_CR20","first-page":"1183","volume":"19","author":"F Niklasson","year":"1984","unstructured":"Niklasson, F. & Agren, H. Brain energy metabolism and blood-brain barrier permeability in depressive patients: analyses of creatine, creatinine, urate, and albumin in CSF and blood. Biol. Psychiatry 19, 1183\u20131206 (1984).","journal-title":"Biol. Psychiatry"},{"key":"10_CR21","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1177\/0271678X16647739","volume":"36","author":"M Roszkowski","year":"2016","unstructured":"Roszkowski, M. & Bohacek, J. Stress does not increase blood-brain barrier permeability in mice. J. Cereb. Blood Flow Metab. 36, 1304\u20131315 (2016).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10_CR22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/physrev.00019.2012","volume":"93","author":"D G\u00fcnzel","year":"2013","unstructured":"G\u00fcnzel, D. & Yu, A. S. Claudins and the modulation of tight junction permeability. Physiol. Rev. 93, 525\u2013569 (2013).","journal-title":"Physiol. Rev."},{"key":"10_CR23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.200302070","volume":"161","author":"T Nitta","year":"2003","unstructured":"Nitta, T. et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol. 161, 653\u2013660 (2003).","journal-title":"J. Cell Biol."},{"key":"10_CR24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.eurpsy.2010.11.006","volume":"26","author":"H Meltzer","year":"2011","unstructured":"Meltzer, H., Vostanis, P., Ford, T., Bebbington, P. & Dennis, M. S. Victims of bullying in childhood and suicide attempts in adulthood. Eur. Psychiatry 26, 498\u2013503 (2011).","journal-title":"Eur. Psychiatry"},{"key":"10_CR25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","volume":"7","author":"O Berton","year":"2006","unstructured":"Berton, O. & Nestler, E. J. New approaches to antidepressant drug discovery: beyond monoamines. Nat. Rev. Neurosci. 7, 137\u2013151 (2006).","journal-title":"Nat. Rev. Neurosci."},{"key":"10_CR26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.05.053","volume":"321","author":"C M\u00e9nard","year":"2016","unstructured":"M\u00e9nard, C., Hodes, G. E. & Russo, S. J. Pathogenesis of depression: Insights from human and rodent studies. Neuroscience 321, 138\u2013162 (2016).","journal-title":"Neuroscience"},{"key":"10_CR27","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/nprot.2011.361","volume":"6","author":"SA Golden","year":"2011","unstructured":"Golden, S. A., Covington, H. E. III, Berton, O. & Russo, S. J. A standardized protocol for repeated social defeat stress in mice. Nat. Protoc. 6, 1183\u20131191 (2011).","journal-title":"Nat. Protoc."},{"key":"10_CR28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrn3381","volume":"14","author":"SJ Russo","year":"2013","unstructured":"Russo, S. J. & Nestler, E. J. The brain reward circuitry in mood disorders. Nat. Rev. Neurosci. 14, 609\u2013625 (2013).","journal-title":"Nat. Rev. Neurosci."},{"key":"10_CR29","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang, Y. et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34, 11929\u201311947 (2014).","journal-title":"J. Neurosci."},{"key":"10_CR30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","volume":"89","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y. et al. Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron 89, 37\u201353 (2016).","journal-title":"Neuron"},{"key":"10_CR31","doi-asserted-by":"crossref","first-page":"16362","DOI":"10.1523\/JNEUROSCI.1392-15.2015","volume":"35","author":"GE Hodes","year":"2015","unstructured":"Hodes, G. E. et al. Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress. J. Neurosci. 35, 16362\u201316376 (2015).","journal-title":"J. Neurosci."},{"key":"10_CR32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nm.3090","volume":"19","author":"SA Golden","year":"2013","unstructured":"Golden, S. A. et al. Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nat. Med. 19, 337\u2013344 (2013).","journal-title":"Nat. Med."},{"key":"10_CR33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/emmm.201100126","volume":"3","author":"M Campbell","year":"2011","unstructured":"Campbell, M. et al. Systemic low-molecular weight drug delivery to pre-selected neuronal regions. EMBO Mol. Med. 3, 235\u2013245 (2011).","journal-title":"EMBO Mol. Med."},{"key":"10_CR34","doi-asserted-by":"crossref","unstructured":"McKim, D.B. et al. Microglial recruitment of IL-1\u03b2-producing monocytes to brain endothelium causes stress-induced anxiety. Mol. Psychiatry \n                        https:\/\/doi.org\/10.1038\/mp.2017.64\n                        \n                     (2017).","DOI":"10.1038\/mp.2017.64"},{"key":"10_CR35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013693","volume":"5","author":"N Saederup","year":"2010","unstructured":"Saederup, N. et al. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5, e13693 (2010).","journal-title":"PLoS One"},{"key":"10_CR36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4049\/jimmunol.1100421","volume":"188","author":"M Mizutani","year":"2012","unstructured":"Mizutani, M. et al. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J. Immunol. 188, 29\u201336 (2012).","journal-title":"J. Immunol."},{"key":"10_CR37","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nri3671","volume":"14","author":"F Ginhoux","year":"2014","unstructured":"Ginhoux, F. & Jung, S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat. Rev. Immunol. 14, 392\u2013404 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"10_CR38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/cyto.1997.0238","volume":"9","author":"M Maes","year":"1997","unstructured":"Maes, M. et al. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine 9, 853\u2013858 (1997).","journal-title":"Cytokine"},{"key":"10_CR39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","volume":"67","author":"Y Dowlati","year":"2010","unstructured":"Dowlati, Y. et al. A meta-analysis of cytokines in major depression. Biol. Psychiatry 67, 446\u2013457 (2010).","journal-title":"Biol. Psychiatry"},{"key":"10_CR40","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.31","volume":"7","author":"DD Kiraly","year":"2017","unstructured":"Kiraly, D. D. et al. Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome. Transl. Psychiatry 7, e1065 (2017).","journal-title":"Transl. Psychiatry"},{"key":"10_CR41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/jnnp.23.2.156","volume":"23","author":"AJ Coppen","year":"1960","unstructured":"Coppen, A. J. Abnormality of the blood-cerebrospinal fluid barrier of patients suffering from a depressive illness. J. Neurol. Neurosurg. Psychiatry 23, 156\u2013161 (1960).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10_CR42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nn.4185","volume":"19","author":"D Hambardzumyan","year":"2016","unstructured":"Hambardzumyan, D., Gutmann, D. H. & Kettenmann, H. The role of microglia and macrophages in glioma maintenance and progression. Nat. Neurosci. 19, 20\u201327 (2016).","journal-title":"Nat. Neurosci."},{"key":"10_CR43","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nm.1999","volume":"15","author":"T Shichita","year":"2009","unstructured":"Shichita, T. et al. Pivotal role of cerebral interleukin-17-producing \u03b3\u03b4T cells in the delayed phase of ischemic brain injury. Nat. Med. 15, 946\u2013950 (2009).","journal-title":"Nat. Med."},{"key":"10_CR44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature18601","volume":"534","author":"SA Golden","year":"2016","unstructured":"Golden, S. A. et al. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature 534, 688\u2013692 (2016).","journal-title":"Nature"},{"key":"10_CR45","volume":"6","author":"V Mishra","year":"2016","unstructured":"Mishra, V. et al. Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: experimental rat injury model. Sci. Rep. 6, 26992 (2016).","journal-title":"Sci. Rep."},{"key":"10_CR46","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500472","volume":"1","author":"J Keaney","year":"2015","unstructured":"Keaney, J. et al. Autoregulated paracellular clearance of amyloid-\u03b2 across the blood-brain barrier. Sci. Adv. 1, e1500472 (2015).","journal-title":"Sci. Adv."},{"key":"10_CR47","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/jgm.1211","volume":"10","author":"M Campbell","year":"2008","unstructured":"Campbell, M. et al. RNAi-mediated reversible opening of the blood-brain barrier. J. Gene Med. 10, 930\u2013947 (2008).","journal-title":"J. Gene Med."},{"key":"10_CR48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007616","volume":"6","author":"SL Doyle","year":"2014","unstructured":"Doyle, S. L. et al. IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration. Sci. Transl. Med. 6, 230ra44 (2014).","journal-title":"Sci. Transl. Med."},{"key":"10_CR49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nprot.2015.002","volume":"10","author":"T W\u00e4lchli","year":"2015","unstructured":"W\u00e4lchli, T. et al. Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain. Nat. Protoc. 10, 53\u201374 (2015).","journal-title":"Nat. Protoc."},{"key":"10_CR50","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.immuni.2016.04.005","volume":"44","author":"T Blank","year":"2016","unstructured":"Blank, T. et al. Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment. Immunity 44, 901\u2013912 (2016).","journal-title":"Immunity"},{"key":"10_CR51","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.expneurol.2004.08.020","volume":"191 (Suppl. 1)","author":"WG Janssen","year":"2005","unstructured":"Janssen, W. G. et al. Cellular and synaptic distribution of NR2A and NR2B in macaque monkey and rat hippocampus as visualized with subunit-specific monoclonal antibodies. Exp. Neurol. 191 (Suppl. 1), S28\u2013S44 (2005).","journal-title":"Exp. Neurol."},{"key":"10_CR52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","volume":"468","author":"A Armulik","year":"2010","unstructured":"Armulik, A. et al. Pericytes regulate the blood-brain barrier. Nature 468, 557\u2013561 (2010).","journal-title":"Nature"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41593-017-0010-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41593-017-0010-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41593-017-0010-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T18:15:08Z","timestamp":1684606508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41593-017-0010-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,13]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10"],"URL":"https:\/\/doi.org\/10.1038\/s41593-017-0010-3","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732106336.793566807","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,13]]}}}